{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T06:30:16Z","timestamp":1745476216560,"version":"3.37.3"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001858","name":"VINNOVA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012558","name":"Sk\u00e5ne County Council's Research and Development Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>Aims<\/jats:title>\n<jats:p>Few studies have examined how improved metabolic control might influence vibration perception thresholds (VPTs). The aim of this study was to evaluate if improved HbA<jats:sub>1c<\/jats:sub> can influence vibration thresholds in adults with type 1 diabetes (T1DM).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>VPTs were investigated at six frequencies (4\u2013125\u00a0Hz) using VibroSense Meter in the sole of the foot at two occasions in 159 T1DM patients, at the heads of the first and fifth metatarsal bones, i.e. MTH1 and MTH5, respectively. The participants were divided into three groups: group A: HbA<jats:sub>1c<\/jats:sub> improved by more than 1\u00a0mmol\/mol (<jats:italic>n<\/jats:italic>\u2009=\u200995), group B: HbA<jats:sub>1c<\/jats:sub> deteriorated by more than 1\u00a0mmol\/mol (<jats:italic>n<\/jats:italic>\u2009=\u200948) and group C: HbA<jats:sub>1c<\/jats:sub> unchanged (\u00b1\u20091\u00a0mmol\/mol) (<jats:italic>n<\/jats:italic>\u2009=\u200916) compared to baseline.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>In group A, the mean <jats:italic>z<\/jats:italic>-score, reflecting the combined effect of all VPTs, improved being lower at the follow-up than at the baseline [0.2 (\u2212\u20090.3 to 1.2) vs. \u22120.1 (\u2212\u20090.7 to 0.8), <jats:italic>p<\/jats:italic>\u2009=\u20090.00002]. VPTs improved at 4 and 64\u00a0Hz at both MTH1 (metatarsal head 1) and MTH5. The VPTs at 125\u00a0Hz frequency improved at MTH5, but not at MTH1. No significant differences were seen in group B or group C.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Lower HbA<jats:sub>1c<\/jats:sub> and lower VPTs in T1DM patients were associated with improved VPT, suggesting a reversible effect on nerve function by improved metabolic control.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00592-019-01450-2","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T18:03:00Z","timestamp":1573236180000},"page":"433-438","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Improved metabolic control using glucose monitoring systems leads to improvement in vibration perception thresholds in type 1 diabetes patients"],"prefix":"10.1007","volume":"57","author":[{"given":"Lars B.","family":"Dahlin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Targ","family":"Elgzyri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"L\u00f6ndahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linn\u00e9a","family":"Ekman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8869-681X","authenticated-orcid":false,"given":"Eero","family":"Lindholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"issue":"1","key":"1450_CR1","doi-asserted-by":"publisher","first-page":"136","DOI":"10.2337\/dc16-2042","volume":"40","author":"R Pop-Busui","year":"2017","unstructured":"Pop-Busui R, Boulton AJ, Feldman EL et al (2017) Diabetic neuropathy: a position statement by the american diabetes association. 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