{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:24:26Z","timestamp":1764689066544},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2015,8,29]],"date-time":"2015-08-29T00:00:00Z","timestamp":1440806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Orthop Surg Traumatol"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s00590-015-1691-5","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T14:39:21Z","timestamp":1440772761000},"page":"1239-1243","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The effects of diabetes medications on post-operative long bone fracture healing"],"prefix":"10.1007","volume":"25","author":[{"given":"C.","family":"Simpson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Jayaramaraju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Agraharam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gudipati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Shanmuganathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. V.","family":"Giannoudis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,8,29]]},"reference":[{"key":"1691_CR1","volume-title":"Diabetic prevelence","author":"NHS","year":"2011","unstructured":"NHS (2011) Diabetic prevelence. NHS England, UK"},{"key":"1691_CR2","volume-title":"NHS hospital episode statistics","author":"NHS","year":"2011","unstructured":"NHS (2011) NHS hospital episode statistics. NHS England, UK"},{"key":"1691_CR3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00003086-197201000-00017","volume":"82","author":"L Cozen","year":"1972","unstructured":"Cozen L (1972) Does diabetes delay fracture healing? Clin Orthop Relat Res 82:134\u2013140","journal-title":"Clin Orthop Relat Res"},{"key":"1691_CR4","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/00003086-198807000-00028","volume":"232","author":"RT Loder","year":"1988","unstructured":"Loder RT (1988) The influence of diabetes mellitus on the healing of closed fractures. Clin Orthop Relat Res 232:210","journal-title":"Clin Orthop Relat Res"},{"issue":"3","key":"1691_CR5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF02556109","volume":"49","author":"R Bouillon","year":"1991","unstructured":"Bouillon R (1991) Diabetic bone disease. Calcif Tissue Int 49(3):155\u2013160","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"1691_CR6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1517\/14740338.2012.639359","volume":"11","author":"CM Simpson","year":"2012","unstructured":"Simpson CM, Calori GM, Giannoudis PV (2012) Diabetes and fracture healing: the skeletal effects of diabetic drugs. Expert Opin Drug Saf 11(2):215\u2013220","journal-title":"Expert Opin Drug Saf"},{"issue":"6","key":"1691_CR7","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/S0736-0266(02)00066-9","volume":"20","author":"HA Beam","year":"2006","unstructured":"Beam HA, Parsons JR, Lin SS (2006) The effects of blood glucose control upon fracture healing in the BB Wistar rat with diabetes mellitus. J Orthop Res 20(6):1210\u20131216","journal-title":"J Orthop Res"},{"issue":"6","key":"1691_CR8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00223-003-0069-6","volume":"74","author":"N Follak","year":"2004","unstructured":"Follak N, Kl\u00f6ting I, Wolf E, Merk H (2004) Improving metabolic control reverses the histomorphometric and biomechanical abnormalities of an experimentally induced bone defect in spontaneously diabetic rats. Calcif Tissue Int 74(6):551\u2013560","journal-title":"Calcif Tissue Int"},{"issue":"6","key":"1691_CR9","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.2337\/diabetes.52.6.1502","volume":"52","author":"RB Santana","year":"2003","unstructured":"Santana RB, Xu L, Chase HB, Amar S, Graves DT, Trackman PC (2003) A role for advanced glycation end products in diminished bone healing in type 1 diabetes. Diabetes 52(6):1502\u20131510","journal-title":"Diabetes"},{"issue":"2","key":"1691_CR10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.bone.2008.10.042","volume":"44","author":"RA Kayal","year":"2009","unstructured":"Kayal RA, Alblowi J, McKenzie E, Krothapalli N, Silkam L, Gerstenfeld L et al (2009) Diabetes causes the accelerated loss of cartilage during fracture repair which is reversed by insulin treatment. Bone 44(2):357\u2013363","journal-title":"Bone"},{"issue":"6","key":"1691_CR11","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.mehy.2005.07.017","volume":"65","author":"S Yamagishi","year":"2005","unstructured":"Yamagishi S, Nakamura K, Inoue H (2005) Possible participation of advanced glycation end products in the pathogenesis of osteoporosis in diabetic patients. Med Hypotheses 65(6):1013","journal-title":"Med