{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T23:07:40Z","timestamp":1767049660503,"version":"3.48.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Orthop Surg Traumatol"],"DOI":"10.1007\/s00590-025-04321-5","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T05:36:17Z","timestamp":1748237777000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synovial fluid calprotectin quantitative rapid diagnostic biomarker for risk stratification of periprosthetic joint infections"],"prefix":"10.1007","volume":"35","author":[{"given":"Angeliki","family":"Banousi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alkiviadis","family":"Vossos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasios","family":"Mourikis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stamatios","family":"Papadakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanouil","family":"Fandridis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"issue":"5","key":"4321_CR1","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1007\/s00264-022-05357-6","volume":"46","author":"AT Hantouly","year":"2022","unstructured":"Hantouly AT, Salameh M, Toubasi AA et al (2022) Synovial fluid calprotectin in diagnosing periprosthetic joint infection: a meta-analysis. Int Orthop 46(5):971\u2013981. https:\/\/doi.org\/10.1007\/s00264-022-05357-6","journal-title":"Int Orthop"},{"issue":"9","key":"4321_CR2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045478","volume":"7","author":"A Cesaro","year":"2012","unstructured":"Cesaro A, Anceriz N, Plante A, Pag\u00e9 N, Tardif MR, Tessier PA (2012) An inflammation loop orchestrated by S100A9 and calprotectin is critical for development of arthritis. PLoS ONE 7(9):e45478. https:\/\/doi.org\/10.1371\/journal.pone.0045478","journal-title":"PLoS ONE"},{"key":"4321_CR3","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9671604","volume":"2017","author":"TS Teng","year":"2017","unstructured":"Teng TS, Ji AL, Ji XY, Li YZ (2017) Neutrophils and immunity: from bactericidal action to being conquered. J Immunol Res 2017:9671604. https:\/\/doi.org\/10.1155\/2017\/9671604","journal-title":"J Immunol Res"},{"key":"4321_CR4","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1056\/NEJMra035415","volume":"350","author":"RO Darouiche","year":"2004","unstructured":"Darouiche RO (2004) Treatment of infections associated with surgical implants. N Engl J Med 350:1422\u20131429","journal-title":"N Engl J Med"},{"key":"4321_CR5","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1086\/514991","volume":"27","author":"EF Berbari","year":"1998","unstructured":"Berbari EF, Hanssen AD, Duffy MC, Steckelberg JM, Ilstrup DM, Harmsen WS et al (1998) Risk factors for prosthetic joint infection: casecontrol study. Clin Infect Dis 27:1247\u20131254","journal-title":"Clin Infect Dis"},{"issue":"3","key":"4321_CR6","doi-asserted-by":"publisher","first-page":"245","DOI":"10.33549\/physiolres.930448","volume":"53","author":"I Str\u00edz","year":"2004","unstructured":"Str\u00edz I, Trebichavsk\u00fd I (2004) Calprotectin - a pleiotropic molecule in acute and chronic inflammation. Physiol Res 53(3):245\u2013253","journal-title":"Physiol Res"},{"key":"4321_CR7","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1302\/0301-620X.66B4.6430907","volume":"66","author":"DA Ainscow","year":"1984","unstructured":"Ainscow DA, Denham RA (1984) The risk of haematogenous infection in total joint replacements. J Bone Joint Surg Br 66:580\u2013582","journal-title":"J Bone Joint Surg Br"},{"issue":"1","key":"4321_CR8","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2307\/2529310","volume":"33","author":"JR Landis","year":"1977","unstructured":"Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33(1):159\u2013174","journal-title":"Biometrics"},{"issue":"9","key":"4321_CR9","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1097\/00004424-198609000-00009","volume":"21","author":"CE Metz","year":"1986","unstructured":"Metz CE (1986) ROC methodology in radiologic imaging. Invest Radiol 21(9):720\u2013733. https:\/\/doi.org\/10.1097\/00004424-198609000-00009","journal-title":"Invest