{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:11:21Z","timestamp":1776409881128,"version":"3.51.2"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Orthop Surg Traumatol"],"DOI":"10.1007\/s00590-023-03590-2","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T07:02:37Z","timestamp":1685343757000},"page":"3585-3596","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Osseointegration reduces aseptic loosening of primary distal femoral implants in pediatric and adolescent osteosarcoma patients: a retrospective clinical and radiographic study"],"prefix":"10.1007","volume":"33","author":[{"given":"Clayton","family":"Welsh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peyton","family":"Hull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teerin","family":"Meckmongkol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aadil","family":"Mumith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Lovejoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Giangarra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4543-4756","authenticated-orcid":false,"given":"Melanie","family":"Coathup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"3590_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-4419-0284-9_1","volume":"152","author":"G Ottaviani","year":"2009","unstructured":"Ottaviani G, Jaffe N (2009) The epidemiology of osteosarcoma. Cancer Treat Res 152:3\u201313. https:\/\/doi.org\/10.1007\/978-1-4419-0284-9_1","journal-title":"Cancer Treat Res"},{"issue":"27","key":"3590_CR2","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1200\/jco.2014.59.4895","volume":"33","author":"MS Isakoff","year":"2015","unstructured":"Isakoff MS, Bielack SS, Meltzer P, Gorlick R (2015) Osteosarcoma: current treatment and a collaborative pathway to success. J Clin Oncol 33(27):3029\u20133035. https:\/\/doi.org\/10.1200\/jco.2014.59.4895","journal-title":"J Clin Oncol"},{"issue":"3","key":"3590_CR3","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1007\/s11999-014-3699-2","volume":"473","author":"E Pala","year":"2015","unstructured":"Pala E, Trovarelli G, Calabr\u00f2 T, Angelini A, Abati CN, Ruggieri P (2015) Survival of modern knee tumor megaprostheses: failures, functional results, and a comparative statistical analysis. Clin Orthop Relat Res 473(3):891\u2013899. https:\/\/doi.org\/10.1007\/s11999-014-3699-2","journal-title":"Clin Orthop Relat Res"},{"key":"3590_CR4","doi-asserted-by":"publisher","first-page":"6537","DOI":"10.1038\/s41598-021-85892-1","volume":"11","author":"GW Kim","year":"2021","unstructured":"Kim GW, Jin QH, Lim JH et al (2021) No difference of survival between cruciate retaining and substitution designs in high flexion total knee arthroplasty. Sci Rep 11:6537. https:\/\/doi.org\/10.1038\/s41598-021-85892-1","journal-title":"Sci Rep"},{"issue":"4","key":"3590_CR5","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/j.arth.2017.10.051","volume":"33","author":"L Haijie","year":"2018","unstructured":"Haijie L, Dasen L, Tao J, Yi Y, Xiaodong T, Wei G (2018) Implant survival and complication profiles of endoprostheses for treating tumor around the knee in adults: a systematic review of the literature over the past 30 years. J Arthroplasty 33(4):1275-1287.e3. https:\/\/doi.org\/10.1016\/j.arth.2017.10.051. (Epub 2017 Nov 7 PMID: 29191444)","journal-title":"J Arthroplasty"},{"key":"3590_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1302\/0301-620X.78B1.0780005","volume":"78","author":"PS Unwin","year":"1996","unstructured":"Unwin PS, Cannon SR, Grimer RJ, Kemp HB, Sneath RS, Walker PS (1996) Aseptic loosening in cemented custom-made prosthetic replacements for bone tumours of the lower limb. J Bone Joint Surg Br 78:5\u201313","journal-title":"J Bone Joint Surg Br"},{"key":"3590_CR7","doi-asserted-by":"publisher","unstructured":"Batta V, Coathup MJ, Parratt MT et al (2014) Uncemented, custom-made, hydroxyapatite-coated collared distal femoral endoprostheses: up to 18 years' follow-up. Bone Joint J 