{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:53:22Z","timestamp":1793393602863,"version":"4.5.0"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"DOI":"10.1007\/s00592-022-01929-5","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T09:06:12Z","timestamp":1661159172000},"page":"151-161","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Automated insulin delivery systems: from early research to routine care of type 1 diabetes"],"prefix":"10.1007","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-7263","authenticated-orcid":false,"given":"Eric","family":"Renard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,22]]},"reference":[{"key":"1929_CR1","doi-asserted-by":"crossref","unstructured":"The Diabetes Control and Complications Trial Research Group (DCCT). The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993; 329:977\u2013986","DOI":"10.1056\/NEJM199309303291401"},{"key":"1929_CR2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2337\/dc13-2112","volume":"37","author":"Nathan DM and for the DCCT\/EDIC Research Group","year":"2014","unstructured":"Nathan DM and for the DCCT\/EDIC Research Group (2014) The diabetes control and complications trial\/epidemiology of diabetes interventions and complications study at 30 years: overview. Diabetes Care 37:9\u201316","journal-title":"Diabetes Care"},{"key":"1929_CR3","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/0002-9343(91)90605-W","volume":"90","author":"The DCCT Research Group","year":"1991","unstructured":"The DCCT Research Group (1991) Epidemiology of severe hypoglycemia in the diabetes control and complications trial. Am J Med 90:450\u2013459","journal-title":"Am J Med"},{"key":"1929_CR4","doi-asserted-by":"publisher","first-page":"830","DOI":"10.2337\/dc15-2623","volume":"39","author":"Y Ruan","year":"2016","unstructured":"Ruan Y, Thabit H, Leelarathna L, Hartnell S, Willinska ME, Dellweg S et al (2016) Variability of insulin requirements over 12 weeks of closed-loop insulin delivery in adults with type 1 diabetes. Diabetes Care 39:830\u2013832","journal-title":"Diabetes Care"},{"key":"1929_CR5","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1089\/dia.2018.0384","volume":"21","author":"NC Foster","year":"2019","unstructured":"Foster NC, Beck RW, Miller KM, Clements MA, Rickels MR, DiMeglio LA et al (2019) State of type 1 diabetes management and outcomes from the T1D exchange in 2016\u20132018. Diabetes Technol Ther 21:66\u201372","journal-title":"Diabetes Technol Ther"},{"key":"1929_CR6","doi-asserted-by":"publisher","first-page":"e3430","DOI":"10.1002\/dmrr.3430","volume":"37","author":"E Renard","year":"2021","unstructured":"Renard E, Ikegami H, Daher Vianna AG, Pozzilli P, Brette S, Bosnyak Z et al (2021) The SAGE study: global observational analysis of glycaemic control, hypoglycaemia and diabetes management in T1DM. Diabetes Metab Res Rev 37:e3430","journal-title":"Diabetes Metab Res Rev"},{"key":"1929_CR7","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.2337\/db11-0654","volume":"60","author":"C Cobelli","year":"2011","unstructured":"Cobelli C, Renard E, Kovatchev B (2011) Artificial pancreas: past, present, future. Diabetes 60:2672\u20132682","journal-title":"Diabetes"},{"key":"1929_CR8","doi-asserted-by":"publisher","first-page":"389","DOI":"10.2337\/diab.23.5.389","volume":"23","author":"AM Albisser","year":"1974","unstructured":"Albisser AM, Leibel BS, Ewart TG, Davidovac Z, Botz CK, Zingg W (1974) An artificial endocrine pancreas. Diabetes 23:389\u2013396","journal-title":"Diabetes"},{"key":"1929_CR9","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/BF01219712","volume":"13","author":"J Mirouze","year":"1977","unstructured":"Mirouze J, Selam JL, Pham TC, Cavadore D (1977) Evaluation of exogenous