{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T11:36:54Z","timestamp":1774179414902,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Orthop Surg Traumatol"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s00590-021-03004-1","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T14:06:24Z","timestamp":1622297184000},"page":"575-581","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hand surgeons and amyloidosis specialists warning: transthyretin-associated amyloidosis with bifid median nerve as a cause of bilateral carpal tunnel syndrome. A case report and literature review"],"prefix":"10.1007","volume":"32","author":[{"given":"Andreu","family":"Triguero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Gonz\u00e1lez-Costello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"L\u00f3pez-Marne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred","family":"Llop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Pan\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-9566","authenticated-orcid":false,"given":"Sergi","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,29]]},"reference":[{"issue":"2","key":"3004_CR1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1001\/jama.282.2.153","volume":"282","author":"I Atroshi","year":"1999","unstructured":"Atroshi I (1999) Prevalence of carpal tunnel syndrome in a general population. JAMA 282(2):153. https:\/\/doi.org\/10.1001\/jama.282.2.153","journal-title":"JAMA"},{"issue":"2","key":"3004_CR2","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1177\/1753193408089572","volume":"34","author":"MM Al-Qattan","year":"2009","unstructured":"Al-Qattan MM, Al-Zahrani K, Al-Omawi M (2009) The bifid median nerve re-visited. J Hand Surg European 34(2):212\u2013214","journal-title":"J Hand Surg European"},{"issue":"1","key":"3004_CR3","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/S0363-5023(77)80009-9","volume":"2","author":"U Lanz","year":"1977","unstructured":"Lanz U (1977) Anatomical variations of the median nerve in the carpal tunnel. J Hand Surg Am 2(1):44\u201353. https:\/\/doi.org\/10.1016\/S0363-5023(77)80009-9","journal-title":"J Hand Surg Am"},{"issue":"4","key":"3004_CR4","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/mus.26145","volume":"58","author":"M-H Pourmemari","year":"2018","unstructured":"Pourmemari M-H, Heli\u00f6vaara M, Viikari-Juntura E, Shiri R (2018) Carpal tunnel release: lifetime prevalence, annual incidence, and risk factors. Muscle Nerve 58(4):497\u2013502. https:\/\/doi.org\/10.1002\/mus.26145","journal-title":"Muscle Nerve"},{"issue":"8","key":"3004_CR5","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.7863\/jum.2008.27.8.1129","volume":"27","author":"IK Bayrak","year":"2008","unstructured":"Bayrak IK, Bayrak AO, Kale M, Turker H, Diren B (2008) Bifid median nerve in patients with carpal tunnel syndrome. J Ultrasound Med 27(8):1129\u20131136. https:\/\/doi.org\/10.7863\/jum.2008.27.8.1129","journal-title":"J Ultrasound Med"},{"issue":"1","key":"3004_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.hcl.2013.08.015","volume":"30","author":"D Lalonde","year":"2014","unstructured":"Lalonde D (2014) Minimally invasive anesthesia in wide awake hand surgery. Hand Clinics 30(1):1\u20136","journal-title":"Hand Clinics"},{"issue":"24","key":"3004_CR7","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1161\/CIRCULATIONAHA.116.021612","volume":"133","author":"JD Gillmore","year":"2016","unstructured":"Gillmore JD et al (2016) Nonbiopsy diagnosis of cardiac transthyretin amyloidosis. Circulation 133(24):2404\u20132412. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.116.021612","journal-title":"Circulation"},{"issue":"3","key":"3004_CR8","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/ejhf.1742","volume":"22","author":"A Milandri","year":"2020","unstructured":"Milandri A et al (2020) Carpal tunnel syndrome in cardiac amyloidosis: implications for early diagnosis and prognostic role across the spectrum of aetiologies. Eur J Heart Fail 22(3):507\u2013515. https:\/\/doi.org\/10.1002\/ejhf.1742","journal-title":"Eur J Heart Fail"},{"issue":"3","key":"3004_CR9","first-page":"471","volume":"18","author":"S Poisel","year":"1974","unstructured":"Poisel S (1974) Ursprung und verlauf des ramus muscularis des nervus digitalis palmaris communis i (N. Medianus). Chir Prax 18(3):471\u2013474","journal-title":"Chir Prax"},{"issue":"8","key":"3004_CR10","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.2106\/00004623-197355080-00019","volume":"55","author":"RJ Schultz","year":"1973","unstructured":"Schultz RJ, Endler PM, Huddleston HD (1973) Anomalous median nerve and an anomalous muscle belly of the first lumbrical associated with carpal tunnel syndrome. Case report. J. Bone Jt Surg Ser A 55(8):1744\u20131746","journal-title":"J. Bone Jt Surg Ser A"},{"issue":"02","key":"3004_CR11","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1142\/S2424835518720165","volume":"23","author":"AK Bhat","year":"2018","unstructured":"Bhat AK, Acharya AM, Narayana Kurup JK, Chakraborti A (2018) Bilateral bifid median nerve with bilateral carpal tunnel syndrome: an atypical presentation, a rare cause and a familiar disease. J Hand Surg Asian-Pacific 23(02):274\u2013277","journal-title":"J Hand Surg Asian-Pacific"},{"issue":"02","key":"3004_CR12","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1142\/S2424835519720123","volume":"24","author":"F Kostoris","year":"2019","unstructured":"Kostoris F, Bassini S, Longo E, Murena L (2019) Carpal tunnel syndrome associated with bifid median nerve and palmaris profundus - case report and literature review. J Hand Surg Asian-Pacific 24(02):238\u2013242","journal-title":"J Hand Surg Asian-Pacific"},{"issue":"17","key":"3004_CR13","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1016\/j.jacc.2018.09.003","volume":"72","author":"MS Maurer","year":"2018","unstructured":"Maurer MS, Ruberg FL (2018) Early diagnosis of cardiac amyloidosis by carpal tunnel surgery: is it all in the wrist? \u2217. J Am Coll Cardiol 72(17):2051\u20132053","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"3004_CR14","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1016\/j.humpath.2011.03.004","volume":"42","author":"Y Sekijima","year":"2011","unstructured":"Sekijima Y et al (2011) High prevalence of wild-type transthyretin deposition in patients with idiopathic carpal tunnel syndrome: a common cause of carpal tunnel syndrome in the elderly. Hum Pathol 42(11):1785\u20131791. https:\/\/doi.org\/10.1016\/j.humpath.2011.03.004","journal-title":"Hum Pathol"},{"issue":"10","key":"3004_CR15","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1016\/j.jhsa.2019.06.016","volume":"44","author":"JP Donnelly","year":"2019","unstructured":"Donnelly JP, Hanna M, Sperry BW, Seitz WH (2019) Carpal tunnel syndrome: a potential early, red-flag sign of amyloidosis. J Hand Surg Am 44(10):868\u2013876. https:\/\/doi.org\/10.1016\/j.jhsa.2019.06.016","journal-title":"J Hand Surg Am"},{"issue":"17","key":"3004_CR16","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1016\/j.jacc.2018.07.092","volume":"72","author":"BW Sperry","year":"2018","unstructured":"Sperry BW et al (2018) Tenosynovial and cardiac amyloidosis in patients undergoing carpal tunnel release. J Am Coll Cardiol 72(17):2040\u20132050. https:\/\/doi.org\/10.1016\/j.jacc.2018.07.092","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"3004_CR17","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.regg.2020.05.001","volume":"55","author":"S Yun","year":"2020","unstructured":"Yun S, Gonz\u00e1lez-Costello J, Formiga F (2020) Amiloidosis por transtiretina: lo que ahora vemos es solo la punta del iceberg. Rev Esp Geriatr Gerontol 55(5):255\u2013257. https:\/\/doi.org\/10.1016\/j.regg.2020.05.001","journal-title":"Rev Esp Geriatr Gerontol"},{"issue":"8","key":"3004_CR18","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.jchf.2019.04.010","volume":"7","author":"RM Witteles","year":"2019","unstructured":"Witteles RM et al (2019) Screening for transthyretin amyloid cardiomyopathy in everyday practice. JACC Hear Fail 7(8):709\u2013716. https:\/\/doi.org\/10.1016\/j.jchf.2019.04.010","journal-title":"JACC Hear Fail"},{"issue":"12","key":"3004_CR19","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1007\/s00392-019-01467-1","volume":"108","author":"F Aus dem Siepen","year":"2019","unstructured":"Aus dem Siepen F et al (2019) Carpal tunnel syndrome and spinal canal stenosis: harbingers of transthyretin amyloid cardiomyopathy? Clin Res Cardiol 108(12):1324\u20131330. https:\/\/doi.org\/10.1007\/s00392-019-01467-1","journal-title":"Clin Res Cardiol"},{"issue":"10","key":"3004_CR20","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1001\/jama.2017.9236","volume":"318","author":"HI Geller","year":"2017","unstructured":"Geller HI, Singh A, Alexander KM, Mirto TM, Falk RH (2017) Association between ruptured distal biceps tendon and wild-type transthyretin cardiac amyloidosis. JAMA J Am Med Ass 318(10):962\u2013963. https:\/\/doi.org\/10.1001\/jama.2017.9236","journal-title":"JAMA J Am Med Ass"},{"issue":"8","key":"3004_CR21","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1016\/j.jhsa.2013.04.032","volume":"38","author":"SM Gancarczyk","year":"2013","unstructured":"Gancarczyk SM, Strauch RJ (2013) Carpal tunnel syndrome and trigger digit: common diagnoses that occur \u2018hand in hand.\u2019 J Hand Surg 38(8):1635\u20131637. https:\/\/doi.org\/10.1016\/j.jhsa.2013.04.032","journal-title":"J Hand Surg"},{"issue":"9","key":"3004_CR22","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/j.humpath.2010.11.017","volume":"42","author":"T Sueyoshi","year":"2011","unstructured":"Sueyoshi T et al (2011) Wild-type transthyretin-derived amyloidosis in various ligaments and tendons. Hum Pathol 42(9):1259\u20131264. https:\/\/doi.org\/10.1016\/j.humpath.2010.11.017","journal-title":"Hum Pathol"},{"issue":"4","key":"3004_CR23","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1080\/13506129.2017.1375908","volume":"24","author":"J Rubin","year":"2017","unstructured":"Rubin J et al (2017) Hip and knee arthroplasty are common among patients with transthyretin cardiac amyloidosis, occurring years before cardiac amyloid diagnosis: can we identify affected patients earlier? Amyloid 24(4):224\u2013228. https:\/\/doi.org\/10.1080\/13506129.2017.1375908","journal-title":"Amyloid"},{"key":"3004_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2140","author":"P Garcia-Pavia","year":"2021","unstructured":"Garcia-Pavia P, Rapezzi C, Adler Y, Arad M, Basso C, Brucato A, Burazor I, Caforio ALP, Damy T, Eriksson U, Fontana M, Gillmore JD, Gonzalez-Lopez E, Grogan M, Heymans S, Imazio M, Kindermann I, Kristen AV, Maurer MS, Merlini G, Pantazis A, Pankuweit S, Rigopoulos AG, Linhart A (2021) Diagnosis and treatment of cardiac amyloidosis. A position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur J Heart Fail. https:\/\/doi.org\/10.1002\/ejhf.2140","journal-title":"Eur J Heart Fail"}],"container-title":["European Journal of Orthopaedic Surgery &amp; Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-021-03004-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00590-021-03004-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-021-03004-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T15:07:55Z","timestamp":1647356875000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00590-021-03004-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,29]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["3004"],"URL":"https:\/\/doi.org\/10.1007\/s00590-021-03004-1","relation":{},"ISSN":["1633-8065","1432-1068"],"issn-type":[{"value":"1633-8065","type":"print"},{"value":"1432-1068","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,29]]},"assertion":[{"value":"26 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration"}},{"value":"The authors declare that they have no conflicts of interest relevant to the content of this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}