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We aimed to assess the association between DISH and calcifications of the coronaries, thoracic aorta, aortic valve, and mitral annulus\/valve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 3514 male individuals with current or past smoking behavior who underwent chest computed tomography (CT) from the NELSON lung cancer screening trial were included. Calcification volumes were quantified on chest CT using in house developed automatic validated software. DISH presence was assessed visually according to Resnick criteria. Associations were evaluated with multivariate linear and logistic regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DISH was present in 241 subjects (6.9%). Subjects with DISH had higher coronary calcification (median 402 mm\n                      <jats:sup>3<\/jats:sup>\n                      , IQR: 78-1281 mm\n                      <jats:sup>3<\/jats:sup>\n                      vs. 173 mm\n                      <jats:sup>3<\/jats:sup>\n                      , IQR: 13\u2013741 mm\n                      <jats:sup>3<\/jats:sup>\n                      ), thoracic aortic calcification volumes (1158 mm\n                      <jats:sup>3<\/jats:sup>\n                      , IQR: 275\u20133889 mm\n                      <jats:sup>3<\/jats:sup>\n                      vs. 486 mm\n                      <jats:sup>3<\/jats:sup>\n                      , IQR: 98-1665 mm\n                      <jats:sup>3<\/jats:sup>\n                      ), and a higher proportion of aortic valve calcifications (39.5% vs. 22.3%) and mitral valve\/annulus calcifications (5.8% vs. 2.8%),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 for all. DISH was associated with the presence of thoracic aortic calcifications (OR:1.55;95%CI:1.09\u20132.20) and aortic valve calcifications (OR:1.53;95%CI:1.14\u20132.04) in multivariate analyses. DISH was associated with more thoracic aortic (\u03b2:0.13; 95%CI:0.03, 0.24), and aortic valve calcification volumes (\u03b2:0.03; 95%CI:0.004, 0.06), but not with coronary artery or mitral valve\/annulus calcification volumes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We observed an independent relationship between DISH and thoracic aortic and aortic valve calcifications, but not with coronary artery calcifications and mitral valve calcifications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00586-026-10282-y","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:36:34Z","timestamp":1786502194000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The relation between cardiovascular calcifications and diffuse idiopathic skeletal hyperostosis"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8196-3949","authenticated-orcid":false,"given":"Netanja I.","family":"Harlianto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Pompe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Foppen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonneke S.","family":"Kuperus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Isgum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorrit-Jan","family":"Verlaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim A.","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozemarijn","family":"Vliegenthart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firdaus A.A.","family":"Mohamed Hoesein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"10282_CR1","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/nrrheum.2013.165","volume":"9","author":"R Mader","year":"2013","unstructured":"Mader R, Verlaan JJ, Buskila D (2013) Diffuse idiopathic skeletal hyperostosis: clinical features and pathogenic mechanisms. 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