insulin homeostasis by the artificial pancreas in insulin-dependent diabetes. Diabetologia 13:273\u2013278","journal-title":"Diabetologia"},{"issue":"Suppl","key":"1929_CR10","first-page":"247","volume":"2","author":"M Shichiri","year":"1978","unstructured":"Shichiri M, Kawamori R, Yamasaki Y, Inoue M, Shigeta Y, Abe H (1978) Computer algorithm for the artificial pancreatic beta cell. Artif Organs 2(Suppl):247\u2013250","journal-title":"Artif Organs"},{"key":"1929_CR11","unstructured":"Clemens AH, Chang PH, Myers RW. The development of Biostator, a glucose-controlled insulin infusion system (GCIIS). Horm Metab Res. 1977; Supplement: 23\u201333"},{"issue":"Supplement 1","key":"1929_CR12","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1089\/15209150050214078","volume":"2","author":"J Mastrototaro","year":"2000","unstructured":"Mastrototaro J (2000) The minimed continuous glucose monitoring system. Diabetes Technol Ther 2(Supplement 1):S13\u2013S18","journal-title":"Diabetes Technol Ther"},{"key":"1929_CR13","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1177\/193229680900300106","volume":"3","author":"BP Kovatchev","year":"2009","unstructured":"Kovatchev BP, Breton MD, Dalla Man C, Cobelli C (2009) In silico preclinical trials: a proof of concept in closed-loop control of type 1 diabetes. J Diabetes Sci Technol 3:44\u201355","journal-title":"J Diabetes Sci Technol"},{"key":"1929_CR14","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/S1471-4892(02)00216-3","volume":"2","author":"E Renard","year":"2002","unstructured":"Renard E (2002) Implantable closed loop glucose-sensing and insulin delivery: the future for insulin pump therapy. Curr Opin Pharmacol 2:708\u2013716","journal-title":"Curr Opin Pharmacol"},{"key":"1929_CR15","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S1262-3636(06)72802-6","volume":"32","author":"E Renard","year":"2006","unstructured":"Renard E, Costalat G, Chevassus H, Bringer J (2006) Artificial beta cell: clinical experience toward an implantable closed-loop insulin delivery system. Diabetes Metab 32:497\u2013502","journal-title":"Diabetes Metab"},{"key":"1929_CR16","doi-asserted-by":"publisher","first-page":"121","DOI":"10.2337\/dc09-1080","volume":"33","author":"E Renard","year":"2010","unstructured":"Renard E, Place J, Cantwell M, Chevassus H, Palerm CC (2010) Closed-loop insulin delivery using a subcutaneous glucose sensor and intraperitoneal insulin delivery: feasibility study testing a new model for the artificial pancreas. Diabetes Care 33:121\u2013127","journal-title":"Diabetes Care"},{"key":"1929_CR17","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1089\/152091504774197990","volume":"6","author":"R Hovorka","year":"2004","unstructured":"Hovorka R, Chassin LJ, Wilinska ME, Canonico V, Akwi JA, Federici MO et al (2004) Closing the loop: the ADICOL experience. Diabetes Technol Ther 6:307\u2013318","journal-title":"Diabetes Technol Ther"},{"key":"1929_CR18","doi-asserted-by":"publisher","first-page":"3344","DOI":"10.2337\/db06-0419","volume":"55","author":"GM Steil","year":"2006","unstructured":"Steil GM, Rebrin K, Darwin C, Hariri F, Saad MF (2006) Feasibility of automating insulin delivery for the treatment of type 1 diabetes. Diabetes 55:3344\u20133350","journal-title":"Diabetes"},{"key":"1929_CR19","doi-asserted-by":"publisher","first-page":"934","DOI":"10.2337\/dc07-1967","volume":"31","author":"SA Weinzimer","year":"2008","unstructured":"Weinzimer SA, Steil GM, Swan KL, Dziura J, Kurtz N, Tamborlane WV (2008) Fully automated closed-loop insulin delivery versus semi-automated hybrid control in pediatric patients with type 1 diabetes using an artificial pancreas. Diabetes Care 31:934\u2013939","journal-title":"Diabetes