{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:02:48Z","timestamp":1770512568926,"version":"3.49.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","award":["01 06 0010.00"],"award-info":[{"award-number":["01 06 0010.00"]}],"id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003545","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","doi-asserted-by":"publisher","award":["01 06 0300.00"],"award-info":[{"award-number":["01 06 0300.00"]}],"id":[{"id":"10.13039\/501100003545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s00592-020-01594-6","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T19:03:38Z","timestamp":1598641418000},"page":"73-80","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Insulin resistance may be misdiagnosed by HOMA-IR in adults with greater fat-free mass: the ELSA-Brasil Study"],"prefix":"10.1007","volume":"58","author":[{"given":"Divanei","family":"Zaniqueli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3150-4239","authenticated-orcid":false,"given":"Rafael","family":"de Oliveira Alvim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosane Harter","family":"Griep","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabela Martins","family":"Bense\u00f1or","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandhi Maria","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Andrade","family":"Lotufo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Geraldo","family":"Mill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"1594_CR1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2174\/187153007780059423","volume":"7","author":"J Ye","year":"2007","unstructured":"Ye J (2007) Role of insulin in the pathogenesis of free fatty acid-induced insulin resistance in skeletal muscle. Endocr Metab Immune Disord Drug Targets 7:65\u201374","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"1594_CR2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.cca.2006.07.005","volume":"375","author":"B Mlinar","year":"2007","unstructured":"Mlinar B, Marc J, Janez A, Pfeifer M (2007) Molecular mechanisms of insulin resistance and associated diseases. Clin Chim Acta 375:20\u201335","journal-title":"Clin Chim Acta"},{"issue":"12","key":"1594_CR3","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.2337\/diab.37.12.1595","volume":"37","author":"GM Reaven","year":"1988","unstructured":"Reaven GM (1988) Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37(12):1595\u20131607","journal-title":"Diabetes"},{"key":"1594_CR4","doi-asserted-by":"publisher","first-page":"802","DOI":"10.7326\/0003-4819-139-10-200311180-00007","volume":"139","author":"T McLaughlin","year":"2003","unstructured":"McLaughlin T, Abbasi F, Cheal K, Chu J, Lamendola C, Reaven G (2003) Use of metabolic markers to identify overweight individuals who are insulin resistant. Ann Intern Med 139:802\u2013809","journal-title":"Ann Intern Med"},{"issue":"7","key":"1594_CR5","doi-asserted-by":"publisher","first-page":"e012107","DOI":"10.1136\/bmjopen-2016-012107","volume":"6","author":"E Reyes-Mu\u00f1oz","year":"2016","unstructured":"Reyes-Mu\u00f1oz E, Ortega-Gonz\u00e1lez C, Mart\u00ednez-Cruz N, Arce-S\u00e1nchez L, Estrada-Gutierrez G, Moran C et al (2016) Association of obesity and overweight with the prevalence of insulin resistance, pre-diabetes and clinical-biochemical characteristics among infertile Mexican women with polycystic ovary syndrome: a cross-sectional study. BMJ Open 6(7):e012107","journal-title":"BMJ Open"},{"issue":"11","key":"1594_CR6","doi-asserted-by":"publisher","first-page":"2928","DOI":"10.2337\/dc07-0360","volume":"30","author":"U Ris\u00e9rus","year":"2007","unstructured":"Ris\u00e9rus U, Arnl\u00f6v J, Berglund L (2007) Long-term predictors of insulin resistance: role of lifestyle and metabolic factors in middle-aged men. Diabetes Care 30(11):2928\u20132933","journal-title":"Diabetes Care"},{"key":"1594_CR7","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/BF00776599","volume":"53","author":"H Yki-Jfirvinen","year":"1984","unstructured":"Yki-Jfirvinen