{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:15:22Z","timestamp":1793704522796,"version":"4.5.1"},"reference-count":118,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100006034","name":"University of Southern California","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006034","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Orthop Surg Traumatol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Systematic reviews and meta-analyses evaluating platelet-rich plasma (PRP) injections are vulnerable to spin (i.e., misrepresentation of study findings). We sought to describe the incidence of spin in the abstracts of systematic reviews and meta-analyses reporting on PRP for knee osteoarthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A Preferred Reporting Items for Systematic Reviews and Meta-Analyses search was conducted in Embase, PubMed, and Cochrane databases to identify systematic reviews and meta-analyses on PRP injections for knee osteoarthritis. Data collected from abstracts included 21 types of spin as originally reported by Yavchitz et al., year and journal of publication, level of evidence, and Scopus CiteScore\u2122. Associations between the most common and severe spin types and abstract characteristics were assessed using Spearman analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all 79 abstracts of systematic reviews and meta-analyses assessed, at least one form of spin was identified. The average spin score per abstract was 5.46\u2009\u00b1\u20092.30 (range 1\u201312). The most common type of spin was \u201cconclusion claiming the beneficial effect of the experimental treatment despite high risk of bias in primary studies\u201d (67\/79, 84.8%). There was a correlation between the spin type \u201cauthors hide or do not present any conflict of interest\u201d and an older publication year (rho: \u2212\u20090.252,\n                      <jats:italic>P<\/jats:italic>\n                      value: 0.025).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Spin favoring PRP is highly prevalent in the abstracts of systematic reviews and meta-analyses that assess the use of PRP for the treatment of knee osteoarthritis. This inaccurate presentation of information identifies a need for (1) high-quality RCTs and (2) reduction of spin in future literature to accurately distribute information regarding PRP for this indication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00590-025-04353-x","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T15:24:54Z","timestamp":1755012294000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Spin and reporting bias in the use of platelet-rich plasma for the treatment of knee osteoarthritis"],"prefix":"10.1007","volume":"35","author":[{"given":"Mary K.","family":"Richardson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie M.","family":"Kistler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory K.","family":"Mayfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay R.","family":"Lieberman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathanael D.","family":"Heckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"4353_CR1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1056\/NEJMcp1903768","volume":"384","author":"L Sharma","year":"2021","unstructured":"Sharma L (2021) Osteoarthritis of the knee. N Engl J Med 384:51\u201359","journal-title":"N Engl J Med"},{"key":"4353_CR2","doi-asserted-by":"crossref","first-page":"9332","DOI":"10.1073\/pnas.1703856114","volume":"114","author":"IJ Wallace","year":"2017","unstructured":"Wallace IJ, Worthington S, Felson DT et al (2017) Knee osteoarthritis has doubled in prevalence since the mid-20th century. Proc Natl Acad Sci U S A 114:9332\u20139336","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4353_CR3","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","volume":"393","author":"DJ Hunter","year":"2019","unstructured":"Hunter DJ, Bierma-Zeinstra S (2019) Osteoarthritis. Lancet 393:1745\u20131759","journal-title":"Lancet"},{"key":"4353_CR4","first-page":"22","volume":"131","author":"S Grazio","year":"2009","unstructured":"Grazio S, Balen D (2009) Obesity: risk factor and predictor of osteoarthritis. Lijec Vjesn 131:22\u201326","journal-title":"Lijec Vjesn"},{"key":"4353_CR5","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1056\/NEJMct1215534","volume":"372","author":"DJ Hunter","year":"2015","unstructured":"Hunter DJ (2015) Viscosupplementation for osteoarthritis of the knee. N Engl J Med 372:2570","journal-title":"N Engl J Med"},{"key":"4353_CR6","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.arth.2018.12.001","volume":"34","author":"RE Delanois","year":"2019","unstructured":"Delanois RE, Etcheson JI, Sodhi N et al (2019) Biologic therapies for the treatment of knee osteoarthritis. J Arthroplasty 34:801\u2013813","journal-title":"J Arthroplasty"},{"key":"4353_CR7","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1016\/j.arth.2021.05.040","volume":"36","author":"SA Cohen","year":"2021","unstructured":"Cohen SA, Zhuang T, Xiao M et al (2021) Google trends analysis shows increasing public interest in platelet-rich plasma injections for hip and knee osteoarthritis. J Arthroplasty 36:3616\u20133622","journal-title":"J Arthroplasty"},{"key":"4353_CR8","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1055\/s-0037-1603795","volume":"30","author":"NS Piuzzi","year":"2017","unstructured":"Piuzzi NS, Chughtai M, Khlopas A et al (2017) Platelet-rich plasma for the treatment of knee osteoarthritis: a review. J Knee Surg 30:627\u2013633","journal-title":"J Knee Surg"},{"key":"4353_CR9","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.arth.2019.03.068","volume":"34","author":"JA Browne","year":"2019","unstructured":"Browne JA, Nho SJ, Goodman SB, Della Valle CJ (2019) American Association of Hip and Knee Surgeons, Hip Society, and Knee Society position statement on biologics for advanced hip and knee arthritis. J Arthroplasty 34:1051\u20131052","journal-title":"J Arthroplasty"},{"key":"4353_CR10","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.3390\/cells11071080","volume":"11","author":"E