{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:23:24Z","timestamp":1788315804785,"version":"build-2803163510"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Orthop Surg Traumatol"],"DOI":"10.1007\/s00590-026-04881-0","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:23:40Z","timestamp":1785129820000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Skin keratin correlates with bone and tendon collagen quality: a proof-of-concept clinical study using FTIR spectroscopy in shoulder arthroplasty patients"],"prefix":"10.1007","volume":"36","author":[{"given":"Alexander J.","family":"Rondon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Querido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Tzeuton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishith","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Karchner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Fertala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Pleshko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3845-7220","authenticated-orcid":false,"given":"Joseph A.","family":"Abboud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"4881_CR1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.5312\/wjo.v6.i2.211","volume":"6","author":"AM Abtahi","year":"2015","unstructured":"Abtahi AM, Granger EK, Tashjian RZ (2015) Factors affecting healing after arthroscopic rotator cuff repair. World J Orthop 6:211\u2013220. https:\/\/doi.org\/10.5312\/wjo.v6.i2.211","journal-title":"World J Orthop"},{"key":"4881_CR2","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.1177\/0363546517717686","volume":"45","author":"JM Cancienne","year":"2017","unstructured":"Cancienne JM, Brockmeier SF, Rodeo SA et al (2017) Perioperative serum lipid status and statin use affect the revision surgery rate after arthroscopic rotator cuff repair. Am J Sports Med 45:2948\u20132954. https:\/\/doi.org\/10.1177\/0363546517717686","journal-title":"Am J Sports Med"},{"key":"4881_CR3","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1016\/j.jse.2017.05.009","volume":"26","author":"GH Garcia","year":"2017","unstructured":"Garcia GH, Liu JN, Wong A et al (2017) Hyperlipidemia increases the risk of retear after arthroscopic rotator cuff repair. J Shoulder Elbow Surg 26:2086\u20132090. https:\/\/doi.org\/10.1016\/j.jse.2017.05.009","journal-title":"J Shoulder Elbow Surg"},{"key":"4881_CR4","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1136\/bjsports-2014-094148","volume":"49","author":"J-S Roy","year":"2015","unstructured":"Roy J-S, Bra\u00ebn C, Leblond J et al (2015) Diagnostic accuracy of ultrasonography, MRI and MR arthrography in the characterisation of rotator cuff disorders: a systematic review and meta-analysis. Br J Sports Med 49:1316\u20131328.","journal-title":"Br J Sports Med"},{"issue":"10","key":"4881_CR5","doi-asserted-by":"publisher","first-page":"232596712110351","DOI":"10.1177\/23259671211035106","volume":"9","author":"AS Farooqi","year":"2021","unstructured":"Farooqi AS, Lee A, Novikov D, Kelly AM, Li X, Kelly JD 4th, Parisien RL (2021) Diagnostic accuracy of ultrasonography for rotator cuff tears: a systematic review and meta-analysis. Orthop J Sports Med 9(10):23259671211035106","journal-title":"Orthop J Sports Med"},{"key":"4881_CR6","doi-asserted-by":"publisher","first-page":"219","DOI":"10.2106\/00004623-200402000-00002","volume":"86","author":"LM Galatz","year":"2004","unstructured":"Galatz LM, Ball CM, Teefey SA et al (2004) The outcome and repair integrity of completely arthroscopically repaired large and massive rotator cuff tears. JBJS 86:219\u2013224","journal-title":"JBJS"},{"key":"4881_CR7","doi-asserted-by":"publisher","first-page":"953","DOI":"10.2106\/jbjs.f.00512","volume":"89","author":"H Sugaya","year":"2007","unstructured":"Sugaya H, Maeda K, Matsuki K et al (2007) Repair integrity and functional outcome after