{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T16:51:23Z","timestamp":1776876683305,"version":"3.51.2"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Orthop Surg Traumatol"],"DOI":"10.1007\/s00590-022-03338-4","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T09:02:51Z","timestamp":1660035771000},"page":"1745-1750","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A major trauma centre experience with gentamicin-coated tibial intramedullary nails (ETN PROtect\u2122) in acute primary open fracture fixation and complex revision surgery"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5154-9357","authenticated-orcid":false,"given":"Kavi H.","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Galanis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabu","family":"Balasubramanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexios D.","family":"Iliadis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nima","family":"Heidari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Vris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"3338_CR1","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.injury.2017.03.030","volume":"48","author":"W-J Metsemakers","year":"2017","unstructured":"Metsemakers W-J, Smeets B, Nijs S, Hoekstra H (2017) Infection after fracture fixation of the tibia: analysis of healthcare utilization and related costs. Injury 48:1204\u20131210","journal-title":"Injury"},{"key":"3338_CR2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00402-018-3048-0","volume":"139","author":"H Bezstarosti","year":"2019","unstructured":"Bezstarosti H, Van Lieshout EMM, Voskamp LW, Kortram K, Obremskey W, McNally MA, Metsemakers WJ, Verhofstad MHJ (2019) Insights into treatment and outcome of fracture-related infection: A systematic literature review. Arch Orthop Trauma Surg 139:61\u201372","journal-title":"Arch Orthop Trauma Surg"},{"issue":"5","key":"3338_CR3","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1007\/s00264-014-2293-2","volume":"38","author":"J Craig","year":"2014","unstructured":"Craig J, Fuchs T, Jenks M, Fleetwood K, Franz D, Iff J et al (2014) Systematic review and meta-analysis of the additional benefit of local prophylactic antibiotic therapy for infection rates in open tibia fractures treated with intramedullary nailing. Int Orthop 38(5):1025\u20131030. https:\/\/doi.org\/10.1007\/s00264-014-2293-2","journal-title":"Int Orthop"},{"issue":"7","key":"3338_CR4","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.injury.2014.03.022","volume":"45","author":"I Ktistakis","year":"2014","unstructured":"Ktistakis I, Giannoudi M, Giannoudis PV (2014) Infection rates after open tibial fractures: are they decreasing? Injury 45(7):1025\u20131027","journal-title":"Injury"},{"issue":"Suppl 5","key":"3338_CR5","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.1016\/S0020-1383(11)70128-0","volume":"42","author":"G Mouzopoulos","year":"2011","unstructured":"Mouzopoulos G, Kanakaris NK, Kontakis G, Obakponovwe O, Townsend R, Giannoudis PV (2011) Management of bone infections in adults: the surgeon\u2019s and microbiologist\u2019s perspectives. Injury 42(Suppl 5):S18-23","journal-title":"Injury"},{"issue":"2","key":"3338_CR6","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1097\/00005131-200502000-00012","volume":"19","author":"M Bhandari","year":"2005","unstructured":"Bhandari M, Zlowodzki M, Tornetta P 3rd, Schmidt A, Templeman DC (2005) Intramedullary nailing following external fixation in femoral and tibial shaft fractures. J Orthop Trauma 19(2):140\u2013144","journal-title":"J Orthop Trauma"},{"key":"3338_CR7","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1471-2474-14-42","volume":"14","author":"E Antonova","year":"2013","unstructured":"Antonova E, Le TK, Burge R, Mershon J (2013) Tibia shaft fractures: Costly burden of nonunions. BMC Musculoskelet Disord 14:42","journal-title":"BMC Musculoskelet Disord"},{"key":"3338_CR8","unstructured":"https:\/\/www.boa.ac.uk\/resources\/boast-4-pdf.html"},{"key":"3338_CR9","doi-asserted-by":"crossref","unstructured":"Gosselin RA, Roberts I, Gillespie WJ (2004) Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev CD003764.","DOI":"10.1002\/14651858.CD003764.pub2"},{"key":"3338_CR10","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1186\/s13018-021-02411-8","volume":"16","author":"N Walter","year":"2021","unstructured":"Walter N, Popp D, Freigang V, Nerlich M, Alt V, Rupp M (2021) Treatment