96-b(2):263\u2013269. https:\/\/doi.org\/10.1302\/0301-620x.96b2.32091.","DOI":"10.1302\/0301-620x.96b2.32091"},{"issue":"6","key":"3590_CR8","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1007\/s00590-017-1965-1","volume":"27","author":"RE Turcotte","year":"2017","unstructured":"Turcotte RE, Stavropoulos NA, Toreson J, Alsultan M (2017) Radiographic assessment of distal femur cemented stems in tumor endoprostheses. Eur J Orthop Surg Traumatol 27(6):821\u2013827. https:\/\/doi.org\/10.1007\/s00590-017-1965-1","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"3590_CR9","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1097\/BLO.0b013e3180514c8e","volume":"459","author":"S Sharma","year":"2007","unstructured":"Sharma S, Turcotte RE, Isler MH, Wong C (2007) Experience with cemented large segment endoprostheses for tumors. Clin Orthop Relat Res 459:54\u201359. https:\/\/doi.org\/10.1097\/BLO.0b013e3180514c8e","journal-title":"Clin Orthop Relat Res"},{"issue":"4","key":"3590_CR10","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1007\/s11999-014-4116-6","volume":"473","author":"MJ Coathup","year":"2015","unstructured":"Coathup MJ, Sanghrajka A, Aston WJ et al (2015) Hydroxyapatite-coated collars reduce radiolucent line progression in cemented distal femoral bone tumor implants. Clin Orthop Relat Res 473(4):1505\u20131514. https:\/\/doi.org\/10.1007\/s11999-014-4116-6","journal-title":"Clin Orthop Relat Res"},{"issue":"1 suppl","key":"3590_CR11","first-page":"171","volume":"75","author":"EY Chao","year":"1990","unstructured":"Chao EY, Sim FH (1990) Composite fixation of segmental bone\/joint defect replacement (SDR) prostheses: biological and biomechanical justifications. Chir Organi Mov 75(1 suppl):171\u2013173","journal-title":"Chir Organi Mov"},{"key":"3590_CR12","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0021-9290(96)00141-8","volume":"30","author":"SJ Taylor","year":"1997","unstructured":"Taylor SJ, Perry JS, Meswania JM, Donaldson N, Walker PS, Cannon SR (1997) Telemetry of forces from proximal femoral replacements and relevance to fixation. J Biomech 30:225\u2013234","journal-title":"J Biomech"},{"key":"3590_CR13","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.medengphy.2016.12.007","volume":"41","author":"P Fromme","year":"2017","unstructured":"Fromme P, Blunn GW, Aston WJ, Abdoola T, Koris J, Coathup MJ (2017) The effect of bone growth onto massive prostheses collars in protecting the implant from fracture. Med Eng Phys 41:19\u201325. https:\/\/doi.org\/10.1016\/j.medengphy.2016.12.007","journal-title":"Med Eng Phys"},{"issue":"17","key":"3590_CR14","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.2106\/jbjs.L.00362","volume":"95","author":"MJ Coathup","year":"2013","unstructured":"Coathup MJ, Batta V, Pollock RC et al (2013) Long-term survival of cemented distal femoral endoprostheses with a hydroxyapatite-coated collar: a histological study and a radiographic follow-up. J Bone Joint Surg Am 95(17):1569\u20131575. https:\/\/doi.org\/10.2106\/jbjs.L.00362","journal-title":"J Bone Joint Surg Am"},{"key":"3590_CR15","doi-asserted-by":"crossref","unstructured":"Heck DA, Chao EY, Sim FH, Pritchard DJ, Shives TC (1986) Titanium fibermetal segmental replacement prostheses. A radiographic analysis and review of current status. Clin Orthop Relat Res (204):266\u201385.","DOI":"10.1097\/00003086-198603000-00030"},{"key":"3590_CR16","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1097\/00003086-198306000-00013","volume":"176","author":"KN Kuo","year":"1983","unstructured":"Kuo KN, Gitelis S, Sim FH, Pritchard D, Chao E, Rostoker W, Galante JO, McDonald P (1983) Segmental replacement of long bones using titanium fiber metal composite following tumor resection. Clin Orthop Relat Res 176:108\u2013114","journal-title":"Clin Orthop Relat Res"},{"issue":"1","key":"3590_CR17","doi-asserted-by":"publisher","first-page":"118","DOI":"10.2106\/00004623-198668010-00015","volume":"68","author":"DA Heck","year":"1986","unstructured":"Heck DA, Nakajima