{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:05:57Z","timestamp":1763535957892,"version":"3.37.3"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s00592-022-01879-y","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T14:47:26Z","timestamp":1648219646000},"page":"843-850","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic significance of reverse dipping status on lower limb event in type 2 diabetic patients without peripheral arterial disease"],"prefix":"10.1007","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3091-6119","authenticated-orcid":false,"given":"Pascal","family":"Delsart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madleen","family":"Lemaitre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Vambergue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Ninni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Bauters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Ledieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane-Flore","family":"Eymard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Baudoux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agathe","family":"Le Chevalier De Preville","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Sobocinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2346-863X","authenticated-orcid":false,"given":"David","family":"Montaigne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Mounier-Vehier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"1879_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108072","author":"R Williams","year":"2020","unstructured":"Williams R, Karuranga S, Malanda B et al (2020) Global and regional estimates and projections of diabetes related health expenditure: results from the international diabetes federation diabetes atlas. Diabetes Res Clin Pract. https:\/\/doi.org\/10.1016\/j.diabres.2020.108072","journal-title":"Diabetes Res Clin Pract"},{"issue":"18","key":"1879_CR2","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1177\/2047487317736824","volume":"24","author":"LC Soriano","year":"2017","unstructured":"Soriano LC, Gerry F, Fowkes R, Johansson S, Allum AM, Rodriguez LAG (2017) Cardiovascular outcomes for patients with symptomatic peripheral artery disease: a cohort study in the health improvement network (THIN) in the UK. Eur J Prev Cardiol 24(18):1927\u20131937. https:\/\/doi.org\/10.1177\/2047487317736824","journal-title":"Eur J Prev Cardiol"},{"issue":"5","key":"1879_CR3","doi-asserted-by":"publisher","first-page":"894","DOI":"10.2337\/diacare.25.5.894","volume":"25","author":"AI Adler","year":"2002","unstructured":"Adler AI, Stevens RJ, Neil A, Stratton IM, Boulton AJIM, Holman RR (2002) UKPDS 59: hyperglycemia and other potentially modifiable risk factors for peripheral vascular disease in type 2 diabetes. Diabetes Care 25(5):894\u2013899. https:\/\/doi.org\/10.2337\/diacare.25.5.894","journal-title":"Diabetes Care"},{"issue":"10","key":"1879_CR4","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.2337\/dc16-0588","volume":"39","author":"K Mohammedi","year":"2016","unstructured":"Mohammedi K, Woodward M, Hirakawa Y et al (2016) Microvascular and macrovascular disease and risk for major peripheral arterial disease in patients with type 2 diabetes. Diabetes Care 39(10):1796\u20131803. https:\/\/doi.org\/10.2337\/dc16-0588","journal-title":"Diabetes Care"},{"key":"1879_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01249-y","author":"CRL Cardoso","year":"2021","unstructured":"Cardoso CRL, Melo JV, Santos TRM, Leite NC, Salles GF (2021) Traditional and non-traditional risk factors for peripheral artery disease development\/progression in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study. Cardiovasc Diabetol. https:\/\/doi.org\/10.1186\/s12933-021-01249-y","journal-title":"Cardiovasc Diabetol"},{"key":"1879_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4835-z","author":"L Potier","year":"2019","unstructured":"Potier L, Roussel R, Velho G et al (2019) Lower limb events in individuals with type 2 diabetes: evidence for an increased risk associated with diuretic use. Diabetologia. https:\/\/doi.org\/10.1007\/s00125-019-4835-z","journal-title":"Diabetologia"},{"key":"1879_CR7","doi-asserted-by":"publisher","DOI":"10.1002\/pds.932","author":"JA Erkens","year":"2004","unstructured":"Erkens JA, Klungel OH, Stolk RP, Spoelstra JA, Grobbee DE, Leufkens HG (2004) Antihypertensive drug therapy and the risk of lower extremity amputations in pharmacologically treated type 2 diabetes patients. Pharmacoepidemiol Drug Saf. https:\/\/doi.org\/10.1002\/pds.932","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"1879_CR8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.033348","author":"NK Itoga","year":"2018","unstructured":"Itoga NK, Tawfik DS, Lee CK, Maruyama S, Leeper NJ, Chang TI (2018) Association of blood pressure measurements with peripheral artery disease events. Circulation. