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FPG reports royalties from OrthoDevelopment Corp.; consulting fees from Seaspine Orthopedics; and private investments in BICMD, Inc. outside the submitted work. FPC reports ownership interest for 4WEB Medical; Healthpoint Capital Partners, LP; Healthpoint Musculoskeletal II LP; ISPH IV, LLC; ISPH V, LLC; Medical Device Partners, LLC; Medical Device Partners II, LLC; Medical Device Partners III, LLC; Orthobond Corporation; Spine Biopharma, LLC; Tissue Differentiation Intelligence, LLC; Tissue Connect Systems, Inc.; VBVP VI, LLC; VBVP XII, LLC; VBVP X, LLC; Woven Orthopedics Technologies; consulting fees from Spine Biopharma, LLC, membership of scientific advisory board\/other office of 4WEB Medical; Healthpoint Capital Partners, Medical Device Partners II, LLC, Orthobond Corporation, Spine Biopharma, LLC, and Woven Orthopedic Technologies; and research support from 4WEB Medical, Camber Spine, Centinel Spine, and Royal Biologics outside the submitted work. APH reports research support from Expanding Innovations, Inc.; private investments in Tissue Connect Systems, Inc.; and fellowship support from Globus Medical, Inc., and Alphatec Spine, Inc. outside the submitted work.All other authors report no financial disclosures.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}