{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:10:17Z","timestamp":1782472217700,"version":"3.54.5"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Spine J"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s00586-025-08899-6","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T18:44:40Z","timestamp":1748976280000},"page":"3337-3344","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessing the utility of MRI\u2011based vertebral bone quality (VBQ) and CT-derived Hounsfield Units for predicting cervical screw loosening"],"prefix":"10.1007","volume":"34","author":[{"given":"Yitong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhui","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haofan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"8899_CR1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/978-3-030-12887-6_20","volume-title":"Complications in neurosurgery","author":"SC Robertson","year":"2023","unstructured":"Robertson SC, Ashley MR (2023) Complications of anterior cervical discectomy and fusion. In: Turel KE, Chernov MF, Sarkar H (eds) Complications in neurosurgery. Springer, Cham, pp 169\u2013178"},{"key":"8899_CR2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199911150-00016","author":"MM Panjabi","year":"1999","unstructured":"Panjabi MM, Wang JL (1999) Loosening at the screw-vertebra junction in multilevel anterior cervical plate constructs. Spine. https:\/\/doi.org\/10.1097\/00007632-199911150-00016","journal-title":"Spine"},{"key":"8899_CR3","doi-asserted-by":"publisher","DOI":"10.1097\/01.bsd.0000090575.08296.9d","author":"CA Reitman","year":"2004","unstructured":"Reitman CA, Nguyen L, Fogel GR (2004) Biomechanical evaluation of relationship of screw pullout strength, insertional torque, and bone mineral density in the cervical spine. J Spinal Disord Tech. https:\/\/doi.org\/10.1097\/01.bsd.0000090575.08296.9d","journal-title":"J Spinal Disord Tech"},{"key":"8899_CR4","unstructured":"Chin-Chu Ko HWT, Wen-Cheng H, Jau-Ching W, Yu-Chun C, Yang-Hsin S, Hung-Chieh C, Ching-Lan W, Henrich C (2010) <Screw loosening in the Dynesys stabilization system radiographic evidence and effect on outcomes.pdf>. Neurosurgical Focus."},{"issue":"7","key":"8899_CR5","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.spinee.2020.02.011","volume":"20","author":"SN Salzmann","year":"2020","unstructured":"Salzmann SN, Okano I, Ortiz Miller C, Chiapparelli E, Reisener M-J, Winter F et al (2020) Regional bone mineral density differences measured by quantitative computed tomography in patients undergoing anterior cervical spine surgery. Spine J 20(7):1056\u20131064","journal-title":"Spine J"},{"issue":"7","key":"8899_CR6","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.spinee.2009.05.002","volume":"9","author":"RT Allen","year":"2009","unstructured":"Allen RT, Lee Y-P, Garfin SR (2009) Spine surgeons survey on attitudes regarding osteoporosis and osteomalacia screening and treatment for fractures, fusion surgery, and pseudoarthrosis. Spine Jl 9(7):602\u2013604","journal-title":"Spine Jl"},{"issue":"1","key":"8899_CR7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.spinee.2020.05.540","volume":"21","author":"J Ehresman","year":"2021","unstructured":"Ehresman J, Schilling A, Yang X, Pennington Z, Ahmed AK, Cottrill E et al (2021) Vertebral bone quality score predicts fragility fractures independently of bone mineral density. Spine J 21(1):20\u201327","journal-title":"Spine J"},{"issue":"8","key":"8899_CR8","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/j.spinee.2022.03.006","volume":"22","author":"SN Salzmann","year":"2022","unstructured":"Salzmann SN, Okano I, Jones C, Zhu J, Lu S, Onyekwere I et al (2022) Preoperative MRI-based vertebral bone quality (VBQ) score assessment in patients undergoing lumbar spinal fusion. Spine J 22(8):1301\u20131308","journal-title":"Spine J"},{"issue":"5","key":"8899_CR9","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1007\/s00586-022-07177-z","volume":"31","author":"R Li","year":"2022","unstructured":"Li R, Yin Y, Ji W, Wu X, Jiang H, Chen J et al (2022) MRI-based vertebral bone quality score effectively reflects bone quality in patients with osteoporotic vertebral compressive fractures. Eur Spine J 31(5):1131\u20131137","journal-title":"Eur Spine J"},{"issue":"4","key":"8899_CR10","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.spinee.2019.10.018","volume":"20","author":"J Ehresman","year":"2020","unstructured":"Ehresman J, Pennington Z, Schilling A, Lubelski D, Ahmed AK, Cottrill E et al (2020) Novel MRI-based score for assessment of bone density in operative spine patients. Spine J 20(4):556\u2013562","journal-title":"Spine J"},{"issue":"1","key":"8899_CR11","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s00586-023-08034-3","volume":"33","author":"Y Gao","year":"2023","unstructured":"Gao Y, Ye W, Ge X, Wang H, Xiong J, Zhu Y et al (2023) Assessing the utility of MRI-based vertebral bone quality (VBQ) for predicting lumbar pedicle screw loosening. Eur Spine J 33(1):289\u2013297","journal-title":"Eur Spine J"},{"issue":"2","key":"8899_CR12","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.spinee.2020.08.020","volume":"21","author":"Z Pennington","year":"2021","unstructured":"Pennington Z, Ehresman J, Lubelski D, Cottrill E, Schilling A, Ahmed AK et al (2021) Assessing underlying bone quality in spine surgery patients: a narrative review of dual-energy X-ray absorptiometry (DXA) and alternatives. Spine J 21(2):321\u2013331","journal-title":"Spine