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We categorized patients into four groups: T1D only (<jats:italic>n\u2009<\/jats:italic>=\u200973,699), T1\u2009+\u2009CD (<jats:italic>n\u2009<\/jats:italic>=\u20093379), T1D\u2009+\u2009depression (<jats:italic>n\u2009<\/jats:italic>=\u20091877), or T1D\u2009+\u2009CD\u2009+\u2009depression (<jats:italic>n\u2009<\/jats:italic>=\u2009112).\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>CD and depression were significantly associated (adjusted OR: 1.25 [1.03\u20131.53]). Females were more frequent in both the depression and the CD group compared with the T1D only group. Insulin pumps were used more frequently in T1D\u2009+\u2009CD and T1D\u2009+\u2009depression compared with T1D only (both <jats:italic>p\u2009<\/jats:italic>&lt;\u2009.001). HbA1c was higher in T1D\u2009+\u2009depression (9.0% [8.9\u20139.0]), T1D\u2009+\u2009CD\u2009+\u2009depression (8.9% [8.6\u20139.2]), both compared with T1D only (8.2% [8.2\u20138.2], all <jats:italic>p\u2009<\/jats:italic>&lt;\u2009.001). We found comorbid autism, attention deficit hyperactivity disorder, anxiety, schizophrenia, and eating disorders more frequently in the T1D\u2009+\u2009CD\u2009+\u2009depression group compared with T1D only (all <jats:italic>p\u2009<\/jats:italic>&lt;\u2009.001).\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>CD and depression are associated in young T1D patients. The double load of T1D and CD may lead to an increased risk for depression. Depression was associated with additional psychological and neurological comorbidities. Aside from imperative CD screening after T1D diagnosis and regular intervals, depression screening might be helpful in routine care, especially in patients with diagnosed CD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00592-020-01649-8","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T03:02:52Z","timestamp":1611370972000},"page":"623-631","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry"],"prefix":"10.1007","volume":"58","author":[{"name":"For the DPV Initiative","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7913-6135","authenticated-orcid":false,"given":"Sascha Ren\u00e9","family":"Tittel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9sir\u00e9e","family":"Dunstheimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f6rte","family":"Hilgard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhild","family":"Knauth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Fr\u00f6hlich-Reiterer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Galler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wurm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard Walter","family":"Holl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,23]]},"reference":[{"key":"1649_CR1","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1097\/MPG.0000000000002497","volume":"70","author":"S Husby","year":"2020","unstructured":"Husby S, Koletzko S, Korponay-Szab\u00f3 I et al (2020) European society paediatric gastroenterology, hepatology and nutrition guidelines for diagnosing coeliac disease 2020. 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The protocol of DPV was approved by the ethics committee of Ulm University (approval no. 202\/09), and data collection was approved by local review board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Statement"}},{"value":"All patients being enrolled into this registry provided written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}