{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:04:15Z","timestamp":1790643855868,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T00:00:00Z","timestamp":1316649600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1007\/s00592-011-0329-2","type":"journal-article","created":{"date-parts":[[2011,9,21]],"date-time":"2011-09-21T18:06:57Z","timestamp":1316628417000},"page":"537-543","source":"Crossref","is-referenced-by-count":55,"title":["Salsalate improves glycemic control in patients with newly diagnosed type 2 diabetes"],"prefix":"10.1007","volume":"50","author":[{"given":"Elham","family":"Faghihimani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Aminorroaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Rezvanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyman","family":"Adibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faramarz","family":"Ismail-Beigi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Amini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,9,22]]},"reference":[{"key":"329_CR1","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2337\/diacare.21.9.1414","volume":"21","author":"H King","year":"1998","unstructured":"King H, Aubert RE, Herman WH (1998) Global burden of diabetes, 1995\u20132025: prevalence, numerical estimates, and projections. Diabetes 21:1414\u20131431","journal-title":"Diabetes"},{"key":"329_CR2","doi-asserted-by":"crossref","unstructured":"zachary t. bloomgarden (2003) Inflammation and insulin resistance. Diabetes Care 26(6):1922\u20131926","DOI":"10.2337\/diacare.26.6.1922"},{"key":"329_CR3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1089\/dia.2006.8.7","volume":"8","author":"BB Duncan","year":"2006","unstructured":"Duncan BB, Schmidt MI (2006) The epidemiology of low-grade chronic systemic inflammation and type 2 diabetes. Diabetes Technol Ther 8:7\u201317","journal-title":"Diabetes Technol Ther"},{"key":"329_CR4","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1161\/01.CIR.0000015507.29953.38","volume":"105","author":"AP Burke","year":"2002","unstructured":"Burke AP, Tracy RP, Kolodgie F, Malcom GT, Zieske A, Kutys R, Pestaner J, Smialek J, Virmani R (2002) Elevated C-reactive protein values and atherosclerosis in sudden coronary death: association with different pathologies. Circulation 105:2019\u20132023","journal-title":"Circulation"},{"key":"329_CR5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/archinte.163.1.93","volume":"163","author":"B Thorand","year":"2003","unstructured":"Thorand B, Lowel H, Schneider A, Kolb H, Meisinger C, Frohlich M, Koenig W (2003) C-reactive protein as a predictor for incident diabetes mellitus among middle aged men: results from the MONICA Ausburg cohort study. Arch Intern Med 163:93\u201399","journal-title":"Arch Intern Med"},{"key":"329_CR6","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.2337\/diacare.25.11.2016","volume":"25","author":"TS Han","year":"2002","unstructured":"Han TS, Sattar N, Williams K, Gonzalez-Villalpando C, Lean ME, Haffner SM (2002) Prospective study of C-reactive protein in relation to the development of diabetes and metabolic syndrome in the Mexico City Diabetes Study. Diabetes Care 25:2016\u20132021","journal-title":"Diabetes Care"},{"key":"329_CR7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1161\/01.CIR.102.1.42","volume":"102","author":"A Festa","year":"2002","unstructured":"Festa A, D\u2019Agostino R Jr, Howard G, Mykkanen L, Tracy RP, Haffner SM (2002) Chronic subclinical inflammation as part of the insulin resistance syndrome: the insulin resistance atherosclerosis study (IRAS). Circulation 102:42\u201347","journal-title":"Circulation"},{"key":"329_CR8","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1210\/jc.2003-030508","volume":"88","author":"M Romano","year":"2003","unstructured":"Romano M, Guagnano MT, Pacini G, Vigneri S, Falco A, Marinopiccoli M, Manigrasso MR, Basili S, Davi G (2003) Association of inflammation markers with impaired insulin sensitivity and coagulative activation in obese healthy women. J