{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:42:21Z","timestamp":1768927341289,"version":"3.49.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,6,27]],"date-time":"2015-06-27T00:00:00Z","timestamp":1435363200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s00592-015-0781-5","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T01:37:48Z","timestamp":1435282668000},"page":"279-293","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["GPR39 receptors and actions of trace metals on pancreatic beta cell function and glucose homoeostasis"],"prefix":"10.1007","volume":"53","author":[{"given":"Brian. M.","family":"Moran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasser H. A.","family":"Abdel-Wahab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srividya","family":"Vasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Flatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aine M.","family":"McKillop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,6,27]]},"reference":[{"key":"781_CR1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1210\/en.2006-1275","volume":"148","author":"F Tremblay","year":"2007","unstructured":"Tremblay F, Perreault M, Klaman LD, Tobin JE, Smith E, Gimeno RE (2007) Normal food intake and body weight in mice lacking the G protein-coupled receptor GPR39. Endocrinology 148:501\u2013506","journal-title":"Endocrinology"},{"key":"781_CR2","doi-asserted-by":"crossref","first-page":"53806","DOI":"10.1074\/jbc.M407676200","volume":"279","author":"B Holst","year":"2004","unstructured":"Holst B, Holliday ND, Bach A, Elling CE, Cox HM, Schwartz TM (2004) Common structural basis for constitutive activity of the ghrelin receptor family. J Biol Chem 279:53806\u201353817","journal-title":"J Biol Chem"},{"key":"781_CR3","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1210\/me.2007-0055","volume":"21","author":"KL Egerod","year":"2007","unstructured":"Egerod KL, Holst B, Petersen PS, Hansen JB, Mulder J, Hokfelt T, Schwartz TW (2007) GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver and white adipose tissue. Mol Endocrinol 21:1685\u20131698","journal-title":"Mol Endocrinol"},{"key":"781_CR4","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1006\/geno.1997.5069","volume":"46","author":"KK McKee","year":"1997","unstructured":"McKee KK, Tan CP, Palyha OC, Liu J, Feighner SD, Hreniuk DL, Smith RG, Howard AD, Van der Ploeg LH (1997) Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to growth hormone secretagogue and neurotensin receptors. Genomics 46:426\u2013434","journal-title":"Genomics"},{"key":"781_CR5","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1365-2265.2007.02777.x","volume":"66","author":"V Catalan","year":"2007","unstructured":"Catalan V, Gomez-Ambrosi J, Rotellar F, Silva C, Gil MJ, Rodriquez A, Cienfuegos JA, Salvador J, Fruhbeck G (2007) The obestatin receptor (GPR39) is expressed in human adipose tissue and is down-regulated in obesity-associated type 2 diabetes mellitus. Clin Endocrinol 66:598\u2013601","journal-title":"Clin Endocrinol"},{"key":"781_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/401258","volume":"2011","author":"KL Egerod","year":"2011","unstructured":"Egerod KL, Jin C, Petersen PS, Wierup N, Sundler F, Holst B, Schwartz TW (2011) \u03b2- cell specific overexpression of GPR39 protects against streptozotocin-induced hyperglycaemia. Int J Endocrinol 2011:1\u20138","journal-title":"Int J Endocrinol"},{"key":"781_CR7","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1210\/en.2008-1250","volume":"150","author":"B Holst","year":"2009","unstructured":"Holst B, Egerod KL, Jin C, Petersen PS, Ostergaard MV, Hald J, Sprinkel AM, Storling J, Mandrup-Poulsen T, Holst JJ et al (2009) G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction. Endocrinology 150:2577\u20132585","journal-title":"Endocrinology"},{"key":"781_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-11-1","volume":"11","author":"F Xie","year":"2011","unstructured":"Xie F, Lui H, Zhu Y, Qin YR, Dai Y, Zeng T, Chen L, Nie C, Tang H, Li Y et al (2011) Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma. BMC Cancer 11:1\u201312","journal-title":"BMC