Tram\u015b","year":"2022","unstructured":"Tram\u015b E, Malesa K, Pomianowski S, Kami\u0144ski R (2022) Role of platelets in osteoarthritis\u2014updated systematic review and meta-analysis on the role of platelet-rich plasma in osteoarthritis. Cells 11:1080","journal-title":"Cells"},{"key":"4353_CR11","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1177\/0363546515570463","volume":"43","author":"C Osterman","year":"2015","unstructured":"Osterman C, McCarthy MBR, Cote MP et al (2015) Platelet-rich plasma increases anti-inflammatory markers in a human coculture model for osteoarthritis. Am J Sports Med 43:1474\u20131484","journal-title":"Am J Sports Med"},{"key":"4353_CR12","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/JSM.0b013e31827c3846","volume":"23","author":"B Halpern","year":"2013","unstructured":"Halpern B, Chaudhury S, Rodeo SA et al (2013) Clinical and MRI outcomes after platelet-rich plasma treatment for knee osteoarthritis. Clin J Sport Med 23:238\u2013239","journal-title":"Clin J Sport Med"},{"key":"4353_CR13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1177\/1947603516670709","volume":"8","author":"L Laver","year":"2017","unstructured":"Laver L, Marom N, Dnyanesh L et al (2017) PRP for degenerative cartilage disease: a systematic review of clinical studies. Cartilage 8:341\u2013364","journal-title":"Cartilage"},{"key":"4353_CR14","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1002\/ksa.12320","volume":"32","author":"E Kon","year":"2024","unstructured":"Kon E, de Girolamo L, Laver L et al (2024) Platelet-rich plasma injections for the management of knee osteoarthritis: the ESSKA-ICRS consensus. Recommendations using the RAND\/UCLA appropriateness method for different clinical scenarios. Knee Surg Sports Traumatol Arthrosc 32:2938\u20132949","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"4353_CR15","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s12178-018-9514-z","volume":"11","author":"IA Jones","year":"2018","unstructured":"Jones IA, Togashi RC, Thomas Vangsness C Jr (2018) The economics and regulation of PRP in the evolving field of orthopedic biologics. Curr Rev Musculoskelet Med 11:558\u2013565","journal-title":"Curr Rev Musculoskelet Med"},{"key":"4353_CR16","doi-asserted-by":"crossref","DOI":"10.2106\/JBJS.19.01446","volume":"102","author":"PV Rajan","year":"2020","unstructured":"Rajan PV, Ng MK, Klika A et al (2020) The cost-effectiveness of platelet-rich plasma injections for knee osteoarthritis: a markov decision analysis. J Bone Joint Surg Am 102:e104","journal-title":"J Bone Joint Surg Am"},{"key":"4353_CR17","unstructured":"Zhao J, Huang H, Liang G, et al Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: a systematic review and meta-analysis"},{"key":"4353_CR18","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/bjsports-2014-094036","volume":"49","author":"ABM Laudy","year":"2015","unstructured":"Laudy ABM, Bakker EWP, Rekers M, Moen MH (2015) Efficacy of platelet-rich plasma injections in osteoarthritis of the knee: a systematic review and meta-analysis. Br J Sports Med 49:657\u2013672","journal-title":"Br J Sports Med"},{"key":"4353_CR19","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.arthro.2015.08.005","volume":"32","author":"CJ Meheux","year":"2016","unstructured":"Meheux CJ, McCulloch PC, Lintner DM et al (2016) Efficacy of intra-articular platelet-rich plasma injections in knee osteoarthritis: a systematic review. Arthroscopy 32:495\u2013505","journal-title":"Arthroscopy"},{"key":"4353_CR20","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.arthro.2015.03.041","volume":"31","author":"KA Campbell","year":"2015","unstructured":"Campbell KA, Saltzman BM, Mascarenhas R et al (2015) Does intra-articular platelet-rich plasma injection provide clinically superior outcomes compared with other therapies in the treatment of knee osteoarthritis? A systematic review of overlapping meta-analyses. Arthroscopy J Arthrosc Relat Surg 31:2213\u20132221","journal-title":"Arthroscopy J Arthrosc Relat Surg"},{"key":"4353_CR21","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.2106\/JBJS.16.01374","volume":"99","author":"J Chahla","year":"2017","unstructured":"Chahla J, Cinque ME, Piuzzi NS et al (2017) A call for standardization in platelet-rich plasma preparation protocols and composition reporting: a systematic review of the clinical orthopaedic literature. J Bone Joint Surg Am 99:1769\u20131779","journal-title":"J Bone Joint Surg Am"},{"key":"4353_CR22","doi-asserted-by":"crossref","first-page":"779","DOI":"10.5435\/JAAOS-D-18-00343","volume":"27","author":"JC Alcerro","year":"2019","unstructured":"Alcerro JC, Lavernia CJ (2019) Stem cells and platelet-rich plasma for knee osteoarthritis: prevalence and cost in South Florida. J Am Acad Orthop Surg 27:779\u2013783","journal-title":"J Am Acad Orthop Surg"},{"key":"4353_CR23","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1016\/j.jse.2022.03.015","volume":"31","author":"MS Kim","year":"2022","unstructured":"Kim MS, Hasan LK, Fathi A et al (2022) Evaluation of spin in systematic reviews and meta-analyses of superior capsular reconstruction. J Shoulder Elbow Surg 31:1743\u20131750","journal-title":"J Shoulder Elbow Surg"},{"key":"4353_CR24","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1136\/ebmed-2015-110250","volume":"20","author":"P Fontelo","year":"2015","unstructured":"Fontelo P, Liu F, Uy RC (2015) How does evidence affect clinical decision-making? Evid Based Med 20:156\u2013161","journal-title":"Evid Based Med"},{"key":"4353_CR25","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1073\/pnas.1710755115","volume":"115","author":"I Boutron","year":"2018","unstructured":"Boutron I, Ravaud P (2018) Misrepresentation and distortion of research in biomedical literature. Proc Natl Acad Sci U S A 115:2613\u20132619","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4353_CR26","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/j.bja.2018.10.023","volume":"122","author":"NC Kinder","year":"2019","unstructured":"Kinder NC, Weaver MD, Wayant C, Vassar M (2019) Presence of \u201cspin\u201d in the abstracts and titles of anaesthesiology