Clin Endocrinol Metab 88:5321\u20135326","journal-title":"J Clin Endocrinol Metab"},{"key":"329_CR9","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.2337\/diabetes.52.7.1799","volume":"52","author":"BB Duncan","year":"2003","unstructured":"Duncan BB et al (2003) Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes 52:1799\u20131805","journal-title":"Diabetes"},{"key":"329_CR10","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1007\/s00125-005-1764-9","volume":"48","author":"H Kolb","year":"2005","unstructured":"Kolb H, Mandrup-Poulsen T (2005) An immune origin of type 2 diabetes? Diabetologia 48:1038\u20131050","journal-title":"Diabetologia"},{"key":"329_CR11","doi-asserted-by":"crossref","unstructured":"Shoelson SE, Lee J, Yuan M (2003) Inflammation and the IKK\u03b2\/I\u03baB\/NF-\u03baB axis in obesity and diet-induced insulin resistance. Int J Obes Relat Metab Disord 27(Suppl. 3):S49\u2013S52","DOI":"10.1038\/sj.ijo.0802501"},{"key":"329_CR12","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1172\/JCI29069","volume":"116","author":"SE Shoelson","year":"2006","unstructured":"Shoelson SE, Lee J, Goldfine AB (2006) Inflammation and insulin resistance. J Clin Invest 116:1793\u20131801","journal-title":"J Clin Invest"},{"key":"329_CR13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nm1166","volume":"11","author":"D Cai","year":"2005","unstructured":"Cai D et al (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK\u03b2 and NF-\u03baB. Nat Med 11:183\u2013190","journal-title":"Nat Med"},{"issue":"3\u20134","key":"329_CR14","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2119\/2007-00119.Tilg","volume":"14","author":"H Tilg","year":"2008","unstructured":"Tilg H, Moschen AR (2008) Inflammatory mechanisms in the regulation of insulin resistance. Mol Med 14(3\u20134):222\u2013231","journal-title":"Mol Med"},{"key":"329_CR15","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1345\/aph.1M483","volume":"44","author":"MM Rumore","year":"2010","unstructured":"Rumore MM, Kim KS (2010) Potential role of salicylates in type 2 diabetes. Ann Pharmacol 44:1207\u20131221","journal-title":"Ann Pharmacol"},{"key":"329_CR16","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00125-008-1239-x","volume":"52","author":"J Koska","year":"2009","unstructured":"Koska J, Ortega E, Bunt JC, Gasser A, Impson J, Hanson RL, Forbes J, de Courten B, Krakoff J (2009) The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomized double-blind placebo-controlled study. Diabetologia 52:385\u2013393","journal-title":"Diabetologia"},{"key":"329_CR17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2337\/dc07-1338","volume":"31","author":"A Fleischman","year":"2008","unstructured":"Fleischman A, Shoelson SE, Bernier R, Goldfine AB (2008) Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care 31:289\u2013294","journal-title":"Diabetes Care"},{"key":"329_CR18","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1126\/science.1061620","volume":"293","author":"M Yuan","year":"2001","unstructured":"Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE (2001) Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IkkB. Science 293:1673\u20131677","journal-title":"Science"},{"key":"329_CR19","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1172\/JCI0214955","volume":"109","author":"RS Hundal","year":"2002","unstructured":"Hundal RS, Petersen KF, Mayerson AB, Randhawa PS, Inzucchi S, Shoelson SE, Shulman GI (2002) Mechanism by which highdose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest 109:1321\u20131326","journal-title":"J Clin Invest"},{"key":"329_CR20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/23948","volume":"396","author":"MJ Yin","year":"1998","unstructured":"Yin MJ, Yamamoto Y, Gaynor RB (1998) The anti-inflammatory agents aspirin and salicylate inhibit the activity of I\u03baB kinase-\u03b2. Nature 396:77\u201380","journal-title":"Nature"},{"key":"329_CR21","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.4049\/jimmunol.163.10.5608","volume":"163","author":"MA