{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:35:46Z","timestamp":1793082946816,"version":"4.5.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Turku (UTU) including Turku University Central Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Orthop Surg Traumatol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Platelet-rich plasma (PRP) injections are challenging the current treatment options for knee osteoarthritis (KOA). Targeting the treatment to optimal stage of the symptomatic KOA may be crucial in the success and failure of treatment. The aim of this study is to compare the outcomes of PRP injections at different stages of KOA in order to determine the optimal stage of the KOA for PRP injection treatments.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 89 consecutive patients with symptomatic KOA Kellgren\u2013Lawrence grade 1 to 3 (Group A grade 1, group B grade 2 and group C grade 3) were given three intra-articular injections of PRP with 2 weeks interval between injections. Visual Analogue Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Range of Motion were measured before injection, at 15\u00a0days, 6\u00a0months, 12\u00a0months and, at last follow-up. Intergroup outcomes were compared.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The comparison of groups A and C showed that WOMAC scores were significantly higher in group C at 15\u00a0days [<jats:italic>p<\/jats:italic>\u2009=\u20090.047] and at last follow-up [<jats:italic>p<\/jats:italic>\u2009=\u20090.008] than in group A, as well as VAS scores at 6\u00a0months [<jats:italic>p<\/jats:italic>\u2009=\u20090.031] and at last follow-up [<jats:italic>p<\/jats:italic>\u2009=\u20090.008]. The overall WOMAC and VAS scores showed decrease in all the groups in minimum follow-up of 14\u00a0months. The other comparisons did not show significant differences in outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>All the groups showed decrease in WOMAC and VAS, but patients with mild KOA benefit significantly more from the treatments than patients with more severe KOA.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00590-023-03481-6","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T09:10:06Z","timestamp":1675329006000},"page":"2611-2617","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The effects of platelet-rich plasma injections in different stages of knee osteoarthritis"],"prefix":"10.1007","volume":"33","author":[{"given":"Juho A","family":"Annaniemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcri","family":"Pere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"3481_CR1","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.joca.2018.11.001","volume":"27","author":"L Mandl","year":"2019","unstructured":"Mandl L (2019) Osteoarthritis year in review 2018: clinical. 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The authors have no competing interests to declare that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study followed ethical principles of the World Medical Association Declaration of Helsinki, and the study was approved by the Institutional Review Board. Individual informed consent was waived due to retrospective nature of this study, as per the local laws in Finland regarding this type of medical research. The data were obtained from patients\u2019 electronic medical records and the source data were deidentified.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}