randomised controlled trials. Br J Anaesth 122:e13\u2013e14","journal-title":"Br J Anaesth"},{"key":"4353_CR27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jclinepi.2016.01.020","volume":"75","author":"A Yavchitz","year":"2016","unstructured":"Yavchitz A, Ravaud P, Altman DG et al (2016) A new classification of spin in systematic reviews and meta-analyses was developed and ranked according to the severity. J Clin Epidemiol 75:56\u201365","journal-title":"J Clin Epidemiol"},{"key":"4353_CR28","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71","journal-title":"BMJ"},{"key":"4353_CR29","unstructured":"Zijlstra H, McCullough R (2016) CiteScore: a new metric to help you track journal performance and make decisions. Elsevier Oceanogr Ser 8"},{"key":"4353_CR30","unstructured":"(2023) Elselvier Scopus CiteScoreTM metrics you can verify and trust. Elsevier, U.S"},{"key":"4353_CR31","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.arth.2019.01.016","volume":"34","author":"JX Checketts","year":"2019","unstructured":"Checketts JX, Riddle J, Zaaza Z et al (2019) An evaluation of spin in lower extremity joint trials. J Arthroplasty 34:1008\u20131012","journal-title":"J Arthroplasty"},{"key":"4353_CR32","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.1200\/JCO.2014.56.7503","volume":"32","author":"I Boutron","year":"2014","unstructured":"Boutron I, Altman DG, Hopewell S et al (2014) Impact of spin in the abstracts of articles reporting results of randomized controlled trials in the field of cancer: the SPIIN randomized controlled trial. J Clin Oncol 32:4120\u20134126","journal-title":"J Clin Oncol"},{"key":"4353_CR33","doi-asserted-by":"crossref","unstructured":"Cole WT, Wittl P, Arthur W, et al (2021) Spin in the abstracts of systematic reviews and metaanalyses focused on percutaneous coronary intervention. J Osteopath Med 723\u2013731","DOI":"10.1515\/jom-2021-0085"},{"key":"4353_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.03.032","author":"S Demla","year":"2021","unstructured":"Demla S, Shinn E, Ottwell R et al (2021) Evaluation of spin in the abstracts of systematic reviews and meta-analyses focused on cataract therapies. Am J Ophthalmol. https:\/\/doi.org\/10.1016\/j.ajo.2021.03.032","journal-title":"Am J Ophthalmol"},{"key":"4353_CR35","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/MEJ.0000000000000864","volume":"29","author":"MC Ferrell","year":"2022","unstructured":"Ferrell MC, Schell J, Ottwell R et al (2022) Evaluation of spin in the abstracts of emergency medicine systematic reviews and meta-analyses. Eur J Emerg Med 29:118\u2013125","journal-title":"Eur J Emerg Med"},{"key":"4353_CR36","doi-asserted-by":"crossref","first-page":"232596712211379","DOI":"10.1177\/23259671221137923","volume":"11","author":"AK Reddy","year":"2023","unstructured":"Reddy AK, Lulkovich K, Wirtz A et al (2023) Assessment of spin in the abstracts of systematic reviews and meta-analyses on platelet-rich plasma treatment in orthopaedics: a cross-sectional analysis. Orthop J Sports Med 11:23259671221137924","journal-title":"Orthop J Sports Med"},{"key":"4353_CR37","first-page":"437","volume":"14","author":"HC Barry","year":"2001","unstructured":"Barry HC, Ebell MH, Shaughnessy AF et al (2001) Family physicians\u2019 use of medical abstracts to guide decision making: style or substance? J Am Board Fam Pract 14:437\u2013442","journal-title":"J Am Board Fam Pract"},{"key":"4353_CR38","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1046\/j.1525-1497.2000.00202.x","volume":"15","author":"S Saint","year":"2000","unstructured":"Saint S, Christakis DA, Saha S et al (2000) Journal reading habits of internists. J Gen Intern Med 15:881\u2013884","journal-title":"J Gen Intern Med"},{"key":"4353_CR39","doi-asserted-by":"crossref","first-page":"2191926","DOI":"10.1155\/2021\/2191926","volume":"2021","author":"M Hong","year":"2021","unstructured":"Hong M, Cheng C, Sun X et al (2021) Efficacy and safety of intra-articular platelet-rich plasma in osteoarthritis knee: a systematic review and meta-analysis. Biomed Res Int 2021:2191926","journal-title":"Biomed Res Int"},{"key":"4353_CR40","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1177\/0363546512471299","volume":"41","author":"S Patel","year":"2013","unstructured":"Patel S, Dhillon MS, Aggarwal S et al (2013) Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial. Am J Sports Med 41:356\u2013364","journal-title":"Am J Sports Med"},{"key":"4353_CR41","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.arthro.2018.06.035","volume":"35","author":"K-Y Lin","year":"2019","unstructured":"Lin K-Y, Yang C-C, Hsu C-J et al (2019) Intra-articular injection of platelet-rich plasma is superior to hyaluronic acid or saline solution in the treatment of mild to moderate knee osteoarthritis: a randomized, double-blind, triple-parallel, placebo-controlled clinical trial. Arthroscopy 35:106\u2013117","journal-title":"Arthroscopy"},{"key":"4353_CR42","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/PHM.0000000000000874","volume":"97","author":"Y-T Wu","year":"2018","unstructured":"Wu Y-T, Hsu K-C, Li T-Y et al (2018) Effects of platelet-rich plasma on pain and muscle strength in patients with knee osteoarthritis. Am J Phys Med Rehabil 97:248\u2013254","journal-title":"Am J Phys Med Rehabil"},{"key":"4353_CR43","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1055\/s-0038-1669953","volume":"32","author":"NS Piuzzi","year":"2019","unstructured":"Piuzzi NS, Ng M, Kantor A et al (2019) What is the price and claimed efficacy of Platelet-Rich Plasma injections for the treatment of knee osteoarthritis in the United States? J Knee Surg 32:879\u2013885","journal-title":"J Knee Surg"},{"key":"4353_CR44","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1051\/sicotj\/2017036","volume":"3","author":"N Hussain","year":"2017","unstructured":"Hussain N, Johal H, Bhandari M (2017) An evidence-based evaluation on the use of platelet rich plasma in orthopedics - a review of the literature. SICOT J 3:57","journal-title":"SICOT J"},{"key":"4353_CR45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s10195-018-0501-3","volume":"19","author":"D