of severely open tibial fractures, non-unions, and fracture-related infections with a gentamicin-coated tibial nail\u2014Clinical outcomes including quality of life analysis and psychological ICD-10-based symptom rating. J Orthop Surg Res 16:270","journal-title":"J Orthop Surg Res"},{"key":"3338_CR11","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1016\/j.injury.2021.04.053","volume":"52","author":"D Franz","year":"2021","unstructured":"Franz D, Raschke M, Giannoudis PV, Leliveld M, Metsemakers WJ, Verhofstad MHJ, Craig JA, Shore J, Smith A, Muehlendyck C (2021) Use of antibiotic coated intramedullary nails in open tibia fractures: a European medical resource use and cost-effectiveness analysis. Injury 52:1951\u20131958","journal-title":"Injury"},{"key":"3338_CR12","unstructured":"https:\/\/ifu.depuysynthes.com\/binary\/org\/DPY_SYN_EMEA\/ifu_documents\/Trauma\/SE_623768_AE_eng_2.pdf"},{"issue":"3","key":"3338_CR13","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.injury.2017.08.040","volume":"49","author":"W Metsemakers","year":"2018","unstructured":"Metsemakers W, Morgenstern M, McNally M et al (2018) Fracture-related infection: a consensus on definition from an international expert group. Injury. 49(3):505\u201310","journal-title":"Injury."},{"issue":"8","key":"3338_CR14","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-035404","volume":"10","author":"T Galvain","year":"2020","unstructured":"Galvain T, Chitnis A, Paparouni K, Tong C, Holy CE, Giannoudis PV (2020) The economic burden of infections following intramedullary nailing for a tibial shaft fracture in England. BMJ Open 10(8):e035404. https:\/\/doi.org\/10.1136\/bmjopen-2019-035404","journal-title":"BMJ Open"},{"key":"3338_CR15","first-page":"63","volume":"34","author":"T Greco","year":"2020","unstructured":"Greco T, Vitiello R, Cazzato G, Cianni L, Malerba G, Maccauro G, Perisano C (2020) Intramedullary antibiotic coated nail in tibial fracture: A systematic review. J Biol Regul Homeost Agents 34:63\u201369","journal-title":"J Biol Regul Homeost Agents"},{"key":"3338_CR16","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1016\/j.injury.2021.04.053","volume":"52","author":"D Franz","year":"2021","unstructured":"Franz D, Raschke M, Giannoudis PV, Leliveld M, Metsemakers WJ, Verhofstad MHJ, Craig JA, Shore J, Smith A, Muehlendyck C (2021) Use of antibiotic coated intramedullary nails in open tibia fractures: A European medical resource use and cost-effectiveness analysis. Injury 52:1951\u20131958. https:\/\/doi.org\/10.1016\/j.injury.2021.04.053","journal-title":"Injury"},{"key":"3338_CR17","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.cjtee.2019.03.006","volume":"22","author":"D Pinto","year":"2019","unstructured":"Pinto D, Manjunatha K, Savur AD, Ahmed NR, Mallya S, Ramya V (2019) Comparative study of the efficacy of gentamicin-coated intramedullary interlocking nail versus regular intramedullary interlocking nail in Gustilo type I and II open tibia fractures. Chin J Traumatol 22:270\u2013273","journal-title":"Chin J Traumatol"},{"key":"3338_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-14-103","author":"K Fong","year":"2013","unstructured":"Fong K, Truong V, Foote C, Petrisor B, Ristevski B, Sprague S, Bhandari M (2013) Predictors of nonunion and reoperation in patients with fractures of the tibia: an observational study. BMC Musculoskelet Disord. https:\/\/doi.org\/10.1186\/1471-2474-14-103","journal-title":"BMC Musculoskelet Disord"},{"issue":"12","key":"3338_CR19","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.2106\/JBJS.G.01694","volume":"90","author":"M Bhandari","year":"2008","unstructured":"Bhandari M, Guyatt G, Tornetta P, Schemitsch E (2008) Randomized trial of reamed and unreamed intramedullary nailing of tibial shaft fractures. J Bone Joint Surg Am 90(12):2567\u20132578","journal-title":"J Bone Joint Surg Am"},{"key":"3338_CR20","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3390\/jfmk6040097","volume":"6","author":"C Perisano","year":"2021","unstructured":"Perisano C, Greco T, Polichetti C, Inverso M, Maccauro G (2021) Antibiotic-coated nail in open tibial fracture: a retrospective case series. J Funct Morphol Kinesiol 6:97","journal-title":"J Funct Morphol Kinesiol"},{"issue":"10","key":"3338_CR21","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1016\/j.injury.2017.07.008","volume":"48","author":"G Schmidmaier","year":"2017","unstructured":"Schmidmaier