{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:42:55Z","timestamp":1782200575813,"version":"3.54.5"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1007\/s00592-020-01558-w","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T19:03:47Z","timestamp":1593716627000},"page":"1367-1373","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Expression of glucose transporters in duodenal mucosa of patients with type 1 diabetes"],"prefix":"10.1007","volume":"57","author":[{"given":"Andrea Mario","family":"Bolla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Butera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Caretto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Bonfanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella Alessia","family":"Zuppardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziano","family":"Barera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia Martina","family":"Cavestro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Sordi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2371-2495","authenticated-orcid":false,"given":"Emanuele","family":"Bosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"issue":"2","key":"1558_CR1","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1152\/physrev.00055.2009","volume":"91","author":"EM Wright","year":"2011","unstructured":"Wright EM, Loo DDF, Hirayama BA (2011) Biology of human sodium glucose transporters. Physiol Rev 91(2):733\u2013794","journal-title":"Physiol Rev"},{"issue":"1","key":"1558_CR2","doi-asserted-by":"publisher","first-page":"187","DOI":"10.2337\/db11-1029","volume":"61","author":"V Gorboulev","year":"2012","unstructured":"Gorboulev V, Schurmann A, Vallon V et al (2012) Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes 61(1):187\u2013196","journal-title":"Diabetes"},{"issue":"4 Pt 1","key":"1558_CR3","first-page":"G541","volume":"270","author":"B Thorens","year":"1996","unstructured":"Thorens B (1996) Glucose transporters in the regulation of intestinal, renal, and liver glucose fluxes. Am J Physiol 270(4 Pt 1):G541\u2013G553","journal-title":"Am J Physiol"},{"key":"1558_CR4","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1113\/jphysiol.1988.sp017015","volume":"397","author":"ES Debnam","year":"1988","unstructured":"Debnam ES, Karasov WH, Thompson CS (1988) Nutrient uptake by rat enterocytes during diabetes mellitus; evidence for an increased sodium electrochemical gradient. J Physiol 397:503\u2013512","journal-title":"J Physiol"},{"issue":"3","key":"1558_CR5","doi-asserted-by":"publisher","first-page":"C601","DOI":"10.1152\/ajpcell.00135.2009","volume":"297","author":"TP Wong","year":"2009","unstructured":"Wong TP, Debnam ES, Leung PS (2009) Diabetes mellitus and expression of the enterocyte renin angiotensin system: implications for control of glucose transport across the brush border membrane. Am J Physiol Cell Physiol 297(3):C601\u2013C610","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"1558_CR6","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1172\/JCI117010","volume":"93","author":"CF Burant","year":"1994","unstructured":"Burant CF, Flink S, DePaoli AM et al (1994) Small intestine hexose transport in experimental diabetes increased transporter mRNA and protein expression in enterocytes. J Clin Invest. 93(2):578\u2013585","journal-title":"J Clin Invest."},{"issue":"2","key":"1558_CR7","doi-asserted-by":"publisher","first-page":"G241","DOI":"10.1152\/ajpgi.00310.2001","volume":"282","author":"J Dyer","year":"2002","unstructured":"Dyer J, Wood IS, Palejwala A, Ellis A, Shirazi-Beechey SP (2002) Expression of monosaccharide transporters in intestine of diabetic humans. Am J Physiol Gastrointest Liver Physiol 282(2):G241\u2013G248","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"11","key":"1558_CR8","doi-asserted-by":"publisher","first-page":"3979","DOI":"10.1210\/jc.2017-00348","volume":"102","author":"TV Fiorentino","year":"2017","unstructured":"Fiorentino TV, Suraci E, Arcidiacono GP et al (2017) Duodenal sodium\/glucose cotransporter 1 expression under fasting conditions is associated with postload hyperglycemia. J Clin Endocrinol Metab 102(11):3979\u20133989","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"1558_CR9","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/S2213-8587(17)30308-X","volume":"5","author":"P Dandona","year":"2017","unstructured":"Dandona P, Mathieu C, Phillip M et al (2017) DEPICT-1 Investigators. efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (DEPICT-1): 24 week results from a multicentre, double-blind, phase 3, randomised controlled trial. Lancet Diabetes Endocrinol. 