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Group 1 consisted of 40 knees that received autologous LP-PRP\u2009+\u2009HA; Group 2 consisted of 40 knees treated with a single dose of AMAT injection. The outcomes were measured by Tegner, Marx, Visual Analogue Scale (VAS) for pain, International Knee Documentation Committee, and Knee Injury and Osteoarthritis Outcome Score (KOOS) at 6 (T<jats:sub>1<\/jats:sub>), 12 (T<jats:sub>2<\/jats:sub>), and 24 (T<jats:sub>3<\/jats:sub>) months. Adverse events were recorded at each follow-up timepoint. To assess score differences among subjects of the same gender and age, a subgroup analysis was performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Both groups had significant clinical and functional improvement at 6, 12, and 24\u00a0months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Comparing the two groups, the AMAT groups showed significantly higher pre-operative Marx score (3.35\u2009\u00b1\u20094.91 vs. 1.78\u2009\u00b1\u20093.91) and VAS score (5.03\u2009\u00b1\u20092.02 vs. 3.85\u2009\u00b1\u20091.68) (<jats:italic>p<\/jats:italic> &lt; 0.05), higher VAS (3.89\u2009\u00b1\u20092.51 vs. 2.64\u2009\u00b1\u20092.00) at <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> and KOOS-ADL (79.60\u2009\u00b1\u200920.20 vs. 65.68\u2009\u00b1\u200923.62), and lower KOOS-Sports (50.30\u2009\u00b1\u200930.15 vs. 68.35\u2009\u00b1\u200930.39) at T<jats:sub>3<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). No patient from either group had experienced major adverse effects. In the LP-PRP group 12 (30%) patients presented swelling, redness, and mild pain for one day after injection and two patients had synovitis for two days and required paracetamol and local ice. In AMAT group 5 (12.5%) patients had ecchymosis and bruising at the fat aspiration site for three days.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>AMAT did not show significant superior clinical improvement compared with three LP-PRP combined with HA injections in terms of functional improvement at different follow-up points. Both procedures were safe with no major complications reporting good results at mid-term follow-up, improving knee function, pain, and quality of live regardless of age and gender.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Level of evidence<\/jats:title>\n                <jats:p>Level I\u2014Prospective Randomized Clinical Trial.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00590-022-03356-2","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T08:03:15Z","timestamp":1661241795000},"page":"1895-1904","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Autologous microfragmented adipose tissue and leukocyte-poor platelet-rich plasma combined with hyaluronic acid show comparable clinical outcomes for symptomatic early knee osteoarthritis over a two-year follow-up period: a prospective randomized clinical trial"],"prefix":"10.1007","volume":"33","author":[{"given":"Alberto","family":"Gobbi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Dallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1216-792X","authenticated-orcid":false,"given":"Riccardo","family":"D\u2019Ambrosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"3356_CR1","doi-asserted-by":"publisher","unstructured":"Naik A, Shanmugasundaram S, Mahadev K, Shetty AA, Kim SJ (2021) Volume index as a new measure of cartilage loss: a retrospective MRI-based study of chondral injury patterns in adult patients with knee pain. 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