Buend\u00eda-L\u00f3pez","year":"2018","unstructured":"Buend\u00eda-L\u00f3pez D, Medina-Quir\u00f3s M, Fern\u00e1ndez-Villaca\u00f1as Mar\u00edn M\u00c1 (2018) Clinical and radiographic comparison of a single LP-PRP injection, a single hyaluronic acid injection and daily NSAID administration with a 52-week follow-up: a randomized controlled trial. J Orthop Traumatol 19:3","journal-title":"J Orthop Traumatol"},{"key":"4353_CR46","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s12178-018-9527-7","volume":"11","author":"ADK Le","year":"2018","unstructured":"Le ADK, Enweze L, DeBaun MR, Dragoo JL (2018) Current clinical recommendations for use of platelet-rich plasma. Curr Rev Musculoskelet Med 11:624\u2013634","journal-title":"Curr Rev Musculoskelet Med"},{"key":"4353_CR47","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1136\/eb-2012-100537","volume":"18","author":"A Marcelo","year":"2013","unstructured":"Marcelo A, Gavino A, Isip-Tan IT et al (2013) A comparison of the accuracy of clinical decisions based on full-text articles and on journal abstracts alone: a study among residents in a tertiary care hospital. Evid Based Med 18:48\u201353","journal-title":"Evid Based Med"},{"key":"4353_CR48","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.knee.2021.08.008","volume":"32","author":"U Anil","year":"2021","unstructured":"Anil U, Markus DH, Hurley ET et al (2021) The efficacy of intra-articular injections in the treatment of knee osteoarthritis: a network meta-analysis of randomized controlled trials. Knee 32:173\u2013182","journal-title":"Knee"},{"key":"4353_CR49","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-63730-3","volume-title":"Platelet Rich Plasma in Orthopaedics and Sports Medicine","author":"E Anitua","year":"2018","unstructured":"Anitua E, Cugat R, S\u00e1nchez M (2018) Platelet Rich Plasma in Orthopaedics and Sports Medicine. Springer"},{"key":"4353_CR50","first-page":"5447","volume":"26","author":"G Anzillotti","year":"2022","unstructured":"Anzillotti G, Conte P, Di Matteo B et al (2022) Injection of biologic agents for treating severe knee osteoarthritis: is there a chance for a good outcome? A systematic review of clinical evidence. Eur Rev Med Pharmacol Sci 26:5447\u20135459","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"4353_CR51","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s40634-021-00415-1","volume":"8","author":"AAL Aw","year":"2021","unstructured":"Aw AAL, Leeu JJ, Tao X, Bin Abd Razak HR (2021) Comparing the efficacy of dual Platelet-Rich Plasma (PRP) and Hyaluronic Acid (HA) therapy with PRP-alone therapy in the treatment of knee osteoarthritis: a systematic review and meta-analysis. J Exp Orthop 8:101","journal-title":"J Exp Orthop"},{"key":"4353_CR52","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1177\/0363546521998010","volume":"50","author":"MR Baria","year":"2022","unstructured":"Baria MR, Vasileff WK, Borchers J et al (2022) Treating knee osteoarthritis with platelet-rich plasma and hyaluronic acid combination therapy: a systematic review. Am J Sports Med 50:273\u2013281","journal-title":"Am J Sports Med"},{"key":"4353_CR53","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11143985","volume":"11","author":"S Berkani","year":"2022","unstructured":"Berkani S, Courties A, Eymard F et al (2022) Time to total knee arthroplasty after intra-articular hyaluronic acid or platelet-rich plasma injections: a systematic literature review and meta-analysis. J Clin Med 11:3985","journal-title":"J Clin Med"},{"key":"4353_CR54","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s40634-021-00387-2","volume":"8","author":"BK Betzler","year":"2021","unstructured":"Betzler BK, Bin Muhamma Dridzwan Chew AH, Bin Abd Razak HR (2021) Intra-articular injection of orthobiologics in patients undergoing high tibial osteotomy for knee osteoarthritis is safe and effective\u2014a systematic review. J Exp Orthop 8:83","journal-title":"J Exp Orthop"},{"key":"4353_CR55","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.apmr.2013.11.006","volume":"95","author":"K-V Chang","year":"2014","unstructured":"Chang K-V, Hung C-Y, Aliwarga F et al (2014) Comparative effectiveness of platelet-rich plasma injections for treating knee joint cartilage degenerative pathology: a systematic review and meta-analysis. Arch Phys Med Rehabil 95:562\u2013575","journal-title":"Arch Phys Med Rehabil"},{"key":"4353_CR56","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12891-019-2525-0","volume":"20","author":"J Charlesworth","year":"2019","unstructured":"Charlesworth J, Fitzpatrick J, Perera NKP, Orchard J (2019) Osteoarthritis- a systematic review of long-term safety implications for osteoarthritis of the knee. BMC Musculoskelet Disord 20:151","journal-title":"BMC Musculoskelet Disord"},{"key":"4353_CR57","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/s13018-019-1363-y","volume":"14","author":"P Chen","year":"2019","unstructured":"Chen P, Huang L, Ma Y et al (2019) Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses. J Orthop Surg Res 14:385","journal-title":"J Orthop Surg Res"},{"key":"4353_CR58","volume":"99","author":"Z Chen","year":"2020","unstructured":"Chen Z, Wang C, You D et al (2020) Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis. Medicine (Baltimore) 99:e19388","journal-title":"Medicine (Baltimore)"},{"key":"4353_CR59","volume":"75","author":"S-H Chou","year":"2021","unstructured":"Chou S-H, Shih C-L (2021) Efficacy of different platelet-rich plasma injections in the treatment of mild-moderate knee osteoarthritis: a systematic review and meta-analysis. Int J Clin Pract 75:e14068","journal-title":"Int J Clin Pract"},{"key":"4353_CR60","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1177\/03635465211062243","volume":"51","author":"LAV Costa","year":"2023","unstructured":"Costa LAV, Lenza M, Irrgang JJ et al (2023) How does platelet-rich plasma compare clinically to other therapies in the treatment of knee osteoarthritis? A systematic review and meta-analysis. Am J Sports Med 51:1074\u20131086","journal-title":"Am J Sports