Radiol"},{"issue":"7","key":"4321_CR10","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1302\/0301-620X.90B7.20417","volume":"90","author":"B Fink","year":"2008","unstructured":"Fink B, Makowiak C, Fuerst M, Berger I, Sch\u00e4fer P, Frommelt L (2008) The value of synovial biopsy, joint aspiration and C-reactive protein in the diagnosis of late peri-prosthetic infection of total knee replacements. J Bone Joint Surg Br 90(7):874\u2013878","journal-title":"J Bone Joint Surg Br"},{"key":"4321_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1749-799X-3-31","volume":"3","author":"M M\u00fcller","year":"2008","unstructured":"M\u00fcller M, Morawietz L, Hasart O, Strube P, Perka C, Tohtz S (2008) Diagnosis of periprosthetic infection following total hip arthroplasty\u2013evaluation of the diagnostic values of pre- and intraoperative parameters and the associated strategy to preoperatively select patients with a high probability of joint infection. J Orthop Surg Res 3:31","journal-title":"J Orthop Surg Res"},{"issue":"3","key":"4321_CR12","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1007\/s11999-009-1102-5","volume":"468","author":"SW Tohtz","year":"2010","unstructured":"Tohtz SW, M\u00fcller M, Morawietz L, Winkler T, Perka C (2010) Validity of frozen sections for analysis of periprosthetic loosening membranes. Clin Orthop Relat Res 468(3):762\u2013768","journal-title":"Clin Orthop Relat Res"},{"key":"4321_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1210345","volume":"13","author":"M Schindler","year":"2023","unstructured":"Schindler M, Walter N, Maderbacher G, Sigmund IK, Alt V, Rupp M (2023) Novel diagnostic markers for periprosthetic joint infection: a systematic review. Front Cell Infect Microbiol 13:1210345. https:\/\/doi.org\/10.3389\/fcimb.2023.1210345","journal-title":"Front Cell Infect Microbiol"},{"issue":"12","key":"4321_CR14","doi-asserted-by":"publisher","first-page":"3724","DOI":"10.1016\/j.arth.2017.07.013","volume":"32","author":"SG Kim","year":"2017","unstructured":"Kim SG, Kim JG, Jang KM, Han SB, Lim HC, Bae JH (2017) Diagnostic value of synovial white blood cell count and serum C-reactive protein for acute periprosthetic joint infection after knee arthroplasty. J Arthroplasty 32(12):3724\u20133728. https:\/\/doi.org\/10.1016\/j.arth.2017.07.013","journal-title":"J Arthroplasty"},{"key":"4321_CR15","unstructured":"Infectious Diseases Society of America. 2004 Bad drugs, no drugs: as antibiotic discovery stagnates, a public health crisis blew. Alexandria, VA, IDSA"},{"issue":"6","key":"4321_CR16","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.molmed.2007.04.004","volume":"13","author":"GD Wright","year":"2007","unstructured":"Wright GD, Sutherland AD (2007) New strategies for combating multidrug-resistant bacteria. Trends Mol Med 13(6):260\u2013267","journal-title":"Trends Mol Med"},{"issue":"2","key":"4321_CR17","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1128\/CMR.00111-13","volume":"27","author":"AJ Tande","year":"2014","unstructured":"Tande AJ, Patel R (2014) Prosthetic joint infection. Clin Microbiol Rev 27(2):302\u2013345","journal-title":"Clin Microbiol Rev"},{"issue":"2","key":"4321_CR18","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/s11999-013-3089-1","volume":"472","author":"PH Yi","year":"2014","unstructured":"Yi PH, Cross MB, Moric M, Sporer SM, Berger RA, Della Valle CJ (2014) The 2013 frank stinchfield award: diagnosis of infection in the early postoperative period after total hip arthroplasty. Clin Orthop Relat Res 472(2):424\u2013429. https:\/\/doi.org\/10.1007\/s11999-013-3089-1","journal-title":"Clin Orthop Relat Res"},{"issue":"4","key":"4321_CR19","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.arth.2017.11.006","volume":"33","author":"M Wouthuyzen-Bakker","year":"2018","unstructured":"Wouthuyzen-Bakker M, Ploegmakers JJW, Ottink K et al (2018) Synovial calprotectin: an inexpensive biomarker to exclude a chronic prosthetic joint infection. J Arthroplasty 33(4):1149\u20131153. https:\/\/doi.org\/10.1016\/j.arth.2017.11.006","journal-title":"J