Cancer"},{"key":"781_CR9","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1126\/science.1117255","volume":"310","author":"JV Zhang","year":"2005","unstructured":"Zhang JV, Ren P, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ (2005) Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin\u2019s effects on food intake. Science 310:996\u2013999","journal-title":"Science"},{"key":"781_CR10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1210\/en.2006-0933","volume":"148","author":"B Holst","year":"2007","unstructured":"Holst B, Egerod KL, Schild E, Vickers SP, Cheetham S, Gerlach LO, Storjohann L, Stidsen CE, Jones R, Beck-Sickinger AG et al (2007) GPR39 signaling is stimulated by zinc ions but not by obestatin. Endocrinology 148:13\u201320","journal-title":"Endocrinology"},{"key":"781_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.regpep.2006.12.023","volume":"141","author":"G Gourcerol","year":"2007","unstructured":"Gourcerol G, St-Pierre DH, Tache Y (2007) Lack of obestatin effects on food intake: should obestatin be renamed ghrelin-associated peptide (GAP)? Regul Pept 141:1\u20137","journal-title":"Regul Pept"},{"key":"781_CR12","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.peptides.2008.01.020","volume":"29","author":"P Kobelt","year":"2008","unstructured":"Kobelt P, Wisser AS, Stengel A, Goebel M, Bannert N, Gourcerol G, Inhoff T, Noetzel S, Wiedenmann B, Klapp BF et al (2008) Peripheral obestatin has no effects on feeding behaviour and brain Fos expression in rodents. Peptides 29:1018\u20131027","journal-title":"Peptides"},{"key":"781_CR13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1055\/s-2007-996266","volume":"12","author":"T Andersson","year":"1980","unstructured":"Andersson T, Berggren PO, Flatt PR (1980) Subcellular distribution of zinc in islet \u03b2-cell fractions. Horm Metab Res 12:275\u2013276","journal-title":"Horm Metab Res"},{"key":"781_CR14","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1096\/fj.11-184531","volume":"25","author":"PS Petersen","year":"2011","unstructured":"Petersen PS, Jin C, Madsen AN, Rasmussen M, Kuhre R, Egerod KL, Nielsen LB, Schwartz TW, Holst B (2011) Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism. FASEB J 25:3803\u20133814","journal-title":"FASEB J"},{"key":"781_CR15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3945\/an.110.000232","volume":"2","author":"SL Kelleher","year":"2011","unstructured":"Kelleher SL, McCormick NH, Velasquez V, Lopez V (2011) Zinc in specialized secretory tissues: roles in the pancreas, prostate, and mammary gland. Adv Nutr 2:101\u2013111","journal-title":"Adv Nutr"},{"key":"781_CR16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00018-010-0517-1","volume":"68","author":"P Popovics","year":"2011","unstructured":"Popovics P, Stewart AJ (2011) GPR39: a Zn2+ -activated G-protein coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions. Cell Mol Life Sci 68:85\u201395","journal-title":"Cell Mol Life Sci"},{"key":"781_CR17","doi-asserted-by":"crossref","first-page":"47662","DOI":"10.1074\/jbc.M202103200","volume":"277","author":"B Holst","year":"2002","unstructured":"Holst B, Elling CE, Schwartz TW (2002) Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors. J Biol Chem 277:47662\u201347670","journal-title":"J Biol Chem"},{"key":"781_CR18","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1007\/s001250050009","volume":"43","author":"P Ohly","year":"2000","unstructured":"Ohly P, Dohle C, Abel J, Seissler J, Gleichmann H (2000) Zinc sulphate induces metallothionein in pancreatic islets of mice and protects against diabetes induced by multiple low doses of streptozotocin. Diabetologia 43:1020\u20131030","journal-title":"Diabetologia"},{"key":"781_CR19","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/jn\/103.12.1739","volume":"103","author":"AM Huber","year":"1973","unstructured":"Huber AM, Gershoff SN (1973) Effect of zinc deficiency in rats on insulin release from the pancreas. J Nutr 103:1739\u20131744","journal-title":"J Nutr"},{"key":"781_CR20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF02789090","volume":"61","author":"MD Chen","year":"1998","unstructured":"Chen MD, Liou