Med"},{"key":"4353_CR61","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.arthro.2016.09.024","volume":"33","author":"W-L Dai","year":"2017","unstructured":"Dai W-L, Zhou A-G, Zhang H, Zhang J (2017) Efficacy of platelet-rich plasma in the treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials. Arthroscopy 33:659-670.e1","journal-title":"Arthroscopy"},{"key":"4353_CR62","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1016\/j.arth.2022.05.031","volume":"37","author":"RE Delanois","year":"2022","unstructured":"Delanois RE, Sax OC, Chen Z et al (2022) Biologic therapies for the treatment of knee osteoarthritis: an updated systematic review. J Arthroplasty 37:2480\u20132506","journal-title":"J Arthroplasty"},{"key":"4353_CR63","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1621-0","author":"Y Di","year":"2018","unstructured":"Di Y, Han C, Zhao L, Ren Y (2018) Is local platelet-rich plasma injection clinically superior to hyaluronic acid for treatment of knee osteoarthritis? A systematic review of randomized controlled trials. Arthritis Res Ther. https:\/\/doi.org\/10.1186\/s13075-018-1621-0","journal-title":"Arthritis Res Ther"},{"key":"4353_CR64","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/01.jsm.0000432855.85143.e5","volume":"24","author":"AP Dold","year":"2014","unstructured":"Dold AP, Zywiel MG, Taylor DW et al (2014) Platelet-rich plasma in the management of articular cartilage pathology: a systematic review. Clin J Sport Med 24:31\u201343","journal-title":"Clin J Sport Med"},{"key":"4353_CR65","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s10067-020-05185-2","volume":"40","author":"Y Dong","year":"2021","unstructured":"Dong Y, Zhang B, Yang Q et al (2021) The effects of platelet-rich plasma injection in knee and hip osteoarthritis: a meta-analysis of randomized controlled trials. Clin Rheumatol 40:263\u2013277","journal-title":"Clin Rheumatol"},{"key":"4353_CR66","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcab104.014","author":"AM El-beltagy","year":"2021","unstructured":"El-beltagy AM, Zakaria ZM, Mohamed Abdel-Samei I (2021) Intra-articular injections of platelet-rich plasma versus hyaluronic acid in treatment of knee osteoarthritis (systematic review and meta-analysis). QJM. https:\/\/doi.org\/10.1093\/qjmed\/hcab104.014","journal-title":"QJM"},{"key":"4353_CR67","doi-asserted-by":"crossref","first-page":"364S","DOI":"10.1177\/1947603520931170","volume":"13","author":"G Filardo","year":"2021","unstructured":"Filardo G, Previtali D, Napoli F et al (2021) PRP injections for the treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials. Cartilage 13:364S-375S","journal-title":"Cartilage"},{"key":"4353_CR68","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00264-020-04801-9","volume":"45","author":"R Gilat","year":"2021","unstructured":"Gilat R, Haunschild ED, Knapik DM et al (2021) Hyaluronic acid and platelet-rich plasma for the management of knee osteoarthritis. Int Orthop 45:345\u2013354","journal-title":"Int Orthop"},{"key":"4353_CR69","volume":"100","author":"H Gong","year":"2021","unstructured":"Gong H, Li K, Xie R et al (2021) Clinical therapy of platelet-rich plasma vs hyaluronic acid injections in patients with knee osteoarthritis. Medicine (Baltimore) 100:e25168","journal-title":"Medicine (Baltimore)"},{"key":"4353_CR70","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.arthro.2020.03.041","volume":"37","author":"S-B Han","year":"2021","unstructured":"Han S-B, Seo I-W, Shin Y-S (2021) Intra-articular injections of hyaluronic acid or steroids associated with better outcomes than platelet-rich plasma, adipose mesenchymal stromal cells, or placebo in knee osteoarthritis: a network meta-analysis. Arthroscopy 37:292\u2013306","journal-title":"Arthroscopy"},{"key":"4353_CR71","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1093\/pm\/pnz011","volume":"20","author":"Y Han","year":"2019","unstructured":"Han Y, Huang H, Pan J et al (2019) Meta-analysis comparing platelet-rich plasma vs hyaluronic acid injection in patients with knee osteoarthritis. Pain Med 20:1418\u20131429","journal-title":"Pain Med"},{"key":"4353_CR72","volume":"0","author":"A Selim","year":"2019","unstructured":"Selim A, Hegazy A, Karabelas P (2019) Meaningful effectiveness of platelet-rich plasma in treating patients with osteoarthritis of the knee: meta-analysis and review. J Int Soc Phys Med Rehabil 0:0","journal-title":"J Int Soc Phys Med Rehabil"},{"key":"4353_CR73","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s00590-020-02623-4","volume":"30","author":"E Hohmann","year":"2020","unstructured":"Hohmann E, Tetsworth K, Glatt V (2020) Is platelet-rich plasma effective for the treatment of knee osteoarthritis? A systematic review and meta-analysis of level 1 and 2 randomized controlled trials. Eur J Orthop Surg Traumatol 30:955\u2013967","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"4353_CR74","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/1941738119834972","volume":"11","author":"H Johal","year":"2019","unstructured":"Johal H, Khan M, Yung S-HP et al (2019) Impact of platelet-rich plasma use on pain in orthopaedic surgery: a systematic review and meta-analysis. Sports Health 11:355\u2013366","journal-title":"Sports Health"},{"key":"4353_CR75","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1007\/s00167-015-3784-4","volume":"24","author":"W Kanchanatawan","year":"2016","unstructured":"Kanchanatawan W, Arirachakaran A, Chaijenkij K et al (2016) Short-term outcomes of platelet-rich plasma injection for treatment of osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc 24:1665\u20131677","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"4353_CR76","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.arthro.2020.11.052","volume":"37","author":"T Karasavvidis","year":"2021","unstructured":"Karasavvidis T, Totlis T, Gilat R, Cole BJ (2021) Platelet-rich plasma combined with hyaluronic acid improves pain and function compared with hyaluronic acid alone in knee osteoarthritis: a systematic review and meta-analysis. Arthroscopy 37:1277-1287.e1","journal-title":"Arthroscopy"},{"key":"4353_CR77","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.arthro.2013.09.006","volume":"29","author":"A