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This study aimed to investigate whether preoperative CS predicts postoperative outcomes in patients undergoing decompression surgery for lumbar spinal stenosis (LSS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty-six patients with LSS who underwent decompression surgery were prospectively evaluated. CS was assessed using the Central Sensitization Inventory (CSI), with a cutoff score of \u2265\u200940 defining CS. Visual analogue scale (VAS) pain, Oswestry Disability Index (ODI), Hospital Anxiety and Depression Scale (HADS), and the 12-Item Short Form Health Survey (SF-12) were recorded preoperatively and at three months. Between-group comparisons and multivariate regression analyses were performed to determine the independent effect of CS on postoperative improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with CS (54.7%) reported significantly greater baseline pain, disability, and anxiety (all\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.05). Although both groups improved postoperatively, the magnitude of improvement was smaller in CS+ patients. Between-group differences were significant for reductions in low back pain (\n                      <jats:italic>p<\/jats:italic>\n                      =0.038), leg pain (\n                      <jats:italic>p<\/jats:italic>\n                      =0.003), numbness (\n                      <jats:italic>p<\/jats:italic>\n                      =0.001), disability (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001), and physical quality of life (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001). Regression analyses found that CS independently predicted poorer improvement in disability (\u03b2 = +22.7,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001), pain (\u03b2 = +2.3,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001), and physical function (\u03b2 = \u221212.4,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001), explaining up to 42% of the variance in postoperative outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preoperative CS is independently associated with less favorable short-term postoperative recovery following lumbar decompression for LSS. Routine assessment of CS may help identify patients at risk for suboptimal outcomes and guide individualized perioperative management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00586-026-09775-7","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:37:04Z","timestamp":1771303024000},"page":"2401-2408","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Central sensitization as a predictor of short-term postoperative outcomes in lumbar spinal stenosis: a prospective observational study"],"prefix":"10.1007","volume":"35","author":[{"given":"Hani\u0307fe","family":"Baykal \u015eahi\u0307n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Aktoklu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"9775_CR1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ijsu.2020.11.014","volume":"85","author":"FL Wei","year":"2021","unstructured":"Wei FL, Zhou CP, Liu R, Zhu KL, Du MR, Gao HR et al (2021) Management for lumbar spinal stenosis: A network meta-analysis and systematic review. 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