SJ, Lin PY, Yang VC, Alexander PS, Lin WH (1998) Effects of zinc supplementation on the plasma glucose level and insulin activity in genetically obese (ob\/ob) mice. Bio Trace Elem Res 61:303\u2013311","journal-title":"Bio Trace Elem Res"},{"key":"781_CR21","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.coph.2012.07.019","volume":"12","author":"I Depoortere","year":"2012","unstructured":"Depoortere I (2012) GI functions of GPR39: novel biology. Curr Opin Pharmacol 12:647\u2013652","journal-title":"Curr Opin Pharmacol"},{"key":"781_CR22","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1053\/j.gastro.2006.07.009","volume":"131","author":"D Moechars","year":"2006","unstructured":"Moechars D, Depoortere I, Moreaux B, de Smet B, Goris I, Hoskens L, Daneels G, Kass S, Ver Donck L, Peeters T et al (2006) Altered gastrointestinal and metabolic function in the GPR39-obestatin receptor knockout mouse. Gastroenterology 131:1131\u20131141","journal-title":"Gastroenterology"},{"key":"781_CR23","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ijo.2010.59","volume":"34","author":"VA Gault","year":"2010","unstructured":"Gault VA, Porter WD, Flatt PR, Holscher C (2010) Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high fat diet. In J Obes 34:1341\u20131344","journal-title":"In J Obes"},{"key":"781_CR24","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1463-1326.2010.01259.x","volume":"12","author":"DW Porter","year":"2010","unstructured":"Porter DW, Kerr BD, Flatt PR, Holscher C, Gault VA (2010) Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with dietary-induced obesity and insulin resistance. Diabetes Obes Metab 12:891\u2013899","journal-title":"Diabetes Obes Metab"},{"key":"781_CR25","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1523\/JNEUROSCI.5093-08.2009","volume":"29","author":"L Besser","year":"2009","unstructured":"Besser L, Chorin E, Sekler I, Silverman WF, Atkin S, Russell J, Hershfinkel M (2009) Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus. J Neurosci 29:2890\u20132901","journal-title":"J Neurosci"},{"key":"781_CR26","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1074\/jbc.M704323200","volume":"283","author":"S Dittmer","year":"2008","unstructured":"Dittmer S, Sahin M, Pantlen A, Saxena A, Toutzaris D, Pina AL, Geerts A, Golz S, Methner A (2008) The constitutively active orphan G-protein-coupled receptor GPR39 protects from cell death by increasing secretion of pigment epithelium-derived growth factor. J Biol Chem 283:7074\u20137081","journal-title":"J Biol Chem"},{"key":"781_CR27","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bbr.2012.10.020","volume":"238","author":"K Mlyneic","year":"2013","unstructured":"Mlyneic K, Budziszewska B, Reczynski W, Sowa-Kucma M, Nowak G (2013) The role of the GPR39 receptor in zinc deficient-animal model of depression. Behav Brain Res 238:30\u201335","journal-title":"Behav Brain Res"},{"key":"781_CR28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0920-1211(99)00121-7","volume":"39","author":"TB Cole","year":"2000","unstructured":"Cole TB, Robbins CA, Wenzel HJ, Schwartzkroin PA, Palmiter RD (2000) Seizures and neuronal damage in mice lacking vesicular zinc. Epilepsy Res 39:153\u2013169","journal-title":"Epilepsy Res"},{"key":"781_CR29","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1038\/jcbfm.2009.80","volume":"29","author":"SW Sun","year":"2009","unstructured":"Sun SW, Won SJ, Hamby AM, Yoo BH, Fan Y, Sheline CT, Tamano H, Takeda A, Liu J (2009) Decreased brain zinc availability reduced hippocampal neurogenesis in mice and rats. J Cereb Blood Flow Metab 29:1579\u20131588","journal-title":"J Cereb Blood Flow Metab"},{"key":"781_CR30","doi-asserted-by":"crossref","first-page":"26097","DOI":"10.1074\/jbc.M110.107490","volume":"285","author":"H Sharir","year":"2010","unstructured":"Sharir H, Zinger A, Nevo N, Sekler I, Hershfinkel M (2010) Zinc released from injured cells is acting via the Zn2+-sensing receptor, ZnR, to trigger signaling leading to epithelial repair. J Biol Chem 285:26097\u201326106","journal-title":"J Biol Chem"},{"key":"781_CR31","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.2337\/diab.45.8.1132","volume":"45","author":"NH