Khoshbin","year":"2013","unstructured":"Khoshbin A, Leroux T, Wasserstein D et al (2013) The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis. Arthroscopy 29:2037\u20132048","journal-title":"Arthroscopy"},{"key":"4353_CR78","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1007\/s00402-022-04637-5","volume":"143","author":"J-H Kim","year":"2023","unstructured":"Kim J-H, Park Y-B, Ha C-W (2023) Are leukocyte-poor or multiple injections of platelet-rich plasma more effective than hyaluronic acid for knee osteoarthritis? A systematic review and meta-analysis of randomized controlled trials. Arch Orthop Trauma Surg 143:3879\u20133897","journal-title":"Arch Orthop Trauma Surg"},{"key":"4353_CR79","first-page":"232596712110119","volume":"9","author":"J-H Kim","year":"2021","unstructured":"Kim J-H, Park Y-B, Ha C-W et al (2021) Adverse reactions and clinical outcomes for leukocyte-poor versus leukocyte-rich platelet-rich plasma in knee osteoarthritis: a systematic review and meta-analysis. Orthop J Sports Med 9:23259671211011948","journal-title":"Orthop J Sports Med"},{"key":"4353_CR80","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.rbr.2015.01.007","volume":"56","author":"E Knop","year":"2016","unstructured":"Knop E, de Paula LE, Fuller R (2016) Platelet-rich plasma for osteoarthritis treatment. Rev Bras Reumatol Engl Ed 56:152\u2013164","journal-title":"Rev Bras Reumatol Engl Ed"},{"key":"4353_CR81","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.pmrj.2015.02.003","volume":"7","author":"LP Lai","year":"2015","unstructured":"Lai LP, Stitik TP, Foye PM et al (2015) Use of platelet-rich plasma in intra-articular knee injections for osteoarthritis: a systematic review. PM R 7:637\u2013648","journal-title":"PM R"},{"key":"4353_CR82","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40001-020-00426-1","volume":"25","author":"B Li","year":"2020","unstructured":"Li B, Zhang Y, Bi L (2020) Comparative efficacy of treatments for patients with knee osteoarthritis: a network meta-analysis. Eur J Med Res 25:27","journal-title":"Eur J Med Res"},{"key":"4353_CR83","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jos.2021.01.006","volume":"27","author":"W Li","year":"2022","unstructured":"Li W, Pan J, Lu Z et al (2022) The application of platelet-rich plasma in the treatment of knee osteoarthritis: a literature review. J Orthop Sci 27:420\u2013428","journal-title":"J Orthop Sci"},{"key":"4353_CR84","volume":"101","author":"X Lin","year":"2022","unstructured":"Lin X, Zhi F, Lan Q et al (2022) Comparing the efficacy of different intra-articular injections for knee osteoarthritis: a network analysis. Medicine (Baltimore) 101:e29655","journal-title":"Medicine (Baltimore)"},{"key":"4353_CR85","first-page":"7587936","volume":"2020","author":"P Luo","year":"2020","unstructured":"Luo P, Xiong Z, Sun W et al (2020) How to choose platelet-rich plasma or hyaluronic acid for the treatment of knee osteoarthritis in overweight or obese patients: a meta-analysis. Pain Res Manag 2020:7587936","journal-title":"Pain Res Manag"},{"key":"4353_CR86","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s12891-021-04308-3","volume":"22","author":"M McLarnon","year":"2021","unstructured":"McLarnon M, Heron N (2021) Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: systematic review and meta-analysis. BMC Musculoskelet Disord 22:550","journal-title":"BMC Musculoskelet Disord"},{"key":"4353_CR87","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s00402-020-03551-y","volume":"141","author":"F Migliorini","year":"2021","unstructured":"Migliorini F, Driessen A, Quack V et al (2021) Comparison between intra-articular infiltrations of placebo, steroids, hyaluronic and PRP for knee osteoarthritis: a bayesian network meta-analysis. Arch Orthop Trauma Surg 141:1473\u20131490","journal-title":"Arch Orthop Trauma Surg"},{"key":"4353_CR88","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.arthro.2021.08.026","volume":"38","author":"ES Mojica","year":"2022","unstructured":"Mojica ES, Markus DH, Hurley ET et al (2022) Estimated time to maximum medical improvement of intra-articular injections in the treatment of knee osteoarthritis-A systematic review. Arthroscopy 38:980-988.e4","journal-title":"Arthroscopy"},{"key":"4353_CR89","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.1016\/j.ijsu.2017.08.408","volume":"47","author":"TA Muchedzi","year":"2017","unstructured":"Muchedzi TA (2017) A systematic review of the use of platelet rich plasma in patients with knee osteoarthritis (OA) and its effect on patient outcomes following surgical interventions for knee OA. Int J Surg 47:S80\u2013S81","journal-title":"Int J Surg"},{"key":"4353_CR90","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.surge.2017.08.004","volume":"16","author":"TA Muchedzi","year":"2017","unstructured":"Muchedzi TA, Roberts SB (2017) A systematic review of the effects of platelet rich plasma on outcomes for patients with knee osteoarthritis and following total knee arthroplasty. Surgeon 16:250\u2013258","journal-title":"Surgeon"},{"key":"4353_CR91","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000028067","volume":"100","author":"M Naja","year":"2021","unstructured":"Naja M, Fernandez De Grado G, Favreau H et al (2021) Comparative effectiveness of nonsurgical interventions in the treatment of patients with knee osteoarthritis: a PRISMA-compliant systematic review and network meta-analysis: a PRISMA-compliant systematic review and network meta-analysis. Medicine (Baltimore) 100:e28067","journal-title":"Medicine (Baltimore)"},{"key":"4353_CR92","first-page":"232596712097328","volume":"9","author":"L-Y Nie","year":"2021","unstructured":"Nie L-Y, Zhao K, Ruan J, Xue J (2021) Effectiveness of platelet-rich plasma in the treatment of knee osteoarthritis: A meta-analysis of randomized controlled clinical trials. Orthop J Sports Med 9:2325967120973284","journal-title":"Orthop J Sports Med"},{"key":"4353_CR93","volume":"15","author":"Y-N Peng","year":"2022","unstructured":"Peng Y-N, Chen J-L, Hsu C-C et al (2022) Intra-articular leukocyte-rich platelet-rich plasma versus