{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:32:19Z","timestamp":1790839939472,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Spine J"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>The purpose of this study was to investigate the association between antidepressant use and inpatient physical therapy performance, as well as discharge disposition after surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Patients undergoing primary 1\u20133 level lumbar fusion at a single, tertiary care institution from 2017 to 2021 were retrospectively identified. Patient characteristics, surgical details, and surgical outcomes were collected via chart review. Medications were collected based on active medication lists at the patient\u2019s preoperative and first postoperative appointment\u2014patients were considered to be taking antidepressants if prescriptions were active at both appointments. Inpatient physical therapy metrics including the distance walked during a single session (session distance) and Activity Measure for Post-Acute Care (AMPAC) scores were collected. Statistical analysis was performed to identify differences between the \u201cantidepressant\u201d and \u201cno antidepressant\u201d groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>493 patients (27.7%) were taking antidepressants perioperatively. Patients in the antidepressant group were more likely to be female (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), current smokers (<jats:italic>p<\/jats:italic>\u2009=\u20090.012), and have a higher Elixhauser comorbidity index (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). On regression analysis, the antidepressant group was associated with discharge to inpatient rehabilitation after surgery (<jats:italic>p<\/jats:italic>\u2009=\u20090.026). Age (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), length of stay (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), 1st PT session distance walked (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and improvement in gait distance (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were associated with non-home discharge.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Antidepressant use was independently associated with discharge to a rehabilitation facility. These patients were still discharged to these facilities without performing significantly worse in their inpatient physical therapy sessions. These findings suggest that psychosocial factors may play an important role in discharge disposition after spine surgery.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00586-025-08815-y","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T03:10:52Z","timestamp":1744773052000},"page":"2438-2444","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Patients on antidepressants are more likely to be discharged to inpatient rehabilitation after lumbar fusion"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7452-2712","authenticated-orcid":false,"given":"Jonathan","family":"Dalton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Fried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Alan","family":"McCurdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkishen","family":"Narayanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe K.","family":"Herczeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsoo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamd","family":"Mahmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Fuleihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark F.","family":"Kurd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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Herczeg, Hamd Mahmood, Marco Goldberg, Nikhil Mehta, and Antony Fuleihan have no non-financial or financial interests to declare.Yunsoo Lee is on the editorial board of the Clinical Spine Surgery journal. The author has no financial interests to declare.Mark F. Kurd is on the editorial\/governing board of the Clinical Spine Surgery journal and is a board\/committee member at the International Society for the Advancement of Spine Surgery. The author has stock or stock options in DuraStat LLC, receives IP royalties from Spinal Elements, Stryker, and the Institute for Musculoskeletal Science & Education, is a paid consultant at K2M Spine, Medtronic, and Spinal Elements, and receives research support from Innovative Surgical Designs.I. David Kaye is a paid consultant at Camber Spine and Nuvasive and has stock ownership in Atlus Spine and Happe Spine. The author has no non-financial interests to declare.Jose A. Canseco is a deputy editor at the Clinical Spine Surgery journal, is a paid consultant at Pathkeeper and Spinal Elements (Future Compensation Expected), receives research support from Ossiform, and is expecting future compensation that is paid directly to his institution\/employer from Accelus and Kuros.Alan S. Hilibrand receives royalties from CTL Amedica and ZimVie and has stock ownership in Spinal Ventures. The author has no non-financial interests to declare.Alexander R. Vaccaro is a member in good standing at AO Spine and is on the Scientific Advisory Board at Accelus, National Spine Health Foundation, and Sentryx. The author consults for Accelus, Curiteva, Ferring Pharmaceutical, Globus, Medcura, Spinal Elements, Stryker Spine, and Wheel House Medical (Future Compensation Expected). The author has private investments in the Rothman Institute and related properties and receives royalties from ATEC, Atlas Spine, Atlas Spine, Curiteva, Elsevier, Globus, Jaypee, Medtronic, Spinal Elements, Spine Wave, Stout Medical, Stryker Spine, Taylor Francis\/Hodder And Stoughton, Thieme, Wheel House Medical (Future Compensation Expected), and Wolters Kluwer. The author has stock ownership in the following companies and organizations: Accelus, Advanced Spinal Intellectual Properties, Atlas Spine, Avaz Surgical, AVKN Patient Driven Care, Cytonics, Deep Health, Dimension Orthotics LLC, Electrocore, Flagship Surgical, Flowpharma, Globus, Harvard Medtech, Innovative Surgical Design, Jushi, NuVasive, Orthobullets, Parvizi Surgical Innovation, Progressive Spinal Technologies, Rothman Institute and related properties, See All AI, Sentryx, Stout Medical, Surgalign, and Viewfi Health.Gregory D. Schroeder is a board\/\/ committee member at AO Spine and the Cervical Spine Research Society and is on the editorial\/governing board at Wolters Kluwer Health - Lippincott Williams & Wilkins. The author has ownership in the Rothman Institute, Rothman ASCs, and Harmoni Neuromonitoring and has a family member with ownership in Altus Spine. The author is a paid consultant and receives IP royalties from Camber and receives other financial or material support from AOSpine.Christopher K. Kepler is on the editorial\/governing board of the Clinical Spine Surgery journal, receives IP royalties from Inion and Curetiva, has equity in Altus, and receives research support from Regeneration Technologies Inc, NIH grants, and the Cervical Spine Research Society.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}