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.033348","journal-title":"Circulation"},{"key":"1879_CR9","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.133900","author":"TW Hansen","year":"2011","unstructured":"Hansen TW, Li Y, Boggia J, Thijs L, Richart T, Staessen JA (2011) Predictive role of the nighttime blood pressure. Hypertension. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.109.133900","journal-title":"Hypertension"},{"key":"1879_CR10","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13023","author":"C Cuspidi","year":"2017","unstructured":"Cuspidi C, Sala C, Tadic M et al (2017) Clinical and prognostic significance of a reverse dipping pattern on ambulatory monitoring: an updated review. J Clin Hypertens. https:\/\/doi.org\/10.1111\/jch.13023","journal-title":"J Clin Hypertens"},{"key":"1879_CR11","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey103","author":"M Sprynger","year":"2018","unstructured":"Sprynger M, Rigo F, Moonen M et al (2018) Focus on echovascular imaging assessment of arterial disease: complement to the ESC guidelines (PARTIM 1) in collaboration with the working group on aorta and peripheral vascular diseases. Eur Heart J Cardiovasc Imaging. https:\/\/doi.org\/10.1093\/ehjci\/jey103","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"1879_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2016.06.096","author":"MD Humphries","year":"2016","unstructured":"Humphries MD, Brunson A, Li CS, Melnikow J, Romano PS (2016) Amputation trends for patients with lower extremity ulcers due to diabetes and peripheral artery disease using statewide data. J Vasc Surg. https:\/\/doi.org\/10.1016\/j.jvs.2016.06.096","journal-title":"J Vasc Surg"},{"key":"1879_CR13","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa956","author":"SK Paul","year":"2016","unstructured":"Paul SK, Bhatt DL, Montvida O (2016) The association of amputations and peripheral artery disease in patients with type 2 diabetes mellitus receiving sodium-glucose cotransporter type-2 inhibitors: real-world study. Eur Heart J. https:\/\/doi.org\/10.1093\/eurheartj\/ehaa956","journal-title":"Eur Heart J"},{"key":"1879_CR14","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010456","author":"D Su","year":"2016","unstructured":"Su D, Guo Q, Gao Y et al (2016) The relationship between red blood cell distribution width and blood pressure abnormal dipping in patients with essential hypertension: a cross-sectional study. BMJ Open. https:\/\/doi.org\/10.1136\/bmjopen-2015-010456","journal-title":"BMJ Open"},{"key":"1879_CR15","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.701489","author":"DE Ayala","year":"2013","unstructured":"Ayala DE, Moy\u00e1 A, Crespo JJ et al (2013) Circadian pattern of ambulatory blood pressure in hypertensive patients with and without type 2 diabetes. Chronobiol Int. https:\/\/doi.org\/10.3109\/07420528.2012.701489","journal-title":"Chronobiol Int"},{"key":"1879_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.294","author":"K Eguchi","year":"2009","unstructured":"Eguchi K, Ishikawa J, Hoshide S et al (2009) Night time blood pressure variability is a strong predictor for cardiovascular events in patients with type 2 diabetes. Am J Hypertens. https:\/\/doi.org\/10.1038\/ajh.2008.294","journal-title":"Am J Hypertens"},{"key":"1879_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2008.05.005","author":"B Bouhanick","year":"2008","unstructured":"Bouhanick B, Bongard V, Amar J, Bousquel S, Chamontin B (2008) Prognostic value of nocturnal blood pressure and reverse-dipping status on the occurrence of cardiovascular events in hypertensive diabetic patients. Diabetes Metab. https:\/\/doi.org\/10.1016\/j.diabet.2008.05.005","journal-title":"Diabetes Metab"},{"key":"1879_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30183-3","author":"K Matsushita","year":"2017","unstructured":"Matsushita K, Ballew SH, Coresh J, Arima H, \u00c4rnl\u00f6v J, Cirillo M et al (2017) Chronic kidney disease prognosis consortium measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data. Lancet Diabetes Endocrinol. https:\/\/doi.org\/10.1016\/S2213-8587(17)30183-3","journal-title":"Lancet Diabetes Endocrinol"},{"key":"1879_CR19","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-011166","author":"J Han","year":"2016","unstructured":"Han J, Gao Y, Guo Q et al (2016) Cross-sectional study on the relationship between the level of serum cystatin C and blood pressure reverse dipping in hypertensive patients. BMJ Open. https:\/\/doi.org\/10.1136\/bmjopen-2016-011166","journal-title":"BMJ Open"},{"key":"1879_CR20","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.100.15.1635","author":"T Uzu","year":"1999","unstructured":"Uzu T, Kimura G (1999) Diuretics shift circadian rhythm of blood pressure from nondipper to dipper in essential hypertension. Circulation. https:\/\/doi.org\/10.1161\/01.cir.100.15.1635","journal-title":"Circulation"},{"key":"1879_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1239","author":"V Spallone","year":"2011","unstructured":"Spallone V, Ziegler D, Freeman R et al (2011) Toronto consensus panel on diabetic neuropathy. Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management. Diabetes Metab Res Rev. https:\/\/doi.org\/10.1002\/dmrr.1239","journal-title":"Diabetes Metab Res Rev"},{"key":"1879_CR22","doi-asserted-by":"publisher","DOI":"10.2337\/diab.42.12.1745","author":"V Spallone","year":"1993","unstructured":"Spallone V, Bernardi L, Ricordi L et al (1993) Relationship between the circadian rhythms of blood pressure and sympathovagal balance in diabetic autonomic neuropathy. Diabetes. https:\/\/doi.org\/10.2337\/diab.42.12.1745","journal-title":"Diabetes"},{"key":"1879_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8091367","author":"C Cuspidi","year":"2019","unstructured":"Cuspidi C, Tadic M, Sala C, Gherbesi E, Grassi G, Mancia G (2019) Blood pressure non-dipping and obstructive sleep apnea syndrome: a meta-analysis. J Clin Med. https:\/\/doi.org\/10.3390\/jcm8091367","journal-title":"J Clin Med"},{"key":"1879_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/s0895-7061(02)03262-4","author":"AG Marinakis","year":"2003","unstructured":"Marinakis AG, Vyssoulis GP, Michaelides AP, Karpanou EA, Cokkinos DV, Toutouzas PK (2003) Impact of abnormal nocturnal blood pressure fall on vascular function. Am J Hypertens. https:\/\/doi.org\/10.1016\/s0895-7061(02)03262-4","journal-title":"Am J Hypertens"},{"key":"1879_CR25","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0764","author":"JI Shin","year":"2019","unstructured":"Shin JI, Grams ME, Coresh J, Chang AR, Matsushita K (2019) Proteinuria and risk of lower-extremity amputation in patients with peripheral artery disease. Diabetes Care. https:\/\/doi.org\/10.2337\/dc19-0764","journal-title":"Diabetes Care"},{"key":"1879_CR26","doi-asserted-by":"publisher","DOI":"10.1002\/path.3964","author":"AH Salmon","year":"2012","unstructured":"Salmon AH, Satchell SC (2012) Endothelial glycocalyx dysfunction in disease: albuminuria and increased microvascular permeability. J Pathol. https:\/\/doi.org\/10.1002\/path.3964","journal-title":"J Pathol"},{"key":"1879_CR27","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328010918b","author":"ML Marcovecchio","year":"2006","unstructured":"Marcovecchio ML, Patricelli L, Zito M et al (2006) Ambulatory blood pressure monitoring in obese children: role of insulin resistance. J Hypertens. https:\/\/doi.org\/10.1097\/HJH.0b013e328010918b","journal-title":"J Hypertens"},{"key":"1879_CR28","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00141","author":"A Di Pino","year":"2019","unstructured":"Di Pino A, DeFronzo RA (2019) Insulin resistance and atherosclerosis: implications for insulin-sensitizing agents. Endocr Rev. https:\/\/doi.org\/10.1210\/er.2018-00141","journal-title":"Endocr Rev"},{"key":"1879_CR29","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03958","author":"NB Rossen","year":"2014","unstructured":"Rossen NB, Knudsen ST, Fleischer J et al (2014) Targeting nocturnal hypertension in type 2 diabetes mellitus. Hypertension. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.114.03958","journal-title":"Hypertension"},{"key":"1879_CR30","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz754","author":"RC Hermida","year":"2020","unstructured":"Hermida RC, Crespo JJ, Dom\u00ednguez-Sardi\u00f1a M et al (2020) Hygia project investigators bedtime hypertension treatment improves cardiovascular risk reduction: the hygia chronotherapy trial. Eur Heart J. https:\/\/doi.org\/10.1093\/eurheartj\/ehz754 (PMID: 31641769)","journal-title":"Eur Heart J"},{"key":"1879_CR31","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313543","author":"D Montaigne","year":"2018","unstructured":"Montaigne D, Staels B (2018) Time to check the clock in cardiovascular research and medicine. Circ Res. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.313543","journal-title":"Circ Res"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-022-01879-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00592-022-01879-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-022-01879-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T03:47:05Z","timestamp":1652154425000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00592-022-01879-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,25]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["1879"],"URL":"https:\/\/doi.org\/10.1007\/s00592-022-01879-y","relation":{},"ISSN":["1432-5233"],"issn-type":[{"type":"electronic","value":"1432-5233"}],"subject":[],"published":{"date-parts":[[2022,3,25]]},"assertion":[{"value":"20 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted according to the guidelines of the declaration oh Helsinski. The present study was approved by the French national data protection commission (Commission Nationale de l\u2019Informatique et des Libert\u00e9s; reference: DEC 2015-9).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Each patient received a verbal explanation and an inform consent of the study\u2019s objectives and a written information about the right to withdraw permission for the subsequent use of his or her personal data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}