arthroscopic double-row rotator cuff repair. J Bone Joint Surg 89:953\u2013960. https:\/\/doi.org\/10.2106\/jbjs.f.00512","journal-title":"J Bone Joint Surg"},{"key":"4881_CR8","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.jse.2009.11.045","volume":"19","author":"A Bedi","year":"2010","unstructured":"Bedi A, Fox AJS, Harris PE et al (2010) Diabetes mellitus impairs tendon-bone healing after rotator cuff repair. J Shoulder Elbow Surg 19:978\u2013988 2010\/03\/19. https:\/\/doi.org\/10.1016\/j.jse.2009.11.045","journal-title":"J Shoulder Elbow Surg"},{"key":"4881_CR9","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3390\/jfb9020031","volume":"9","author":"P Saeedi","year":"2018","unstructured":"Saeedi P, Shavandi A, Meredith-Jones K (2018) Nail Properties and Bone Health: A Review. J Funct Biomater 9:31. https:\/\/doi.org\/10.3390\/jfb9020031","journal-title":"J Funct Biomater"},{"key":"4881_CR10","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.eml.2018.01.009","volume":"20","author":"J Yeo","year":"2018","unstructured":"Yeo J, Jung G, Tarakanova A et al (2018) Multiscale modeling of keratin, collagen, elastin and related human diseases: perspectives from atomistic to coarse-grained molecular dynamics simulations. Extreme Mech Lett 20:112\u2013124. 2018\/02\/24","journal-title":"Extreme Mech Lett"},{"key":"4881_CR11","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s10856-006-0018-9","volume":"18","author":"MR Towler","year":"2006","unstructured":"Towler MR, Wren A, Rushe N et al (2006) Raman spectroscopy of the human nail: a potential tool for evaluating bone health? J Mater Science: Mater Med 18:759\u2013763. https:\/\/doi.org\/10.1007\/s10856-006-0018-9","journal-title":"J Mater Science: Mater Med"},{"key":"4881_CR12","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.bbadis.2017.10.020","volume":"1864","author":"MC Caraher","year":"2018","unstructured":"Caraher MC, Sophocleous A, Beattie JR et al (2018) Raman spectroscopy predicts the link between claw keratin and bone collagen structure in a rodent model of oestrogen deficiency. Biochim et Biophys Acta (BBA) - Mol Basis Disease 1864:398\u2013406. https:\/\/doi.org\/10.1016\/j.bbadis.2017.10.020","journal-title":"Biochim et Biophys Acta (BBA) - Mol Basis Disease"},{"key":"4881_CR13","doi-asserted-by":"publisher","first-page":"e64822","DOI":"10.1371\/journal.pone.0064822","volume":"8","author":"A Hanifi","year":"2013","unstructured":"Hanifi A, McCarthy H, Roberts S et al (2013) Fourier transform infrared imaging and infrared fiber optic probe spectroscopy identify collagen type in connective tissues. PLoS ONE 8:e64822\u2013e64822. https:\/\/doi.org\/10.1371\/journal.pone.0064822","journal-title":"PLoS ONE"},{"key":"4881_CR14","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/s13018-019-1217-7","volume":"14","author":"A Steplewski","year":"2019","unstructured":"Steplewski A, Fertala J, Tomlinson R et al (2019) The impact of cholesterol deposits on the fibrillar architecture of the Achilles tendon in a rabbit model of hypercholesterolemia. J Orthop Surg Res 14:172\u2013172. https:\/\/doi.org\/10.1186\/s13018-019-1217-7","journal-title":"J Orthop Surg Res"},{"key":"4881_CR15","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/978-3-662-53270-6_14","volume-title":"Percutaneous Penetration Enhancers Drug Penetration Into\/Through the Skin","author":"J Covi-Schwarz","year":"2017","unstructured":"Covi-Schwarz J, Klang V, Valenta C (2017) ATR-FTIR Spectroscopy and the Skin Barrier: Evaluation of Penetration-Enhancement Effects. Percutaneous Penetration Enhancers Drug Penetration Into\/Through the Skin. Springer, Berlin Heidelberg, pp 247\u2013254"},{"key":"4881_CR16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ijpharm.2012.06.005","volume":"435","author":"GK Menon","year":"2012","unstructured":"Menon GK, Cleary GW, Lane ME (2012) The