H, Koivisto VA, Taskinen M-R, Nikkilfi EA (1984) Glucose tolerance, plasma lipoproteins, and tissue lipoprotein lipase activities in body builders. Eur J Appl Physiol 53:253\u2013259","journal-title":"Eur J Appl Physiol"},{"issue":"1","key":"1594_CR8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1055\/s-2007-1024870","volume":"10","author":"M Szczypaczewska","year":"1989","unstructured":"Szczypaczewska M, Nazar K, Kaciuba-Uscilko H (1989) Glucose tolerance and insulin response to glucose load in body builders. Int J Sports Med 10(1):34\u201337","journal-title":"Int J Sports Med"},{"key":"1594_CR9","first-page":"664","volume":"15","author":"C Castaneda","year":"2005","unstructured":"Castaneda C, Janssen I (2005) Ethnic comparisons of sarcopenia and obesity in diabetes. Ethn Dis 15:664\u2013670","journal-title":"Ethn Dis"},{"issue":"9","key":"1594_CR10","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.1210\/jc.2011-0435","volume":"96","author":"P Srikanthan","year":"2011","unstructured":"Srikanthan P, Karlamangla AS (2011) Relative muscle mass is inversely associated with insulin resistance and prediabetes. Findings from the third National Health and Nutrition Examination Survey. J Clin Endocrinol Metab 96(9):2898\u20132903","journal-title":"J Clin Endocrinol Metab"},{"key":"1594_CR11","doi-asserted-by":"publisher","first-page":"3208","DOI":"10.1210\/jc.2014-1684","volume":"99","author":"DR Weber","year":"2014","unstructured":"Weber DR, Leonard MB, Shults J, Zemel BS (2014) A comparison of fat and lean body mass index to BMI for the identification of metabolic syndrome in children and adolescents. J Clin Endocrinol Metab 99:3208\u20133216","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"1594_CR12","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s40520-018-0993-y","volume":"31","author":"A Ghachem","year":"2019","unstructured":"Ghachem A, Lagac\u00e9 JC, Brochu M, Dionne IJ (2019) Fat-free mass and glucose homeostasis: is greater fat-free mass an independent predictor of insulin resistance? Aging Clin Exp Res 31(4):447\u2013454","journal-title":"Aging Clin Exp Res"},{"key":"1594_CR13","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.metabol.2009.02.027","volume":"58","author":"E Atlantis","year":"2009","unstructured":"Atlantis E, Martin SA, Haren MT, Taylor AW, Wittert GA (2009) Members of the Florey Adelaide Male Ageing Study. Inverse associations between muscle mass, strength, and the metabolic syndrome. Metabolism 58:1013\u20131022","journal-title":"Metabolism"},{"key":"1594_CR14","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1097\/gme.0b013e31802e426b","volume":"14","author":"M Aubertin-Leheudre","year":"2007","unstructured":"Aubertin-Leheudre M, Lord C, Khalil A, Dionne IJ (2007) Effect of 6\u00a0months of exercise and isoflavone supplementation on clinical cardiovascular risk factors in obese postmenopausal women: a randomized, double-blind study. Menopause 14:624\u2013629","journal-title":"Menopause"},{"issue":"4","key":"1594_CR15","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1093\/aje\/kwr294","volume":"175","author":"EM Aquino","year":"2012","unstructured":"Aquino EM, Barreto SM, Bensenor IM, Carvalho MS, Chor D, Duncan BB et al (2012) Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): objectives and design. Am J Epidemiol 175(4):315\u2013324","journal-title":"Am J Epidemiol"},{"issue":"1","key":"1594_CR16","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1093\/ije\/dyu027","volume":"44","author":"MI Schmidt","year":"2015","unstructured":"Schmidt MI, Duncan BB, Mill JG, Lotufo PA, Chor D, Barreto SM, Aquino EM, Passos VM, Matos SM, Molina Mdel C, Carvalho MS, Bensenor IM (2015) Cohort Profile: Longitudinal Study of Adult Health (ELSA-Brasil). Int J Epidemiol 44(1):68\u201375","journal-title":"Int J Epidemiol"},{"issue":"Suppl 2","key":"1594_CR17","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1590\/S0034-8910.2013047003807","volume":"47","author":"LG Fedeli","year":"2013","unstructured":"Fedeli LG, Vidigal