McClenaghan","year":"1996","unstructured":"McClenaghan NH, Barnett CR, Ah-Sing E, Abdel-Wahab YH, O\u2019Harte FP, Yoon TW, Swanston-Flatt SK, Flatt PR (1996) Characterisation of a novel glucose-responsive insulin-secreting cell line, BRIN BD11, produced by electrofusion. Diabetes 45:1132\u20131140","journal-title":"Diabetes"},{"key":"781_CR32","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/BF00252768","volume":"20","author":"PR Flatt","year":"1981","unstructured":"Flatt PR, Bailey CJ (1981) Abnormal plasma glucose and insulin responses in heterozygous lean (ob\/+) mice. Diabetologia 20:573\u2013577","journal-title":"Diabetologia"},{"key":"781_CR33","first-page":"157","volume":"72","author":"S Moskalewski","year":"1969","unstructured":"Moskalewski S (1969) Studies on the culture and transplantation of isolated islets of Langerhans of the guinea pig. Proc K Ned Akad Wet C 72:157\u2013171","journal-title":"Proc K Ned Akad Wet C"},{"key":"781_CR34","first-page":"11","volume":"6","author":"CJ Bailey","year":"1982","unstructured":"Bailey CJ, Flatt PR (1982) Influence of genetic background and age on the expression of the obese hyperglycaemic syndrome in Aston ob\/ob mice. Int J Obes 6:11\u201321","journal-title":"Int J Obes"},{"key":"781_CR35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1677\/joe.1.06615","volume":"189","author":"JMA Hannan","year":"2006","unstructured":"Hannan JMA, Marenah L, Ali L, Rokeya B, Flatt PR, Abdel-Wahab YHA (2006) Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic \u03b2-cells. J Endocrinol 189:127\u2013136","journal-title":"J Endocrinol"},{"key":"781_CR36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ceca.2003.11.007","volume":"36","author":"JC Miguel","year":"2004","unstructured":"Miguel JC, Patterson S, Abdel-Wahab YHA, Mathias PC, Flatt PR (2004) Time-correlation between membrane depolarization and intracellular calcium in insulin secretion BRIN-BD11 cells: studies using FLIPR. Cell Calcium 36:43\u201350","journal-title":"Cell Calcium"},{"key":"781_CR37","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/dom.12330","volume":"16","author":"BM Moran","year":"2014","unstructured":"Moran BM, Abdel-Wahab YH, Flatt PR, McKillop AM (2014) Evaluation of the insulin releasing and glucose lowering effects of GPR120 activation in pancreatic beta cells. Diabetes Obes Metab 16:1128\u20131139","journal-title":"Diabetes Obes Metab"},{"key":"781_CR38","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","volume":"160","author":"C Kilkenny","year":"2010","unstructured":"Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG (2010) Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol 160:1577\u20131579","journal-title":"Br J Pharmacol"},{"key":"781_CR39","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/2042018810375656","volume":"1","author":"V Vangaveti","year":"2010","unstructured":"Vangaveti V, Shashidhar V, Jarrod G, Baune BT, Kennedy RL (2010) Free fatty acid receptors: emerging targets for treatment of diabetes and its complications. Ther Adv Endocrinol Metab 1:165\u2013175","journal-title":"Ther Adv Endocrinol Metab"},{"key":"781_CR40","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s11892-005-0093-1","volume":"5","author":"CJ Bailey","year":"2005","unstructured":"Bailey CJ (2005) Drugs on the horizon for diabesity. Curr Diabet Rep 5:353\u2013359","journal-title":"Curr Diabet Rep"},{"key":"781_CR41","doi-asserted-by":"crossref","first-page":"S175","DOI":"10.2337\/dcS13-2037","volume":"36","author":"CF Burant","year":"2013","unstructured":"Burant CF (2013) Activation of GPR40 as a therapeutic target for the treatment of type 2 diabetes. Diabetes Care 36:S175\u2013S179","journal-title":"Diabetes Care"},{"key":"781_CR42","doi-asserted-by":"crossref","first-page":"e35482","DOI":"10.1371\/journal.pone.0035482","volume":"7","author":"L Cohen","year":"2012","unstructured":"Cohen L, Azriel-Tamir H, Arotsker N, Sekler I, Hershfinkel M (2012) Zinc sensing receptor signalling, mediated by GPR39, reduces butyrate-induced cell death in HT29 colonocytes via upregulation of clusterin. PloS One 7:e35482","journal-title":"PloS