{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:09:05Z","timestamp":1784628545260,"version":"3.55.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Orthop Surg Traumatol"],"DOI":"10.1007\/s00590-025-04378-2","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T05:47:44Z","timestamp":1750139264000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of histological response across patients with Ewing sarcoma treated with preoperative chemotherapy with or without preoperative radiotherapy"],"prefix":"10.1007","volume":"35","author":[{"given":"Hisaki","family":"Aiba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayano","family":"Aso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Righi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gambarotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Cammelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Spinnato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Traversari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Atherley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Solou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Zuccheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Dozza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Frega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Donati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"Errani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"4378_CR1","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1016\/j.ijrobp.2017.08.020","volume":"99","author":"SK Ahmed","year":"2017","unstructured":"Ahmed SK, Randall RL, DuBois SG et al (2017) Identification of patients with localized ewing sarcoma at higher risk for local failure: a report from the children\u2019s oncology group. Int J Radiat Oncol Biol Phys 99:1286\u20131294. https:\/\/doi.org\/10.1016\/j.ijrobp.2017.08.020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4378_CR2","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1002\/pbc.23040","volume":"57","author":"M Stahl","year":"2011","unstructured":"Stahl M, Ranft A, Paulussen M et al (2011) Risk of recurrence and survival after relapse in patients with Ewing sarcoma. Pediatr Blood Cancer 57:549\u2013553. https:\/\/doi.org\/10.1002\/pbc.23040","journal-title":"Pediatr Blood Cancer"},{"key":"4378_CR3","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1002\/cncr.10192","volume":"94","author":"C Rodriguez-Galindo","year":"2002","unstructured":"Rodriguez-Galindo C, Billups CA, Kun KE et al (2002) Survival after recurrence of Ewing tumors: the St Jude Children\u2019s Research Hospital experience, 1979\u20131999. Cancer 94:561\u2013569. https:\/\/doi.org\/10.1002\/cncr.10192","journal-title":"Cancer"},{"key":"4378_CR4","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1055\/s-2008-1033716","volume":"200","author":"H J\u00fcrgens","year":"1988","unstructured":"J\u00fcrgens H, Bier V, Harms D et al (1988) The German society of pediatric oncology cooperative ewing sarcoma studies CESS 81\/86: report after 6 1\/2 years. Klin Padiatr 200:243\u2013252. https:\/\/doi.org\/10.1055\/s-2008-1033716","journal-title":"Klin Padiatr"},{"key":"4378_CR5","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1200\/jco.2001.19.6.1818","volume":"19","author":"M Paulussen","year":"2001","unstructured":"Paulussen M, Ahrens S, Dunst J et al (2001) Localized Ewing tumor of bone: final results of the cooperative Ewing\u2019s Sarcoma Study CESS 86. J Clin Oncol 19:1818\u20131829. https:\/\/doi.org\/10.1200\/jco.2001.19.6.1818","journal-title":"J Clin Oncol"},{"key":"4378_CR6","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1055\/s-2008-1043800","volume":"211","author":"M Paulussen","year":"1999","unstructured":"Paulussen M, Ahrens S, Braun-Munzinager G et al (1999) EICESS 92 (European Intergroup Cooperative Ewing\u2019s Sarcoma Study)\u2013 preliminary results. Klin Padiatr 211:276\u2013283. https:\/\/doi.org\/10.1055\/s-2008-1043800","journal-title":"Klin Padiatr"},{"key":"4378_CR7","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/s0360-3016(02)03797-5","volume":"55","author":"A Schuck","year":"2003","unstructured":"Schuck A, Ahrens S, Paulussen M et al (2003) Local therapy in localized Ewing tumors: results of 1058 patients treated in