{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:07:24Z","timestamp":1793362044843,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Orthop Surg Traumatol"],"DOI":"10.1007\/s00590-025-04334-0","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T12:12:20Z","timestamp":1748607140000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transdermal buprenorphine patch in the management of post-operative pain in orthopaedic patients: a systematic review looking at efficacy, safety, adverse effects and cost\u2013benefit analysis"],"prefix":"10.1007","volume":"35","author":[{"given":"Amr","family":"Basha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeyinka","family":"Titiloye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isik","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutaz","family":"Alsaleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"4334_CR1","unstructured":"Sampognaro G, Harrell R (2024) Multimodal post-operative pain control after orthopaedic surgery. In: StatPearls. StatPearls Publishing, Treasure Island (FL). https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK572072\/. Updated 29 Jan 2023"},{"issue":"2","key":"4334_CR2","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/S2215-0366(18)30471-1","volume":"6","author":"HJ Curtis","year":"2019","unstructured":"Curtis HJ et al (2019) Opioid prescribing trends and geographical variation in England, 1998\u20132018: a retrospective database study. The Lancet Psychiatry 6(2):140\u2013150","journal-title":"The Lancet Psychiatry"},{"key":"4334_CR3","unstructured":"Royal College of Surgery, England. Surgery and the NHS in numbers. https:\/\/www.rcseng.ac.uk\/news-and-events\/media-centre\/media-background-briefings-and-statistics\/surgery-and-the-nhs-in-numbers\/"},{"issue":"6","key":"4334_CR4","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.suponc.2012.05.002","volume":"10","author":"MP Davis","year":"2012","unstructured":"Davis MP (2012) Twelve reasons for considering buprenorphine as a frontline analgesic in the management of pain. J Support Oncol 10(6):209\u2013219. https:\/\/doi.org\/10.1016\/j.suponc.2012.05.002","journal-title":"J Support Oncol"},{"issue":"10","key":"4334_CR5","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1185\/03007995.2012.719864","volume":"28","author":"T Setti","year":"2012","unstructured":"Setti T, Sanfilippo F, Leykin Y (2012) Transdermal buprenorphine for post-operative pain control in gynecological surgery: a prospective randomized study. Curr Med Res Opin 28(10):1597\u20131608. https:\/\/doi.org\/10.1185\/03007995.2012.719864","journal-title":"Curr Med Res Opin"},{"issue":"3","key":"4334_CR6","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.ejpain.2008.04.011","volume":"13","author":"HG Kress","year":"2009","unstructured":"Kress HG (2009) Clinical update on the pharmacology, efficacy and safety of transdermal buprenorphine. Eur J Pain 13(3):219\u2013230. https:\/\/doi.org\/10.1016\/j.ejpain.2008.04.011. (ISSN 1090-3801)","journal-title":"Eur J Pain"},{"issue":"5","key":"4334_CR7","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1093\/bja\/ael051","volume":"96","author":"A Dahan","year":"2006","unstructured":"Dahan A, Yassen A, Romberg R, Sarton E, Teppema L, Olofsen E, Danhof M (2006) Buprenorphine induces ceiling in respiratory depression but not in analgesia. Br J Anaesth 96(5):627\u2013632. https:\/\/doi.org\/10.1093\/bja\/ael051. (ISSN 0007-0912)","journal-title":"Br J Anaesth"},{"key":"4334_CR8","doi-asserted-by":"publisher","first-page":"965","DOI":"10.2165\/00003088-200746110-00004","volume":"46","author":"A Yassen","year":"2007","unstructured":"Yassen A, Olofsen E, van Dorp E et al (2007) Mechanism-based pharmacokinetic-pharmacodynamic modelling of the reversal of buprenorphine-induced respiratory depression by naloxone. Clin Pharmacokinet 46:965\u2013980. https:\/\/doi.org\/10.2165\/00003088-200746110-00004","journal-title":"Clin Pharmacokinet"},{"issue":"3","key":"4334_CR9","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.bja.2021.12.001","volume":"128","author":"A Dahan","year":"2022","unstructured":"Dahan A et al (2022) Buprenorphine: a treatment and cause of opioid-induced respiratory depression. Br J Anaesth 128(3):402\u2013404","journal-title":"Br J Anaesth"},{"issue":"3","key":"4334_CR10","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.bja.2019.05.044","volume":"123","author":"S Ayad","year":"2019","unstructured":"Ayad S et al (2019) Characterisation and monitoring of post-operative respiratory depression: current approaches and future conadverserations. Br J Anaesth 123(3):378\u2013391","journal-title":"Br J