Care"},{"key":"1929_CR20","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.2337\/dc13-2108","volume":"37","author":"FJ Doyle 3rd","year":"2014","unstructured":"Doyle FJ 3rd, Huyett LM, Lee JB, Zisser HC, Dassau E (2014) Closed-loop artificial pancreas systems: engineering the algorithms. Diabetes Care 37:1191\u20131197","journal-title":"Diabetes Care"},{"key":"1929_CR21","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/S0140-6736(09)61998-X","volume":"375","author":"R Hovorka","year":"2010","unstructured":"Hovorka R, Allen JM, Elleri D, Chassin LJ, Harris J, Xing D et al (2010) Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial. The Lancet 375:743\u2013751","journal-title":"The Lancet"},{"key":"1929_CR22","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1177\/193229681000400611","volume":"4","author":"B Kovatchev","year":"2010","unstructured":"Kovatchev B, Cobelli C, Renard E, Anderson S, Breton M, Patek S et al (2010) Multinational study of subcutaneous model-predictive closed-loop control in type 1 diabetes mellitus: summary of the results. J Diabetes Sci Technol 4:1374\u20131381","journal-title":"J Diabetes Sci Technol"},{"key":"1929_CR23","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.2337\/dc12-0071","volume":"35","author":"SJ Russell","year":"2012","unstructured":"Russell SJ, El-Khatib FH, Nathan DM, Magyar KL, Jiang J, Damiano ER (2012) Blood glucose control in type 1 diabetes with a bihormonal bionic endocrine pancreas. Diabetes Care 35:2148\u20132155","journal-title":"Diabetes Care"},{"key":"1929_CR24","doi-asserted-by":"publisher","first-page":"2986","DOI":"10.1109\/TBME.2012.2192930","volume":"29","author":"SD Patek","year":"2012","unstructured":"Patek SD, Magni L, Dassau E, Karvetski C, Toffanin C, De Nicolao G et al (2012) Modular closed-loop control of diabetes. IEEE Trans Biomedical Eng 29:2986\u20133000","journal-title":"IEEE Trans Biomedical Eng"},{"key":"1929_CR25","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.2337\/db11-1445","volume":"61","author":"M Breton","year":"2012","unstructured":"Breton M, Farret A, Bruttomesso D, Anderson S, Magni L, Patek S et al (2012) Fully integrated artificial pancreas in type 1 diabetes: modular closed-loop glucose control maintains near normoglycemia. Diabetes 61:2230\u20132237","journal-title":"Diabetes"},{"key":"1929_CR26","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1056\/NEJMoa1206881","volume":"368","author":"M Phillip","year":"2013","unstructured":"Phillip M, Battelino T, Atlas E, Kordonouri O, Bratina N, Miller S et al (2013) Nocturnal glucose control with an artificial pancreas at a diabetes camp. N Engl J Med 368:824\u2013833","journal-title":"N Engl J Med"},{"key":"1929_CR27","doi-asserted-by":"publisher","first-page":"3882","DOI":"10.2337\/dc12-1956","volume":"36","author":"YM Luijf","year":"2013","unstructured":"Luijf YM, Devries JH, Zwinderman K, Leelarathna L, Nodale M, Caldwell K et al (2013) Day and night closed-loop control in adults with type 1 diabetes mellitus: a comparison of two closed-loop algorithms driving continuous subcutaneous insulin infusion versus patient self-management. Diabetes Care 36:3882\u20133887","journal-title":"Diabetes Care"},{"key":"1929_CR28","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.2337\/dc14-0147","volume":"37","author":"TT Ly","year":"2014","unstructured":"Ly TT, Breton MD, Keith-Hynes P, De Salvo D, Clinton P, Benassi K et al (2014) Overnight glucose control win automated, unified safety system in children and adolescents with type 1 diabetes at diabetes camp. Diabetes Care 37:2310\u20132316","journal-title":"Diabetes Care"},{"key":"1929_CR29","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.2337\/dc14-3073","volume":"38","author":"TT Ly","year":"2015","unstructured":"Ly TT, Roy A, Grosman D, Shin