{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T21:53:13Z","timestamp":1784929993987,"version":"3.55.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T00:00:00Z","timestamp":1443052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Orthop Surg Traumatol"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s00590-015-1693-3","type":"journal-article","created":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T15:39:18Z","timestamp":1443109158000},"page":"1321-1326","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Efficacy and safety profile of a compound composed of platelet-rich plasma and hyaluronic acid in the treatment for knee osteoarthritis (preliminary results)"],"prefix":"10.1007","volume":"25","author":[{"given":"Michele","family":"Abate","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Verna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosima","family":"Schiavone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Di Gregorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Salini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,9,24]]},"reference":[{"issue":"1","key":"1693_CR1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.12816\/0006075","volume":"8","author":"AM Alshami","year":"2014","unstructured":"Alshami AM (2014) Knee osteoarthritis related pain: a narrative review of diagnosis and treatment. Int J Health Sci (Qassim) 8(1):85\u2013104","journal-title":"Int J Health Sci (Qassim)"},{"issue":"9","key":"1693_CR2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.5435\/JAAOS-21-09-571","volume":"21","author":"DS Jevsevar","year":"2013","unstructured":"Jevsevar DS (2013) Treatment of osteoarthritis of the knee: evidence-based guideline, 2nd edition. J Am Acad Orthop Surg 21(9):571\u2013576","journal-title":"J Am Acad Orthop Surg"},{"issue":"5","key":"1693_CR3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1517\/14712598.2014.889677","volume":"14","author":"I Andia","year":"2014","unstructured":"Andia I, Abate M (2014) Knee osteoarthritis: hyaluronic acid, platelet-rich plasma or both in association? Expert Opin Biol Ther 14(5):635\u2013649","journal-title":"Expert Opin Biol Ther"},{"issue":"2","key":"1693_CR4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.5312\/wjo.v5.i2.80","volume":"5","author":"G Musumeci","year":"2014","unstructured":"Musumeci G, Castrogiovanni P, Leonardi R, Trovato FM, Szychlinska MA, DiGiunta A, Loreto C, Castorina S (2014) New perspectives for articular cartilage repair treatment through tissue engineering: a contemporary review. World J Orthop 5(2):80\u201388","journal-title":"World J Orthop"},{"issue":"4","key":"1693_CR5","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/01.PHM.0000156899.18885.06","volume":"84","author":"R Petrella","year":"2005","unstructured":"Petrella R (2005) Hyaluronic Acid for the treatment of knee osteoarthritis: long-term outcomes from a naturalistic primary care experience. Am J Phys Med Rehabil 84(4):278\u2013283","journal-title":"Am J Phys Med Rehabil"},{"issue":"1","key":"1693_CR6","first-page":"5","volume":"1","author":"EC Rodriguez-Merchan","year":"2013","unstructured":"Rodriguez-Merchan EC (2013) Intraarticular injections of platelet-rich plasma (PRP) in the management of knee osteoarthritis. Arch Bone Jt Surg 1(1):5\u20138","journal-title":"Arch Bone Jt Surg"},{"issue":"4","key":"1693_CR7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/01.ASW.0000396302.05959.d3","volume":"24","author":"V Cervelli","year":"2011","unstructured":"Cervelli V, Lucarini L, Spallone D, Palla L, Colicchia GM, Gentile P, De Angelis B (2011) Use of platelet-rich plasma and hyaluronic acid in the loss of substance with bone exposure. Adv Skin Wound Care 24(4):176\u2013181","journal-title":"Adv Skin Wound Care"},{"issue":"4","key":"1693_CR8","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1742-481X.2012.00992.x","volume":"10","author":"B Angelis De","year":"2013","unstructured":"De Angelis B, Lucarini L, Orlandi F, Agovino A, Migner A, Cervelli V, Izzo V, Curcio C (2013) Regenerative surgery of the complications with Morton\u2019s neuroma surgery: use of platelet rich plasma and hyaluronic acid. Int Wound J 10(4):372\u2013376","journal-title":"Int Wound J"},{"issue":"2","key":"1693_CR9","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1177\/1099800414535840","volume":"17","author":"J Ramos-Torrecillas","year":"2015","unstructured":"Ramos-Torrecillas J, Garc\u00eda-Mart\u00ednez O, De Luna-Bertos E, Oca\u00f1a-Peinado FM, Ruiz C (2015) Effectiveness of platelet-rich plasma and hyaluronic acid for the treatment and care of pressure ulcers. Biol Res Nurs 17(2):152\u2013158","journal-title":"Biol Res Nurs"},{"issue":"4","key":"1693_CR10","first-page":"318","volume":"14","author":"V Vlad","year":"2012","unstructured":"Vlad V, Iagnocco A (2012) Ultrasound of the knee in rheumatology. Med Ultrason 14(4):318\u2013325","journal-title":"Med Ultrason"},{"issue":"5","key":"1693_CR11","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1053\/sarh.2002.50013","volume":"32","author":"G Kolarz","year":"2003","unstructured":"Kolarz G, Kotz R, Hochmayer I (2003) Long-term benefits and