5(11):864\u2013876","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"24","key":"1558_CR10","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1056\/NEJMoa1708337","volume":"377","author":"SK Garg","year":"2017","unstructured":"Garg SK, Henry RR, Banks P et al (2017) Effects of sotagliflozin added to insulin in patients with type 1 diabetes. N Engl J Med 377(24):2337\u20132348","journal-title":"N Engl J Med"},{"issue":"12","key":"1558_CR11","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.2337\/dc18-1749","volume":"41","author":"J Rosenstock","year":"2018","unstructured":"Rosenstock J, Marquard J, Laffel LM et al (2018) Empagliflozin as adjunctive to insulin therapy in type 1 diabetes: the ease trials. Diabetes Care 41(12):2560\u20132569","journal-title":"Diabetes Care"},{"issue":"5","key":"1558_CR12","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1210\/jc.2016-3222","volume":"102","author":"S Pellegrini","year":"2017","unstructured":"Pellegrini S, Sordi V, Bolla AM et al (2017) Duodenal mucosa of patients with type 1 diabetes shows distinctive inflammatory profile and microbiota. J Clin Endocrinol Metab 102(5):1468\u20131477","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 1","key":"1558_CR13","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.2337\/dc19-S002","volume":"42","author":"American Diabetes Association","year":"2019","unstructured":"American Diabetes Association (2019) 2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2019. Diabetes Care 42(Suppl 1):S13\u2013S28","journal-title":"Diabetes Care"},{"issue":"5","key":"1558_CR14","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/ajg.2013.79","volume":"108","author":"A Rubio-Tapia","year":"2013","unstructured":"Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA (2013) American College of Gastroenterology ACG clinical guidelines: diagnosis and management of celiac disease. Am J Gastroenterol. 108(5):656\u2013676","journal-title":"Am J Gastroenterol."},{"issue":"1","key":"1558_CR15","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1074\/jbc.M113.526814","volume":"289","author":"JR Zapata Morales","year":"2014","unstructured":"Zapata Morales JR, Galicia-Cruz OG, Franco M, y Morales FM (2014) Hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) protein diminishes sodium glucose transport 1 (SGLT1) and SGLT2 protein expression in renal epithelial tubular cells (LLC-PK1) under hypoxia. J Biol Chem. 289(1):346\u2013357","journal-title":"J Biol Chem."},{"issue":"7","key":"1558_CR16","doi-asserted-by":"publisher","first-page":"3360","DOI":"10.1210\/jc.2010-0293","volume":"95","author":"E Bonifacio","year":"2010","unstructured":"Bonifacio E, Yu L, Williams AK et al (2010) Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for national institute of diabetes and digestive and kidney diseases consortia. J Clin Endocrinol Metab 95(7):3360\u20133367","journal-title":"J Clin Endocrinol Metab"},{"key":"1558_CR17","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1373\/clinchem.2011.170662","volume":"57","author":"V Lampasona","year":"2011","unstructured":"Lampasona V, Schlosser M, Mueller PW et al (2011) Diabetes antibody standardization program: first proficiency evaluation of assays for autoantibodies to zinc transporter 8. Clin Chem 57:1693\u20131702","journal-title":"Clin Chem"},{"issue":"1","key":"1558_CR18","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1006\/jaut.1998.0253","volume":"12","author":"E Bazzigaluppi","year":"1999","unstructured":"Bazzigaluppi E, Lampasona V, Barera G et al (1999) Comparison of tissue transglutaminase-specific antibody assays with established antibody measurements for coeliac disease. J Autoimmun 12(1):51\u201356","journal-title":"J Autoimmun"},{"issue":"2","key":"1558_CR19","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1210\/en.2007-1088","volume":"149","author":"HS Freitas","year":"2008","unstructured":"Freitas HS, Anh\u00ea GF, Melo KF et al (2008) Na(+) -glucose transporter-2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: involvement of hepatocyte nuclear factor-1alpha expression and activity. Endocrinology 149(2):717\u2013724","journal-title":"Endocrinology"},{"key":"1558_CR20","doi-asserted-by":"publisher","first-page":"3427","DOI":"10.2337\/diabetes.54.12.3427","volume":"54","author":"H Rahmoune","year":"2005","unstructured":"Rahmoune H, Thompson PW, Ward JM et al (2005) Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. Diabetes 54:3427\u20133434","journal-title":"Diabetes"},{"issue":"9","key":"1558_CR21","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1111\/dom.13003","volume":"19","author":"L Norton","year":"2017","unstructured":"Norton L, Shannon CE, Fourcaudot M et al (2017) Sodium-glucose co-transporter (SGLT) and glucose transporter (GLUT) expression in the kidney of type 2 diabetic subjects. Diabetes Obes Metab 19(9):1322\u20131326","journal-title":"Diabetes Obes Metab"},{"issue":"9","key":"1558_CR22","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1111\/dom.12970","volume":"19","author":"A Solini","year":"2017","unstructured":"Solini A, Rossi C, Mazzanti CM et al (2017) Sodium-glucose co-transporter (SGLT)2 and SGLT1 renal expression in patients with type 2 diabetes. Diabetes Obes Metab 19(9):1289\u20131294","journal-title":"Diabetes Obes Metab"},{"issue":"13","key":"1558_CR23","doi-asserted-by":"publisher","first-page":"5335","DOI":"10.1074\/jbc.M117.779520","volume":"292","author":"XX Wang","year":"2017","unstructured":"Wang XX, Levi J, Luo Y et al (2017) SGLT2 protein expression is increased in human diabetic nephropathy: SGLT2 protein inhibition decreases renal lipid accumulation, inflammation, and the development of nephropathy in diabetic mice. J Biol Chem 292(13):5335\u20135348","journal-title":"J Biol Chem"},{"issue":"6","key":"1558_CR24","doi-asserted-by":"publisher","first-page":"452","DOI":"10.2133\/dmpk.20.452","volume":"20","author":"M Nishimura","year":"2005","unstructured":"Nishimura M, Naito S (2005) Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamilies. Drug Metab Pharmacokinet 20(6):452\u2013477","journal-title":"Drug Metab Pharmacokinet"},{"issue":"2","key":"1558_CR25","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s13300-010-0006-4","volume":"1","author":"J Chen","year":"2010","unstructured":"Chen J, Williams S, Hon S et al (2010) Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members. Diabetes Ther 1(2):57\u201392","journal-title":"Diabetes Ther"},{"key":"1558_CR26","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1210\/er.2010-0029","volume":"32","author":"MA Abdul-Ghani","year":"2011","unstructured":"Abdul-Ghani MA, Norton L, Defronzo RA (2011) Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes. Endocr Rev 32:515\u2013531","journal-title":"Endocr Rev"},{"issue":"8","key":"1558_CR27","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.2337\/dc12-2391","volume":"36","author":"D Polidori","year":"2013","unstructured":"Polidori D, Sha S, Mudaliar S et al (2013) Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: results of a randomized, placebo-controlled study. Diabetes Care 36(8):2154\u20132161","journal-title":"Diabetes Care"},{"issue":"2","key":"1558_CR28","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1111\/dom.12418","volume":"17","author":"S Sha","year":"2015","unstructured":"Sha S, Polidori D, Farrell K et al (2015) Pharmacodynamic differences between canagliflozin and dapagliflozin: results of a randomized, double-blind, crossover study. Diabetes Obes Metab 17(2):188\u2013197","journal-title":"Diabetes Obes Metab"},{"issue":"Suppl 2","key":"1558_CR29","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/dom.13650","volume":"21","author":"E Brown","year":"2019","unstructured":"Brown E, Rajeev SP, Cuthbertson DJ, Wilding JPH (2019) A review of the mechanism of action, metabolic profile and haemodynamic effects of sodium-glucose co-transporter-2 inhibitors. Diabetes Obes Metab 21(Suppl 2):9\u201318","journal-title":"Diabetes Obes Metab"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-020-01558-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00592-020-01558-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-020-01558-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:14:29Z","timestamp":1625184869000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00592-020-01558-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,2]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["1558"],"URL":"https:\/\/doi.org\/10.1007\/s00592-020-01558-w","relation":{},"ISSN":["0940-5429","1432-5233"],"issn-type":[{"value":"0940-5429","type":"print"},{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,2]]},"assertion":[{"value":"23 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"EmBo received advisory boards, consultancy and lectures fees from AstraZeneca and Lexicon Pharmaceuticals. No other dualities relevant to this article are reported by the remaining authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Ethics Committee of the San Raffaele Hospital and was conducted according to the Declaration of Helsinki standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standard statement"}},{"value":"Written informed consent was obtained from all adult and from parents of children participating to the study, before biopsy collection.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}