Hypotheses"},{"issue":"1","key":"1691_CR12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ejphar.2006.02.030","volume":"536","author":"AM Cortizo","year":"2006","unstructured":"Cortizo AM, Sedlinsky C, McCarthy AD, Blanco A, Shurman L (2006) Osteogenic actions of the anti-diabetic drug metformin on osteoblasts in culture. Eur J Pharmacol 536(1):38\u201346","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"1691_CR13","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bbrc.2008.08.034","volume":"375","author":"I Kanazawa","year":"2008","unstructured":"Kanazawa I, Yamaguchi T, Yano S, Yamauchi M, Sugimoto T (2008) Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression. Biochem Biophys Res Commun 375(3):414\u2013419","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"1691_CR14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1359\/jbmr.090732","volume":"25","author":"MS Molinuevo","year":"2010","unstructured":"Molinuevo MS, Schurman L, McCarthy AD, Cortizo AM, Tolosa MJ, Gangoiti MV (2010) Effect of metformin on bone marrow progenitor cell differentiation: in vivo and in vitro studies. J Bone Miner Res 25(2):211\u2013221","journal-title":"J Bone Miner Res"},{"issue":"1","key":"1691_CR15","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ejphar.2010.02.051","volume":"635","author":"Y Gao","year":"2010","unstructured":"Gao Y, Li Y, Xue J, Jia Y, Hu J (2010) Effect of the anti-diabetic drug metformin on bone mass in ovariectomized rats. Eur J Pharmacol 635(1):231\u2013236","journal-title":"Eur J Pharmacol"},{"issue":"10","key":"1691_CR16","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1007\/s00198-006-0155-5","volume":"17","author":"M Saito","year":"2006","unstructured":"Saito M, Fujii K, Moti Y, Marumo K (2006) Role of collagen enzymatic and glycation induced cross-links as a determinant of bone quality in spontaneously diabetic WBN\/Kob rats. Osteoporos Int 17(10):1514\u20131523","journal-title":"Osteoporos Int"},{"issue":"2","key":"1691_CR17","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/jcb.21994","volume":"106","author":"KR Shockley","year":"2008","unstructured":"Shockley KR, Rosen CJ, Churchill GA, Lecka-Czernik B (2008) PPAR\u03b32 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells. J Cell Biochem 106(2):232\u2013246","journal-title":"J Cell Biochem"},{"issue":"4","key":"1691_CR18","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.bone.2007.06.017","volume":"41","author":"TH Lin","year":"2007","unstructured":"Lin TH, Yang RS, Tang CH, Lin CP, Fu WM (2007) PPAR\u03b3 inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats. Bone 41(4):562\u2013574","journal-title":"Bone"},{"issue":"4","key":"1691_CR19","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1210\/jc.2006-2646","volume":"92","author":"A Grey","year":"2007","unstructured":"Grey A, Bolland M, Gamble G, Wattie D, Horne A, Davisdon J, Reid IR (2007) The peroxisome proliferator-activated receptor-\u03b3 agonist rosiglitazone decreases bone formation and bone mineral density in healthy postmenopausal women: a randomized, controlled trial. J Clin Endocrinol Metab 92(4):1305\u20131310","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"1691_CR20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s11914-010-0027-y","volume":"8","author":"B Lecka-Czernik","year":"2010","unstructured":"Lecka-Czernik B (2010) Bone loss in diabetes: use of antidiabetic thiazolidinediones and secondary osteoporosis. Curr Osteoporos Rep 8(4):178\u2013184","journal-title":"Curr Osteoporos Rep"},{"issue":"2","key":"1691_CR21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1210\/en.2010-1098","volume":"152","author":"KA Kyle","year":"2011","unstructured":"Kyle KA, Willett TL, Baggio LL, Drucker DJ, Grynpas MD (2011) Differential effects of PPAR-\u03b3 activation versus chemical or genetic reduction of DPP-4 activity on bone quality in mice. Endocrinology 152(2):457\u2013467","journal-title":"Endocrinology"}],"container-title":["European Journal of Orthopaedic Surgery &amp; Traumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-015-1691-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00590-015-1691-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-015-1691-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T02:11:50Z","timestamp":1653099110000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00590-015-1691-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,29]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["1691"],"URL":"https:\/\/doi.org\/10.1007\/s00590-015-1691-5","relation":{},"ISSN":["1633-8065","1432-1068"],"issn-type":[{"value":"1633-8065","type":"print"},{"value":"1432-1068","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,29]]}}}