{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:57:19Z","timestamp":1790420239343,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Orthop Surg Traumatol"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s00590-020-02821-0","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T16:05:08Z","timestamp":1603987508000},"page":"689-693","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Regional vitamin C in Bier block reduces the incidence of CRPS-1 following distal radius fracture surgery"],"prefix":"10.1007","volume":"31","author":[{"given":"Mahzad","family":"Alimian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Sobhani Eraghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Alireza","family":"Chavoshizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7756-2878","authenticated-orcid":false,"given":"Masood","family":"Mohseni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Mousavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shima","family":"Movassaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"issue":"9","key":"2821_CR1","doi-asserted-by":"publisher","first-page":"566","DOI":"10.5435\/JAAOS-22-09-566","volume":"22","author":"K Koval","year":"2014","unstructured":"Koval K, Haidukewych GJ, Zirgibel BJ (2014) Controversies in the management of distal radius fractures. J Am Acad Orthop Surg 22(9):566\u2013575","journal-title":"J Am Acad Orthop Surg"},{"key":"2821_CR2","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1302\/0301-620X.72B1.2298766","volume":"72","author":"RM Atkins","year":"1990","unstructured":"Atkins RM, Duckworth T, Kanis JA (1990) Features of algodystrophy after Colles\u2019 fracture. J Bone Jt Surg Br 72:105\u2013110","journal-title":"J Bone Jt Surg Br"},{"issue":"2","key":"2821_CR3","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/pme.12033","volume":"14","author":"RN Harden","year":"2013","unstructured":"Harden RN, Oaklander AL, Burton AW et al (2013) Complex regional pain syndrome: practical diagnostic and treatment guidelines, 4th edition. Pain Med. 14(2):180\u2013229. https:\/\/doi.org\/10.1111\/pme.12033","journal-title":"Pain Med."},{"key":"2821_CR4","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1097\/ACO.0000000000000114","volume":"27","author":"M Rockett","year":"2014","unstructured":"Rockett M (2014) Diagnosis, mechanisms and treatment of complex regional pain syndrome. Curr Opin Anaesthesiol 27:494\u2013500. https:\/\/doi.org\/10.1097\/ACO.0000000000000114","journal-title":"Curr Opin Anaesthesiol"},{"key":"2821_CR5","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1016\/S0140-6736(99)03059-7","volume":"354","author":"PE Zollinger","year":"1999","unstructured":"Zollinger PE, Tuinebreijer WE, Kreis RW, Breederveld RS (1999) Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: a randomised trial. Lancet 354:2025\u20132028. https:\/\/doi.org\/10.1016\/S0140-6736(99)03059-7","journal-title":"Lancet"},{"issue":"1","key":"2821_CR6","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1053\/j.jfas.2012.08.003","volume":"52","author":"N Shibuya","year":"2013","unstructured":"Shibuya N, Humphers JM, Agarwal MR, Jupiter DC (2013) Efficacy and safety of high-dose vitamin C on complex regional pain syndrome in extremity trauma and surgery\u2014systematic review and meta-analysis. J Foot Ankle Surg 52(1):62\u201366. https:\/\/doi.org\/10.1053\/j.jfas.2012.08.003","journal-title":"J Foot Ankle Surg"},{"issue":"3","key":"2821_CR7","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1177\/147323000203000312","volume":"30","author":"B Saris\u00f6zen","year":"2002","unstructured":"Saris\u00f6zen B, Durak K, Din\u00e7er G, Bilgen OF (2002) The effects of vitamins E and C on fracture healing in rats. J Int Med Res 30(3):309\u2013313. https:\/\/doi.org\/10.1177\/147323000203000312","journal-title":"J Int Med Res"},{"issue":"8","key":"2821_CR8","doi-asserted-by":"publisher","first-page":"e235","DOI":"10.1097\/BOT.0000000000000305","volume":"29","author":"N Evaniew","year":"2015","unstructured":"Evaniew N, McCarthy C, Kleinlugtenbelt YV, Ghert M, Bhandari M (2015) Vitamin C to prevent complex regional pain syndrome in patients with distal radius fractures: a meta-analysis of randomized controlled trials. J Orthop Trauma 29(8):e235\u2013e241. https:\/\/doi.org\/10.1097\/BOT.0000000000000305","journal-title":"J Orthop Trauma"},{"issue":"4","key":"2821_CR9","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s00590-014-1573-2","volume":"25","author":"S1 Meena","year":"2015","unstructured":"Meena S1, Sharma P, Gangary SK, Chowdhury B (2015) Role of vitamin C in