{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:59:20Z","timestamp":1785423560638,"version":"3.56.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Spine J"],"DOI":"10.1007\/s00586-026-09933-x","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:00:39Z","timestamp":1776704439000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lower calcium\/phosphorus ratio is associated with the severity of deformity in patients with scoliosis"],"prefix":"10.1007","author":[{"given":"Ruicong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"9933_CR1","doi-asserted-by":"crossref","unstructured":"Yu P, Tang Z, Chang W, Jia L, Ma Z, Li H et al (2025) Degenerative scoliosis may trigger higher incidence of adjacent vertebral fractures following percutaneous vertebroplasty: a clinical evidence-based biomechanical research. Osteoporosis international: a journal established as result of cooperation between the. European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","DOI":"10.1007\/s00198-025-07760-2"},{"issue":"9","key":"9933_CR2","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.molmed.2023.05.012","volume":"29","author":"E Petrosyan","year":"2023","unstructured":"Petrosyan E, Fares J, Lesniak MS, Koski TR, El Tecle NE (2023) Biological principles of adult degenerative scoliosis. Trends Mol Med 29(9):740\u2013752","journal-title":"Trends Mol Med"},{"issue":"4","key":"9933_CR3","doi-asserted-by":"publisher","first-page":"e220158","DOI":"10.1148\/ryai.220158","volume":"5","author":"A Suri","year":"2023","unstructured":"Suri A, Tang S, Kargilis D, Taratuta E, Kneeland BJ, Choi G et al (2023) Conquering the Cobb Angle: A Deep Learning Algorithm for Automated, Hardware-Invariant Measurement of Cobb Angle on Radiographs in Patients with Scoliosis. Radiol Artif Intell 5(4):e220158","journal-title":"Radiol Artif Intell"},{"issue":"7","key":"9933_CR4","doi-asserted-by":"publisher","first-page":"e70298","DOI":"10.1002\/mco2.70298","volume":"6","author":"W Qin","year":"2025","unstructured":"Qin W, Yu SY, Gao JL, Yan JF, Wan QQ, Jia SL et al (2025) Phosphate in Physiological and Pathological Mineralization: Important yet Often Unheeded. MedComm 6(7):e70298","journal-title":"MedComm"},{"issue":"11","key":"9933_CR5","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1093\/jbmr\/zjaf118","volume":"40","author":"AL Bonnet","year":"2025","unstructured":"Bonnet AL, Aboishava L, Mannstadt M (2025) Advances in Parathyroid Hormone-based medicines. J bone mineral research: official J Am Soc Bone Mineral Res 40(11):1195\u20131206","journal-title":"J bone mineral research: official J Am Soc Bone Mineral Res"},{"issue":"3","key":"9933_CR6","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/s41581-022-00665-x","volume":"19","author":"R Agoro","year":"2023","unstructured":"Agoro R, White KE (2023) Regulation of FGF23 production and phosphate metabolism by bone-kidney interactions. Nat Rev Nephrol 19(3):185\u2013193","journal-title":"Nat Rev Nephrol"},{"issue":"3","key":"9933_CR7","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.kint.2022.06.017","volume":"102","author":"KM Hill Gallant","year":"2022","unstructured":"Hill Gallant KM, Zheng XY (2022) Natural stable calcium isotope ratios: a new gold standard for bone balance? Kidney Int 102(3):473\u2013476","journal-title":"Kidney Int"},{"issue":"1","key":"9933_CR8","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1681\/ASN.2021060825","volume":"33","author":"WG Goodman","year":"2022","unstructured":"Goodman WG, Ward DT, Martin KJ, Drayer D, Moore C, Xu J et al (2022) Activation of the Calcium Receptor by Calcimimetic Agents Is Preserved Despite Modest Attenuating Effects of Hyperphosphatemia. J Am Soc Nephrology: JASN 33(1):201\u2013212","journal-title":"J Am Soc Nephrology: JASN"},{"issue":"3","key":"9933_CR9","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.kint.2022.04.024","volume":"102","author":"R