{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T23:08:43Z","timestamp":1771542523401,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Department of Science and Technology (DECIT), Health Ministry"},{"DOI":"10.13039\/501100008783","name":"National Research Council of Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008783","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Agency for Funding of Studies and Projects","award":["01080606\/01"],"award-info":[{"award-number":["01080606\/01"]}]},{"DOI":"10.13039\/501100003810","name":"Hospital de Cl\u00ednicas de Porto Alegre","doi-asserted-by":"publisher","award":["GPPG: 08-621"],"award-info":[{"award-number":["GPPG: 08-621"]}],"id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s00592-020-01611-8","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T03:39:27Z","timestamp":1602560367000},"page":"215-220","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effectiveness of chlorthalidone\/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial"],"prefix":"10.1007","volume":"58","clinical-trial-number":[{"clinical-trial-number":"nct00971165","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Fl\u00e1vio D.","family":"Fuchs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz C. N.","family":"Scala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 F.","family":"Vilela-Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul K.","family":"Whelton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.","family":"Poli-de-Figueiredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Pereira E Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Gus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz A.","family":"Bortolotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda M.","family":"Consolim-Colombo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosane P.","family":"Schlatter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 E.","family":"Cesarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iran","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Figueiredo Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilton","family":"Chaves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 A.","family":"Steffens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o G.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9a A.","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos R.","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo C.","family":"Jardim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila B.","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto S.","family":"Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco M.","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abrah\u00e3o","family":"Afiune Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe C.","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario C.","family":"Sobral Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f4nio C.","family":"N\u00f3brega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Nobre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ot\u00e1vio","family":"Berwanger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6351-9588","authenticated-orcid":false,"given":"Sandra C.","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"1611_CR1","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","volume":"39","author":"B Williams","year":"2018","unstructured":"Williams B, Mancia G, Spieng W et al (2018) ESC scientific document group. 2018 ESC\/ESH guidelines for the management of arterial hypertension. Eur Heart J 39:3021\u20133104. https:\/\/doi.org\/10.1093\/eurheartj\/ehy339","journal-title":"Eur Heart J"},{"key":"1611_CR2","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1097\/HJH.0000000000001276","volume":"35","author":"C Thomopoulos","year":"2017","unstructured":"Thomopoulos C, Parati G, Zanchetti A (2017) Effects of blood-pressure-lowering treatment on outcome incidence in hypertension: 10 - Should blood pressure management differ in hypertensive patients with and without diabetes mellitus? Overview and meta-analyses of randomized trials. J Hypertens 35:922\u2013944. https:\/\/doi.org\/10.1097\/HJH.0000000000001276","journal-title":"J Hypertens"},{"key":"1611_CR3","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1161\/HYP.0000000000000065","volume":"71","author":"PK Whelton","year":"2018","unstructured":"Whelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, Dennison-Himmelfarb C et al (2018) 2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American college of cardiology\/American heart association task force on clinical practice guidelines. Hypertension 71:e13\u2013e115. https:\/\/doi.org\/10.1161\/HYP.0000000000000065","journal-title":"Hypertension"},{"key":"1611_CR4","doi-asserted-by":"publisher","first-page":"e000236","DOI":"10.1136\/openhrt-2014-000236","volume":"2","author":"FD Fuchs","year":"2015","unstructured":"Fuchs FD, DiNicolantonio JJ (2015) Angiotensin receptor blockers for prevention of cardiovascular disease: where does the evidence stand? Open Heart 2:e000236. https:\/\/doi.org\/10.1136\/openhrt-2014-000236","journal-title":"Open Heart"},{"key":"1611_CR5","doi-asserted-by":"publisher","first-page":"d2234","DOI":"10.1136\/bmj.d2234","volume":"342","author":"S Bangalore","year":"2011","unstructured":"Bangalore S, Kumar S, Wetterslev J, Messerli FH (2011) Angiotensin receptor blockers and risk of myocardial infarction: meta-analyses and trial sequential analyses of 147 020 patients from randomised trials. BMJ 342:d2234. https:\/\/doi.org\/10.1136\/bmj.d2234","journal-title":"BMJ"},{"key":"1611_CR6","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1093\/eurheartj\/ehs075","volume":"33","author":"LC