Arthroplasty"},{"issue":"2","key":"4321_CR20","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.arth.2019.08.052","volume":"35","author":"P Salari","year":"2020","unstructured":"Salari P, Grassi M, Cinti B, Onori N, Gigante A (2020) Synovial fluid calprotectin for the preoperative diagnosis of chronic periprosthetic joint infection. J Arthroplasty 35(2):534\u2013537. https:\/\/doi.org\/10.1016\/j.arth.2019.08.052","journal-title":"J Arthroplasty"},{"issue":"8","key":"4321_CR21","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1016\/j.arth.2024.02.064","volume":"39","author":"MF Alkadhem","year":"2024","unstructured":"Alkadhem MF, Ettema H, Wagenmakers-Huizenga LMF et al (2024) Synovial calprotectin is superior to synovial leukocyte count in excluding chronic periprosthetic joint infections, a retrospective cohort study. J Arthroplasty 39(8):1926\u20131931. https:\/\/doi.org\/10.1016\/j.arth.2024.02.064","journal-title":"J Arthroplasty"},{"issue":"6","key":"4321_CR22","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/j.arth.2022.01.082","volume":"37","author":"JA Warren","year":"2022","unstructured":"Warren JA, Klika AK, Bowers K, Colon-Franco J, Piuzzi NS, Higuera CA (2022) Calprotectin lateral flow test: consistent across criteria for ruling out periprosthetic joint infection. J Arthroplasty 37(6):1153\u20131158. https:\/\/doi.org\/10.1016\/j.arth.2022.01.082","journal-title":"J Arthroplasty"},{"issue":"7","key":"4321_CR23","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1007\/s00264-022-05421-1","volume":"46","author":"I Lazic","year":"2022","unstructured":"Lazic I, Prodinger P, Stephan M et al (2022) Synovial calprotectin is a reliable biomarker for periprosthetic joint infections in acute-phase inflammation - a prospective cohort study. Int Orthop 46(7):1473\u20131479. https:\/\/doi.org\/10.1007\/s00264-022-05421-1","journal-title":"Int Orthop"},{"issue":"11","key":"4321_CR24","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.2106\/JBJS.20.01089","volume":"103","author":"J Warren","year":"2021","unstructured":"Warren J, Anis HK, Bowers K et al (2021) Diagnostic utility of a novel point-of-care test of calprotectin for periprosthetic joint infection after total knee arthroplasty: a prospective cohort study. J Bone Joint Surg Am 103(11):1009\u20131015. https:\/\/doi.org\/10.2106\/JBJS.20.01089","journal-title":"J Bone Joint Surg Am"},{"issue":"5","key":"4321_CR25","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1302\/2046-3758.95.BJR-2019-0213.R1","volume":"9","author":"AJ Trotter","year":"2020","unstructured":"Trotter AJ, Dean R, Whitehouse CE et al (2020) Preliminary evaluation of a rapid lateral flow calprotectin test for the diagnosis of prosthetic joint infection. Bone Joint Res. 9(5):202\u2013210. https:\/\/doi.org\/10.1302\/2046-3758.95.BJR-2019-0213.R1","journal-title":"Bone Joint Res."},{"issue":"7","key":"4321_CR26","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.jse.2014.12.021","volume":"24","author":"SJ Frangiamore","year":"2015","unstructured":"Frangiamore SJ, Saleh A, Grosso MJ et al (2015) \u03b1-Defensin as a predictor of periprosthetic shoulder infection. J Shoulder Elbow Surg 24(7):1021\u20131027. https:\/\/doi.org\/10.1016\/j.jse.2014.12.021","journal-title":"J Shoulder Elbow Surg"}],"container-title":["European Journal of Orthopaedic Surgery &amp; Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-025-04321-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00590-025-04321-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-025-04321-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T23:03:10Z","timestamp":1767049390000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00590-025-04321-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,26]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4321"],"URL":"https:\/\/doi.org\/10.1007\/s00590-025-04321-5","relation":{},"ISSN":["1432-1068"],"issn-type":[{"type":"electronic","value":"1432-1068"}],"subject":[],"published":{"date-parts":[[2025,5,26]]},"assertion":[{"value":"29 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}],"article-number":"216"}}