G, Kerstan M, Schwabe P, S\u00fcdkamp N, Raschke M (2017) Clinical experiences in the use of a gentamicin-coated titanium nail in tibia fractures. Injury 48(10):2235\u20132241. https:\/\/doi.org\/10.1016\/j.injury.2017.07.008","journal-title":"Injury"},{"key":"3338_CR22","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.injury.2019.07.009","volume":"50","author":"A Moghaddam","year":"2019","unstructured":"Moghaddam A, Weis J, Haubruck P, Raven TF, Addali A, Schmidmaier G (2019) Evaluation of the clinicaluse of the ETN PROtect\u00aein non-union therapy. Injury 50:32\u201339","journal-title":"Injury"},{"issue":"22","key":"3338_CR23","doi-asserted-by":"publisher","first-page":"5471","DOI":"10.3390\/molecules25225471","volume":"25","author":"D De Meo","year":"2020","unstructured":"De Meo D, Cannari FM, Petriello L, Persiani P, Villani C (2020) Gentamicin-coated tibia nail in fractures and nonunion to reduce fracture-related infections: a systematic review. Molecules 25(22):5471","journal-title":"Molecules"},{"issue":"12","key":"3338_CR24","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1016\/j.injury.2015.09.028","volume":"46","author":"WJ Metsemakers","year":"2015","unstructured":"Metsemakers WJ, Reul M, Nijs S (2015) The use of gentamicin-coated nails in complex open tibia fracture and revision cases: a retrospective analysis of a single centre case series and review of the literature. Injury 46(12):2433\u20132437. https:\/\/doi.org\/10.1016\/j.injury.2015.09.028","journal-title":"Injury"},{"issue":"8","key":"3338_CR25","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/j.injury.2013.05.001","volume":"44","author":"MK Wasko","year":"2013","unstructured":"Wasko MK, Borens O (2013) Antibiotic cement nail for the treatment of posttraumatic intramedullary infections of the tibia: midterm results in 10 cases. Injury 44(8):1057\u20131060","journal-title":"Injury"},{"key":"3338_CR26","doi-asserted-by":"publisher","first-page":"7421582","DOI":"10.1155\/2021\/7421582","volume":"2021","author":"T Greco","year":"2021","unstructured":"Greco T, Cianni L, Polichetti C, Inverso M, Maccauro G, Perisano C (2021) Uncoated vs. Antibiotic-coated tibia nail in open diaphyseal tibial fracture (42 according to AO classification): a single center experience. BioMed Res Int 2021:7421582","journal-title":"BioMed Res Int"},{"issue":"1","key":"3338_CR27","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1177\/0885328216630912","volume":"31","author":"S Nast","year":"2016","unstructured":"Nast S, Fassbender M, Bormann N, Beck S, Montali A, Lucke M, Schmidmaier G, Wildemann B (2016) In vivo quantification of gentamicin released from an implant coating. J Biomat Appl 31(1):45\u201354","journal-title":"J Biomat Appl"},{"issue":"Suppl 3","key":"3338_CR28","doi-asserted-by":"publisher","first-page":"S86","DOI":"10.1016\/j.injury.2019.09.024","volume":"51","author":"G Vicenti","year":"2020","unstructured":"Vicenti G, Bizzoca D, Cotugno D, Carrozzo M, Riefoli F, Rifino F, Belviso V, Elia R, Solarino G, Moretti B (2020) The use of a gentamicin-coated titanium nail, combined with RIA system, in the management of non-unions of open tibial fractures: a single centre prospective study. Injury 51(Suppl 3):S86\u2013S91. https:\/\/doi.org\/10.1016\/j.injury.2019.09.024","journal-title":"Injury"}],"container-title":["European Journal of Orthopaedic Surgery &amp; Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-022-03338-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00590-022-03338-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-022-03338-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T13:06:50Z","timestamp":1686920810000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00590-022-03338-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,9]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["3338"],"URL":"https:\/\/doi.org\/10.1007\/s00590-022-03338-4","relation":{},"ISSN":["1432-1068"],"issn-type":[{"value":"1432-1068","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,9]]},"assertion":[{"value":"15 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare we have no conflicts of interest and no funds\/grants were received for this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was not required as no patients were contacted for this study and all data were anonymised. The study was registered with the hospital\u2019s research department.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}