{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T05:52:03Z","timestamp":1768715523962,"version":"3.49.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,3,3]],"date-time":"2012-03-03T00:00:00Z","timestamp":1330732800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s00592-012-0383-4","type":"journal-article","created":{"date-parts":[[2012,3,3]],"date-time":"2012-03-03T22:29:47Z","timestamp":1330813787000},"page":"451-457","source":"Crossref","is-referenced-by-count":20,"title":["Polycystic ovary syndrome is not associated with genetic variants that mark risk of type 2 diabetes"],"prefix":"10.1007","volume":"50","author":[{"given":"R.","family":"Saxena","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. K.","family":"Welt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,3,3]]},"reference":[{"key":"383_CR1","doi-asserted-by":"crossref","unstructured":"The Rotterdam ESHRE\/ASRM-sponsored PCOS consensus workshop group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19:41\u201347","DOI":"10.1093\/humrep\/deh098"},{"key":"383_CR2","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2337\/diabetes.38.9.1165","volume":"38","author":"A Dunaif","year":"1989","unstructured":"Dunaif A, Segal KR, Futterweit W, Dobrjansky A (1989) Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 38:1165\u20131174","journal-title":"Diabetes"},{"key":"383_CR3","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1210\/jcem-57-2-356","volume":"57","author":"RJ Chang","year":"1983","unstructured":"Chang RJ, Nakamura RM, Judd HL, Kaplan SA (1983) Insulin resistance in nonobese patients with polycystic ovarian disease. J Clin Endocrinol Metab 57:356\u2013359","journal-title":"J Clin Endocrinol Metab"},{"key":"383_CR4","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1172\/JCI118064","volume":"96","author":"DA Ehrmann","year":"1995","unstructured":"Ehrmann DA, Sturis J, Byrne MM, Karrison T, Rosenfield RL, Polonsky KS (1995) Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus. J Clin Invest 96:520\u2013527","journal-title":"J Clin Invest"},{"key":"383_CR5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2337\/diacare.22.1.141","volume":"22","author":"DA Ehrmann","year":"1999","unstructured":"Ehrmann DA, Barnes RB, Rosenfield RL, Cavaghan MK, Imperial J (1999) Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care 22:141\u2013146","journal-title":"Diabetes Care"},{"key":"383_CR6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1210\/jc.84.1.165","volume":"84","author":"RS Legro","year":"1999","unstructured":"Legro RS, Kunselman AR, Dodson WC, Dunaif A (1999) Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 84:165\u2013169","journal-title":"J Clin Endocrinol Metab"},{"key":"383_CR7","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1210\/jc.2006-1191","volume":"91","author":"CK Welt","year":"2006","unstructured":"Welt CK, Arason G, Gudmundsson JA et al (2006) Defining constant versus variable phenotypic features of women with polycystic ovary syndrome using different ethnic groups and populations. J Clin Endocrinol Metab 91:4361\u20134368","journal-title":"J Clin Endocrinol Metab"},{"key":"383_CR8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1046\/j.1365-2265.2000.00884.x","volume":"52","author":"JJ Conn","year":"2000","unstructured":"Conn JJ, Jacobs HS, Conway GS (2000) The prevalence of polycystic ovaries in women with type 2 diabetes mellitus. Clin Endocrinol (Oxf) 52:81\u201386","journal-title":"Clin Endocrinol (Oxf)"},{"key":"383_CR9","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1210\/jc.2004-0229","volume":"90","author":"DA Ehrmann","year":"2005","unstructured":"Ehrmann DA, Kasza K, Azziz R, Legro RS, Ghazzi MN (2005) Effects of race and family history of type 2 diabetes on metabolic status of women with polycystic ovary syndrome. J Clin Endocrinol Metab 90:66\u201371","journal-title":"J Clin Endocrinol Metab"},{"key":"383_CR10","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.1142364","volume":"316","author":"E Zeggini","year":"2007","unstructured":"Zeggini E, Weedon MN, Lindgren CM et al (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336\u20131341","journal-title":"Science"},{"key":"383_CR11","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/ng.120","volume":"40","author":"E Zeggini","year":"2008","unstructured":"Zeggini E, Scott LJ, Saxena R et al (2008) Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40:638\u2013645","journal-title":"Nat Genet"},{"key":"383_CR12","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1126\/science.1142358","volume":"316","author":"R Saxena","year":"2007","unstructured":"Saxena R, Voight BF, Lyssenko V et al (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331\u20131336","journal-title":"Science"},{"key":"383_CR13","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1126\/science.1142382","volume":"316","author":"LJ Scott","year":"2007","unstructured":"Scott LJ, Mohlke KL, Bonnycastle LL et al (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341\u20131345","journal-title":"Science"},{"key":"383_CR14","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.2337\/db07-1336","volume":"57","author":"JB McAteer","year":"2008","unstructured":"McAteer JB, Prudente S, Bacci S et al (2008) The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects. Diabetes 57:1125\u20131130","journal-title":"Diabetes"},{"key":"383_CR15","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/ng.609","volume":"42","author":"BF Voight","year":"2010","unstructured":"Voight BF, Scott LJ, Steinthorsdottir V et al (2010) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 42:579\u2013589","journal-title":"Nat Genet"},{"key":"383_CR16","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/ng.443","volume":"41","author":"J Rung","year":"2009","unstructured":"Rung J, Cauchi S, Albrechtsen A et al (2009) Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet 41:1110\u20131115","journal-title":"Nat Genet"},{"key":"383_CR17","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ng1732","volume":"38","author":"SF Grant","year":"2006","unstructured":"Grant SF, Thorleifsson G, Reynisdottir I et al (2006) Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320\u2013323","journal-title":"Nat Genet"},{"key":"383_CR18","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/ng2067","volume":"39","author":"MS Sandhu","year":"2007","unstructured":"Sandhu MS, Weedon MN, Fawcett KA et al (2007) Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet 39:951\u2013953","journal-title":"Nat Genet"},{"key":"383_CR19","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1016\/j.fertnstert.2011.02.050","volume":"95","author":"KG Ewens","year":"2011","unstructured":"Ewens KG, Jones MR, Ankener W et al (2011) Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome. Fertil Steril 95:2538\u20132541","journal-title":"Fertil Steril"},{"key":"383_CR20","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1007\/s00125-007-0804-z","volume":"50","author":"TM Barber","year":"2007","unstructured":"Barber TM, Bennett AJ, Groves CJ et al (2007) Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS. Diabetologia 50:2318\u20132322","journal-title":"Diabetologia"},{"key":"383_CR21","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/sj.ejhg.5201802","volume":"15","author":"TM Barber","year":"2007","unstructured":"Barber TM, Bennett AJ, Gloyn AL et al (2007) Relationship between E23K (an established type II diabetes-susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels. Eur J Hum Genet 15:679\u2013684","journal-title":"Eur J Hum Genet"},{"key":"383_CR22","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00125-008-1028-6","volume":"51","author":"TM Barber","year":"2008","unstructured":"Barber TM, Bennett AJ, Groves CJ et al (2008) Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome. Diabetologia 51:1153\u20131158","journal-title":"Diabetologia"},{"key":"383_CR23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/molehr\/gaq087","volume":"17","author":"C Li","year":"2011","unstructured":"Li C, Shi Y, You L, Wang L, Chen ZJ (2011) Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chinese women with polycystic ovary syndrome. Mol Hum Reprod 17:193\u2013198","journal-title":"Mol Hum