{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:04:24Z","timestamp":1775520264418,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Orthop Surg Traumatol"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s00590-020-02730-2","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T17:04:31Z","timestamp":1593709471000},"page":"1481-1486","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The effect of platelet-rich plasma on fracture healing in long-bone pseudoarthrosis"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0235-4497","authenticated-orcid":false,"given":"Koray","family":"Ba\u015fdelio\u011flu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6khan","family":"Meri\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"Sarg\u0131n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziz","family":"Atik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Engin","family":"Ulusal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devrim","family":"Akseki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"issue":"2","key":"2730_CR1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00402-012-1641-1","volume":"133","author":"A Malhotra","year":"2013","unstructured":"Malhotra A, Pellethier MH, Yu Y et al (2013) Can platelet-rich plasma (PRP) improve bone healing? A comparison between the theory and experimental outcomes. Arch Orthop Trauma Surg 133(2):153\u2013165. https:\/\/doi.org\/10.1007\/s00402-012-1641-1","journal-title":"Arch Orthop Trauma Surg"},{"issue":"4","key":"2730_CR2","first-page":"436","volume":"13","author":"IC Nwagbara","year":"2010","unstructured":"Nwagbara IC (2010) Osseous union in cases of non-union in long bones treated by osteosynthesis. Niger J Clin Pract 13(4):436\u2013440","journal-title":"Niger J Clin Pract"},{"issue":"8","key":"2730_CR3","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.2106\/00004623-200208000-00004","volume":"84","author":"IF Rubel","year":"2002","unstructured":"Rubel IF, Kloen P, Campbell D et al (2002) Open reduction and internal fixation of humeral non-unions: a biomechanical and clinical study. J Bone Joint Surg Am 84(8):1315\u20131322. https:\/\/doi.org\/10.2106\/00004623-200208000-00004","journal-title":"J Bone Joint Surg Am"},{"issue":"2","key":"2730_CR4","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1097\/01.ta.0000229979.06520.72","volume":"66","author":"T Nakase","year":"2009","unstructured":"Nakase T, Kawai H, Yoshikawa H (2009) In situ grafting of excised fracture callus followed by Ilizarov external fixation for treatment of nonunion after open fracture of tibia. J Trauma 66(2):550\u2013552. https:\/\/doi.org\/10.1097\/01.ta.0000229979.06520.72","journal-title":"J Trauma"},{"issue":"3","key":"2730_CR5","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1097\/00005373-199903000-00007","volume":"46","author":"PR Wolinsky","year":"1999","unstructured":"Wolinsky PR, McCarty E, Shyr Y et al (1999) Reamed intramedullary nailing of the femur: 551 cases. J Trauma 46(3):392\u2013399. https:\/\/doi.org\/10.1097\/00005373-199903000-00007","journal-title":"J Trauma"},{"issue":"1","key":"2730_CR6","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1097\/BOT.0b013e31818faded","volume":"23","author":"M Sanchez","year":"2009","unstructured":"Sanchez M, Anitua E, Cugat R et al (2009) Nonunions Treated With Autologous Preparation Rich in Growth Factors. J Orthop Trauma 23(1):52\u201359. https:\/\/doi.org\/10.1097\/BOT.0b013e31818faded","journal-title":"J Orthop Trauma"},{"issue":"5","key":"2730_CR7","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.jcyt.2013.01.004","volume":"15","author":"IF Bances","year":"2013","unstructured":"Bances IF, Basterrechea MP, Lopez SP et al (2013) Repair of long-bone pseudoarthrosis with autologous bone marrow mononuclear cells combined with allogenic bone graft. Cytotherapy 15(5):571\u2013577. https:\/\/doi.org\/10.1016\/j.jcyt.2013.01.004","journal-title":"Cytotherapy"},{"issue":"4","key":"2730_CR8","doi-asserted-by":"publisher","first-page":"CD008471","DOI":"10.1002\/14651858.CD008471.pub2","volume":"13","author":"XL Griffin","year":"2011","unstructured":"Griffin XL, Costa ML, Parsons N et al (2011) Electromagnetic field stimulation for treating delayed union or non-union of long bone fractures in adults. Cochrane Database Syst Rev 13(4):CD008471. https:\/\/doi.org\/10.1002\/14651858.CD008471.pub2","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"2730_CR9","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.injury.2011.03.046","volume":"42","author":"GM Calori","year":"2011","unstructured":"Calori GM, Mazza E, Colombo M et al (2011) Treatment of long bone non-unions with polytherapy: indications and clinical results. Injury 42(6):587\u2013590. https:\/\/doi.org\/10.1016\/j.injury.2011.03.046","journal-title":"Injury"},{"key":"2730_CR10","first-page":"3125","volume-title":"CAMPBELL cirugia ortopedica","author":"D La Velle","year":"2004","unstructured":"La Velle