J"},{"key":"8899_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-019-3036-8","author":"C Ji","year":"2020","unstructured":"Ji C, Yu S, Yan N, Wang J, Hou F, Hou T et al (2020) Risk factors for subsidence of titanium mesh cage following single-level anterior cervical corpectomy and fusion. BMC Musculoskelet Disord. https:\/\/doi.org\/10.1186\/s12891-019-3036-8","journal-title":"BMC Musculoskelet Disord"},{"issue":"16","key":"8899_CR14","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1097\/BRS.0000000000004375","volume":"47","author":"E Balouch","year":"2022","unstructured":"Balouch E, Burapachaisri A, Woo D, Norris Z, Segar A, Ayres EW et al (2022) Assessing postoperative pseudarthrosis in anterior cervical discectomy and fusion (ACDF) on dynamic radiographs using novel angular measurements. Spine 47(16):1151\u20131156","journal-title":"Spine"},{"key":"8899_CR15","first-page":"E335","volume":"24","author":"J Chengyue","year":"2021","unstructured":"Chengyue J, Yuluo R, Jiaxing W, Shunzhi Y, Guoyong Y, Jin F, Pengyu T, Dongdong J, Wei L, Fangyi G, Xuhui G, Weihua C (2021) Risk factors for refracture following primary osteoporotic vertebral compression fractures. Pain Physician 24:E335\u2013E340","journal-title":"Pain Physician"},{"issue":"2","key":"8899_CR16","doi-asserted-by":"publisher","first-page":"385","DOI":"10.4184\/asj.2016.10.2.385","volume":"10","author":"JPY Cheung","year":"2016","unstructured":"Cheung JPY, Luk KDK (2016) Complications of anterior and posterior cervical spine surgery. Asian Spine J 10(2):385","journal-title":"Asian Spine J"},{"issue":"24","key":"8899_CR17","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1001\/jama.2018.7498","volume":"319","author":"SJ Curry","year":"2018","unstructured":"Curry SJ, Krist AH, Owens DK, Barry MJ, Caughey AB, Davidson KW et al (2018) Screening for osteoporosis to prevent fractures. JAMA 319(24):2521","journal-title":"JAMA"},{"key":"8899_CR18","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-8-201304160-00003","author":"PJ Pickhardt","year":"2013","unstructured":"Pickhardt PJ, Lauder T, Mu\u00f1oz del Rio A, Bruce RJ, Binkley N (2013) Opportunistic screening for osteoporosis using abdominal computed tomography scans obtained for other indications. Ann Int Med. https:\/\/doi.org\/10.7326\/0003-4819-158-8-201304160-00003","journal-title":"Ann Int Med"},{"issue":"6","key":"8899_CR19","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.bone.2011.03.720","volume":"48","author":"Y-X He","year":"2011","unstructured":"He Y-X, Zhang G, Pan X-H, Liu Z, Zheng L-Z, Chan C-W et al (2011) Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: a drill-hole defect model. Bone 48(6):1388\u20131400","journal-title":"Bone"},{"key":"8899_CR20","doi-asserted-by":"publisher","first-page":"e830","DOI":"10.1016\/j.wneu.2022.05.058","volume":"164","author":"ZW Pinter","year":"2022","unstructured":"Pinter ZW, Monsef JB, Salmons HI, Sebastian AS, Freedman BA, Currier BL et al (2022) Does preoperative bone mineral density impact fusion success in anterior cervical spine surgery? A prospective cohort study. World Neurosurg 164:e830\u2013e834","journal-title":"World Neurosurg"},{"key":"8899_CR21","doi-asserted-by":"publisher","DOI":"10.1007\/BF01676569","author":"N Boos","year":"1997","unstructured":"Boos N (1997) Pedicle screw fixation in spinal disorders: a European view. Eur Spine J. https:\/\/doi.org\/10.1007\/BF01676569","journal-title":"Eur Spine J"},{"key":"8899_CR22","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2014.1590","author":"J Pang","year":"2014","unstructured":"Pang J, Ye M, Cao Y, Zheng Y, Guo H, Zhao Y et al (2014) Ovariectomy-induced osteopenia influences the middle and late periods of bone healing in a mouse femoral osteotomy model. Rejuven Res. https:\/\/doi.org\/10.1089\/rej.2014.1590","journal-title":"Rejuven Res"},{"key":"8899_CR23","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200104150-00021","author":"TH Lim","year":"2001","unstructured":"Lim TH, Jeon CH, Kim JG, Sokolowski M, Natarajan R, An HS, Andersson GB (2001) Effect of endplate conditions and bone mineral density on the compressive strength of the graft-endplate interface in anterior cervical spine fusion. Spine. https:\/\/doi.org\/10.1097\/00007632-200104150-00021","journal-title":"Spine"}],"container-title":["European Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-025-08899-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00586-025-08899-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-025-08899-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T17:28:58Z","timestamp":1757179738000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00586-025-08899-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,4]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["8899"],"URL":"https:\/\/doi.org\/10.1007\/s00586-025-08899-6","relation":{},"ISSN":["0940-6719","1432-0932"],"issn-type":[{"value":"0940-6719","type":"print"},{"value":"1432-0932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,4]]},"assertion":[{"value":"3 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Approved by the Hospital Ethics Committee and Internal Review Board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"MRI-based VBQ score, and CT-based HU value can be used to predict cervical screw loosening, to determine whether to use anti-osteoporosis medication before surgery. This also provides a new approach for assessing the quality of cervical bone.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical relevance"}}]}}