the CESS 81, CESS 86, and EICESS 92 trials. Int J Radiat Oncol Biol Phys 55:168\u2013177. https:\/\/doi.org\/10.1016\/s0360-3016(02)03797-5","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4378_CR8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/jso.20752","volume":"96","author":"D Donati","year":"2007","unstructured":"Donati D, Yin J, Di Bella C et al (2007) Local and distant control in non-metastatic pelvic Ewing\u2019s sarcoma patients. J Surg Oncol 96:19\u201325. https:\/\/doi.org\/10.1002\/jso.20752","journal-title":"J Surg Oncol"},{"key":"4378_CR9","doi-asserted-by":"publisher","first-page":"3838","DOI":"10.1200\/jco.2006.05.9188","volume":"24","author":"TI Yock","year":"2006","unstructured":"Yock TI, Krailo M, Fryer CJ et al (2006) Local control in pelvic Ewing sarcoma: analysis from INT-0091\u2013a report from the Children\u2019s Oncology Group. J Clin Oncol 24:3838\u20133843. https:\/\/doi.org\/10.1200\/jco.2006.05.9188","journal-title":"J Clin Oncol"},{"key":"4378_CR10","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1093\/annonc\/mdq573","volume":"22","author":"S Ferrari","year":"2011","unstructured":"Ferrari S, Sundby Hall K, Luksch R et al (2011) Nonmetastatic Ewing family tumors: high-dose chemotherapy with stem cell rescue in poor responder patients. Results of the Italian Sarcoma Group\/Scandinavian Sarcoma Group III protocol. Ann Oncol 22:1221\u20131227. https:\/\/doi.org\/10.1093\/annonc\/mdq573","journal-title":"Ann Oncol"},{"key":"4378_CR11","doi-asserted-by":"publisher","first-page":"3046","DOI":"10.3390\/cancers13123046","volume":"13","author":"SD Asaftei","year":"2021","unstructured":"Asaftei SD, Puma N, Paioli A et al (2021) Front-line window therapy with temozolomide and irinotecan in patients with primary disseminated multifocal Ewing sarcoma: Results of the ISG\/AIEOP EW-2 Study. Cancers (Basel) 13:3046. https:\/\/doi.org\/10.3390\/cancers13123046","journal-title":"Cancers (Basel)"},{"key":"4378_CR12","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.1093\/annonc\/mds117","volume":"23","author":"R Luksch","year":"2012","unstructured":"Luksch R, Tienghi A, Sundby Hall K et al (2012) Primary metastatic Ewing\u2019s family tumors: results of the Italian Sarcoma Group and Scandinavian Sarcoma Group ISG\/SSG IV Study including myeloablative chemotherapy and total-lung irradiation. Ann Oncol 23:2970\u20132976. https:\/\/doi.org\/10.1093\/annonc\/mds117","journal-title":"Ann Oncol"},{"key":"4378_CR13","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1097\/corr.0000000000000962","volume":"478","author":"D Andreou","year":"2020","unstructured":"Andreou D, Ranft A, Gosheger G et al (2020) Which factors are associated with local control and survival of patients with localized pelvic Ewing\u2019s sarcoma? A retrospective analysis of data from the Euro-EWING99 trial. Clin Orthop Relat Res 478:290\u2013302. https:\/\/doi.org\/10.1097\/corr.0000000000000962","journal-title":"Clin Orthop Relat Res"},{"key":"4378_CR14","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1016\/j.ejso.2021.02.009","volume":"47","author":"A Righi","year":"2021","unstructured":"Righi A, Pacheco M, Palmerini E et al (2021) Histological response to neoadjuvant chemotherapy in localized Ewing sarcoma of the bone: A retrospective analysis of available scoring tools. Eur J Surg Oncol 47:1778\u20131783. https:\/\/doi.org\/10.1016\/j.ejso.2021.02.009","journal-title":"Eur J Surg Oncol"},{"key":"4378_CR15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s002560050339","volume":"27","author":"HJ van der Woude","year":"1998","unstructured":"van der Woude HJ, Bloem JL, Hogendoorn PC (1998) Preoperative evaluation and monitoring chemotherapy in patients with high-grade osteogenic and Ewing\u2019s sarcoma: review of current imaging modalities. Skeletal Radiol 27:57\u201371. https:\/\/doi.org\/10.1007\/s002560050339","journal-title":"Skeletal Radiol"},{"key":"4378_CR16","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1097\/00003086-198011000-00013","volume":"153","author":"WF Enneking","year":"1980","unstructured":"Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res 153:106\u2013120","journal-title":"Clin Orthop Relat