I, Kelly PJ, Chao EY (1986) The effect of load alteration on the biological and biomechanical performance of a titanium fiber-metal segmental prosthesis. J Bone Joint Surg Am 68(1):118\u2013126","journal-title":"J Bone Joint Surg Am"},{"key":"3590_CR18","doi-asserted-by":"crossref","unstructured":"Ward WG, Johnston KS, Dorey FJ, Eckardt JJ (1993) Extramedullary porous coating to prevent diaphyseal osteolysis and radiolucent lines around proximal tibial replacements. A preliminary report. J Bone Joint Surg Am 75(7):976\u2013987.","DOI":"10.2106\/00004623-199307000-00003"},{"key":"3590_CR19","doi-asserted-by":"crossref","unstructured":"Okada Y, Suka T, Sim FH, Gorski JP, Chao EYS (1988) Comparison of replacement prostheses for segmental defects of bone. Different porous coatings for extracortical fixation. J Bone Joint Surg Am ;70(2):160\u2013172.","DOI":"10.2106\/00004623-198870020-00002"},{"issue":"3","key":"3590_CR20","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/s11999-011-2159-5","volume":"470","author":"AC Pedtke","year":"2012","unstructured":"Pedtke AC, Wustrack RL, Fang AS, Grimer RJ, O\u2019Donnell RJ (2012) Aseptic failure: how does the Compress(\u00ae) implant compare to cemented stems? Clin Orthop Relat Res 470(3):735\u2013742. https:\/\/doi.org\/10.1007\/s11999-011-2159-5","journal-title":"Clin Orthop Relat Res"},{"issue":"6","key":"3590_CR21","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s00264-006-0186-8","volume":"30","author":"AA Bhangu","year":"2006","unstructured":"Bhangu AA, Kramer MJ, Grimer RJ, O\u2019Donnell RJ (2006) Early distal femoral endoprosthetic survival: cemented stems versus the Compress implant. Int Orthop 30(6):465\u2013472. https:\/\/doi.org\/10.1007\/s00264-006-0186-8","journal-title":"Int Orthop"},{"issue":"2","key":"3590_CR22","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1007\/s11999-015-4552-y","volume":"474","author":"MN Zimel","year":"2016","unstructured":"Zimel MN, Farfalli GL, Zindman AM et al (2016) Revision distal femoral arthroplasty with the Compress(\u00ae) prosthesis has a low rate of mechanical failure at 10 years. Clin Orthop Relat Res 474(2):528\u2013536. https:\/\/doi.org\/10.1007\/s11999-015-4552-y","journal-title":"Clin Orthop Relat Res"},{"issue":"11","key":"3590_CR23","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.1007\/s11999-009-0912-9","volume":"467","author":"GL Farfalli","year":"2009","unstructured":"Farfalli GL, Boland PJ, Morris CD, Athanasian EA, Healey JH (2009) Early equivalence of uncemented press-fit and Compress femoral fixation. Clin Orthop Relat Res 467(11):2792\u20132799. https:\/\/doi.org\/10.1007\/s11999-009-0912-9","journal-title":"Clin Orthop Relat Res"},{"issue":"3","key":"3590_CR24","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1007\/s11999-012-2635-6","volume":"471","author":"JH Healey","year":"2013","unstructured":"Healey JH, Morris CD, Athanasian EA, Boland PJ (2013) Compress knee arthroplasty has 80% 10-year survivorship and novel forms of bone failure. Clin Orthop Relat Res 471(3):774\u2013783. https:\/\/doi.org\/10.1007\/s11999-012-2635-6","journal-title":"Clin Orthop Relat Res"},{"key":"3590_CR25","doi-asserted-by":"publisher","unstructured":"Henderson ER, O'Connor MI, Ruggieri P, Windhager R, Funovics PT, Gibbons CL, Guo W, Hornicek FJ, Temple HT, Letson GD (2014) Classification of failure of limb salvage after reconstructive surgery for bone tumours: a modified system Including biological and expandable reconstructions. Bone Joint J 96-B(11):1436\u20131440. https:\/\/doi.org\/10.1302\/0301-620X.96B11.34747. PMID: 25371453.","DOI":"10.1302\/0301-620X.96B11.34747"},{"issue":"7","key":"3590_CR26","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1302\/2046-3758.97.BJR-2019-0122.R1","volume":"9","author":"A Mumith","year":"2020","unstructured":"Mumith A, Coathup M, Edwards TC, Gikas P, Aston W, Blunn G (2020) Multidrug chemotherapy causes early radiological signs of loosening in distal femoral replacements. Bone Joint Res 9(7):333\u2013340. https:\/\/doi.org\/10.1302\/2046-3758.97.BJR-2019-0122.R1","journal-title":"Bone Joint Res"},{"key":"3590_CR27","unstructured":"Bielack SS, Bernstein ML (2005) Cancer in children: clinical management,\u00a05th edn. Oxford University Press, New York."