Reprod"},{"issue":"2486","key":"383_CR24","first-page":"2489","volume":"94","author":"L Wang","year":"2010","unstructured":"Wang L, Wang Y, Zhang X et al (2010) Common genetic variation in MTNR1B is associated with serum testosterone, glucose tolerance, and insulin secretion in polycystic ovary syndrome patients. Fertil Steril 94(2486):2489","journal-title":"Fertil Steril"},{"key":"383_CR25","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2010) Diagnosis and classification of diabetes mellitus. Diabetes Care 33(Suppl 1):S62\u2013S69","DOI":"10.2337\/dc10-S062"},{"key":"383_CR26","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1210\/jc.2008-1664","volume":"94","author":"A Biyasheva","year":"2009","unstructured":"Biyasheva A, Legro RS, Dunaif A, Urbanek M (2009) Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2. J Clin Endocrinol Metab 94:2617\u20132625","journal-title":"J Clin Endocrinol Metab"},{"key":"383_CR27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ng.732","volume":"43","author":"ZJ Chen","year":"2011","unstructured":"Chen ZJ, Zhao H, He L et al (2011) Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet 43:55\u201359","journal-title":"Nat Genet"},{"key":"383_CR28","doi-asserted-by":"crossref","first-page":"e236","DOI":"10.1371\/journal.pgen.0030236","volume":"4","author":"AL Price","year":"2008","unstructured":"Price AL, Butler J, Patterson N et al (2008) Discerning the ancestry of European Americans in genetic association studies. PLoS Genet 4:e236","journal-title":"PLoS Genet"},{"key":"383_CR29","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1086\/518313","volume":"80","author":"AL Price","year":"2007","unstructured":"Price AL, Patterson N, Yu F et al (2007) A genomewide admixture map for Latino populations. Am J Hum Genet 80:1024\u20131036","journal-title":"Am J Hum Genet"},{"key":"383_CR30","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1086\/420856","volume":"74","author":"MW Smith","year":"2004","unstructured":"Smith MW, Patterson N, Lautenberger JA et al (2004) A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet 74:1001\u20131013","journal-title":"Am J Hum Genet"},{"key":"383_CR31","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K et al (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559\u2013575","journal-title":"Am J Hum Genet"},{"key":"383_CR32","doi-asserted-by":"crossref","first-page":"541","DOI":"10.7326\/0003-4819-150-8-200904210-00008","volume":"150","author":"MC Cornelis","year":"2009","unstructured":"Cornelis MC, Qi L, Zhang C et al (2009) Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry. Ann Intern Med 150:541\u2013550","journal-title":"Ann Intern Med"},{"key":"383_CR33","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1080\/09513590802196379","volume":"24","author":"P Christopoulos","year":"2008","unstructured":"Christopoulos P, Mastorakos G, Gazouli M et al (2008) Genetic variants in TCF7L2 and KCNJ11 genes in a Greek population with polycystic ovary syndrome. Gynecol Endocrinol 24:486\u2013490","journal-title":"Gynecol Endocrinol"},{"key":"383_CR34","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1210\/jc.2004-0643","volume":"89","author":"GA Maciel","year":"2004","unstructured":"Maciel GA, Baracat EC, Benda JA et al (2004) Stockpiling of transitional and classic primary follicles in ovaries of women with polycystic ovary syndrome. J Clin Endocrinol Metab 89:5321\u20135327","journal-title":"J Clin Endocrinol Metab"},{"key":"383_CR35","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0140-6736(03)14410-8","volume":"362","author":"LJ Webber","year":"2003","unstructured":"Webber LJ, Stubbs S, Stark J et al (2003) Formation and early development of follicles in the polycystic ovary. Lancet 362:1017\u20131021","journal-title":"Lancet"},{"key":"383_CR36","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.2337\/db09-0143","volume":"58","author":"KS Hamming","year":"2009","unstructured":"Hamming KS, Soliman D, Matemisz LC et al (2009) Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel. Diabetes 58:2419\u20132424","journal-title":"Diabetes"},{"key":"383_CR37","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0014-5793(96)01438-X","volume":"401","author":"C