Res"},{"key":"4378_CR17","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1148\/radiol.2252011604","volume":"225","author":"SR Prasad","year":"2002","unstructured":"Prasad SR, Jhaveri KS, Saini S, Hahn PF, Halpern EF, Sumner JE (2002) CT tumor measurement for therapeutic response assessment: comparison of unidimensional, bidimensional, and volumetric techniques initial observations. Radiology 225:416\u2013419. https:\/\/doi.org\/10.1148\/radiol.2252011604","journal-title":"Radiology"},{"key":"4378_CR18","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1002\/cncr.29065","volume":"121","author":"SG DuBois","year":"2015","unstructured":"DuBois SG, Krailo MD, Gebhardt MC et al (2015) Comparative evaluation of local control strategies in localized Ewing sarcoma of bone: a report from the Children\u2019s Oncology Group. Cancer 121:467\u2013475. https:\/\/doi.org\/10.1002\/cncr.29065","journal-title":"Cancer"},{"key":"4378_CR19","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.ejca.2016.03.075","volume":"61","author":"S Foulon","year":"2016","unstructured":"Foulon S, Brennan B, Gaspar N et al (2016) Can postoperative radiotherapy be omitted in localised standard-risk Ewing sarcoma? An observational study of the Euro-E.W.I.N.G group. Eur J Cancer 61:128\u2013136. https:\/\/doi.org\/10.1016\/j.ejca.2016.03.075","journal-title":"Eur J Cancer"},{"key":"4378_CR20","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1016\/s0959-8049(99)00144-6","volume":"35","author":"AG Shankar","year":"1999","unstructured":"Shankar AG, Pinkerton CR, Atra A et al (1999) Local therapy and other factors influencing site of relapse in patients with localised Ewing\u2019s sarcoma. United Kingdom Children\u2019s Cancer Study Group (UKCCSG). Eur J Cancer 35:1698\u20131704. https:\/\/doi.org\/10.1016\/s0959-8049(99)00144-6","journal-title":"Eur J Cancer"},{"key":"4378_CR21","first-page":"509","volume":"36","author":"T Sokolov","year":"2000","unstructured":"Sokolov T, Stoyanova A, Mumdjiev I, Mihova A (2000) Comparison of two treatment approaches to localized Ewing\u2019s sarcoma. Ortopediya i Travmatologiya 36:509\u2013515","journal-title":"Ortopediya i Travmatologiya"},{"key":"4378_CR22","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.ijrobp.2006.01.019","volume":"65","author":"G Bacci","year":"2006","unstructured":"Bacci G, Longhi A, Briccoli A, Bertni F, Versari M, Picci P (2006) The role of surgical margins in treatment of Ewing\u2019s sarcoma family tumors: experience of a single institution with 512 patients treated with adjuvant and neoadjuvant chemotherapy. Int J Radiat Oncol Biol Phys 65:766\u2013772. https:\/\/doi.org\/10.1016\/j.ijrobp.2006.01.019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4378_CR23","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.suronc.2015.11.002","volume":"25","author":"J Werier","year":"2016","unstructured":"Werier J, Yao X, Caudrelier JM et al (2016) A systematic review of optimal treatment strategies for localized Ewing\u2019s sarcoma of bone after neo-adjuvant chemotherapy. Surg Oncol 25:16\u201323. https:\/\/doi.org\/10.1016\/j.suronc.2015.11.002","journal-title":"Surg Oncol"},{"key":"4378_CR24","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1002\/pbc.25830","volume":"63","author":"K Grevener","year":"2016","unstructured":"Grevener K, Haveman LM, Ranft A et al (2016) Management and outcome of Ewing sarcoma of the head and neck. Pediatr Blood Cancer 63:604\u2013610. https:\/\/doi.org\/10.1002\/pbc.25830","journal-title":"Pediatr Blood Cancer"},{"key":"4378_CR25","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1097\/bpo.0000000000000860","volume":"38","author":"M Laitinen","year":"2018","unstructured":"Laitinen M, Parry M, Albergo JI, Jeys L, Sumathi V, Grimer R (2018) Outcome of pelvic bone sarcomas in children. J Pediatr Orthop 38:537\u2013542. https:\/\/doi.org\/10.1097\/bpo.0000000000000860","journal-title":"J Pediatr Orthop"},{"key":"4378_CR26","doi-asserted-by":"publisher","first-page":"e26504","DOI":"10.1002\/pbc.26504","volume":"64","author":"SK Ahmed","year":"2017","unstructured":"Ahmed SK, Robinson SI, Arndt CAS et al (2017) Pelvis Ewing sarcoma: local control and survival in the modern era. Pediatr Blood Cancer 64:e26504. https:\/\/doi.org\/10.1002\/pbc.26504","journal-title":"Pediatr Blood