structure and function of the stratum corneum. Int J Pharm 435:3\u20139. https:\/\/doi.org\/10.1016\/j.ijpharm.2012.06.005","journal-title":"Int J Pharm"},{"key":"4881_CR17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.saa.2017.07.001","volume":"188","author":"S Olszty\u0144ska-Janus","year":"2018","unstructured":"Olszty\u0144ska-Janus S, Pietruszka A, Kie\u0142bowicz Z et al (2018) ATR-IR study of skin components: lipids, proteins and water. Part I: temperature effect. Spectrochim Acta Part A Mol Biomol Spectrosc 188:37\u201349. https:\/\/doi.org\/10.1016\/j.saa.2017.07.001","journal-title":"Spectrochim Acta Part A Mol Biomol Spectrosc"},{"key":"4881_CR18","doi-asserted-by":"publisher","first-page":"922","DOI":"10.3390\/molecules26040922","volume":"26","author":"W Querido","year":"2021","unstructured":"Querido W, Kandel S, Pleshko N (2021) Applications of vibrational spectroscopy for analysis of connective tissues. Molecules 26:922. https:\/\/doi.org\/10.3390\/molecules26040922","journal-title":"Molecules"},{"key":"4881_CR19","doi-asserted-by":"publisher","first-page":"11448","DOI":"10.1038\/srep11448","volume":"5","author":"ZS Silva J\u00fanior","year":"2015","unstructured":"Silva J\u00fanior ZS, Botta SB, Ana PA et al (2015) Effect of papain-based gel on type I collagen\u2013spectroscopy applied for microstructural analysis. Sci Rep 5:11448\u201311448. https:\/\/doi.org\/10.1038\/srep11448","journal-title":"Sci Rep"},{"key":"4881_CR20","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1366\/000370208784658156","volume":"62","author":"Y Miyamae","year":"2008","unstructured":"Miyamae Y, Yamakawa Y, Kawabata M et al (2008) A noninvasive method for assessing interior skin damage caused by chronological aging and photoaging based on near-infrared diffuse reflection spectroscopy. Appl Spectrosc 62:677\u2013681. https:\/\/doi.org\/10.1366\/000370208784658156","journal-title":"Appl Spectrosc"},{"key":"4881_CR21","doi-asserted-by":"publisher","first-page":"e642","DOI":"10.1002\/ams2.642","volume":"8","author":"M Oi","year":"2021","unstructured":"Oi M, Maruhashi T, Kumazawa K et al (2021) Diagnosis of skin and soft tissue infections using near-infrared spectroscopy. Acute Med Surg 8:e642\u2013e642. https:\/\/doi.org\/10.1002\/ams2.642","journal-title":"Acute Med Surg"},{"key":"4881_CR22","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.joca.2005.07.008","volume":"13","author":"X Bi","year":"2005","unstructured":"Bi X, Li G, Doty SB et al (2005) A novel method for determination of collagen orientation in cartilage by Fourier transform infrared imaging spectroscopy (FT-IRIS). Osteoarthr Cartil 13:1050\u20131058. https:\/\/doi.org\/10.1016\/j.joca.2005.07.008","journal-title":"Osteoarthr Cartil"},{"key":"4881_CR23","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1007\/s00216-009-3019-y","volume":"395","author":"K Belbachir","year":"2009","unstructured":"Belbachir K, Noreen R, Gouspillou G et al (2009) Collagen types analysis and differentiation by FTIR spectroscopy. Anal Bioanal Chem 395:829\u2013837. https:\/\/doi.org\/10.1007\/s00216-009-3019-y","journal-title":"Anal Bioanal Chem"},{"key":"4881_CR24","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0378-5122(94)90126-0","volume":"18","author":"C Castelo-Branco","year":"1994","unstructured":"Castelo-Branco C, Pons F, Gratac\u00f3s E et al (1994) Relationship between skin collagen and bone changes during aging. Maturitas 18:199\u2013206. https:\/\/doi.org\/10.1016\/0378-5122(94)90126-0","journal-title":"Maturitas"},{"key":"4881_CR25","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s00198-009-1066-z","volume":"21","author":"M Saito","year":"2009","unstructured":"Saito M, Marumo K (2009) Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporos Int 21:195\u2013214. https:\/\/doi.org\/10.1007\/s00198-009-1066-z","journal-title":"Osteoporos