{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:47:23Z","timestamp":1788216443636,"version":"build-2803163510"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005609","name":"University of Turku","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005609","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Orthop Surg Traumatol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Obesity is a common comorbidity in patients with knee osteoarthritis (KOA). Both viscosupplementation and platelet-rich plasma (PRP) intra-articular injections may alleviate KOA symptoms. To better guide patient selection for PRP therapy, we compared the outcomes of these treatments in obese individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study included 99 obese patients who received intra-articular injections of either PRP (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943) or hyaluronic acid (HA,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200956) between January 2014 and October 2017. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual analogue scale (VAS), and range of motion (ROM) were assessed before the injection and at 15\u00a0days, 6\u00a0months, 12\u00a0months, and the final follow-up. Outcomes were then compared between the two treatment groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Obese patients treated with HA had a higher rate of arthroplasty (35.7% vs. 9.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), reduced ROM, poorer VAS and WOMAC scores, and a higher overall risk of arthroplasty (log-rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.177) compared with those treated with PRP. Cox proportional hazards analysis indicated a non-significant trend toward a reduced risk of knee arthroplasty in the PRP group (HR\u2009=\u20090.46, 95% CI 0.15\u20131.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.176) over average follow-up of 16.5\u00a0month for all patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intra-articular PRP injections were associated with better outcomes than HA in obese patients with KOA. PRP may delay the need for arthroplasty and could serve as a valuable therapeutic option for selected patients who do not respond to conventional treatments. Due to several limitations, further large-scale studies are warranted to confirm the effectiveness of this promising approach in this high-risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00590-026-04922-8","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:33:02Z","timestamp":1786534382000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of PRP versus hyaluronic acid in obese individuals with knee osteoarthritis: a retrospective study"],"prefix":"10.1007","volume":"36","author":[{"given":"Aleksi","family":"Annaniemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcri","family":"Pere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5981-6870","authenticated-orcid":false,"given":"Salvatore","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"4922_CR1","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.joca.2025.08.015","volume":"4","author":"A Dell\u2019Isola","year":"2025","unstructured":"Dell\u2019Isola A, Recenti F, Giardulli B, Lawford BJ, Kiadaliri A (2025) Osteoarthritis year in review 2025: epidemiology and therapy. 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All content was generated, reviewed, and edited solely by the authors, who take full responsibility for the accuracy and integrity of the work.","order":3,"name":"Ethics","label":"Declaration of AI and AI-assisted technologies in the writing process","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"336"}}