PG, Leite CM, Castilhos CD, Pimentel RA, Maniero VC et al (2013) Logistics of collection and transportation of biological samples and the organization of the central laboratory in the ELSA-Brasil. Rev Saude Publica 47(Suppl 2):63\u201371","journal-title":"Rev Saude Publica"},{"issue":"5","key":"1594_CR18","doi-asserted-by":"publisher","first-page":"e0126469","DOI":"10.1371\/journal.pone.0126469","volume":"10","author":"J Yarmolinsky","year":"2015","unstructured":"Yarmolinsky J, Mueller NT, Duncan BB, Bisi Molina Mdel C, Goulart AC, Schmidt MI (2015) Coffee consumption, newly diagnosed diabetes, and other alterations in glucose homeostasis: a cross-sectional analysis of the longitudinal study of adult health (ELSA-Brasil). PLoS ONE 10(5):e0126469","journal-title":"PLoS ONE"},{"issue":"7","key":"1594_CR19","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7):412\u2013419","journal-title":"Diabetologia"},{"key":"1594_CR20","doi-asserted-by":"crossref","unstructured":"Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997). Diabetes Care 20:1183\u201397","DOI":"10.2337\/diacare.20.7.1183"},{"key":"1594_CR21","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.arr.2016.04.007","volume":"28","author":"K Perreault","year":"2016","unstructured":"Perreault K, Lagac\u00e9 J-C, Brochu M, Dionne IJ (2016) Association between fat free mass and glucose homeostasis: common knowledge revisited. Age Res Rev 28:46\u201361","journal-title":"Age Res Rev"},{"key":"1594_CR22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1515\/hmbci-2015-0041","volume":"26","author":"AS Deshmukh","year":"2016","unstructured":"Deshmukh AS (2016) Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle. Horm Mol Biol Clin Investig 26:13\u201324","journal-title":"Horm Mol Biol Clin Investig"},{"key":"1594_CR23","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/oby.2008.23","volume":"16","author":"M Brochu","year":"2008","unstructured":"Brochu M, Mathieu ME, Karelis AD, Doucet E, Lavoie ME, Garrel D, Rabasa-Lhoret R (2008) Contribution of the lean body mass to insulin resistance in postmenopausal women with visceral obesity: a Monet study. Obesity 16:1085\u20131093","journal-title":"Obesity"},{"key":"1594_CR24","first-page":"116","volume":"12","author":"J Lebon","year":"2012","unstructured":"Lebon J, Aubertin-Leheudre M, Bobeuf F, Lord C, Labonte M, Dionne IJ (2012) Is a small muscle mass index really detrimental for insulin sensitivity in postmenopausal women of various body composition status? J Musculoskelet Neuronal Interact 12:116\u2013126","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"1594_CR25","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1016\/j.metabol.2012.02.004","volume":"61","author":"KB Comerford","year":"2012","unstructured":"Comerford KB, Almario RU, Kim K, Karakas SE (2012) Lean mass and insulin resistance in women with polycystic ovary syndrome. Metabolism 61:1256\u20131260","journal-title":"Metabolism"},{"key":"1594_CR26","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.2337\/diacare.27.9.2204","volume":"27","author":"D Tripathy","year":"2004","unstructured":"Tripathy D, Almgren P, Tuomi T, Groop L (2004) Contribution of insulin-stimulated glucose uptake and basal hepatic insulin sensitivity to surrogate measures of insulin sensitivity. Diab Care 27:2204\u20132210","journal-title":"Diab Care"},{"issue":"1","key":"1594_CR27","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1055\/s-2002-23506","volume":"2","author":"MG Clark","year":"2002","unstructured":"Clark MG, Barrett EJ, Wallis MG, Vincent MA, Rattigan S (2002) The microvasculature in insulin resistance and type 2 diabetes. Semin Vasc Med 2(1):21\u201331","journal-title":"Semin Vasc Med"},{"issue":"3","key":"1594_CR28","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1152\/jappl.1987.62.3.1285","volume":"62","author":"RB Armstrong","year":"1987","unstructured":"Armstrong RB, Delp MD, Goljan EF, Laughlin MH (1987) Distribution of blood flow in muscles of miniature swine during exercise. J Appl Physiol 