D (2004) Delay in union and pseudoarthrosis fracture. In: Canale S (ed) CAMPBELL cirugia ortopedica. Elsevier, Madrid, Spain Espa\u00f1a SA, pp 3125\u20133126"},{"issue":"3","key":"2730_CR11","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s10195-008-0021-7","volume":"9","author":"O Galasso","year":"2008","unstructured":"Galasso O, Mariconda M, Romano G et al (2008) Expandable intramedullary nailing and platelet rich plasma to treat long bone non-unions. J Orthopaed Traumatol 9(3):129\u2013134. https:\/\/doi.org\/10.1007\/s10195-008-0021-7","journal-title":"J Orthopaed Traumatol"},{"issue":"6","key":"2730_CR12","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1302\/0301-620X.88B6.17524","volume":"88","author":"AHRW Simpson","year":"2006","unstructured":"Simpson AHRW, Mills L, Noble B (2006) The role of growth factors and related agents in accelerating fracture healing. J Bone Joint Surg Br 88(6):701\u2013705. https:\/\/doi.org\/10.1302\/0301-620X.88B6.17524","journal-title":"J Bone Joint Surg Br"},{"key":"2730_CR13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.injury.2007.02.006","volume":"38","author":"E Tsiridis","year":"2007","unstructured":"Tsiridis E, Upadhyay N, Giannoudis P (2007) Molecular aspects of fracture healing: which are the important molecules? Injury 38:11\u201325. https:\/\/doi.org\/10.1016\/j.injury.2007.02.006","journal-title":"Injury"},{"key":"2730_CR14","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.injury.2007.02.009","volume":"38","author":"CJ Veillette","year":"2007","unstructured":"Veillette CJ, McKee MD (2007) Growth factors\u2014BMPs, DBMs, and buffy coat products: are there any proven differences amongst them? Injury 38:38\u201348. https:\/\/doi.org\/10.1016\/j.injury.2007.02.009","journal-title":"Injury"},{"issue":"5","key":"2730_CR15","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1002\/jor.1100130504","volume":"13","author":"M Slater","year":"1995","unstructured":"Slater M, Patava J, Kingham K et al (1995) Involvement of platelets in stimulating osteogenic activity. J Orthop Res 13(5):655\u2013663. https:\/\/doi.org\/10.1002\/jor.1100130504","journal-title":"J Orthop Res"},{"issue":"2","key":"2730_CR16","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/bf02850128","volume":"23","author":"TS Roukis","year":"2006","unstructured":"Roukis TS, Zgonis T, Tiernan B (2006) Autologous platelet-rich plasma for wound and osseous healing: a review of the literature and commercially available products. Adv Ther 23(2):218\u2013237. https:\/\/doi.org\/10.1007\/bf02850128","journal-title":"Adv Ther"},{"issue":"3","key":"2730_CR17","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.tibtech.2008.11.009","volume":"27","author":"EDM Dohan","year":"2009","unstructured":"Dohan EDM, Rasmusson L, Albrektsson T (2009) Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol 27(3):158\u2013167. https:\/\/doi.org\/10.1016\/j.tibtech.2008.11.009","journal-title":"Trends Biotechnol"},{"issue":"28","key":"2730_CR18","doi-asserted-by":"publisher","first-page":"4956","DOI":"10.1016\/j.biomaterials.2009.05.055","volume":"30","author":"G Intini","year":"2009","unstructured":"Intini G (2009) The use of platelet-rich plasma in bone reconstruction therapy. Biomaterials 30(28):4956\u20134966. https:\/\/doi.org\/10.1016\/j.biomaterials.2009.05.055","journal-title":"Biomaterials"},{"issue":"1","key":"2730_CR19","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1590\/S1679-45082013000100023","volume":"11","author":"M Lenza","year":"2013","unstructured":"Lenza M, Ferraz SB, Viola DCM et al (2013) Platelet-rich plasma for long bone healing. Einstein (Sao Paulo) 11(1):122\u2013127. https:\/\/doi.org\/10.1590\/S1679-45082013000100023","journal-title":"Einstein (Sao Paulo)"},{"issue":"8","key":"2730_CR20","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1097\/00005131-200209000-00004","volume":"16","author":"M Bhandari","year":"2002","unstructured":"Bhandari M, Guyatt GH, Swiontkowski MF et al (2002) A lack of consensus in the assessment of fracture healing among Orthopaedic surgeons. J Orthop Trauma 16(8):562\u2013566. https:\/\/doi.org\/10.1097\/00005131-200209000-00004","journal-title":"J Orthop Trauma"},{"issue":"6","key":"2730_CR21","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/s1079-2104(98)90029-4","volume":"85","author":"RE Marx","year":"1998","unstructured":"Marx RE, Carlson ER, Eichstaedt RM et al (1998) Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85(6):638\u2013646. https:\/\/doi.org\/10.1016\/s1079-2104(98)90029-4","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"5","key":"2730_CR22","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1097\/BOT.0b013e318172cea5","volume":"22","author":"M Mariconda","year":"2008","unstructured":"Mariconda M, Cozzolino F, Cozzolino A et al (2008) Platelet gel supplementation in long bone nonunions treated by external fixation. J Orthop Trauma 