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The aim of this study was to evaluate the early-stage outcomes of ACXF in treating two-level cervical spondylosis (CS) through comparisons with ACCF.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A retrospectively comparative study was conducted in two cohorts of patients who underwent single-vertebral ACXF or ACCF to treat two-level CS during September 2019 and October 2021. Clinical and radiological data of all the patients were collected from pre-operation to 1\u00a0year after the surgery, following by intra- and intergroup analyses and comparisons.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Fifty-seven patients were included, with 24 undergoing ACXF and 33 undergoing ACCF. ACXF group had significantly shorter drainage duration (2.13\u2009\u00b1\u20090.61 days vs. 3.48\u2009\u00b1\u20091.30 days, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and less drainage volume (30.21\u2009\u00b1\u200926.88 ml vs. 69.30\u2009\u00b1\u200937.65 ml, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) than ACCF group. Both techniques significantly improved all the clinical parameters\u00a0(<jats:italic>P<\/jats:italic> &lt; 0.01) with comparable effects (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Each complication rate in ACXF group was lower than that in ACCF group without significant difference (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). ACXF showed a significantly smaller transverse decompression range than ACCF (11.93\u2009\u00b1\u20091.27\u00a0mm vs. 16.29\u2009\u00b1\u20091.88\u00a0mm, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Postoperatively, ACXF yielded a comparable fusion rate (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05) and a significantly lower subsidence rate (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) than ACCF technique at all time points.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>ACXF is a potential surgical alternative for certain patients with two-level CS, as it provides both adequate decompression range and fewer adverse events than ACCF. The further modifications on ACXF worth exploration.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00586-023-07986-w","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T11:01:50Z","timestamp":1698663710000},"page":"205-215","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anterior cervical X-shape-corpectomy and fusion vs. anterior cervical corpectomy and fusion for two-level cervical spondylosis"],"prefix":"10.1007","volume":"33","author":[{"given":"Hong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingkui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junbo","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangkang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Rong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beiyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5330-4193","authenticated-orcid":false,"given":"Hao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,10,30]]},"reference":[{"key":"7986_CR1","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1097\/BSD.0000000000001410","volume":"35","author":"PK Louie","year":"2022","unstructured":"Louie PK, Nemani VM, Leveque J-CA (2022) Anterior cervical corpectomy and fusion for degenerative cervical spondylotic myelopathy: case presentation with surgical technique demonstration and review of literature. 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