prevention of complex regional pain syndrome after distal radius fractures: a meta-analysis. Eur J Orthop Surg Traumatol 25(4):637\u2013641. https:\/\/doi.org\/10.1007\/s00590-014-1573-2","journal-title":"Eur J Orthop Surg Traumatol"},{"issue":"11","key":"2821_CR10","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1016\/j.jhsa.2014.08.009","volume":"39","author":"S Malay","year":"2014","unstructured":"Malay S, Chung KC (2014) Testing the validity of preventing chronic regional pain syndrome with vitamin C after distal radius fracture. J Hand Surg Am 39(11):2251\u20132257. https:\/\/doi.org\/10.1016\/j.jhsa.2014.08.009","journal-title":"J Hand Surg Am"},{"issue":"3","key":"2821_CR11","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.otsr.2016.12.021","volume":"103","author":"F Aim","year":"2017","unstructured":"Aim F, Klouche S, Frison A, Bauer T, Hardy P (2017) Efficacy of vitamin C in preventing complex regional pain syndrome after wrist fracture: a systematic review and meta-analysis. Orthop Traumatol Surg Res 103(3):465\u2013470. https:\/\/doi.org\/10.1016\/j.otsr.2016.12.021","journal-title":"Orthop Traumatol Surg Res"},{"key":"2821_CR12","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/0140-6736(93)92877-v","volume":"342","author":"PH Veldman","year":"1993","unstructured":"Veldman PH, Reynen HM, Arntz IE, Goris RJ (1993) Signs and symptoms of reflex sympathetic dystrophy: prospective study of 829 patients. Lancet 342:1012\u20131016. https:\/\/doi.org\/10.1016\/0140-6736(93)92877-v","journal-title":"Lancet"},{"issue":"Suppl 1","key":"2821_CR13","doi-asserted-by":"publisher","first-page":"e6184","DOI":"10.5867\/medwave.2015.6184","volume":"15","author":"J Cabrolier","year":"2015","unstructured":"Cabrolier J, Molina M (2015) Does vitamin C prevent the occurrence of complex regional pain syndrome in patients with extremity trauma requiring surgery? Medwave 15(Suppl 1):e6184. https:\/\/doi.org\/10.5867\/medwave.2015.6184","journal-title":"Medwave"},{"issue":"2","key":"2821_CR14","doi-asserted-by":"publisher","first-page":"e424","DOI":"10.1016\/j.bja.2019.03.030","volume":"123","author":"H Shim","year":"2019","unstructured":"Shim H, Rose J, Halle S, Shekane P (2019) Complex regional pain syndrome: a narrative review for the practising clinician. Br J Anaesth 123(2):e424\u2013e433. https:\/\/doi.org\/10.1016\/j.bja.2019.03.030","journal-title":"Br J Anaesth"},{"issue":"1","key":"2821_CR15","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1080\/09629350210307","volume":"11","author":"FJ Huygen","year":"2002","unstructured":"Huygen FJ, De Bruijn AG, De Bruin MT et al (2002) Evidence for local inflammation in complex regional pain syndrome type 1. Med Inflamm 11(1):47\u201351. https:\/\/doi.org\/10.1080\/09629350210307","journal-title":"Med Inflamm"},{"issue":"12","key":"2821_CR16","first-page":"516","volume":"11","author":"HA Lehr","year":"2006","unstructured":"Lehr HA, Germann G, McGregor GP et al (2006) Consensus meeting on \u201cRelevance of parenteral vitamin C in acute endothelial dependent pathophysiological conditions (EDPC).\u201d Eur J Med Res 11(12):516\u2013526","journal-title":"Eur J Med Res"},{"issue":"10","key":"2821_CR17","doi-asserted-by":"publisher","first-page":"232596711880454","DOI":"10.1177\/2325967118804544","volume":"6","author":"NN DePhillipo","year":"2018","unstructured":"DePhillipo NN, Aman ZS, Kennedy MI, Begley JP, Moatshe G, LaPrade RF (2018) Efficacy of vitamin C supplementation on collagen synthesis and oxidative stress after musculoskeletal injuries: a systematic review. Orthop J Sports Med 6(10):2325967118804544. https:\/\/doi.org\/10.1177\/2325967118804544","journal-title":"Orthop J Sports Med"},{"issue":"4","key":"2821_CR18","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1080\/15360288.2019.1598530","volume":"32","author":"T Keef","year":"2018","unstructured":"Keef T, Keef S (2018) The efficacy of vitamin C in the prevention of complex regional pain syndrome after distal radius fractures: a synthesis. J Pain Palliat Care Pharmacother 32(4):208\u2013211. https:\/\/doi.org\/10.1080\/15360288.2019.1598530","journal-title":"J Pain Palliat Care Pharmacother"},{"issue":"17","key":"2821_CR19","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.2106\/JBJS.M.00268","volume":"96","author":"I Ekrol","year":"2014","unstructured":"Ekrol I, Duckworth AD, Ralston SH, Court-Brown CM, McQueen MM (2014) J Bone Jt Surg Am 96(17):1451\u20131459. https:\/\/doi.org\/10.2106\/JBJS.M.00268","journal-title":"J Bone Jt Surg Am"},{"issue":"7","key":"2821_CR20","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.2106\/JBJS.F.01147","volume":"89","author":"PE Zollinger","year":"2007","unstructured":"Zollinger PE, Tuinebreijer WE, Breederveld RS et al (2007) Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures? A randomized, controlled, multicenter dose-response study. J Bone Joint Surg Am 89(7):1424\u20131431. https:\/\/doi.org\/10.2106\/JBJS.F.01147","journal-title":"J Bone Joint Surg Am"},{"key":"2821_CR21","unstructured":"New AAOS guideline addresses distal radius fractures. 