{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:33:15Z","timestamp":1761895995248},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T00:00:00Z","timestamp":1420588800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1007\/s00592-014-0695-7","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T01:09:12Z","timestamp":1420506552000},"page":"753-761","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of short-term manipulation of serum FFA concentrations on left ventricular energy metabolism and function in patients with heart failure: no association with circulating bio-markers of inflammation"],"prefix":"10.1007","volume":"52","author":[{"given":"A.","family":"Salerno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Fragasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Canu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lattuada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Manzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Del Maschio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Margonato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"De Cobelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Perseghin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,1,7]]},"reference":[{"key":"695_CR1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1152\/physrev.00015.2009","volume":"90","author":"GD Lopaschuk","year":"2010","unstructured":"Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC (2010) Myocardial fatty acid metabolism in health and disease. Physiol Rev 90:207\u2013258","journal-title":"Physiol Rev"},{"key":"695_CR2","doi-asserted-by":"crossref","first-page":"H3225","DOI":"10.1152\/ajpheart.01119.2007","volume":"293","author":"JS Ingwall","year":"2007","unstructured":"Ingwall JS (2007) On substrate selection for ATP synthesis in the failing human myocardium. Am J Physiol Heart Circ Physiol 293:H3225\u2013H3226","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"695_CR3","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1161\/01.CIR.0000012466.50373.E8","volume":"105","author":"H Taegtmeyer","year":"2002","unstructured":"Taegtmeyer H, McNulty P, Young ME (2002) Adaptation and maladaptation of the heart in diabetes: part I: general concepts. Circulation 105:1727\u20131733","journal-title":"Circulation"},{"key":"695_CR4","doi-asserted-by":"crossref","first-page":"H1345","DOI":"10.1152\/ajpheart.2000.278.4.H1345","volume":"278","author":"CEO Korvald","year":"2000","unstructured":"Korvald CEO, Myrmel T (2000) Myocardial substrate metabolism influences left ventricular energetics in vivo. Am J Physiol Heart Circ Physiol 278:H1345\u2013H1351","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"695_CR5","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1161\/CIRCULATIONAHA.105.551457","volume":"112","author":"L Lee","year":"2005","unstructured":"Lee L, Campbell R, Scheuermann-Freestone M, Taylor R, Gunaruwan P, Williams L, Ashrafian H, Horowitz J, Fraser AG, Clarke K, Frenneaux M (2005) Metabolic modulation with perhexiline in chronic heart failure. A randomized, controlled trial of short-term use of a novel treatment. Circulation 112:3280\u20133288","journal-title":"Circulation"},{"key":"695_CR6","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/01.RES.86.5.580","volume":"86","author":"PF Kantor","year":"2000","unstructured":"Kantor PF, Lucien A, Kozak R, Lopaschuk GD (2000) The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res 86:580\u2013588","journal-title":"Circ Res"},{"key":"695_CR7","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJMra063052","volume":"356","author":"S Neubauer","year":"2007","unstructured":"Neubauer S (2007) The failing heart. An engine out of fuel. N Engl J Med 356:1140\u20131151","journal-title":"N Engl J Med"},{"key":"695_CR8","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/eurheartj\/ehi816","volume":"27","author":"G Fragasso","year":"2006","unstructured":"Fragasso G, Perseghin G, De Cobelli F, Esposito A, Palloshi A, Lattuada G, Scifo