J, Campbell A, Monirabbasi S et al (2015) Day and night closed-loop control using the integrated Medtronic hybrid closed-loop system in type 1 diabetes at diabetes camp. Diabetes Care 38:1205\u20131211","journal-title":"Diabetes Care"},{"key":"1929_CR30","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1056\/NEJMoa1314474","volume":"371","author":"SJ Russell","year":"2014","unstructured":"Russell SJ, El-Khatib FH, Sinha M, Magyar KL, McKeon K, Goergen LG et al (2014) Outpatient glycemic control with a bionic pancreas in type 1 diabetes. N Engl J Med 371:313\u2013325","journal-title":"N Engl J Med"},{"key":"1929_CR31","doi-asserted-by":"publisher","first-page":"e65","DOI":"10.2337\/dc12-0660","volume":"35","author":"C Cobelli","year":"2012","unstructured":"Cobelli C, Renard E, Kovatchev BP, Keith-Hynes P, Ben Brahim N, Place J et al (2012) Pilot studies of wearable outpatient artificial pancreas in type 1 diabetes. Diabetes Care 35:e65\u2013e67","journal-title":"Diabetes Care"},{"key":"1929_CR32","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.2337\/dc12-1965","volume":"36","author":"BP Kovatchev","year":"2013","unstructured":"Kovatchev BP, Renard E, Cobelli C, Zisser HC, Keith-Hynes P, Anderson SM et al (2013) Feasibility of outpatient fully integrated closed-loop control: first studies of wearable artificial pancreas. Diabetes Care 36:1851\u20131858","journal-title":"Diabetes Care"},{"key":"1929_CR33","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.2337\/dc13-2076","volume":"37","author":"BP Kovatchev","year":"2014","unstructured":"Kovatchev BP, Renard E, Cobelli C, Zisser HC, Keith-Hynes P, Anderson SM et al (2014) Safety of outpatient closed-loop control: first randomized crossover trials of a wearable artificial pancreas. Diabetes Care 37:1789\u20131796","journal-title":"Diabetes Care"},{"key":"1929_CR34","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1111\/dom.12440","volume":"17","author":"S Del Favero","year":"2015","unstructured":"Del Favero S, Place J, Kropff J, Keith-Hynes P, Visentin R, Monaro M et al (2015) Multicenter outpatient dinner\/overnight reduction of hypoglycemia and increased time of glucose in target with a wearable artificial pancreas using modular model predictive control in adults with type 1 diabetes. Diabetes Obes Metab 17:468\u2013476","journal-title":"Diabetes Obes Metab"},{"key":"1929_CR35","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1089\/dia.2014.0259","volume":"17","author":"SA Brown","year":"2015","unstructured":"Brown SA, Kovatchev BP, Breton MD, Anderson SM, Keith-Hynes P, Patek SD et al (2015) Multinight \u00ab\u202fbedside\u202f\u00bb closed-loop control for patients with type 1 diabetes. Diabetes Technol Ther 17:203\u2013209","journal-title":"Diabetes Technol Ther"},{"key":"1929_CR36","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.2337\/dc14-0835","volume":"37","author":"R Nimri","year":"2014","unstructured":"Nimri R, Muller I, Atlas E, Miller S, Fogel A, Bratina N et al (2014) MD-Logic overnight control for 6 weeks of home use in patients with type 1 diabetes: randomized crossover trial. Diabetes Care 37:3025\u20133032","journal-title":"Diabetes Care"},{"key":"1929_CR37","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/S2213-8587(14)70114-7","volume":"2","author":"H Thabit","year":"2014","unstructured":"Thabit H, Lubina-Solomon A, Stadler M, Leelarathna L, Walkinshaw E, Pernet A et al (2014) Home use of closed-loop insulin delivery for overnight glucose control in adults with type 1 diabetes: a 4-week, multicentre, randomised crossover study. Lancet Diabetes Endocrinol 2:701\u2013709","journal-title":"Lancet Diabetes Endocrinol"},{"key":"1929_CR38","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S2213-8587(15)00335-6","volume":"3","author":"J