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One-step plasma glucose (PG) evaluation procedure was performed to assess gestational diabetes mellitus (GDM) and diabetes mellitus (DM) in pregnancy as defined by the World Health Organization (WHO) criteria with International Association of Diabetes in Pregnancy Study Group (IADPSG) thresholds. The main outcome studied was large for gestational age neonates (LGA).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 2,709 participants were recruited with a mean age of 28\u00a0years (SD\u2009=\u20095.4) and a median gestational age (GA) of eight weeks (interquartile range [IQR]\u2009=\u20092). The prevalence of GDM in first trimester (T1) was 15.0% (95% confidence interval [CI]\u2009=\u200913.7\u201316.4). Previously undiagnosed DM was detected among 2.5% of the participants. Out of 2,285 live births with a median delivery GA of 38\u00a0weeks (IQR\u2009=\u20093), 7.0% were LGA neonates. The cumulative incidence of LGA neonates in women with GDM and DM was 11.1 and 15.5 per 100 women, respectively. The relative risk of having an LGA neonate among women with DM and GDM was 2.30 (95% CI\u2009=\u20091.23\u20134.28) and 1.80 (95% CI\u2009=\u20091.27\u20132.53), respectively. The attributable risk percentage of a LGA neonate for hyperglycaemia was 15.01%. T1 fasting\u00a0PG was significantly correlated with both neonatal birth weight and birth weight centile.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The proposed WHO criteria for hyperglycaemia in pregnancy are valid, even in T1, for predicting LGA neonates. The use of IADPSG threshold for Fasting\u00a0PG, for risk assessment in early pregnancy in high-risk populations is recommended.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00592-021-01828-1","type":"journal-article","created":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T07:16:29Z","timestamp":1641021389000},"page":"535-543","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Early pregnancy hyperglycaemia as a significant predictor of large for gestational age neonates"],"prefix":"10.1007","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2251-0998","authenticated-orcid":false,"given":"Imasha Upulini","family":"Jayasinghe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5479-8554","authenticated-orcid":false,"given":"Iresha Sandamali","family":"Koralegedara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7810-1774","authenticated-orcid":false,"given":"Suneth Buddhika","family":"Agampodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,1]]},"reference":[{"key":"1828_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/fendo.2018.00696","volume":"9","author":"EA Huhn","year":"2018","unstructured":"Huhn EA, Rossi SW, Hoesli I, G\u00f6bl CS (2018) Controversies in Screening and Diagnostic Criteria for Gestational Diabetes in Early and Late Pregnancy. 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