Anaesth"},{"key":"4334_CR11","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.ejpain.2008.09.005","volume":"13","author":"S Wirz","year":"2009","unstructured":"Wirz S, Wittmann M, Schenk M, Schroeck A, Schaefer N, Mueller M et al (2009) Gastrointestinal symptoms under opioid therapy: a prospective comparison of oral sustained-release hydromorphone, transdermal fentanyl, and transdermal buprenorphine. Eur J Pain 13:737\u2013743","journal-title":"Eur J Pain"},{"key":"4334_CR12","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.2147\/JPR.S144066","volume":"10","author":"TJ Gan","year":"2017","unstructured":"Gan TJ (2017) Poorly controlled post-operative pain: prevalence, consequences, and prevention. J Pain Res 10:2287\u20132298. https:\/\/doi.org\/10.2147\/JPR.S144066","journal-title":"J Pain Res"},{"key":"4334_CR13","unstructured":"Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors) (2024) Cochrane handbook for systematic reviews of interventions version 6.5 (updated August 2024). Cochrane. www.training.cochrane.org\/handbook"},{"key":"4334_CR14","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I, Cates CJ, Cheng H-Y, Corbett MS, Eldridge SM, Hern\u00e1n MA, Hopewell S, Hr\u00f3bjartsson A, Junqueira DR, J\u00fcni P, Kirkham JJ, Lasserson T, Li T, McAleenan A, Reeves BC, Shepperd S, Shrier I, Stewart LA, Tilling K, White IR, Whiting PF, Higgins JPT (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898","journal-title":"BMJ"},{"key":"4334_CR15","unstructured":"BNF is only available in the UK (2025) NICE. https:\/\/bnf.nice.org.uk\/. Accessed 21 Apr 2025"},{"issue":"Suppl 2","key":"4334_CR16","doi-asserted-by":"publisher","first-page":"111395","DOI":"10.1016\/j.injury.2024.111395","volume":"55","author":"SB Londhe","year":"2024","unstructured":"Londhe SB, Patwardhan M, Shah RV, Desouza C, Oak M, Antao NA (2024) Comparison of the efficacy and safety of transdermal buprenorphine patch to conventional analgesics after operative fixation of extra capsular fracture of proximal femur. Injury 55(Suppl 2):111395. https:\/\/doi.org\/10.1016\/j.injury.2024.111395","journal-title":"Injury"},{"issue":"11","key":"4334_CR17","doi-asserted-by":"publisher","first-page":"923","DOI":"10.4103\/ija.IJA_118_17","volume":"61","author":"S Niyogi","year":"2017","unstructured":"Niyogi S, Bhunia P, Nayak J, Santra S, Acharjee A, Chakraborty I (2017) Efficacy of transdermal buprenorphine patch on post-operative pain relief after elective spinal instrumentation surgery. Indian J Anaesth 61(11):923\u2013929. https:\/\/doi.org\/10.4103\/ija.IJA_118_17","journal-title":"Indian J Anaesth"},{"issue":"2","key":"4334_CR18","doi-asserted-by":"publisher","first-page":"272","DOI":"10.4103\/joacp.JOACP_405_20","volume":"37","author":"H Khandelwal","year":"2021","unstructured":"Khandelwal H, Negi A, Govil N, Singh A, Parag K, Bhardwaj BB (2021) Comparative evaluation of analgesic efficacy of buprenorphine transdermal patch and fentanyl patch in management of post-operative pain after arthroscopic lower limb surgery: a randomized controlled trial. J Anaesthesiol Clin Pharmacol 37(2):272\u2013278. https:\/\/doi.org\/10.4103\/joacp.JOACP_405_20","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"4334_CR19","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/s43465-022-00668-7","volume":"56","author":"SB Londhe","year":"2022","unstructured":"Londhe SB, Patwardhan M, Shah RV et al (2022) Comparison of efficacy and safety of transdermal buprenorphine patch and conventional analgesics in intra-capsular femur neck fracture post hemiarthroplasty. JOIO 56:1363\u20131369. https:\/\/doi.org\/10.1007\/s43465-022-00668-7","journal-title":"JOIO"},{"issue":"5","key":"4334_CR20","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.otsr.2020.04.010","volume":"106","author":"X Xu","year":"2020","unstructured":"Xu X, Xie L, Liu H, Hu Y (2020) Transdermal buprenorphine patch versus oral celecoxib for pain management after total knee arthroplasty: an open-label, randomized controlled trial. Orthop Traumatol Surg Res 106(5):915\u2013919. https:\/\/doi.org\/10.1016\/j.otsr.2020.04.010","journal-title":"Orthop Traumatol Surg Res"},{"issue":"6S","key":"4334_CR21","doi-asserted-by":"publisher","first-page":"S178","DOI":"10.1016\/j.arth.2020.02.015","volume":"35","author":"S Londhe","year":"2020","unstructured":"Londhe S, Patwardhan M, Shah R, Oak M (2020) Efficacy and safety of buprenorphine transdermal patch for immediate post-operative analgesia after total knee arthroplasty surgery. J Arthroplast 35(6S):S178\u2013S181. https:\/\/doi.org\/10.1016\/j.arth.2020.02.015","journal-title":"J Arthroplast"},{"key":"4334_CR22","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jor.2024.02.002","volume":"52","author":"L