{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:22:29Z","timestamp":1791249749896,"version":"4.1.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,3,16]],"date-time":"2014-03-16T00:00:00Z","timestamp":1394928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1007\/s00592-014-0570-6","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T04:13:40Z","timestamp":1395116020000},"page":"731-738","source":"Crossref","is-referenced-by-count":32,"title":["The degree of fetal metformin exposure does not influence fetal outcome in gestational diabetes mellitus"],"prefix":"10.1007","volume":"51","author":[{"given":"Kristiina","family":"Tertti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Laine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Ekblad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valtteri","family":"Rinne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapani","family":"R\u00f6nnemaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,16]]},"reference":[{"key":"570_CR1","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1056\/NEJMoa0707193","volume":"358","author":"JA Rowan","year":"2008","unstructured":"Rowan JA, Hague WM, Gao W, Battin MR, Moore MP, MiG Trial Investigators (2008) Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med 358:2003\u20132015","journal-title":"N Engl J Med"},{"key":"570_CR2","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/j.1471-0528.2010.02763.x","volume":"118","author":"H Ij\u00e4s","year":"2011","unstructured":"Ij\u00e4s H, V\u00e4\u00e4r\u00e4sm\u00e4ki M, Morin-Papunen L, Keravuo R, Ebeling T, Saarela T et al (2011) Metformin should be considered in the treatment of gestational diabetes: a prospective randomized study. BJOG 118:880\u2013885","journal-title":"BJOG"},{"key":"570_CR3","first-page":"1011","volume":"52","author":"LE Moore","year":"2007","unstructured":"Moore LE, Briery CM, Clokey D, Martin RW, Williford NJ, Bofill JA et al (2007) Metformin and insulin in the management of gestational diabetes mellitus: preliminary results of a comparison. J Reprod Med 52:1011\u20131015","journal-title":"J Reprod Med"},{"key":"570_CR4","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/dom.12017","volume":"15","author":"K Tertti","year":"2013","unstructured":"Tertti K, Ekblad U, Koskinen P, Vahlberg T, R\u00f6nnemaa T (2013) Metformin versus insulin in gestational diabetes. A randomized study characterizing metformin patients needing additional insulin. Diabetes Obes Metab 15:246\u2013251","journal-title":"Diabetes Obes Metab"},{"key":"570_CR5","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.diabres.2012.09.031","volume":"98","author":"S Niromanesh","year":"2012","unstructured":"Niromanesh S, Alavi A, Sharbaf F, Amjadi N, Moosavi S, Akbari S (2012) Metformin compared with insulin in the management of gestational diabetes mellitus: a randomized clinical trial. Diabetes Res Clin Pract 98:422\u2013429","journal-title":"Diabetes Res Clin Pract"},{"key":"570_CR6","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1600-0412.2012.01385.x","volume":"91","author":"G Ghazeeri","year":"2012","unstructured":"Ghazeeri G, Nassar A, Younes Z, Awwad J (2012) Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview. Acta Obstet Gynecol Scand 91:658\u2013678","journal-title":"Acta Obstet Gynecol Scand"},{"key":"570_CR7","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.ajog.2006.05.047","volume":"195","author":"TN Nanovskaya","year":"2006","unstructured":"Nanovskaya TN, Nekhayeva IA, Patrikeeva SL, Hankins GD, Ahmed MS (2006) Transfer of metformin across the dually perfused human placental lobule. Am J Obstet Gynecol 195:1081\u20131085","journal-title":"Am J Obstet Gynecol"},{"key":"570_CR8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejogrb.2007.01.013","volume":"136","author":"M Kovo","year":"2008","unstructured":"Kovo M, Haroutiunian S, Feldman N, Hoffman A, Glezerman M (2008) Determination of metformin transfer across the human placenta using a dually perfused ex vivo placental cotyledon model. Eur J Obst Gyn Reprod Biol 136:29\u201333","journal-title":"Eur J Obst Gyn Repr Biol"},{"key":"570_CR9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejps.2009.10.014","volume":"39","author":"K Tertti","year":"2010","unstructured":"Tertti K, Ekblad U, Heikkinen T, Rahi M, R\u00f6nnemaa T, Laine K (2010) The role of organic cation transporters (OCTs) in the transfer of metformin in the dually perfused human placenta. Eur J Pharm Sci 39:76\u201381","journal-title":"Eur J Pharm Sci"},{"key":"570_CR10","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1136\/bmj.327.7420.880","volume":"327","author":"WM Hague","year":"2003","unstructured":"Hague WM, Davoren PM, McIntyre HD, Norris R, Xiaonian X, Charles B (2003) Metformin crosses the placenta: a modulator of fetal insulin resistance? BMJ 327:880\u2013881","journal-title":"BMJ"},{"key":"570_CR11","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.fertnstert.2004.11.051","volume":"83","author":"E Vanky","year":"2005","unstructured":"Vanky E, Zahlsen K, Spigset O, Carlsen SM (2005) Placental passage of metformin in women with polycystic ovary syndrome. Fertil Steril 83:1575\u20131578","journal-title":"Fertil Steril"},{"key":"570_CR12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/01.ftd.0000184161.52573.0e","volume":"28","author":"B Charles","year":"2006","unstructured":"Charles B, Norris R, Xiao S, Hague W (2006) Population pharmacokinetics of metformin in late pregnancy. Ther Drug Monit 28:67\u201372","journal-title":"Ther Drug Monit"},{"key":"570_CR13","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1124\/dmd.109.031245","volume":"38","author":"S Eyal","year":"2010","unstructured":"Eyal S, Easterling T, Carr D, Umans J, Miodovnik M, Hankins G et al (2010) Pharmacokinetics of metformin during pregnancy. Drug Metab Dispos 38:833\u2013840","journal-title":"Drug Metab Dispos"},{"key":"570_CR14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","volume":"16","author":"D Cockroft","year":"1976","unstructured":"Cockroft D, Gault M (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16:31\u201341","journal-title":"Nephron"},{"key":"570_CR15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0009-8981(83)90078-5","volume":"127","author":"RN Johnson","year":"1983","unstructured":"Johnson RN, Metcalf PA, Baker JR (1983) Fructosamine: a new approach to the estimation serum glycosylprotein. An index of diabetic control. Clin Chim Acta 127:87\u201395","journal-title":"Clin Chim Acta"},{"key":"570_CR16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1046\/j.1463-1326.2003.00241.x","volume":"5","author":"JD Lalau","year":"2003","unstructured":"Lalau JD, Lacroix G (2003) Measurement of metformin concentration in erythrocytes: clinical implications. Diabetes Obes Metab 5:93\u201398","journal-title":"Diabetes Obes Metab"},{"key":"570_CR17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/10641950801986720","volume":"28","author":"S Ahmed","year":"2009","unstructured":"Ahmed S, Bentley-Lewis R, Hollenberg N, Graves S, Seely E (2009) A comparison of prediction equations for estimating glomerular filtration rate in pregnancy. Hypertens Pregnancy 28:243\u2013255","journal-title":"Hypertens Pregnancy"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-014-0570-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00592-014-0570-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-014-0570-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T14:00:35Z","timestamp":1559138435000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00592-014-0570-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,16]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["570"],"URL":"https:\/\/doi.org\/10.1007\/s00592-014-0570-6","relation":{},"ISSN":["0940-5429","1432-5233"],"issn-type":[{"value":"0940-5429","type":"print"},{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,16]]}}}