{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:48:32Z","timestamp":1787737712226,"version":"build-2784847793"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,5,28]],"date-time":"2010-05-28T00:00:00Z","timestamp":1275004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1007\/s00592-010-0201-9","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T06:48:47Z","timestamp":1274942927000},"page":"265-270","source":"Crossref","is-referenced-by-count":22,"title":["Serum levels of proamylin and amylin in normal subjects and patients with impaired glucose regulation and type 2 diabetes mellitus"],"prefix":"10.1007","volume":"47","author":[{"given":"Xiaoya","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaochu","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,5,28]]},"reference":[{"key":"201_CR1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00125-002-1009-0","volume":"46","author":"SE Kahn","year":"2003","unstructured":"Kahn SE (2003) The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46:3\u201319","journal-title":"Diabetologia"},{"issue":"2","key":"201_CR2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00592-008-0063-6","volume":"46","author":"M Manco","year":"2009","unstructured":"Manco M, Giordano U, Turchetta A et al (2009) Insulin resistance and exercise capacity in male children and adolescents with non-alcholic fatty liver disease. Acta Diabetol 46(2):97\u2013104","journal-title":"Acta Diabetol"},{"key":"201_CR3","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","volume":"52","author":"AE Butler","year":"2003","unstructured":"Butler AE, Janson J, Bonner-Weir S et al (2003) \u03b2-cell deficit and increased \u03b2-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102\u2013110","journal-title":"Diabetes"},{"issue":"3","key":"201_CR4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00592-008-0080-5","volume":"46","author":"SM Ruchat","year":"2009","unstructured":"Ruchat SM, Elks CE, Loos RJ et al (2009) Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies. Acta Diabetol 46(3):217\u2013226","journal-title":"Acta Diabetol"},{"key":"201_CR5","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1126\/science.1104345","volume":"307","author":"CJ Rhodes","year":"2005","unstructured":"Rhodes CJ (2005) Type 2 diabetes: a matter of beta-cell life and death? Science 307:380\u2013384","journal-title":"Science"},{"issue":"1","key":"201_CR6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00592-008-0056-5","volume":"46","author":"DA Chistiakov","year":"2009","unstructured":"Chistiakov DA, Potapov VA, Khodirev DC et al (2009) Genetic variations in the pancreatic ATP-sensitive potassium channel, beta-cell dysfunction, and susceptibility to type 2 diabetes. Acta Diabetol 46(1):43\u201349","journal-title":"Acta Diabetol"},{"key":"201_CR7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2337\/diabetes.48.2.241","volume":"48","author":"SE Kahn","year":"1999","unstructured":"Kahn SE, Andrikopoulos S, Verchere CB (1999) Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes. Diabetes 48:241\u2013253","journal-title":"Diabetes"},{"key":"201_CR8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00125-003-1304-4","volume":"47","author":"A Clark","year":"2004","unstructured":"Clark A, Nilsson MR (2004) Islet amyloid: a complication of islet dysfunction or an aetiological factor in type 2 diabetes? Diabetologia 47:157\u2013169","journal-title":"Diabetologia"},{"issue":"6","key":"201_CR9","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.2337\/diabetes.50.6.1290","volume":"50","author":"M Federici","year":"2001","unstructured":"Federici M, Hribal M, Perego L et al (2001) High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. Diabetes 50(6):1290\u20131301","journal-title":"Diabetes"},{"issue":"1","key":"201_CR10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00592-008-0055-6","volume":"46","author":"SI Chisalita","year":"2009","unstructured":"Chisalita SI, Lindstr\u00f6m T, Eson Jennersj\u00f6 P et al (2009) Differential lipid profile and hormonal response in type 2 diabetes by exogenous insulin aspart versus the insulin secretagogue repaglinide, at the same glycemic control. Acta Diabetol 46(1):35\u201342","journal-title":"Acta Diabetol"},{"key":"201_CR11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/BF00404025","volume":"34","author":"E Hartter","year":"1991","unstructured":"Hartter E, Svoboda T, Ludvik B et al (1991) Basal and stimulated plasma levels of pancreatic amylin indicate its co-secretion with insulin in humans. Diabetologia 