Shroff","year":"2022","unstructured":"Shroff R, Lalayiannis AD, Fewtrell M, Schmitt CP, Bayazit A, Askiti V et al (2022) Naturally occurring stable calcium isotope ratios are a novel biomarker of bone calcium balance in chronic kidney disease. Kidney Int 102(3):613\u2013623","journal-title":"Kidney Int"},{"issue":"4","key":"9933_CR10","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1002\/jbmr.4778","volume":"38","author":"H Hariri","year":"2023","unstructured":"Hariri H, Kose O, Bezdjian A, Daniel SJ, St-Arnaud R (2023) USP53 Regulates Bone Homeostasis by Controlling Rankl Expression in Osteoblasts and Bone Marrow Adipocytes. J bone mineral research: official J Am Soc Bone Mineral Res 38(4):578\u2013596","journal-title":"J bone mineral research: official J Am Soc Bone Mineral Res"},{"issue":"11","key":"9933_CR11","doi-asserted-by":"publisher","first-page":"e3818","DOI":"10.1210\/clinem\/dgaf120","volume":"110","author":"A Uehara","year":"2025","unstructured":"Uehara A, Mok Y, Matsushita K, Lutsey PL, Ishigami J, Serum Sodium (2025) Potassium, Magnesium, Calcium, and Phosphorus Levels and Risk of Fracture in the Community. J Clin Endocrinol Metab 110(11):e3818\u2013e26","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"9933_CR12","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1093\/jbmr\/zjaf003","volume":"40","author":"R Eastell","year":"2025","unstructured":"Eastell R, Brown JP, Adler RA, Lewiecki EM, Binkley N, Orwoll ES et al (2025) Bone turnover markers predict changes in bone mineral density in men treated with abaloparatide: results from the abaloparatide for the treatment of men with osteoporosis (ATOM) study. J bone mineral research: official J Am Soc Bone Mineral Res 40(3):315\u2013322","journal-title":"J bone mineral research: official J Am Soc Bone Mineral Res"},{"key":"9933_CR13","doi-asserted-by":"crossref","unstructured":"Shibata T, Takeda K, Suzuki S, Iga T, Okubo T, Ozaki M et al (2025) Lower Bone Mineral Density is Associated with Severity of Deformity in Adolescent Idiopathic Scoliosis. Spine","DOI":"10.1097\/BRS.0000000000005538"},{"key":"9933_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.trsl.2021.07.003","volume":"238","author":"C Zechner","year":"2021","unstructured":"Zechner C, Adams-Huet B, Gregory B, Neyra JA, Rule JA, Li X et al (2021) Hypophosphatemia in acute liver failure of a broad range of etiologies is associated with phosphaturia without kidney damage or phosphatonin elevation. Translational research: J Lab Clin Med 238:1\u201311","journal-title":"Translational research: J Lab Clin Med"},{"issue":"6","key":"9933_CR15","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/s41574-024-01075-8","volume":"21","author":"S Khan","year":"2025","unstructured":"Khan S, Khan AA (2025) Hypoparathyroidism: diagnosis, management and emerging therapies. Nat reviews Endocrinol 21(6):360\u2013374","journal-title":"Nat reviews Endocrinol"},{"issue":"8","key":"9933_CR16","doi-asserted-by":"publisher","first-page":"573","DOI":"10.7326\/0003-4819-147-8-200710160-00010","volume":"147","author":"E von Elm","year":"2007","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP (2007) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med 147(8):573\u2013577","journal-title":"Ann Intern Med"},{"key":"9933_CR17","doi-asserted-by":"publisher","first-page":"102277","DOI":"10.1016\/j.media.2021.102277","volume":"75","author":"K Zhang","year":"2022","unstructured":"Zhang K, Xu N, Guo C, Wu J (2022) MPF-net: An effective framework for automated cobb angle estimation. Med Image Anal 75:102277","journal-title":"Med Image Anal"},{"key":"9933_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2025.01.055","volume":"196","author":"FA Shah","year":"2025","unstructured":"Shah FA (2025) Revisiting the physical and chemical