2009 at https:\/\/www.aaos.org\/Research\/guidelines\/DRFguideline.asp"},{"issue":"5","key":"2821_CR22","first-page":"481","volume":"68","author":"JF Cazeneuve","year":"2002","unstructured":"Cazeneuve JF, Leborgne JM, Kermad K, Hassan Y (2002) Vitamine C et pr\u00e9vention du syndrome douloureux r\u00e9gional complexe de type 1 apr\u00e8s fracture du radius distal trait\u00e9e chirurgicalement [Vitamin C and prevention of reflex sympathetic dystrophy following surgical management of distal radius fractures]. Acta Orthop Belg 68(5):481\u2013484","journal-title":"Acta Orthop Belg"},{"issue":"4","key":"2821_CR23","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.fas.2009.02.002","volume":"15","author":"JL Besse","year":"2009","unstructured":"Besse JL, Gadeyne S, Galand-Desm\u00e9 S, Lerat JL, Moyen B (2009) Effect of vitamin C on prevention of complex regional pain syndrome type I in foot and ankle surgery. Foot Ankle Surg 15(4):179\u2013182. https:\/\/doi.org\/10.1016\/j.fas.2009.02.002","journal-title":"Foot Ankle Surg"},{"issue":"23","key":"2821_CR24","doi-asserted-by":"publisher","first-page":"3116","DOI":"10.1001\/jama.287.23.3116","volume":"287","author":"KM Fairfield","year":"2002","unstructured":"Fairfield KM, Fletcher RH (2002) Vitamins for chronic disease prevention in adults: scientific review. JAMA 287(23):3116\u20133126. https:\/\/doi.org\/10.1001\/jama.287.23.3116","journal-title":"JAMA"},{"issue":"5","key":"2821_CR25","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/s1090-3801(03)00015-6","volume":"7","author":"PU Dijkstra","year":"2003","unstructured":"Dijkstra PU, Groothoff JW, ten Duis HJ, Geertzen JH (2003) Incidence of complex regional pain syndrome type I after fractures of the distal radius. Eur J Pain 7(5):457\u2013462. https:\/\/doi.org\/10.1016\/s1090-3801(03)00015-6","journal-title":"Eur J Pain"},{"issue":"1","key":"2821_CR26","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1097\/00005373-199307000-00010","volume":"35","author":"S Suso","year":"1993","unstructured":"Suso S, Combal\u00eda A, Segur JM, Garc\u00eda-Ramiro S, Ram\u00f3n R (1993) Comminuted intra-articular fractures of the distal end of the radius treated with the Hoffmann external fixator. J Trauma 35(1):61\u201366. https:\/\/doi.org\/10.1097\/00005373-199307000-00010","journal-title":"J Trauma"},{"issue":"12","key":"2821_CR27","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1055\/s-2003-44851","volume":"128","author":"G Gradl","year":"2003","unstructured":"Gradl G, Steinborn M, Wizgall I, Mittlmeier T, Sch\u00fcrmann M (2003) Das akute CRPS I (Morbus Sudeck) nach distaler Radiusfraktur-Methoden der Fr\u00fchdiagnostik [Acute CRPS I (morbus sudeck) following distal radial fractures\u2013methods for early diagnosis]. Zentralbl Chir 128(12):1020\u20131026. https:\/\/doi.org\/10.1055\/s-2003-44851","journal-title":"Zentralbl Chir"}],"container-title":["European Journal of Orthopaedic Surgery & Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-020-02821-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00590-020-02821-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-020-02821-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T04:10:50Z","timestamp":1618632650000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00590-020-02821-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,29]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["2821"],"URL":"https:\/\/doi.org\/10.1007\/s00590-020-02821-0","relation":{},"ISSN":["1633-8065","1432-1068"],"issn-type":[{"value":"1633-8065","type":"print"},{"value":"1432-1068","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,29]]},"assertion":[{"value":"20 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Hereby, I as the corresponding author on behalf of all authors whose names are listed above certify that there is no conflict of interest (financial or nonfinancial) to disclose. The authors have no financial or nonfinancial conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all participants before inclusion.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed constant"}}]}}