intra-articular hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis of 14 randomized controlled trials. Pharmaceuticals (Basel) 15:974","journal-title":"Pharmaceuticals (Basel)"},{"key":"4353_CR94","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1007\/s00167-019-05763-1","volume":"28","author":"M Phillips","year":"2020","unstructured":"Phillips M, Vannabouathong C, Devji T et al (2020) Differentiating factors of intra-articular injectables have a meaningful impact on knee osteoarthritis outcomes: a network meta-analysis. Knee Surg Sports Traumatol Arthrosc 28:3031\u20133039","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"4353_CR95","doi-asserted-by":"crossref","DOI":"10.2144\/fsoa-2021-0069","volume":"7","author":"SA Raeissadat","year":"2021","unstructured":"Raeissadat SA, Rayegani SM, Sohrabi MR et al (2021) Effectiveness of intra-articular autologous-conditioned serum injection in knee osteoarthritis: a meta-analysis study. Future Sci OA 7:FSO759","journal-title":"Future Sci OA"},{"key":"4353_CR96","doi-asserted-by":"crossref","first-page":"300060520964661","DOI":"10.1177\/0300060520964661","volume":"48","author":"H Ren","year":"2020","unstructured":"Ren H, Zhang S, Wang X et al (2020) Role of platelet-rich plasma in the treatment of osteoarthritis: a meta-analysis. J Int Med Res 48:300060520964661","journal-title":"J Int Med Res"},{"key":"4353_CR97","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1177\/0363546515580787","volume":"44","author":"JC Riboh","year":"2016","unstructured":"Riboh JC, Saltzman BM, Yanke AB et al (2016) Effect of leukocyte concentration on the efficacy of platelet-rich plasma in the treatment of knee osteoarthritis. Am J Sports Med 44:792\u2013800","journal-title":"Am J Sports Med"},{"key":"4353_CR98","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2021-001658","volume":"7","author":"SC Rodriguez-Garc\u00eda","year":"2021","unstructured":"Rodriguez-Garc\u00eda SC, Castellanos-Moreira R, Uson J et al (2021) Efficacy and safety of intra-articular therapies in rheumatic and musculoskeletal diseases: an overview of systematic reviews. RMD Open 7:e001658","journal-title":"RMD Open"},{"key":"4353_CR99","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.19082\/2115","volume":"8","author":"HN Sadabad","year":"2016","unstructured":"Sadabad HN, Behzadifar M, Arasteh F et al (2016) Efficacy of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: a systematic review and meta-analysis. Electron Physician 8:2115\u20132122","journal-title":"Electron Physician"},{"key":"4353_CR100","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1016\/j.arth.2022.05.014","volume":"37","author":"OC Sax","year":"2022","unstructured":"Sax OC, Chen Z, Mont MA, Delanois RE (2022) The efficacy of platelet-rich plasma for the treatment of knee osteoarthritis symptoms and structural changes: a systematic review and meta-analysis. J Arthroplasty 37:2282-2290.e2","journal-title":"J Arthroplasty"},{"key":"4353_CR101","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13018-017-0521-3","volume":"12","author":"L Shen","year":"2017","unstructured":"Shen L, Yuan T, Chen S et al (2017) The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials. J Orthop Surg Res 12:16","journal-title":"J Orthop Surg Res"},{"key":"4353_CR102","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/00913847.2017.1357421","volume":"45","author":"WJ Shi","year":"2017","unstructured":"Shi WJ, Tjoumakaris FP, Lendner M, Freedman KB (2017) Biologic injections for osteoarthritis and articular cartilage damage: can we modify disease? Phys Sportsmed 45:203\u2013223","journal-title":"Phys Sportsmed"},{"key":"4353_CR103","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1177\/03635465211029659","volume":"50","author":"H Singh","year":"2022","unstructured":"Singh H, Knapik DM, Polce EM et al (2022) Relative efficacy of intra-articular injections in the treatment of knee osteoarthritis: a systematic review and network meta-analysis. Am J Sports Med 50:3140\u20133148","journal-title":"Am J Sports Med"},{"key":"4353_CR104","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1053\/j.trap.2016.09.012","volume":"19","author":"D Souzdalnitski","year":"2015","unstructured":"Souzdalnitski D, Narouze SN, Lerman IR, Calodney A (2015) Platelet-rich plasma injections for knee osteoarthritis: systematic review of duration of clinical benefit. Tech Reg Anesth Pain Manag 19:67\u201372","journal-title":"Tech Reg Anesth Pain Manag"},{"key":"4353_CR105","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.arthro.2020.07.011","volume":"37","author":"J Tan","year":"2021","unstructured":"Tan J, Chen H, Zhao L, Huang W (2021) Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis of 26 randomized controlled trials. Arthroscopy 37:309\u2013325","journal-title":"Arthroscopy"},{"key":"4353_CR106","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1186\/s13018-020-01919-9","volume":"15","author":"JZ Tang","year":"2020","unstructured":"Tang JZ, Nie MJ, Zhao JZ et al (2020) Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis. J Orthop Surg Res 15:403","journal-title":"J Orthop Surg Res"},{"key":"4353_CR107","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3810\/psm.2014.05.2055","volume":"42","author":"DC Tietze","year":"2014","unstructured":"Tietze DC, Geissler K, Borchers J (2014) The effects of platelet-rich plasma in the treatment of large-joint osteoarthritis: a systematic review. Phys Sportsmed 42:27\u201337","journal-title":"Phys Sportsmed"},{"key":"4353_CR108","doi-asserted-by":"crossref","DOI":"10.3390\/life10060094","volume":"10","author":"E Trams","year":"2020","unstructured":"Trams E, Kulinski K, Kozar-Kaminska K et al (2020) The clinical use of platelet-rich plasma in knee disorders and surgery-a systematic review and meta-analysis. Life 10:94","journal-title":"Life"},{"key":"4353_CR109","doi-asserted-by":"crossref","DOI":"10.5867\/medwave.2018.03.7216","volume":"18","author":"D Ubilla","year":"2018","unstructured":"Ubilla D, Anan\u00edas J, Ortiz-Mu\u00f1oz L, Irarr\u00e1zaval S (2018) Is platelet-rich plasma effective for osteoarthritis? Medwave 