van Vark","year":"2012","unstructured":"van Vark LC, Bertrand M, Akkerhuis KM, Brugts JJ, Fox K, Mourad JJ et al (2012) Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomized clinical trials of renin-angiotensin-aldosterone system inhibitors involving 158 998 patients. Eur Heart J 33:2088\u20132097. https:\/\/doi.org\/10.1093\/eurheartj\/ehs075","journal-title":"Eur Heart J"},{"key":"1611_CR7","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1001\/jamainternmed.2014.348","volume":"174","author":"J Cheng","year":"2014","unstructured":"Cheng J, Zhang W, Zhang X, Han F, Li X, He X et al (2014) Effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on all-cause mortality, cardiovascular deaths, and cardiovascular events in patients with diabetes mellitus: a meta-analysis. JAMA Intern Med 174:773\u2013785. https:\/\/doi.org\/10.1001\/jamainternmed.2014.348","journal-title":"JAMA Intern Med"},{"key":"1611_CR8","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1097\/HJH.0000000000000837","volume":"34","author":"FD Fuchs","year":"2016","unstructured":"Fuchs FD, Scala LC, Vilela-Martin JF, Bandeira-de-Mello R, Mosele F, Whelton PK et al (2016) Effectiveness of chlorthalidone\/amiloride versus losartan in patients with stage I hypertension: results from the PREVER-Treatment randomized trial. J Hypertens 34:798\u2013806. https:\/\/doi.org\/10.1097\/HJH.0000000000000837","journal-title":"J Hypertens"},{"key":"1611_CR9","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/1745-6215-12-53","volume":"12","author":"FD Fuchs","year":"2011","unstructured":"Fuchs FD, Fuchs SC, Moreira LB, Gus M, N\u00f3brega AC, Poli-de-Figueiredo CE et al (2011) A comparison between diuretics and angiotensin-receptor blocker agents in patients with stage I hypertension (PREVER-Treatment trial): study protocol for a randomized double-blind controlled trial. Trials 12:53. https:\/\/doi.org\/10.1186\/1745-6215-12-53","journal-title":"Trials"},{"key":"1611_CR10","doi-asserted-by":"publisher","first-page":"b1665","DOI":"10.1136\/bmj.b1665","volume":"338","author":"MR Law","year":"2009","unstructured":"Law MR, Morris JK, Wald NJ (2009) Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ 338:b1665. https:\/\/doi.org\/10.1136\/bmj.b1665","journal-title":"BMJ"},{"key":"1611_CR11","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1080\/14779072.2020.1750369","volume":"8","author":"LG Bottino","year":"2020","unstructured":"Bottino LG, Fuchs FD (2020) The role of angiotensin receptor blockers in CVD risk management. Expert Rev Cardiovasc Ther 8:181\u2013185. https:\/\/doi.org\/10.1080\/14779072.2020.1750369","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"1611_CR12","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1161\/HYPERTENSIONAHA.119.14240","volume":"75","author":"FD Fuchs","year":"2020","unstructured":"Fuchs FD, Whelton PK (2020) High Blood Pressure and Cardiovascular Disease. Hypertension 75:285\u2013292. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.119.14240","journal-title":"Hypertension"},{"key":"1611_CR13","volume-title":"Essentials of Hypertension","year":"2018","unstructured":"Fuchs FD (ed) (2018) Essentials of Hypertension. Springer, Cham"},{"key":"1611_CR14","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1056\/NEJMoa011489","volume":"345","author":"HH Parving","year":"2001","unstructured":"Parving HH, Lehnert H, Brochner-Mortensen J, Gomis R, Andersen S, Arner P (2001) The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 345:870\u2013878. https:\/\/doi.org\/10.1056\/NEJMoa011489","journal-title":"N Engl J Med"},{"issue":"12","key":"1611_CR15","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1056\/NEJMoa011161","volume":"345","author":"BM Brenner","year":"2001","unstructured":"Brenner BM, Cooper ME, Zeeuw D, Keane WF, Mitch WE, Parving HH et al (2001) Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Eng J Med 345(12):861\u2013869. https:\/\/doi.org\/10.1056\/NEJMoa011161","journal-title":"N Eng J Med"}],"updated-by":[{"DOI":"10.1007\/s00592-021-01689-8","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000}}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-020-01611-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00592-020-01611-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-020-01611-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T09:20:01Z","timestamp":1634116801000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00592-020-01611-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,13]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["1611"],"URL":"https:\/\/doi.org\/10.1007\/s00592-020-01611-8","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00592-021-01689-8","asserted-by":"object"}]},"ISSN":["0940-5429","1432-5233"],"issn-type":[{"value":"0940-5429","type":"print"},{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,13]]},"assertion":[{"value":"3 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00592-021-01689-8","URL":"https:\/\/doi.org\/10.1007\/s00592-021-01689-8","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Ethics Committee of the Hospital de Clinicas de Porto Alegre (GPPG 08-621), which is accredited by the Office of Human Research Protections as an Institutional Review Board, and by the ethics committee at each medical center. The PREVER-Treatment trial was conducted in 21 academic medical centers in Brazil, and was approved by the Research Ethics Board of each participant institution.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Eligible participants were enrolled in the trial and gave written informed consent prior to their inclusion in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}