Kropff","year":"2015","unstructured":"Kropff J, Del Favero S, Place J, Toffanin C, Visentin R, Monaro M et al (2015) 2 month evening and night closed-loop glucose control in patients with type 1 diabetes under free-living conditions: a randomised crossover trial. Lancet Diabetes Endocrinol 3:939\u2013947","journal-title":"Lancet Diabetes Endocrinol"},{"key":"1929_CR39","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.2337\/dc16-0008","volume":"39","author":"E Renard","year":"2016","unstructured":"Renard E, Farret A, Kropff J, Bruttomesso D, Messori M, Place J et al (2016) Day-and-night closed-loop glucose control in patients with type 1 diabetes under free-living conditions: results of a single-arm 1-month experience compared with a previously reported feasibility study of evening and night at home. Diabetes Care 39:1151\u20131160","journal-title":"Diabetes Care"},{"key":"1929_CR40","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.2337\/dc15-2468","volume":"39","author":"SM Anderson","year":"2016","unstructured":"Anderson SM, Raghinaru D, Pinsker JE, Boscari F, Renard E, Buckingham BA et al (2016) Multinational home use of closed-loop control is safe and effective. Diabetes Care 39:1143\u20131150","journal-title":"Diabetes Care"},{"key":"1929_CR41","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1056\/NEJMoa1509351","volume":"373","author":"H Thabit","year":"2015","unstructured":"Thabit H, Tauschmann M, Allen JM, Leelarathna L, Hartnell S, Wilinska ME et al (2015) Home use of an artificial beta cell in type 1 diabetes. N Engl J Med 373:2129\u20132140","journal-title":"N Engl J Med"},{"key":"1929_CR42","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1089\/dia.2016.0333","volume":"19","author":"B Kovatchev","year":"2017","unstructured":"Kovatchev B, Cheng P, Anderson SM, Pinsker JE, Boscari F, Buckingham BA et al (2017) Feasibility of long-term closed-loop control: a multicenter 6-month trial of 24\/7 automated insulin delivery. Diabetes Technol Ther 19:18\u201324","journal-title":"Diabetes Technol Ther"},{"key":"1929_CR43","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1001\/jama.2016.11708","volume":"316","author":"RM Bergenstal","year":"2016","unstructured":"Bergenstal RM, Garg S, Weinzimer SA, Buckingham BA, Bode BW, Tamborlane WV et al (2016) Safety of a hybrid closed-loop insulin delivery system in patients with type 1 diabetes. JAMA 316:1407\u20131408","journal-title":"JAMA"},{"key":"1929_CR44","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1089\/dia.2016.0421","volume":"19","author":"SK Garg","year":"2017","unstructured":"Garg SK, Weinzimer SA, Tamborlane WV, Buckingham BA, Bode BW, Bailey TS et al (2017) Glucose outcomes with the in-home use of a hybrid closed-loop insulin delivery system in adolescents and adults with type 1 diabetes. Diabetes Technol Ther 19:155\u2013163","journal-title":"Diabetes Technol Ther"},{"key":"1929_CR45","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1089\/dia.2017.0346","volume":"20","author":"BA Buckingham","year":"2018","unstructured":"Buckingham BA, Forlenza GP, Pinsker JE, Christiansen MP, Wadwa RP, Schneider J et al (2018) Safety and feasibility of the omnipod hybrid closed-loop system in adult, adolescent, and pediatric patients with type 1 diabetes using a personalized model predictive control algorithm. Diabetes Technol Ther 20:257\u2013262","journal-title":"Diabetes Technol Ther"},{"issue":"6","key":"1929_CR46","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00592-018-1123-1","volume":"55","author":"PY Benhamou","year":"2018","unstructured":"Benhamou PY, Huneker E, Franc S, Doron M, Charpentier G (2018) Customization of home closed-loop insulin delivery in adult patients with type 1 diabetes, assisted with