},{"issue":"6","key":"3590_CR28","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s00264-006-0192-x","volume":"30","author":"D Carrle","year":"2006","unstructured":"Carrle D, Bielack SS (2006) Current strategies of chemotherapy in osteosarcoma. Int Orthop 30(6):445\u2013451","journal-title":"Int Orthop"},{"issue":"6","key":"3590_CR29","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.2106\/jbjs.F.01324","volume":"90","author":"LM Jeys","year":"2008","unstructured":"Jeys LM, Kulkarni A, Grimer RJ, Carter SR, Tillman RM, Abudu A (2008) Endoprosthetic reconstruction for the treatment of musculoskeletal tumors of the appendicular skeleton and pelvis. J Bone Joint Surg Am 90(6):1265\u20131271. https:\/\/doi.org\/10.2106\/jbjs.F.01324","journal-title":"J Bone Joint Surg Am"},{"issue":"3","key":"3590_CR30","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1002\/cncr.25446","volume":"117","author":"R Nagarajan","year":"2011","unstructured":"Nagarajan R, Kamruzzaman A, Ness KK, Marchese VG, Sklar C, Mertens A, Yasui Y, Robison LL, Marina N (2011) Twenty years of follow-up of survivors of childhood osteosarcoma: a report from the Childhood Cancer Survivor Study. Cancer 117(3):625\u2013634","journal-title":"Cancer"},{"key":"3590_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1200\/JGO.17.00241.PMID:30946633;PMCID:PMC6528739","volume":"5","author":"B Abou Ali","year":"2019","unstructured":"Abou Ali B, Salman M, Ghanem KM, Boulos F, Haidar R, Saghieh S, Akel S, Muwakkit SA, El-Solh H, Saab R, Tamim H, Abboud MR (2019) Clinical prognostic factors and outcome in pediatric osteosarcoma: effect of delay in local control and degree of necrosis in a multidisciplinary setting in Lebanon. J Glob Oncol 5:1\u20138. https:\/\/doi.org\/10.1200\/JGO.17.00241.PMID:30946633;PMCID:PMC6528739","journal-title":"J Glob Oncol"},{"key":"3590_CR32","doi-asserted-by":"crossref","unstructured":"Ottaviani G, Robert RS, Huh WW, Jaffe N (2009) Functional, psychosocial and professional outcomes in long-term survivors of lower-extremity osteosarcomas: amputation versus limb salvage. Cancer Treat Res 152:421\u2013436.","DOI":"10.1007\/978-1-4419-0284-9_23"},{"key":"3590_CR33","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1097\/01.blo.0000180050.27961.8a","volume":"438","author":"AM Griffin","year":"2005","unstructured":"Griffin AM, Parsons JA, Davis AM, Bell RS, Wunder JS (2005) Uncemented tumor endoprostheses at the knee: root causes of failure. Clin Orthop Relat Res 438:71\u201379","journal-title":"Clin Orthop Relat Res"},{"issue":"6","key":"3590_CR34","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1302\/0301-620X.88B6.17519","volume":"88","author":"ER Ahlmann","year":"2006","unstructured":"Ahlmann ER, Menendez LR, Kermani C, Gotha H (2006) Survivorship and clinical outcome of modular endoprosthetic reconstruction for neoplastic disease of the lower limb. J Bone Joint Surg Br 88(6):790\u2013795","journal-title":"J Bone Joint Surg Br"},{"issue":"6","key":"3590_CR35","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.ejso.2006.10.007","volume":"33","author":"IW Sim","year":"2007","unstructured":"Sim IW, Tse LF, Ek ET, Powell GJ, Choong PF (2007) Salvaging the limb salvage: management of complications following endoprosthetic reconstruction for tumours around the knee. Eur J Surg Oncol 33(6):796\u2013802","journal-title":"Eur J Surg Oncol"},{"issue":"12","key":"3590_CR36","doi-asserted-by":"publisher","first-page":"2718","DOI":"10.1097\/CORR.0000000000000949","volume":"477","author":"I Barrientos-Ruiz","year":"2019","unstructured":"Barrientos-Ruiz I, Ortiz-Cruz EJ, Peleteiro-Pensado M, Merino-Rueda R (2019) Early mechanical failure of a tumoral endoprosthetic rotating hinge in the knee: does bumper wear