Karschin","year":"1997","unstructured":"Karschin C, Ecke C, Ashcroft FM, Karschin A (1997) Overlapping distribution of K(ATP) channel-forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain. FEBS Lett 401:59\u201364","journal-title":"FEBS Lett"},{"key":"383_CR38","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/77660","volume":"3","author":"D Spanswick","year":"2000","unstructured":"Spanswick D, Smith MA, Mirshamsi S, Routh VH, Ashford ML (2000) Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci 3:757\u2013758","journal-title":"Nat Neurosci"},{"key":"383_CR39","doi-asserted-by":"crossref","first-page":"831","DOI":"10.2337\/diabetes.50.4.831","volume":"50","author":"BV Costanzo","year":"2001","unstructured":"Costanzo BV, Trischitta V, Di PR et al (2001) The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121). Diabetes 50:831\u2013836","journal-title":"Diabetes"},{"key":"383_CR40","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/oby.2003.86","volume":"11","author":"JL Gonzalez-Sanchez","year":"2003","unstructured":"Gonzalez-Sanchez JL, Martinez-Larrad MT, Fernandez-Perez C, Kubaszek A, Laakso M, Serrano-Rios M (2003) K121Q PC-1 gene polymorphism is not associated with insulin resistance in a Spanish population. Obes Res 11:603\u2013605","journal-title":"Obes Res"},{"key":"383_CR41","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00592-011-0281-1","volume":"48","author":"X Shi","year":"2011","unstructured":"Shi X, Wang L, Jin F et al (2011) The ENPP1 K121Q polymorphism is not associated with type 2 diabetes in northern Chinese. Acta Diabetol 48:303\u2013310","journal-title":"Acta Diabetol"},{"key":"383_CR42","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.fertnstert.2004.03.031","volume":"82","author":"S Heinonen","year":"2004","unstructured":"Heinonen S, Korhonen S, Helisalmi S, Koivunen R, Tapanainen JS, Laakso M (2004) The 121Q allele of the plasma cell membrane glycoprotein 1 gene predisposes to polycystic ovary syndrome. Fertil Steril 82:743\u2013745","journal-title":"Fertil Steril"},{"key":"383_CR43","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/2441","volume":"20","author":"H Inoue","year":"1998","unstructured":"Inoue H, Tanizawa Y, Wasson J et al (1998) A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat Genet 20:143\u2013148","journal-title":"Nat Genet"},{"issue":"6","key":"383_CR44","doi-asserted-by":"crossref","first-page":"e16390","DOI":"10.1371\/journal.pone.0016390","volume":"20","author":"KG Ewens","year":"2011","unstructured":"Ewens KG, Jones MR, Ankener W et al (2011) FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome. PLoS ONE 20(6):e16390","journal-title":"PLoS ONE"},{"key":"383_CR45","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.metabol.2009.08.023","volume":"59","author":"E Wehr","year":"2010","unstructured":"Wehr E, Schweighofer N, Moller R, Giuliani A, Pieber TR, Obermayer-Pietsch B (2010) Association of FTO gene with hyperandrogenemia and metabolic parameters in women with polycystic ovary syndrome. Metabolism 59:575\u2013580","journal-title":"Metabolism"},{"key":"383_CR46","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.2337\/db07-1466","volume":"57","author":"RM Freathy","year":"2008","unstructured":"Freathy RM, Timpson NJ, Lawlor DA et al (2008) Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes 57:1419\u20131426","journal-title":"Diabetes"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-012-0383-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00592-012-0383-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-012-0383-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T20:37:37Z","timestamp":1561408657000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00592-012-0383-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,3]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["383"],"URL":"https:\/\/doi.org\/10.1007\/s00592-012-0383-4","relation":{},"ISSN":["0940-5429","1432-5233"],"issn-type":[{"value":"0940-5429","type":"print"},{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,3]]}}}