nature of the mineral component of bone. Acta Biomater 196:1\u201316","journal-title":"Acta Biomater"},{"issue":"7","key":"9933_CR19","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.1039\/D2FO04092A","volume":"14","author":"M Jia","year":"2023","unstructured":"Jia M, Luo J, Gao B, Huangfu Y, Bao Y, Li D et al (2023) Preparation of synbiotic milk powder and its effect on calcium absorption and the bone microstructure in calcium deficient mice. Food Funct 14(7):3092\u20133106","journal-title":"Food Funct"},{"issue":"7","key":"9933_CR20","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1093\/jbmr\/zjae083","volume":"39","author":"KG Yang","year":"2024","unstructured":"Yang KG, Lee WY, Hung AL, Kumar A, Chui EC, Hung VW et al (2024) Distinguishing risk of curve progression in adolescent idiopathic scoliosis with bone microarchitecture phenotyping: a 6-year longitudinal study. J bone mineral research: official J Am Soc Bone Mineral Res 39(7):956\u2013966","journal-title":"J bone mineral research: official J Am Soc Bone Mineral Res"},{"issue":"1","key":"9933_CR21","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s43856-025-01003-5","volume":"5","author":"FM Wang","year":"2025","unstructured":"Wang FM, Ruby JG, Sethi A, Veras MA, Telis N, Melamud E (2025) Characterizing aging-related genetic and physiological determinants of spinal curvature. Commun Med 5(1):291","journal-title":"Commun Med"},{"issue":"9","key":"9933_CR22","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1002\/jbmr.4330","volume":"36","author":"H Zeng","year":"2021","unstructured":"Zeng H, Ge J, Xu W, Ma H, Chen L, Xia M et al (2021) Type 2 Diabetes Is Causally Associated With Reduced Serum Osteocalcin: A Genomewide Association and Mendelian Randomization Study. J bone mineral research: official J Am Soc Bone Mineral Res 36(9):1694\u20131707","journal-title":"J bone mineral research: official J Am Soc Bone Mineral Res"},{"key":"9933_CR23","doi-asserted-by":"crossref","unstructured":"Liu Y, Le S, Liu Y, Jiang H, Ruan B, Huang Y et al (2022) The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials. eLife. ;11:e79002","DOI":"10.7554\/eLife.79002"},{"issue":"12","key":"9933_CR24","doi-asserted-by":"publisher","first-page":"e873","DOI":"10.1016\/S2665-9913(25)00105-5","volume":"7","author":"The global","year":"2025","unstructured":"The global (2025) regional, and national burden attributable to low bone mineral density, 1990\u20132020: an analysis of a modifiable risk factor from the Global Burden of Disease Study 2021. Lancet Rheumatol 7(12):e873\u2013e94","journal-title":"Lancet Rheumatol"}],"container-title":["European Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-026-09933-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00586-026-09933-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-026-09933-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:00:41Z","timestamp":1776704441000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00586-026-09933-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":24,"alternative-id":["9933"],"URL":"https:\/\/doi.org\/10.1007\/s00586-026-09933-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-8748126\/v1","asserted-by":"object"}]},"ISSN":["0940-6719","1432-0932"],"issn-type":[{"value":"0940-6719","type":"print"},{"value":"1432-0932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]},"assertion":[{"value":"31 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable. The data of the patients included in the study does not contain identifiable information.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"This study was approved by the Ethics Committee of Guangzhou First People's Hospital (No. K-2026-052-01) and conducted in accordance with the STROBE guidelines.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics committee approval and informed consent"}}]}}