22(5):342\u2013345. https:\/\/doi.org\/10.1097\/BOT.0b013e318172cea5","journal-title":"J Orthop Trauma"},{"issue":"11","key":"2730_CR23","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.2106\/00004623-200211000-00001","volume":"84","author":"P Kloen","year":"2002","unstructured":"Kloen P, Doty SB, Gordon E et al (2002) Expression and activation of the BMP signaling components in human fracture nonunions. J Bone Joint Surg Am 84(11):1909\u20131918. https:\/\/doi.org\/10.2106\/00004623-200211000-00001","journal-title":"J Bone Joint Surg Am"},{"key":"2730_CR24","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/00003086-200402000-00003","volume":"419","author":"EC Rodriguez-Merchan","year":"2004","unstructured":"Rodriguez-Merchan EC, Forriol F (2004) Nonunion: general principles and experimental data. Clin Orthop 419:4\u201312","journal-title":"Clin Orthop"},{"key":"2730_CR25","volume-title":"Diagnosis of bone joint disorders","author":"D Resnick","year":"1988","unstructured":"Resnick D, Goevgen T, Niwayama G (1988) Diagnosis of bone joint disorders. WB Saunders, Philadelphia"},{"issue":"1","key":"2730_CR26","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.injury.2006.02.040","volume":"37","author":"PN Soucacos","year":"2006","unstructured":"Soucacos PN, Dailiana Z, Beris AE et al (2006) Vascularised bone grafts for the management of non-union. Injury 37(1):41\u201350. https:\/\/doi.org\/10.1016\/j.injury.2006.02.040","journal-title":"Injury"},{"issue":"3","key":"2730_CR27","first-page":"134","volume":"4","author":"F Ghaffarpasand","year":"2016","unstructured":"Ghaffarpasand F, Shahrezaei M, Dehghankhalili M (2016) Effects of platelet rich plasma on healing rate of long bone nonunion fractures: a randomized double-blind placebo controlled clinical trial. Bull Emerg Trauma 4(3):134\u2013140","journal-title":"Bull Emerg Trauma"},{"issue":"3","key":"2730_CR28","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s12306-015-0378-8","volume":"99","author":"R Malhotra","year":"2015","unstructured":"Malhotra R, Kumar V, Garg B et al (2015) Role of autologous platelet-rich plasma in treatment of long-bone nonunions: a prospective study. Musculoskelet Surg 99(3):243\u2013248. https:\/\/doi.org\/10.1007\/s12306-015-0378-8","journal-title":"Musculoskelet Surg"},{"issue":"3","key":"2730_CR29","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1097\/SAP.0b013e318157a185","volume":"61","author":"R Simman","year":"2008","unstructured":"Simman R, Hoffmann A, Bohinc RJ et al (2008) Role of platelet-rich plasma in acceleration of bone fracture healing. Ann Plast Surg 61(3):337\u2013344. https:\/\/doi.org\/10.1097\/SAP.0b013e318157a185","journal-title":"Ann Plast Surg"},{"issue":"5","key":"2730_CR30","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1007\/s00167-013-2734-2","volume":"23","author":"Y Guzel","year":"2015","unstructured":"Guzel Y, Karalezli N, Bilge O et al (2015) The biomechanical and histological effects of platelet-rich plasma on fracture healing. Knee Surg Sports Traumatol Arthrosc 23(5):1378\u20131383. https:\/\/doi.org\/10.1007\/s00167-013-2734-2","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"9","key":"2730_CR31","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1016\/j.biomaterials.2005.10.039","volume":"27","author":"MR Sarkar","year":"2006","unstructured":"Sarkar MR, Augat P, Shefelbine SJ et al (2006) Bone formation in a long bone defect model using a platelet-rich plasma-loaded collagen scaffold. Biomaterials 27(9):1817\u20131823. https:\/\/doi.org\/10.1016\/j.biomaterials.2005.10.039","journal-title":"Biomaterials"},{"issue":"7","key":"2730_CR32","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.injury.2012.10.018","volume":"44","author":"A Hernandez-Fernandez","year":"2013","unstructured":"Hernandez-Fernandez A, V\u00e9lez R, Soldado F et al (2013) Effect of administration of platelet-rich plasma in early phases of distraction osteogenesis: an experimental study in an ovine femur model. Injury 44(7):901\u2013907. https:\/\/doi.org\/10.1016\/j.injury.2012.10.018","journal-title":"Injury"}],"container-title":["European Journal of Orthopaedic Surgery & Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-020-02730-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00590-020-02730-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-020-02730-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:13:13Z","timestamp":1625184793000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00590-020-02730-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,2]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["2730"],"URL":"https:\/\/doi.org\/10.1007\/s00590-020-02730-2","relation":{},"ISSN":["1633-8065","1432-1068"],"issn-type":[{"value":"1633-8065","type":"print"},{"value":"1432-1068","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,2]]},"assertion":[{"value":"28 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The author(s) declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}