P, Calori G, Del Maschio A, Margonato A (2006) Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine\/adenosine triphosphate ratio in patients with heart failure. Eur Heart J 27:942\u2013948","journal-title":"Eur Heart J"},{"key":"695_CR9","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1161\/CIRCULATIONAHA.106.645184","volume":"114","author":"H Tuunanen","year":"2006","unstructured":"Tuunanen H, Engblom E, Naum A, N\u00e5gren K, Hesse B, Airaksinen KEJ, Nuutila P, Iozzo P, Ukkonen H, Opie LH, Knuuti J (2006) Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure. Circulation 114:2130\u20132137","journal-title":"Circulation"},{"key":"695_CR10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ijcard.2009.08.023","volume":"147","author":"G Fragasso","year":"2011","unstructured":"Fragasso G, Montano C, Lattuada G, Salerno A, Palloshi A, Calori G, Luzi L, Perseghin G, Margonato A (2011) A high carbohydrate meal yields a lower ischemic threshold than a high fat meal in patients with stable coronary disease. Int J Cardiol 147:209\u2013213","journal-title":"Int J Cardiol"},{"key":"695_CR11","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0735-1097(01)01768-5","volume":"39","author":"G Fragasso","year":"2002","unstructured":"Fragasso G, Piatti PM, Monti L, Palloshi A, Lu C, Valsecchi G, Setola E, Calori G, Pozza G, Margonato A, Chierchia S (2002) Acute effects of heparin administration on the ischemic threshold of patients with coronary artery disease. Evaluation of the protective role of the metabolic modulator trimetazidine. J Am Coll Cardiol 39:413\u2013419","journal-title":"J Am Coll Cardiol"},{"key":"695_CR12","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.jacc.2005.05.075","volume":"46","author":"G Perseghin","year":"2005","unstructured":"Perseghin G, Fiorina P, De Cobelli F, Scifo P, Esposito A, Danna M, Canu T, Gremizzi C, Secchi A, Luzi L, Del Maschio A (2005) Cross-sectional assessment of the effect of kidney and kidney-pancreas transplantation on resting left ventricular energy metabolism in type 1 diabetic-uremic patients: a 31P-MRS study. J Am Coll Cardiol 46:1085\u20131092","journal-title":"J Am Coll Cardiol"},{"key":"695_CR13","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.jacc.2005.11.067","volume":"47","author":"F Cobelli De","year":"2006","unstructured":"De Cobelli F, Pieroni M, Esposito A, Belloni E, Chimenti C, Mellone R, Canu T, Perseghin G, Gaudio C, Maseri A, Frustaci A, Del Maschio A (2006) Delayed gadolinium-enhanced cardiac magnetic resonance in patients with chronic myocarditis presenting with heart failure or recurrent arrhythmias. J Am Coll Cardiol 47:1649\u20131654","journal-title":"J Am Coll Cardiol"},{"key":"695_CR14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/(SICI)1099-1492(199608)9:5<217::AID-NBM419>3.0.CO;2-G","volume":"9","author":"HJ Lamb","year":"1996","unstructured":"Lamb HJ, Doornbos J, den Hollander JA, Luyten PR, Beyerbacht HP, van der Wall EE, de Roos A (1996) Reproducibility of human cardiac 31P-NMR spectroscopy. NMR Biomed 9:217\u2013227","journal-title":"NMR Biomed"},{"key":"695_CR15","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1210\/jc.2007-0325","volume":"92","author":"G Perseghin","year":"2007","unstructured":"Perseghin G, Lattuada G, De Cobelli F, Esposito A, Belloni E, Canu T, Ragogna F, Scifo P, Del Maschio A, Luzi L (2007) Plasma retinol binding protein-4 (RBP-4), leptin and adiponectin concentrations are related to ectopic fat accumulation. J Clin Endocrinol Metab 92:4883\u20134888","journal-title":"J Clin Endocrinol Metab"},{"key":"695_CR16","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1093\/oxfordjournals.eurheartj.a060425","volume":"15","author":"JW Swan","year":"1994","unstructured":"Swan JW, Walton C, Godsland IF, Clark AL, Coats AJ, Oliver MF (1994) Insulin resistance in chronic heart failure. Eur Heart J 15:1528\u20131532","journal-title":"Eur Heart J"},{"key":"695_CR17","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.jacc.2009.07.024","volume":"54","author":"LH