Stevenson","year":"1999","unstructured":"Stevenson MA, Zhao MJ, Asea A, Coleman CN, Calderwood SK (1999) Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- and NF-kappa B-responsive genes. J Immunol 163:5608\u20135616","journal-title":"J Immunol"},{"key":"329_CR22","doi-asserted-by":"crossref","unstructured":"Anonymous (2010) Diagnosis and classification of diabetes mellitus. Diabetes Care 33:S62, 8 pp","DOI":"10.2337\/dc10-S062"},{"key":"329_CR23","doi-asserted-by":"crossref","first-page":"346","DOI":"10.7326\/0003-4819-152-6-201003160-00004","volume":"152","author":"AB Goldfine","year":"2010","unstructured":"Goldfine AB, Fonseca V, Jablonski KA, Pyle L, Staten MA, Shoelson SE, for the TINSAL-T2D (Targeting Inflammation Using Salsalate in Type 2 Diabetes) Study Team (2010) The effects of Salsalate on glycemic control in patients with type 2 diabetes: a randomized trial. Ann Intern Med 152:346\u2013357","journal-title":"Ann Intern Med"},{"key":"329_CR24","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2337\/diabetes.51.4.1131","volume":"51","author":"A Festa","year":"2002","unstructured":"Festa A, D\u2019Agostino R Jr, Tracy RP, Haffner SM (2002) Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes 51:1131\u20131137","journal-title":"Diabetes"},{"key":"329_CR25","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.271.5249.665","volume":"271","author":"GS Hostamisligil","year":"1996","unstructured":"Hostamisligil GS et al (1996) IRS-1 mediated inhibition of insulin receptor tyrosine kinase activity in TNF-\u03b1- and obesity-induced insulin resistance. Science 271:665\u2013668","journal-title":"Science"},{"key":"329_CR26","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2337\/diabetes.51.2.455","volume":"51","author":"B Vozarova","year":"2002","unstructured":"Vozarova B et al (2002) High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. Diabetes 51:455\u2013461","journal-title":"Diabetes"},{"key":"329_CR27","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","volume":"112","author":"Xu Haiyan","year":"2003","unstructured":"Haiyan Xu, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Hong Chen J (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Clin Invest 112:1821\u20131830","journal-title":"Clin Invest"},{"key":"329_CR28","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1210\/jc.2007-1212","volume":"93","author":"J-M Fernandez-Real","year":"2008","unstructured":"Fernandez-Real J-M, Lopez-Berejo A et al (2008) Salicylates increase insulin secretion in healthy obese subjects. J Clin Endocrinol Met 93:2523\u20132530","journal-title":"J Clin Endocrinol Met"},{"key":"329_CR29","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/BF00291974","volume":"28","author":"PR Bratusch-Marrain","year":"1985","unstructured":"Bratusch-Marrain PR, Vierhapper H, Komjati M, Waldh\u00e4usl WK (1985) Acetyl-salicylic acid impairs insulin-mediated glucose utilization and reduces insulin clearance in healthy and non-insulin-dependent diabetic man. Diabetologia 28:671\u2013676","journal-title":"Diabetologia"},{"key":"329_CR30","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2337\/diacare.27.6.1487","volume":"27","author":"TA Wallace","year":"2004","unstructured":"Wallace TA, Levy JC, Mathews DR (2004) Use and abuse of HOMA modeling. Diabetes Care 27:1487\u20131495","journal-title":"Diabetes Care"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-011-0329-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00592-011-0329-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-011-0329-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T20:58:49Z","timestamp":1686344329000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00592-011-0329-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,22]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["329"],"URL":"https:\/\/doi.org\/10.1007\/s00592-011-0329-2","relation":{},"ISSN":["0940-5429","1432-5233"],"issn-type":[{"value":"0940-5429","type":"print"},{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,22]]}}}