One"},{"key":"781_CR43","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1210\/en.2008-1251","volume":"150","author":"F Tremblay","year":"2009","unstructured":"Tremblay F, Richard A, Will S, Syed J, Stedman N, Perreault M, Gimeno RE (2009) Distribution of G-protein-coupled receptor 39 impairs insulin secretion in vivo. Endocrinology 150:2586\u20132595","journal-title":"Endocrinology"},{"key":"781_CR44","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4161\/isl.2.1.10259","volume":"2","author":"GA Rutter","year":"2010","unstructured":"Rutter GA (2010) Think zinc: new roles for zinc in the control of insulin secretion. Islets 2:49\u201350","journal-title":"Islets"},{"key":"781_CR45","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.tiv.2012.12.019","volume":"27","author":"U Lodemann","year":"2013","unstructured":"Lodemann U, Einspanier R, Scharfen F, Martens H, Bondzio A (2013) Effects of zinc on epithelial barrier properties and viability in a human and a porcine intestinal cell culture model. Toxicol In Vitro 27:834\u2013843","journal-title":"Toxicol In Vitro"},{"key":"781_CR46","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2220\/biomedres.8.153","volume":"8","author":"PR Flatt","year":"1987","unstructured":"Flatt PR, Rorsman P, Swanston-Flatt SK (1987) Effect of cationic modifications on superficial binding and intracellular 45Ca uptake by decapsulated ob\/ob mouse pancreatic islets. Biomed Res 8:153\u2013159","journal-title":"Biomed Res"},{"key":"781_CR47","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1469-7793.2000.00723.x","volume":"529","author":"A Bloc","year":"2000","unstructured":"Bloc A, Cens T, Cruz H, Dunant Y (2000) Zinc-induced changes in ionic currents of clonal rat pancreatic \u03b2-cells: activation of ATP-sensitive K+ channels. J Physiol 529:723\u2013734","journal-title":"J Physiol"},{"key":"781_CR48","first-page":"1529","volume":"74","author":"C Acuna-Castillo","year":"2000","unstructured":"Acuna-Castillo C, Morales B, Huidobro-Toro JP (2000) Zinc and copper modulate differentially the P2X4 receptor. J Neurosci 74:1529\u20131537","journal-title":"J Neurosci"},{"key":"781_CR49","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.mam.2005.07.013","volume":"26","author":"CG Fraga","year":"2005","unstructured":"Fraga CG (2005) Relevance, essentiality and toxicity of trace elements in human health. Mol Asp Med 26:235\u2013244","journal-title":"Mol Asp Med"},{"key":"781_CR50","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00210-007-0250-y","volume":"377","author":"T Tanaka","year":"2008","unstructured":"Tanaka T, Yano T, Adachi T, Koshimizu TA, Hirasawa A, Tsujimoto G (2008) Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells. N-S Arch Pharmacol 377:515\u2013522","journal-title":"N-S Arch Pharmacol"},{"key":"781_CR51","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.2337\/db08-1237","volume":"58","author":"LM Lauffer","year":"2009","unstructured":"Lauffer LM, Iakoubov R, Brubaker PL (2009) GPR119 is essential for oleoylethanolamide\u2013induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cells. Diabetes 58:1058\u20131066","journal-title":"Diabetes"},{"key":"781_CR52","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbrc.2006.10.014","volume":"351","author":"Y Adachi","year":"2006","unstructured":"Adachi Y, Yoshida J, Kodera Y, Kiss T, Jakusch T, Enyedy EA, Yoshikawa Y, Sakurai H (2006) Oral administration of a zinc complex improves type 2 diabetes and metabolic syndromes. Biochem Biophys Res Commun 351:165\u2013170","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-015-0781-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00592-015-0781-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-015-0781-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T18:24:58Z","timestamp":1717957498000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00592-015-0781-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,27]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["781"],"URL":"https:\/\/doi.org\/10.1007\/s00592-015-0781-5","relation":{},"ISSN":["0940-5429","1432-5233"],"issn-type":[{"value":"0940-5429","type":"print"},{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,27]]}}}