Ni","year":"2024","unstructured":"Ni L, Yan Y, Fu Y, Sheng J, Qu H, Ru X (2024) Analgesic effect and safety of a half-dose transdermal buprenorphine patch after arthroscopic rotator cuff repair. J Orthop 52:85\u201389. https:\/\/doi.org\/10.1016\/j.jor.2024.02.002. (ISSN 0972-978X)","journal-title":"J Orthop"},{"key":"4334_CR23","doi-asserted-by":"publisher","first-page":"2071494","DOI":"10.1155\/2017\/2071494","volume":"2017","author":"JH Lee","year":"2017","unstructured":"Lee JH, Kim JH, Kim JH, Kim HS, Min WK, Park YS, Lee KY, Lee JH (2017) Efficacy and safety of transdermal buprenorphine versus oral tramadol\/acetaminophen in patients with persistent post-operative pain after spinal surgery. Pain Res Manag 2017:2071494. https:\/\/doi.org\/10.1155\/2017\/2071494","journal-title":"Pain Res Manag"},{"issue":"20","key":"4334_CR24","doi-asserted-by":"publisher","first-page":"e6844","DOI":"10.1097\/MD.0000000000006844","volume":"96","author":"J Tang","year":"2017","unstructured":"Tang J, Fan J, Yao Y, Cai W, Yin G, Zhou W (2017) Application of a buprenorphine transdermal patch for the perioperative analgesia in patients who underwent simple lumbar discectomy. Medicine (Baltimore) 96(20):e6844. https:\/\/doi.org\/10.1097\/MD.0000000000006844","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"4334_CR25","doi-asserted-by":"publisher","first-page":"225","DOI":"10.4103\/ija.IJA_208_16","volume":"61","author":"SN Desai","year":"2017","unstructured":"Desai SN, Badiger SV, Tokur SB, Naik PA (2017) Safety and efficacy of transdermal buprenorphine versus oral tramadol for the treatment of post-operative pain following surgery for fracture neck of femur: a prospective, randomised clinical study. Indian J Anaesth 61(3):225\u2013229. https:\/\/doi.org\/10.4103\/ija.IJA_208_16","journal-title":"Indian J Anaesth"},{"key":"4334_CR26","doi-asserted-by":"publisher","first-page":"867","DOI":"10.2147\/JPR.S153456","volume":"11","author":"C Xu","year":"2018","unstructured":"Xu C, Li M, Wang C, Li H, Liu H (2018) Perioperative analgesia with a buprenorphine transdermal patch for hallux valgus surgery: a prospective, randomized, controlled study. J Pain Res 11:867\u2013873. https:\/\/doi.org\/10.2147\/JPR.S153456","journal-title":"J Pain Res"},{"key":"4334_CR27","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1007\/s00586-017-5213-5","volume":"26","author":"HJ Kim","year":"2017","unstructured":"Kim HJ, Ahn HS, Nam Y et al (2017) Comparative study of the efficacy of transdermal buprenorphine patches and prolonged-release tramadol tablets for post-operative pain control after spinal fusion surgery: a prospective, randomized controlled non-inferiority trial. Eur Spine J 26:2961\u20132968. https:\/\/doi.org\/10.1007\/s00586-017-5213-5","journal-title":"Eur Spine J"},{"issue":"3","key":"4334_CR28","doi-asserted-by":"publisher","first-page":"376","DOI":"10.47009\/jamp.2024.6.3.77","volume":"6","author":"P Sowmya","year":"2024","unstructured":"Sowmya P, Nayak RR, Ray SS, Jeetendra C, Mohapatra S, Jena J (2024) Comparison between transdermal buprenorphine and transdermal fentanyl for post-operative pain relief in lumbar spine surgeries. Int J Acad Med Pharm 6(3):376\u2013380. https:\/\/doi.org\/10.47009\/jamp.2024.6.3.77. (Section: Anaesthesiologists)","journal-title":"Int J Acad Med Pharm"},{"key":"4334_CR29","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG, For the PRISMA Group (2009) Preferred reporting items for systematic reviews and\nmeta-analyses: the PRISMA statement. PLoS Med 6:e1000097. https:\/\/doi.org\/10.1371\/journal.pmed.1000097","journal-title":"PLoS Med"},{"key":"4334_CR30","unstructured":"Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (eds) (2021) Cochrane handbook for systematic\nreviews of interventions version 6.2 (updated February 2021). Cochrane. http:\/\/www.training.cochrane.org\/handbook."}],"container-title":["European Journal of Orthopaedic Surgery &amp; Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-025-04334-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00590-025-04334-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-025-04334-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:40:34Z","timestamp":1767015634000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00590-025-04334-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4334"],"URL":"https:\/\/doi.org\/10.1007\/s00590-025-04334-0","relation":{},"ISSN":["1432-1068"],"issn-type":[{"value":"1432-1068","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,30]]},"assertion":[{"value":"5 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"221"}}