18:e7215","journal-title":"Medwave"},{"key":"4353_CR110","doi-asserted-by":"crossref","DOI":"10.2106\/JBJS.RVW.17.00167","volume":"6","author":"C Vannabouathong","year":"2018","unstructured":"Vannabouathong C, Bhandari M, Bedi A et al (2018) Nonoperative treatments for knee osteoarthritis: an evaluation of treatment characteristics and the intra-articular placebo effect: a systematic review. JBJS Rev 6:e5","journal-title":"JBJS Rev"},{"key":"4353_CR111","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s00402-021-04304-1","volume":"143","author":"F Vilchez-Cavazos","year":"2023","unstructured":"Vilchez-Cavazos F, Bl\u00e1zquez-Salda\u00f1a J, Gamboa-Alonso AA et al (2023) The use of platelet-rich plasma in studies with early knee osteoarthritis versus advanced stages of the disease: a systematic review and meta-analysis of 31 randomized clinical trials. Arch Orthop Trauma Surg 143:1393\u20131408","journal-title":"Arch Orthop Trauma Surg"},{"key":"4353_CR112","doi-asserted-by":"crossref","DOI":"10.1177\/2325967119887116","volume":"7","author":"F Vilchez-Cavazos","year":"2019","unstructured":"Vilchez-Cavazos F, Mill\u00e1n-Alan\u00eds JM, Bl\u00e1zquez-Salda\u00f1a J et al (2019) Comparison of the clinical effectiveness of single versus multiple injections of platelet-rich plasma in the treatment of knee osteoarthritis: a systematic review and meta-analysis. Orthop J Sports Med 7:2325967119887116","journal-title":"Orthop J Sports Med"},{"key":"4353_CR113","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3928\/01477447-20211001-07","volume":"44","author":"X Wei","year":"2021","unstructured":"Wei X, Riehl JT (2021) Platelet-rich plasma and stem cell injections in the treatment of arthritis of the knee. Orthopedics 44:376\u2013383","journal-title":"Orthopedics"},{"key":"4353_CR114","first-page":"230949901988766","volume":"28","author":"Q Wu","year":"2020","unstructured":"Wu Q, Luo X, Xiong Y et al (2020) Platelet-rich plasma versus hyaluronic acid in knee osteoarthritis: a meta-analysis with the consistent ratio of injection. J Orthop Surg (Hong Kong) 28:2309499019887660","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"4353_CR115","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1111\/1756-185X.13233","volume":"20","author":"D Xing","year":"2017","unstructured":"Xing D, Wang B, Zhang W et al (2017) Intra-articular platelet-rich plasma injections for knee osteoarthritis: an overview of systematic reviews and risk of bias considerations. Int J Rheum Dis 20:1612\u20131630","journal-title":"Int J Rheum Dis"},{"key":"4353_CR116","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1097\/PHM.0000000000000746","volume":"96","author":"Z Xu","year":"2017","unstructured":"Xu Z, Luo J, Huang X et al (2017) Efficacy of platelet-rich plasma in pain and self-report function in knee osteoarthritis: a best-evidence synthesis. Am J Phys Med Rehabil 96:793\u2013800","journal-title":"Am J Phys Med Rehabil"},{"key":"4353_CR117","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2147\/DDDT.S156724","volume":"12","author":"H-F Zhang","year":"2018","unstructured":"Zhang H-F, Wang C-G, Li H et al (2018) Intra-articular platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis. Drug Des Devel Ther 12:445\u2013453","journal-title":"Drug Des Devel Ther"},{"key":"4353_CR118","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1016\/j.arthro.2021.02.045","volume":"37","author":"D Zhao","year":"2021","unstructured":"Zhao D, Pan J-K, Yang W-Y et al (2021) Intra-articular injections of platelet-rich plasma, adipose mesenchymal stem cells, and bone marrow mesenchymal stem cells associated with better outcomes than hyaluronic acid and saline in knee osteoarthritis: a systematic review and network meta-analysis. Arthroscopy 37:2298-2314.e10","journal-title":"Arthroscopy"}],"container-title":["European Journal of Orthopaedic Surgery &amp; Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-025-04353-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00590-025-04353-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-025-04353-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:44:53Z","timestamp":1767015893000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00590-025-04353-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,12]]},"references-count":118,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4353"],"URL":"https:\/\/doi.org\/10.1007\/s00590-025-04353-x","relation":{},"ISSN":["1432-1068"],"issn-type":[{"value":"1432-1068","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,12]]},"assertion":[{"value":"9 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Author J.R.L and N.D.H declare the following: 1. Royalties from a company or supplier (The following conflicts were disclosed) Corin U.S.A, Depuy: A Johnson & Johnson Company 2. Speakers bureau\/paid presentations for a company or supplier (The following conflicts were disclosed) None 3A. Paid employee for a company or supplier (The following conflicts were disclosed) None 3B. Paid consultant for a company or supplier (The following conflicts were disclosed) Intellijoint Surgical, MicroPort Orthopedics, Corin U.S.A, Zimmer, Depuy: A Johnson & Johnson Company 3C. Unpaid consultants for a company or supplier (The following conflicts were disclosed) None 4. Stock or stock options in a company or supplier (The following conflicts were disclosed) Intellijoint Surgical, BD Surgiphor, Hip Innovations Technologies 5. Research support from a company or supplier as a Principal Investigator (The following conflicts were disclosed) None 6. Other financial or material support from a company or supplier (The following conflicts were disclosed) None 7. Royalties, financial or material support from publishers (The following conflicts were disclosed) Saunders\/Mosby-Elsevier 8. Medical\/Orthopaedic publications editorial\/governing board (The following conflicts were disclosed) None 9. Board member\/committee appointments for a society (The following conflicts were disclosed) AAOS, AJRR, AAHKS, Knee Society, Hip Society, Musculoskeletal Transplant Foundation, Western Orthopaedic Association.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"348"}}