{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T18:56:27Z","timestamp":1781636187053,"version":"3.54.5"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007594","name":"Comenius University in Bratislava","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007594","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Orthop Surg Traumatol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to evaluate the outcomes of surgical treatment for extremity soft tissue sarcomas in a country without a legislatively designated sarcoma center and to assess the impact of non-centralized surgical care on local recurrence, amputation rates, and patient survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 97 patients treated over a five-year period at our orthopedic oncology unit, with a minimum follow-up of 24 months, were included. Patients were stratified into four groups according to the time point at which they were referred from regional hospitals to our department (before biopsy, after biopsy, after resection, and after local recurrence). Using descriptive statistics, we compared local recurrence rates, amputation rates, and overall survival among these groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients who were both diagnosed and initially operated on at the specialized orthopedic oncology unit had a substantially lower local recurrence rate (13.8%, CI [0.04, 0.23]. vs. 33.3\u201353.8%, CI [0.12, 0.72]) and a higher 24-month overall survival rate (80.5%, CI [0.67, 0.93] vs. 46.1\u201371.4%, CI [0.27, 0.90]) compared with those whose initial management occurred at regional facilities. Amputation rates varied between groups, with the lowest rate observed in patients diagnosed and treated at the specialized unit (2.8%, CI [0, 0.07] vs. 7.1\u201319.2%, CI [0, 0.36]); however, these differences did not reach statistical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings are consistent with previously published data and support the centralization of care for extremity soft tissue sarcomas, which is associated with lower local recurrence and improved survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00590-026-04680-7","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T14:04:21Z","timestamp":1771596261000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of non-centralised surgical treatment on local recurrence, amputation rate and survival in patients with extremity soft tissue sarcoma"],"prefix":"10.1007","volume":"36","author":[{"given":"M\u00e1rio","family":"Malina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"\u0160vec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matej","family":"Majer\u010d\u00edk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bibza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Karo\u013e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Hudec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jergu\u0161","family":"Kocour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Kokavec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"4680_CR1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/jso.24112","volume":"113","author":"S Byerly","year":"2016","unstructured":"Byerly S, Chopra S, Nassif NA, Chen P, Sener SF et al (2016) The role of margins in extremity soft tissue sarcoma. 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The data used in the study are available from the corresponding author and will be provided upon request.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"114"}}