contribute to hyperextension failure? Clin Orthop Relat Res 477(12):2718\u20132725","journal-title":"Clin Orthop Relat Res"},{"key":"3590_CR37","first-page":"560","volume-title":"Limb Salvage: current trends","author":"S Taylor","year":"1993","unstructured":"Taylor S, Perry J, Adler J, Unwin PS, Walker PS (1993) The telemetry of forces in vivo developed in massive orthopaedic implants: the first 18 months results from walking. In: Tan SK (ed) Limb Salvage: current trends. ISOLS, Singapore, p 560"},{"key":"3590_CR38","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1302\/0301-620X.70B1.2828374","volume":"70B","author":"RGT Geesink","year":"1988","unstructured":"Geesink RGT, de Groot K, Klein CPAT (1988) Bonding of bone to apatite-coated implants. J Bone Joint Surg 70B:17\u201322","journal-title":"J Bone Joint Surg"},{"issue":"21","key":"3590_CR39","doi-asserted-by":"publisher","first-page":"5199","DOI":"10.1016\/j.biomaterials.2003.12.018","volume":"25","author":"AE Porter","year":"2004","unstructured":"Porter AE, Taak P, Hobbs LW, Coathup MJ, Blunn GW, Spector M (2004) Bone bonding to hydroxyapatite and titanium surfaces on femoral stems retrieved from human subjects at autopsy. Biomaterials 25(21):5199\u20135208. https:\/\/doi.org\/10.1016\/j.biomaterials.2003.12.018. (PMID: 15109844)","journal-title":"Biomaterials"},{"issue":"9","key":"3590_CR40","doi-asserted-by":"publisher","first-page":"3014","DOI":"10.1007\/s11999-015-4407-6","volume":"473","author":"FM Wodajo","year":"2015","unstructured":"Wodajo FM (2015) CORR Insights(\u00ae): CORR insights(\u00ae): are complications associated with the Repiphysis(\u00ae) expandable distal femoral prosthesis acceptable for its continued use? Clin Orthop Relat Res 473(9):3014\u20133016. https:\/\/doi.org\/10.1007\/s11999-015-4407-6","journal-title":"Clin Orthop Relat Res"},{"issue":"5","key":"3590_CR41","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.2106\/JBJS.I.00591","volume":"92","author":"KS Beebe","year":"2010","unstructured":"Beebe KS, Uglialoro AD, Patel N, Benevenia J, Patterson FR (2010) Mechanical failure of the Repiphysis expandable prosthesis: a case report. J Bone Joint Surg Am 92(5):1250\u20131253","journal-title":"J Bone Joint Surg Am"},{"issue":"13","key":"3590_CR42","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.00841","volume":"93","author":"AV Maheshwari","year":"2011","unstructured":"Maheshwari AV, Bergin PF, Henshaw RM (2011) Modes of failure of custom expandable repiphysis prostheses: a report of three cases. J Bone Joint Surg Am 93(13):e72","journal-title":"J Bone Joint Surg Am"},{"issue":"3","key":"3590_CR43","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1007\/s11999-014-3564-3","volume":"473","author":"CA Cipriano","year":"2015","unstructured":"Cipriano CA, Gruzinova IS, Frank RM, Gitelis S, Virkus WW (2015) Frequent complications and severe bone loss associated with the repiphysis expandable distal femoral prosthesis. Clin Orthop Relat Res 473(3):831\u2013838","journal-title":"Clin Orthop Relat Res"},{"key":"3590_CR44","doi-asserted-by":"publisher","first-page":"3003","DOI":"10.1007\/s11999-015-4355-1","volume":"473","author":"EL Staals","year":"2015","unstructured":"Staals EL, Colangeli M, Ali N, Casanova JM, Donati DM, Manfrini M (2015) Are complications associated with the Repiphysis(\u00ae) expandable distal femoral prosthesis acceptable for its continued use? Clin Orthop 473:3003\u20133013","journal-title":"Clin Orthop"},{"key":"3590_CR45","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-020-03712-z","author":"R Dukan","year":"2021","unstructured":"Dukan R, Mascard E, Langlais T et al (2021) Long-term outcomes of non-invasive expandable endoprostheses for primary malignant tumors around the knee in skeletally-immature patients. Arch Orthop Trauma Surg. https:\/\/doi.org\/10.1007\/s00402-020-03712-z","journal-title":"Arch Orthop Trauma Surg"},{"issue":"2","key":"3590_CR46","first-page":"129","volume":"88","author":"E Pala","year":"2017","unstructured":"Pala