62(3):1285\u20131298","journal-title":"J Appl Physiol"},{"issue":"6","key":"1594_CR29","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1172\/JCI115254","volume":"87","author":"BB Kahn","year":"1991","unstructured":"Kahn BB, Rossetti L, Lodish HF, Charron MJ (1991) Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats. J Clin Invest 87(6):2197\u20132206","journal-title":"J Clin Invest"},{"key":"1594_CR30","doi-asserted-by":"publisher","first-page":"E1191","DOI":"10.1152\/ajpendo.00416.2001","volume":"282","author":"CJ Tanner","year":"2002","unstructured":"Tanner CJ, Barakat HA, Dohm GL, Pories WJ, MacDonald KG, Cunningham PR et al (2002) Muscle fiber type is associated with obesity and weight loss. Am J Physiol Endocrinol Metab 282:E1191\u2013E1196","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"51","key":"1594_CR31","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1301\/nr.2003.may.157-167","volume":"61","author":"K Kamel Hosam","year":"2003","unstructured":"Kamel Hosam K (2003) Sarcopenia and aging. Nutr Rev 61(51):157\u2013167","journal-title":"Nutr Rev"},{"issue":"4","key":"1594_CR32","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1210\/jc.2006-2360","volume":"92","author":"H Storgaard","year":"2007","unstructured":"Storgaard H, Masbad S, Richter EA, Vaag AA (2007) Altered skeletal muscle fiber composition and size precede whole-body insulin resistance in young men with low birth weight. J Clin Endocrinol Metab 92(4):1530\u20131534","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"1594_CR33","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1590\/0001-3765201520140225","volume":"87","author":"RO Alvim","year":"2015","unstructured":"Alvim RO, Cheuhen MR, Machado SR, Sousa AG, Santos PC (2015) General aspects of muscle glucose uptake. An Acad Bras Cienc 87(1):351\u2013368","journal-title":"An Acad Bras Cienc"},{"issue":"4","key":"1594_CR34","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1152\/jappl.1986.60.4.1327","volume":"60","author":"HC Lukaski","year":"1986","unstructured":"Lukaski HC, Bolonchuk WW, Hall CB, Siders WA (1986) Validation of tetrapolar bioelectrical impedance method to assess human body composition. J Appl Physiol 60(4):1327\u20131332","journal-title":"J Appl Physiol"},{"key":"1594_CR35","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1159\/000499607","volume":"12","author":"B Jensen","year":"2019","unstructured":"Jensen B, Braun W, Geisler C, Both M, Kl\u00fcckmann K, M\u00fcller MJ, Bosy-Westphal A (2019) Limitations of fat-free mass for the assessment of muscle mass in obesity. Obes Facts 12:307\u2013315","journal-title":"Obes Facts"},{"issue":"5","key":"1594_CR36","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.clnu.2008.07.010","volume":"27","author":"P Ritz","year":"2008","unstructured":"Ritz P, Vol S, Berrut G, Tack I, Arnaud MJ, Tichet J (2008) Influence of gender and body composition on hydration and body water spaces. Clin Nutr 27(5):740\u2013746","journal-title":"Clin Nutr"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-020-01594-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00592-020-01594-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-020-01594-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T13:19:52Z","timestamp":1696598392000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00592-020-01594-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,28]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["1594"],"URL":"https:\/\/doi.org\/10.1007\/s00592-020-01594-6","relation":{},"ISSN":["0940-5429","1432-5233"],"issn-type":[{"value":"0940-5429","type":"print"},{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,28]]},"assertion":[{"value":"18 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval was obtained from the Ethics Committee of the six affiliated institutions. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standard statement"}},{"value":"Informed written consent was obtained from all volunteers.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}