34:52\u201354","journal-title":"Diabetologia"},{"key":"201_CR12","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2337\/diab.39.5.634","volume":"39","author":"SE Kahn","year":"1990","unstructured":"Kahn SE, D\u2019Alessio DA, Schwartz MW et al (1990) Evidence of cosecretion of islet amyloid polypeptide and insulin by beta cells. Diabetes 39:634\u2013638","journal-title":"Diabetes"},{"key":"201_CR13","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1042\/bst0240594","volume":"24","author":"A Clark","year":"1996","unstructured":"Clark A, Charge SB, Badman MK et al (1996) Islet amyloid polypeptide: actions and role in the pathogenesis of diabetes. Biochem Soc Trans 24:594\u2013599","journal-title":"Biochem Soc Trans"},{"key":"201_CR14","doi-asserted-by":"crossref","unstructured":"Guardado-Mendoza R, Davalli AM, Chavez AO, et al (2009) Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons. Proc Natl Acad Sci 18; 106(33):13992\u201313997","DOI":"10.1073\/pnas.0906471106"},{"issue":"8","key":"201_CR15","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.2337\/db07-0197","volume":"56","author":"CJ Huang","year":"2007","unstructured":"Huang CJ, Lin CY, Haataja L et al (2007) High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes. Diabetes 56(8):2016\u20132027","journal-title":"Diabetes"},{"key":"201_CR16","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.2337\/diabetes.52.9.2304","volume":"52","author":"AE Butler","year":"2003","unstructured":"Butler AE, Janson J, Soeller WC et al (2003) Increased beta cell apoptosis prevents adaptive increase in beta cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes 52:2304\u20132314","journal-title":"Diabetes"},{"key":"201_CR17","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.2337\/diabetes.53.6.1509","volume":"53","author":"AE Butler","year":"2004","unstructured":"Butler AE, Jang J, Gurlo T et al (2004) Diabetes due to a progressive defect in beta cell mass in rats transgenic for human islet amyloid polypeptide (HIP rat): a new model for type 2 diabetes. Diabetes 53:1509\u20131516","journal-title":"Diabetes"},{"issue":"4","key":"201_CR18","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s00125-008-1255-x","volume":"52","author":"S Zraika","year":"2009","unstructured":"Zraika S, Hull RL, Udayasankar J et al (2009) Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis. Diabetologia 52(4):626\u2013635","journal-title":"Diabetologia"},{"issue":"4","key":"201_CR19","doi-asserted-by":"crossref","first-page":"906","DOI":"10.2337\/db08-1464","volume":"58","author":"AV Matveyenko","year":"2009","unstructured":"Matveyenko AV, Gurlo T, Daval M et al (2009) Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress. Diabetes 58(4):906\u2013916","journal-title":"Diabetes"},{"key":"201_CR20","first-page":"1333","volume":"38","author":"D Porte Jr","year":"1989","unstructured":"Porte D Jr, Kahn SE (1989) Hyperproinsulinemia and amyloid in NIDDM: clues to etiology of islet \u03b2-cell dysfunction? Diabetes 38:1333\u20131336","journal-title":"Diabetes"},{"key":"201_CR21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0168-8227(89)90008-9","volume":"7","author":"P Westermark","year":"1989","unstructured":"Westermark P, Engstrom U, Westermark GT et al (1989) Islet amyloid polypeptide (IAPP) and pro-IAPP immunoreactivity in human islets of Langerhans. Diabetes Res Clin Pract 7:219\u2013226","journal-title":"Diabetes Res Clin Pract"},{"key":"201_CR22","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s001250051138","volume":"42","author":"X Hou","year":"1999","unstructured":"Hou X, Ling Z, Quartier E et al (1999) Prolonged exposure of pancreatic beta cells to raised glucose concentrations results in increased cellular content of islet amyloid polypeptide precursors. Diabetologia 42:188\u2013194","journal-title":"Diabetologia"},{"issue":"8","key":"201_CR23","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.2337\/db05-1566","volume":"55","author":"L Marzban","year":"2006","unstructured":"Marzban L, Rhodes CJ, Steiner DF et al (2006) Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death. Diabetes 55(8):2192\u20132201","journal-title":"Diabetes"},{"issue":"3","key":"201_CR24","doi-asserted-by":"crossref","first-page":"534","DOI":"10.2337\/diabetes.50.3.534","volume":"50","author":"J Wang","year":"2001","unstructured":"Wang J, Xu J, Finnerty J et al (2001) The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site. Diabetes 50(3):534\u2013539","journal-title":"Diabetes"},{"key":"201_CR25","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0531-5565(03)00004-4","volume":"38","author":"L