E, Trovarelli A, Angelini A, Maraldi M, Berizzi A, Ruggieri P (2017) Megaprosthesis of the knee in tumor and revision surgery. Acta Biomed 88(2):129\u2013138","journal-title":"Acta Biomed"},{"key":"3590_CR47","doi-asserted-by":"publisher","unstructured":"Sigmund IK, Gamper J, Weber C, Holinka J, Panotopoulos J, Funovics PT, Windhager R (2018) Efficacy of different revision procedures for infected megaprostheses in musculoskeletal tumour surgery of the lower limb. PLoS One 13(7):e0200304. https:\/\/doi.org\/10.1371\/journal.pone.0200304. PMID: 29975769; PMCID: PMC6033467.","DOI":"10.1371\/journal.pone.0200304"},{"key":"3590_CR48","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1471-2474-14-51.PMID:23369129;PMCID:PMC3599741","volume":"14","author":"T Morii","year":"2013","unstructured":"Morii T, Morioka H, Ueda T, Araki N, Hashimoto N, Kawai A, Mochizuki K, Ichimura S (2013) Deep infection in tumor endoprosthesis around the knee: a multi-institutional study by the Japanese musculoskeletal oncology group. BMC Musculoskelet Disord 14:51. https:\/\/doi.org\/10.1186\/1471-2474-14-51.PMID:23369129;PMCID:PMC3599741","journal-title":"BMC Musculoskelet Disord"},{"key":"3590_CR49","doi-asserted-by":"crossref","unstructured":"Butte Z, Tanaka K, Andaya V, Zimel M, O\u2019Donnell RJ, Wustrack R (2020) Risk of endoprosthetic infection and impact of health-related quality of life in patients with osteosarcoma and giant cell tumor of bone; a retrospective case-control study. Ann Joint, 5. https:\/\/aoj.amegroups.com\/article\/view\/5732.","DOI":"10.21037\/aoj.2020.02.03"},{"issue":"11","key":"3590_CR50","doi-asserted-by":"publisher","first-page":"2800","DOI":"10.1007\/s11999-009-0946-z","volume":"467","author":"WK Tyler","year":"2009","unstructured":"Tyler WK, Healey JH, Morris CD, Boland PJ, O\u2019Donnell RJ (2009) Compress periprosthetic fractures: interface stability and ease of revision. Clin Orthop Relat Res 467(11):2800\u20132806. https:\/\/doi.org\/10.1007\/s11999-009-0946-z","journal-title":"Clin Orthop Relat Res"},{"key":"3590_CR51","doi-asserted-by":"publisher","unstructured":"Goulding KA, Schwartz A, Hattrup SJ, Randall RL, Lee D, Rispoli DM, Lerman DM, Beauchamp C (2017) Use of compressive osseointegration endoprostheses for massive bone loss from tumor and failed arthroplasty: a viable option in the upper extremity. Clin Orthop Relat Res 475(6):1702\u20131711. https:\/\/doi.org\/10.1007\/s11999-017-5258-0. Epub 2017 Feb 13. Erratum in: Clin Orthop Relat Res. 2017 Jun; 475(6):1752. PMID: 28194713; PMCID: PMC5406340","DOI":"10.1007\/s11999-017-5258-0"}],"container-title":["European Journal of Orthopaedic Surgery &amp; Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-023-03590-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00590-023-03590-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-023-03590-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T06:06:12Z","timestamp":1700028372000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00590-023-03590-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,29]]},"references-count":51,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["3590"],"URL":"https:\/\/doi.org\/10.1007\/s00590-023-03590-2","relation":{},"ISSN":["1432-1068"],"issn-type":[{"value":"1432-1068","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,29]]},"assertion":[{"value":"14 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest:"}},{"value":"This study received ethical board approval from the Nemours Office of Human Subjects Protection (# 1351573), and all experiments were performed in accordance with relevant guidelines and regulations within the Helsinki Declaration.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Our study was retrospective, and as such, a waiver of consent was approved by the Institutional Review Board Committee. The corresponding author is prepared to collect documentation of compliance with ethical standards and send if requested.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}