Cancer"},{"key":"4378_CR27","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.radonc.2009.06.009","volume":"93","author":"G Bacci","year":"2009","unstructured":"Bacci G, Palmerini E, Staals EL et al (2009) Ewing\u2019s sarcoma family tumors of the humerus: outcome of patients treated with radiotherapy, surgery or surgery and adjuvant radiotherapy. Radiother Oncol 93:383\u2013387. https:\/\/doi.org\/10.1016\/j.radonc.2009.06.009","journal-title":"Radiother Oncol"},{"key":"4378_CR28","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1002\/(sici)1096-911x(199911)33:5<444::aid-mpo2>3.0.co;2-d","volume":"33","author":"C Carrie","year":"1999","unstructured":"Carrie C, Mascard E, Gomez F et al (1999) Nonmetastatic pelvic Ewing sarcoma: report of the French society of pediatric oncology. Med Pediatr Oncol 33:444\u2013449. https:\/\/doi.org\/10.1002\/(sici)1096-911x(199911)33:5%3c444::aid-mpo2%3e3.0.co;2-d","journal-title":"Med Pediatr Oncol"},{"key":"4378_CR29","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s13312-020-1850-6","volume":"57","author":"H Zhu","year":"2020","unstructured":"Zhu H, Li Y, Xie X, Zhang S, Xue Y, Fan T (2020) Efficacy of local control strategies for Ewing sarcoma after neoadjuvant chemotherapy: a network meta-analysis. Indian Pediatr 57:527\u2013532","journal-title":"Indian Pediatr"},{"issue":"10","key":"4378_CR30","doi-asserted-by":"publisher","first-page":"2618","DOI":"10.1016\/j.ejso.2021.05.027","volume":"47","author":"JR Lex","year":"2021","unstructured":"Lex JR, Kurisunkal V, Kaneuchi Y et al (2021) Pelvic Ewing sarcoma: should all patients receive pre-operative radiotherapy, or should it be delivered selectively? Eur J Surg Oncol 47(10):2618\u20132626. https:\/\/doi.org\/10.1016\/j.ejso.2021.05.027","journal-title":"Eur J Surg Oncol"},{"key":"4378_CR31","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1002\/pbc.20754","volume":"48","author":"AC Paulino","year":"2007","unstructured":"Paulino AC, Nguyen TX, Mai WY (2007) An analysis of primary site control and late effects according to local control modality in non-metastatic Ewing sarcoma. Pediatr Blood Cancer 48:423\u2013429. https:\/\/doi.org\/10.1002\/pbc.20754","journal-title":"Pediatr Blood Cancer"},{"key":"4378_CR32","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.ejca.2008.02.027","volume":"44","author":"F Navid","year":"2008","unstructured":"Navid F, Billups C, Liu T, Krasin MJ, Rodriguez-Galindo C (2008) Second cancers in patients with the Ewing sarcoma family of tumours. Eur J Cancer 44:983\u2013991. https:\/\/doi.org\/10.1016\/j.ejca.2008.02.027","journal-title":"Eur J Cancer"},{"key":"4378_CR33","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1056\/nejm198709033171002","volume":"317","author":"MA Tucker","year":"1987","unstructured":"Tucker MA, D\u2019Angio GJD, Boice JD Jr et al (1987) Bone sarcomas linked to radiotherapy and chemotherapy in children. N Engl J Med 317:588\u2013593. https:\/\/doi.org\/10.1056\/nejm198709033171002","journal-title":"N Engl J Med"},{"key":"4378_CR34","doi-asserted-by":"publisher","first-page":"2818","DOI":"10.1200\/jco.1996.14.10.2818","volume":"14","author":"JF Kuttesch Jr","year":"1996","unstructured":"Kuttesch JF Jr, Wexler LH, Marcus RB et al (1996) Second malignancies after Ewing\u2019s sarcoma: radiation dose-dependency of secondary sarcomas. J Clin Oncol 14:2818\u20132825. https:\/\/doi.org\/10.1200\/jco.1996.14.10.2818","journal-title":"J Clin Oncol"}],"container-title":["European Journal of Orthopaedic Surgery &amp; Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-025-04378-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00590-025-04378-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-025-04378-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T23:02:30Z","timestamp":1767049350000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00590-025-04378-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,17]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4378"],"URL":"https:\/\/doi.org\/10.1007\/s00590-025-04378-2","relation":{},"ISSN":["1432-1068"],"issn-type":[{"value":"1432-1068","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,17]]},"assertion":[{"value":"27 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"251"}}