Opie","year":"2009","unstructured":"Opie LH, Knuuti J (2009) The adrenergic-fatty acid load in heart failure. J Am Coll Cardiol 54:1637\u20131646","journal-title":"J Am Coll Cardiol"},{"key":"695_CR18","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1172\/JCI118742","volume":"97","author":"M Roden","year":"1996","unstructured":"Roden M, Price TB, Perseghin G, Petersen KF, Cline GW, Shulman GI (1996) Mechanism of free fatty acid induced insulin resistance in humans. J Clin Invest 97:2859\u20132865","journal-title":"J Clin Invest"},{"key":"695_CR19","doi-asserted-by":"crossref","first-page":"810","DOI":"10.2337\/diabetes.50.4.810","volume":"50","author":"G Boden","year":"2001","unstructured":"Boden G, Chen X, Capulong E, Mozzoli M (2001) Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes. Diabetes 50:810\u2013816","journal-title":"Diabetes"},{"key":"695_CR20","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.2337\/db07-0768","volume":"56","author":"RW Meer van der","year":"2007","unstructured":"van der Meer RW, Hammer S, Smit JW, Fr\u00f6lich M, Bax JJ, Diamant M, Rijzewijk LJ, de Roos A, Romijn JA, Lamb HJ (2007) Short-term caloric restriction induces accumulation of myocardial triglycerides and decreases left ventricular diastolic function in healthy subjects. Diabetes 56:2849\u20132853","journal-title":"Diabetes"},{"key":"695_CR21","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1210\/jc.2007-2015","volume":"93","author":"S Hammer","year":"2008","unstructured":"Hammer S, van der Meer RW, Lamb HJ, Schar M, de Roos A, Smit JWA, Romijn JA (2008) Progressive caloric restriction induces dose-dependent changes in myocardial triglyceride content and diastolic function in healthy men. J Clin Endocrinol Metab 93:497\u2013503","journal-title":"J Clin Endocrinol Metab"},{"key":"695_CR22","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.2337\/dc06-2429","volume":"30","author":"G Perseghin","year":"2007","unstructured":"Perseghin G, Ntali G, De Cobelli F, Lattuada G, Esposito A, Costantino F, Ragogna F, Canu T, Belloni E, Scifo P, Del Maschio A, Luzi L (2007) Abnormal left ventricular energy metabolism in obese men with preserved systolic and diastolic functions is associated with insulin resistance. Diabetes Care 30:1520\u20131527","journal-title":"Diabetes Care"},{"key":"695_CR23","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1161\/CIRCULATIONAHA.111.069518","volume":"125","author":"OJ Rider","year":"2012","unstructured":"Rider OJ, Francis JM, Ali MK, Holloway C, Pegg T, Robson MD, Tyler D, Byrne J, Clarke K, Neubauer S (2012) Effects of catecholamine stress on diastolic function and myocardial energetics in obesity. Circulation 125:1511\u20131519","journal-title":"Circulation"},{"key":"695_CR24","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1161\/01.CIR.0000127959.28627.F8","volume":"109","author":"LR Peterson","year":"2004","unstructured":"Peterson LR, Herrero P, Schechtman KB, Racette SB, Waggoner AD, Kisrieva-Ware Z, Dence C, Klein S, Marsala J, Meyer T, Gropler RJ (2004) Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women. Circulation 109:2191\u20132196","journal-title":"Circulation"},{"key":"695_CR25","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1161\/CIRCULATIONAHA.108.778019","volume":"118","author":"H Tuunanen","year":"2008","unstructured":"Tuunanen H, Engblom E, Naum A, N\u00e5gren K, Scheinin M, Hesse B, Airaksinen KEJ, Nuutila P, Iozzo P, Ukkonen H, Opie LH, Knuuti J (2008) Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy. Circulation 118:1250\u20131258","journal-title":"Circulation"},{"key":"695_CR26","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1136\/hrt.2011.226332","volume":"97","author":"G Fragasso","year":"2011","unstructured":"Fragasso G, Salerno A, Lattuada G, Cuko A, Calori G, Scollo A, Arioli F, Bassanelli G, Spoladore R, Luzi L, Margonato A, Perseghin G (2011) Effect of partial inhibition of fatty-acid oxidation by trimetazidine on whole body energy metabolism