{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:46:18Z","timestamp":1789757178304,"version":"4.0.1"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005727","name":"Universidade de Coimbra","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005727","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Spine J"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Cervical total disc arthroplasty (TDA) is a motion-preserving alternative to anterior cervical discectomy and fusion that has gained popularity among spine surgeons. Although generally effective, TDA has been associated with rare cases of progressive osteolysis, a complication whose natural history and impact on clinical outcomes are not well understood. This case report aims to present a case of progressive osteolysis following cervical TDA with the SpinalKinetics<jats:sup>\u00ae<\/jats:sup> M6-C Artificial Cervical Disc and to discuss the clinical approach and implications for patient management.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We reviewed the clinical course of a patient who underwent cervical TDA with the SpinalKinetics<jats:sup>\u00ae<\/jats:sup> M6-C Artificial Cervical Disc and subsequently developed progressive osteolysis. The patient\u2019s symptoms, diagnostic findings, and treatment progression were documented, with a focus on the timing of symptom onset, imaging, and the therapeutic interventions applied.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The patient demonstrated a delayed onset of symptoms related to osteolysis, which was identified through CT imaging as a progressive complication. The slow progression of osteolysis in this case underscores the need for careful monitoring, as early symptoms may be subtle but can lead to significant clinical implications if unaddressed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This case highlights the potential for progressive osteolysis as a complication following cervical TDA, emphasizing the importance of ongoing surveillance and increased awareness among spine surgeons. Early identification and monitoring of osteolysis may mitigate the risk of severe outcomes and guide timely intervention.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00586-024-08585-z","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T16:03:54Z","timestamp":1733241834000},"page":"64-68","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Osteolysis after cervical disc arthroplasty with artificial cervical disc"],"prefix":"10.1007","volume":"34","author":[{"given":"Joana Margarida","family":"Silva Tavares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Maria","family":"J\u00e1come Morgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Seromenho Santos Nora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Isabel","family":"Lopes Lu\u00eds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"8585_CR1","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.wneu.2018.11.070","volume":"122","author":"E Cedric Baltus","year":"2019","unstructured":"Cedric Baltus E, Costa G, Vaz, Raftopoulos C (2019) Granulomatous reaction on a double-level cervical total disc arthroplasty. World Neurosurg 122:360\u2013363","journal-title":"World Neurosurg"},{"key":"8585_CR2","doi-asserted-by":"crossref","unstructured":"Nicholas J, Clark EL, Francois, Brett A, Freedman (2020) and Bradford Currier. Early Implant Failure of a 2-Level M6-Cervical Total Disc Replacement: A Case Report. JBJS Case Connector 10, 3: e19.00644-e19.00644","DOI":"10.2106\/JBJS.CC.19.00644"},{"key":"8585_CR3","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1007\/s00586-021-07092-9","volume":"31","author":"M Jenna","year":"2022","unstructured":"Jenna M, Wahbeh S-H, Park P, Campbell E, Ebramzadeh, Sophia N, Sangiorgio (2022) The lexicon for periprosthetic bone loss versus osteolysis after cervical disc arthroplasty: a systematic review. Eur Spine J 31:4: 830\u2013842","journal-title":"Eur Spine J"},{"key":"8585_CR4","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1007\/s00586-021-07094-7","volume":"31","author":"MS-YE Rathbone","year":"2022","unstructured":"Rathbone MS-YE, Grierson L (2022) Midterm osteolysis-induced aseptic failure of the M6-C\u2122 cervical total disc replacement secondary to polyethylene wear debris. Eur Spine J 31:5: 1273\u20131282","journal-title":"Eur Spine J"},{"key":"8585_CR5","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3349\/ymj.2022.63.1.72","volume":"63","author":"JJ Shin","year":"2022","unstructured":"Shin JJ, Kim K-R, Son DW et al (2022) Radiological changes in adjacent and index levels after cervical disc arthroplasty. Yonsei Med J 63:1: 72","journal-title":"Yonsei Med J"},{"key":"8585_CR6","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1055\/s-0039-1698435","volume":"81","author":"A Harati","year":"2020","unstructured":"Harati A, Oni P, Oles L, Reuter T, Hamdan M (2020) Vertebral body osteolysis 6 years after cervical disk arthroplasty. J Neurol Surg Part A: Cent Eur Neurosurg 81:02: 188\u2013192","journal-title":"J Neurol Surg Part A: Cent Eur Neurosurg"},{"key":"8585_CR7","doi-asserted-by":"publisher","first-page":"5284","DOI":"10.12998\/wjcc.v8.i21.5284","volume":"8","author":"X-F Wang","year":"2020","unstructured":"Wang X-F, Meng Y, Liu H, Ying Hong, and, Bei-Yu W (2020) Anterior bone loss after cervical disc replacement: a systematic review. World J Clin Cases 8:21: 5284\u20135295","journal-title":"World J Clin Cases"}],"container-title":["European Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-024-08585-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00586-024-08585-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-024-08585-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T17:39:49Z","timestamp":1737567589000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00586-024-08585-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,3]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["8585"],"URL":"https:\/\/doi.org\/10.1007\/s00586-024-08585-z","relation":{},"ISSN":["0940-6719","1432-0932"],"issn-type":[{"value":"0940-6719","type":"print"},{"value":"1432-0932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,3]]},"assertion":[{"value":"13 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}