repeated treatment cycles of intra-articular sodium hyaluronate (Hyalgan) in patients with osteoarthritis of the knee. Semin Arthritis Rheum 32(5):310\u2013319","journal-title":"Semin Arthritis Rheum"},{"issue":"12","key":"1693_CR12","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrrheum.2013.141","volume":"9","author":"I Andia","year":"2013","unstructured":"Andia I, Maffulli N (2013) Platelet-rich plasma for managing pain and inflammation in osteoarthritis. Nat Rev Rheumatol 9(12):721\u2013730","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"1693_CR13","doi-asserted-by":"crossref","first-page":"645","DOI":"10.2217\/rme.13.59","volume":"8","author":"I Andia","year":"2013","unstructured":"Andia I, Abate M (2013) Platelet-rich plasma: underlying biology and clinical correlates. Regen Med 8(5):645\u2013658","journal-title":"Regen Med"},{"issue":"6","key":"1693_CR14","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2174\/138161210790883859","volume":"16","author":"M Abate","year":"2010","unstructured":"Abate M, Pulcini D, Di Iorio A, Schiavone C (2010) Viscosupplementation with intra-articular hyaluronic acid for treatment of osteoarthritis in the elderly. Curr Pharm Des 16(6):631\u2013640","journal-title":"Curr Pharm Des"},{"issue":"3","key":"1693_CR15","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00590-014-1517-x","volume":"25","author":"O Guler","year":"2015","unstructured":"Guler O, Mutlu S, Isyar M, Seker A, Kayaalp ME, Mahirogullari M (2015) Comparison of short-term results of intraarticular platelet-rich plasma (PRP) and hyaluronic acid treatments in early-stage gonarthrosis patients. Eur J Orthop Surg Traumatol 25(3):509\u2013513","journal-title":"Eur J Orthop Surg Traumatol"},{"issue":"4","key":"1693_CR16","doi-asserted-by":"crossref","first-page":"278","DOI":"10.55095\/achot2013\/046","volume":"80","author":"F Say","year":"2013","unstructured":"Say F, G\u00fcrler D, Yener K, B\u00fclb\u00fcl M, Malkoc M (2013) Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis. Acta Chir Orthop Traumatol Cech 80(4):278\u2013283","journal-title":"Acta Chir Orthop Traumatol Cech"},{"issue":"5","key":"1693_CR17","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/PHM.0b013e3182aab72","volume":"91","author":"T Spakov\u00e1","year":"2012","unstructured":"Spakov\u00e1 T, Rosocha J, Lacko M, Harvanov\u00e1 D, Gharaibeh A (2012) Treatment of knee joint osteoarthritis with autologous platelet-rich plasma in comparison with hyaluronic acid. Am J Phys Med Rehabil 91(5):411\u2013417","journal-title":"Am J Phys Med Rehabil"},{"issue":"1","key":"1693_CR18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/0363546513507766","volume":"42","author":"EA Sundman","year":"2014","unstructured":"Sundman EA, Cole BJ, Karas V, Della Valle C, Tetreault MW, Mohammed HO, Fortier LA (2014) The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis. Am J Sports Med 42(1):35\u201341","journal-title":"Am J Sports Med"},{"issue":"9","key":"1693_CR19","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1007\/s00167-011-1697-4","volume":"20","author":"E Anitua","year":"2012","unstructured":"Anitua E, Sanchez M, De la Fuente M, Zalduendo MM, Orive G (2012) Plasma rich in growth factors (PRGF-Endoret) stimulates tendon and synovial fibroblasts migration and improves the biological properties of hyaluronic acid. Knee Surg Sports Traumatol Arthrosc 20(9):1657\u20131665","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"12","key":"1693_CR20","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1007\/s00167-012-1920-y","volume":"20","author":"A Marmotti","year":"2012","unstructured":"Marmotti A, Bruzzone M, Bonasia DE, Castoldi F, Rossi R, Piras L, Maiello A, Realmuto C, Peretti GM (2012) One-step osteochondral repair with cartilage fragments in a composite scaffold. Knee Surg Sports Traumatol Arthrosc 20(12):2590\u20132601","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"2","key":"1693_CR21","doi-asserted-by":"crossref","first-page":"024109","DOI":"10.1088\/1748-6041\/7\/2\/024109","volume":"7","author":"PP Srinivasan","year":"2012","unstructured":"Srinivasan PP, McCoy SY, Jha AK, Yang W, Jia X, Farach-Carson MC, Kirn-Safran CB (2012) Injectable perlecan domain 1-hyaluronan microgels potentiate the cartilage repair effect of BMP2 in a murine model of early osteoarthritis. Biomed Mater 7(2):024109","journal-title":"Biomed Mater"}],"container-title":["European Journal of Orthopaedic Surgery &amp; Traumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-015-1693-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00590-015-1693-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-015-1693-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T14:13:27Z","timestamp":1692022407000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00590-015-1693-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,24]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["1693"],"URL":"https:\/\/doi.org\/10.1007\/s00590-015-1693-3","relation":{},"ISSN":["1633-8065","1432-1068"],"issn-type":[{"value":"1633-8065","type":"print"},{"value":"1432-1068","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,24]]}}}