Int"},{"key":"4881_CR26","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/nyas.13572","volume":"1410","author":"AL Boskey","year":"2017","unstructured":"Boskey AL, Imbert L (2017) Bone quality changes associated with aging and disease: a review. Ann N Y Acad Sci 1410:93\u2013106. https:\/\/doi.org\/10.1111\/nyas.13572","journal-title":"Ann N Y Acad Sci"},{"issue":"20180329","key":"4881_CR27","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1177\/0363546518762386","volume":"46","author":"HY Jeong","year":"2018","unstructured":"Jeong HY, Kim HJ, Jeon YS et al (2018) Factors predictive of healing in large rotator cuff tears: is it possible to predict retear preoperatively? Am J Sports Med 46(20180329):1693\u20131700. https:\/\/doi.org\/10.1177\/0363546518762386","journal-title":"Am J Sports Med"},{"key":"4881_CR28","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1177\/0363546517695234","volume":"45","author":"YS Lee","year":"2017","unstructured":"Lee YS, Jeong JY, Park C-D et al (2017) Evaluation of the risk factors for a rotator cuff retear after repair surgery. Am J Sports Med 45:1755\u20131761. https:\/\/doi.org\/10.1177\/0363546517695234","journal-title":"Am J Sports Med"},{"key":"4881_CR29","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1016\/j.jse.2017.07.012","volume":"26","author":"S Gyftopoulos","year":"2017","unstructured":"Gyftopoulos S, Guja KE, Subhas N et al (2017) Cost-effectiveness of magnetic resonance imaging versus ultrasound for the detection of symptomatic full-thickness supraspinatus tendon tears. J Shoulder Elbow Surg 26:2067\u20132077. https:\/\/doi.org\/10.1016\/j.jse.2017.07.012","journal-title":"J Shoulder Elbow Surg"},{"key":"4881_CR30","doi-asserted-by":"publisher","first-page":"365902","DOI":"10.1155\/2014\/365902","volume":"2014","author":"S Juric","year":"2014","unstructured":"Juric S, Flis V, Debevc M et al (2014) Towards a low-cost mobile subcutaneous vein detection solution using near-infrared spectroscopy. Sci World J 2014:365902\u2013365902. https:\/\/doi.org\/10.1155\/2014\/365902","journal-title":"ScientificWorldJournal"},{"key":"4881_CR31","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.emc.2019.09.009","volume":"38","author":"R Simard","year":"2020","unstructured":"Simard R (2020) Ultrasound Imaging of Orthopedic Injuries. Emerg Med Clin North Am 38:243\u2013265. https:\/\/doi.org\/10.1016\/j.emc.2019.09.009","journal-title":"Emerg Med Clin North Am"}],"container-title":["European Journal of Orthopaedic Surgery & Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-026-04881-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00590-026-04881-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00590-026-04881-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:11:53Z","timestamp":1785514313000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00590-026-04881-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4881"],"URL":"https:\/\/doi.org\/10.1007\/s00590-026-04881-0","relation":{},"ISSN":["1432-1068"],"issn-type":[{"value":"1432-1068","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]},"assertion":[{"value":"1 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"JAA would like to disclose: royalties from Osteocentric Technologies, Enovis, Zimmer-Biomet, Stryker, and Globus Medical; Stocks has stock or stock options held in Shoulder Jam, Aevumed, Oberd, OTS Medical, Orthobullets, Atreon, and Restore 3D; has received research institutional support from Enovis and Arthrex; serves as a board member, owner, officer, or committee member of American Shoulder and Elbow Society, MID Atlantic Shoulder and Elbow Society, Shoulder 360, Pacira.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"approval was obtained from the institutional review board. The research was conducted according to the declaration of Helsinki.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"299"}}