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This study aims to evaluate the clinical efficacy and safety of PTM-based Sphereplasty for the treatment of post-traumatic thoracolumbar VCFs and compared the results with data from the literature on standard PMMA-based kyphoplasty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-two patients (32 females), treated with PTMs Sphereplasty for 57 post-traumatic AO Spine A1 and A3 thoracolumbar VCFs, were prospectively enrolled. Data on demographics, fracture types, surgical details, pain scores (NRS) and disability (ODI) were analyzed. Imaging included x-ray, MRI and CT. Vertebral Body Height (VBH), Wedge Angle (WA) and Kyphosis Angle (KA) were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median age was 62.7 years and median follow-up was 334.0 days. Median NRS scores decreased from 8.0 to 4.0 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and ODI improved from 66.35% to 28.45% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Radiological evaluation demonstrated median KA values of 6.9\u00b0 preoperatively, 5.5\u00b0 postoperatively and 7.71\u00b0 at final follow-up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026). WA decreased from 8.4\u00b0 to 5.0\u00b0 and 5.1\u00b0, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Anterior and middle VBH improved significantly, from 19.52 to 21.65\u00a0mm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and from 17.49 to 21.20\u00a0mm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas there was no clinically relevant change in cranial and caudal VBHs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sphereplasty is a safe and effective treatment for post-traumatic thoracolumbar VCFs, providing primary stability, pain relief and functional improvement. PTMs may represent a promising alternative to PMMA kyphoplasty, promoting bony fusion and reducing long-term complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00586-026-10251-5","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T01:52:32Z","timestamp":1786326752000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sphereplasty with 3D porous titanium microspheres for thoracolumbar vertebral compression fractures: analysis of clinical efficacy and safety profile of a novel technique"],"prefix":"10.1007","author":[{"given":"Giuseppe Maria Vincenzo","family":"Barbagallo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Cammarata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Grasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Basile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Maugeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Buscema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppa","family":"Fiuman\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Agodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Servadei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Certo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"issue":"1","key":"10251_CR1","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1359\/jbmr.1999.14.1.90","volume":"14","author":"DM Black","year":"1999","unstructured":"Black DM, Palermo L, Nevitt MC, Genant HK, Christensen L, Cummings SR (1999) Defining incident vertebral deformity: a prospective comparison of several approaches. 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