in patients with chronic heart failure. Heart 97:1495\u20131500","journal-title":"Heart"},{"key":"695_CR27","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1161\/CIRCHEARTFAILURE.113.000187","volume":"6","author":"R Nielsen","year":"2013","unstructured":"Nielsen R, Norrelund H, Kampmann U, Kim WY, Ringgaard S, Schar M, Moller N, Botker HE, Wiggers H (2013) Failing heart of patients with type 2 diabetes mellitus can adapt to extreme short term increases in circulating lipids and does not display features of acute myocardial lipotoxicity. Circ Heart Fail 6:845\u2013852","journal-title":"Circ Heart Fail"},{"key":"695_CR28","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1210\/jc.2012-1219","volume":"97","author":"H-R Lehto","year":"2012","unstructured":"Lehto H-R, P\u00e4rkk\u00e4 K, Borra R, Tuunanen H, Lepomaki V, Parkkola R, Knuuti J, Nuutila P, Iozzo P (2012) Effects of acute and one-week fatty acid lowering on cardiac function and insulin sensitivity in relation with myocardial and muscle fat and adiponectin levels. J Clin Endocrinol Metab 97:3277\u20133284","journal-title":"J Clin Endocrinol Metab"},{"key":"695_CR29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1056\/NEJMoa0808431","volume":"360","author":"W Duckworth","year":"2009","unstructured":"Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N, Reaven PD, Zieve FJ, Marks J, Davis SN, Hayward R, Warren SR, Goldman S, McCarren M, Vitek ME, Henderson WG, Huang GD, the VADT Investigators (2009) Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 360:129\u2013139","journal-title":"N Engl J Med"},{"key":"695_CR30","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1056\/NEJMoa0802743","volume":"358","author":"The Action to Control Cardiovascular Risk in Diabetes Study Group","year":"2008","unstructured":"The Action to Control Cardiovascular Risk in Diabetes Study Group (2008) Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 358:2545\u20132559","journal-title":"N Engl J Med"},{"key":"695_CR31","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00134-013-2874-3","volume":"39","author":"G Berghe Van den","year":"2013","unstructured":"Van den Berghe G (2013) What\u2019s new in glucose control in the ICU? Intensive Care Med 39:823\u2013825","journal-title":"Intensive Care Med"},{"key":"695_CR32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1755-5922.2011.00275.x","volume":"30","author":"M Bucci","year":"2012","unstructured":"Bucci M, Borra R, N\u00e5gren K, P\u00e4rkk\u00e4 JP, Ry S, Del Maggio R, Tuunanen H, Viljanen T, Cabiati M, Rigazio S, Taittonen M, Pagotto U, Parkkola R, Opie LH, Nuutila P, Knuuti J, Iozzo P (2012) Trimetazidine reduces endogenous free fatty acid oxidation and improves myocardial efficiency in obese humans. Cardiovasc Ther 30:333\u2013341","journal-title":"Cardiovasc Ther"},{"key":"695_CR33","doi-asserted-by":"crossref","first-page":"e000279","DOI":"10.1161\/JAHA.113.000279","volume":"2","author":"RV Shah","year":"2013","unstructured":"Shah RV, Abbasi SA, Neilan TG, Hulten E, Coelho-Filho O, Hoppin A, Levitsky L, de Ferranti S, Rhodes ET, Traum A, Goodman E, Feng H, Heydari B, Harris WS, Hoefner DM, McConnell JP, Seethamraju R, Rickers C, Kwong RY, Jerosch-Herold M (2013) Myocardial tissue remodeling in adolescent obesity. J Am Heart Assoc 2:e000279","journal-title":"J Am Heart Assoc"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-014-0695-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00592-014-0695-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-014-0695-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:39:13Z","timestamp":1650933553000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00592-014-0695-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,7]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["695"],"URL":"https:\/\/doi.org\/10.1007\/s00592-014-0695-7","relation":{},"ISSN":["0940-5429","1432-5233"],"issn-type":[{"value":"0940-5429","type":"print"},{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,7]]}}}