Marzban","year":"2003","unstructured":"Marzban L, Park K, Verchere CB (2003) Islet amyloid polypeptide and type 2 diabetes. Exp Gerontol 38:347\u2013351","journal-title":"Exp Gerontol"},{"key":"201_CR26","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S1074-5521(00)00034-X","volume":"7","author":"M Krampert","year":"2000","unstructured":"Krampert M, Bernhagen J, Schmucker J et al (2000) Amyloidogenicity of recombinant human proislet amyloid polypeptide (ProIAPP). Chem Biol 7:855\u2013871","journal-title":"Chem Biol"},{"key":"201_CR27","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00125-006-0206-7","volume":"49","author":"JF Paulsson","year":"2006","unstructured":"Paulsson JF, Andersson A, Westermark P et al (2006) Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets. Diabetologia 49:1237\u20131246","journal-title":"Diabetologia"},{"key":"201_CR28","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","volume":"15","author":"KG Alberti","year":"1998","unstructured":"Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. 1. Diagnosis and classification of diabetes mellitus, provisional report of a WHO consultation. Diabetes Med 15:539\u2013553","journal-title":"Diabetes Med"},{"key":"201_CR29","doi-asserted-by":"crossref","unstructured":"Jha S, Sellin D, Seidel R, et al (2009) Amyloidogenic propensities and conformational properties of ProIAPP and IAPP in the presence of lipid bilayer membranes. J Mol Biol 26; 389(5):907\u2013920","DOI":"10.1016\/j.jmb.2009.04.077"},{"key":"201_CR30","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1210\/jc.2004-0405","volume":"89","author":"RL Hull","year":"2004","unstructured":"Hull RL, Westermark GT, Westermark P et al (2004) Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes. J Clin Endocrinol Metab 89:3629\u20133643","journal-title":"J Clin Endocrinol Metab"},{"key":"201_CR31","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1172\/JCI117748","volume":"95","author":"C Alarcon","year":"1995","unstructured":"Alarcon C, Leahy JL, Schuppin GT et al (1995) Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulindependent diabetes mellitus. J Clin Invest 95:1032\u20131039","journal-title":"J Clin Invest"},{"key":"201_CR32","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2337\/diabetes.48.3.491","volume":"48","author":"J Janson","year":"1999","unstructured":"Janson J, Ashley RH, Harrison D et al (1999) The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediatesized toxic amyloid particles. Diabetes 48:491\u2013498","journal-title":"Diabetes"},{"key":"201_CR33","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.2337\/diabetes.52.9.2304","volume":"52","author":"AE Butler","year":"2003","unstructured":"Butler AE, Janson J, Soeller WC et al (2003) Increased \u03b2-cell apoptosis prevents adaptive increase in \u03b2-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes 52:2304\u20132314","journal-title":"Diabetes"},{"key":"201_CR34","doi-asserted-by":"crossref","first-page":"17294","DOI":"10.1074\/jbc.M500997200","volume":"280","author":"A Demuro","year":"2005","unstructured":"Demuro A, Mina E, Kayed R et al (2005) Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J Biol Chem 280:17294\u201317300","journal-title":"J Biol Chem"},{"key":"201_CR35","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.pathol.1.110304.100113","volume":"1","author":"DM Skovronsky","year":"2006","unstructured":"Skovronsky DM, Lee VM-Y, Trojanowski JQ (2006) Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications. Annu Rev Pathol Mech Dis 1:151\u2013170","journal-title":"Annu Rev Pathol Mech Dis"},{"issue":"7","key":"201_CR36","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.2337\/diabetes.54.7.2117","volume":"54","author":"JF Paulsson","year":"2005","unstructured":"Paulsson JF, Westermark GT (2005) Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation. Diabetes 54(7):2117\u20132125","journal-title":"Diabetes"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-010-0201-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00592-010-0201-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-010-0201-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T23:45:19Z","timestamp":1559087119000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00592-010-0201-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,28]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["201"],"URL":"https:\/\/doi.org\/10.1007\/s00592-010-0201-9","relation":{},"ISSN":["0940-5429","1432-5233"],"issn-type":[{"value":"0940-5429","type":"print"},{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,28]]}}}