structured remote monitoring: the pilot WP7 Diabeloop study. Acta Diabetol 55(6):549\u2013556. https:\/\/doi.org\/10.1007\/s00592-018-1123-1","journal-title":"Acta Diabetol"},{"issue":"7","key":"1929_CR47","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1111\/dom.12663","volume":"18","author":"H Blauw","year":"2016","unstructured":"Blauw H, van Bon AC, Koops R, DeVries JH (2016) Performance and safety of an integrated bihormonal artificial pancreas for fully automated glucose control at home. Diabetes Obes Metabol 18(7):671\u2013677. https:\/\/doi.org\/10.1111\/dom.12663","journal-title":"Diabetes Obes Metabol"},{"key":"1929_CR48","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1089\/dia.2017.0353","volume":"20","author":"A Abitbol","year":"2018","unstructured":"Abitbol A, Rabasa-Lhoret R, Messier V, Legault L, Smaoui M, Cohen N et al (2018) Overnight glucose control with dual- and single-hormone artificial pancreas in type 1 diabetes with hypoglycemia unawareness: a randomized controlled trial. Diabetes Technol Ther 20:189\u2013196","journal-title":"Diabetes Technol Ther"},{"key":"1929_CR49","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.2337\/dc19-0855","volume":"42","author":"RA Lal","year":"2019","unstructured":"Lal RA, Basina M, Maahs DM, Hood K, Buckingham B, Wilson DM (2019) One year clinical experience of the first commercial hybrid closed-loop system. Diabetes Care 42:2190\u20132196","journal-title":"Diabetes Care"},{"key":"1929_CR50","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1089\/dia.2021.0176","volume":"23","author":"SN DuBose","year":"2021","unstructured":"DuBose SN, Bauza C, Verdejo A, Beck RW, Bergenstal RM, Sherr J (2021) Real-world, patient-reported and clinic data from individuals with type 1 diabetes using the minimed 670g hybrid closed-loop system. Diabetes Technol Ther 23:791\u2013798","journal-title":"Diabetes Technol Ther"},{"key":"1929_CR51","doi-asserted-by":"publisher","first-page":"969","DOI":"10.2337\/dc20-2250","volume":"44","author":"OJ Collyns","year":"2021","unstructured":"Collyns OJ, Meier RA, Betts ZL, Chan DSH, Frampton C, Frewen CM et al (2021) Improved glycemic outcomes with medtronic minimed advanced hybrid closed-loop delivery: results from a randomized crossover trial comparing automated insulin delivery with predictive low glucose suspend in people with type 1 diabetes. Diabetes Care 44:969\u2013975","journal-title":"Diabetes Care"},{"key":"1929_CR52","doi-asserted-by":"crossref","unstructured":"Carlson AL, Sherr JL, Shulman DI, Garg SK, Pop-Busui R, Bode BW, et al. Safety and glycemic outcomes during the minimed\u2122 advanced hybrid closed-loop system pivotal trial in adolescents and adults with type 1 diabetes. Diabetes Technol Ther 2021 Nov 16 Online ahead of print","DOI":"10.1089\/dia.2021.0319"},{"key":"1929_CR53","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/S0140-6736(20)32514-9","volume":"397","author":"RM Bergenstal","year":"2021","unstructured":"Bergenstal RM, Nimri R, Beck RW, Criego A, Laffel L, Schatz D et al (2021) A comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes (FLAIR): a multicentre, randomised, crossover trial. Lancet 397:208\u2013219","journal-title":"Lancet"},{"key":"1929_CR54","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1089\/dia.2021.0153","volume":"23","author":"KK Hood","year":"2021","unstructured":"Hood KK, Laffel LM, Danne T, Nimri R, Weinzimer SA, Sibayan J et al (2021) Lived experience of advanced hybrid closed-loop versus hybrid closed-loop: patient-reported outcomes and perspectives. Diabetes Technol Ther 23:857\u2013861","journal-title":"Diabetes Technol Ther"},{"key":"1929_CR55","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1056\/NEJMoa1907863","volume":"381","author":"SA Brown","year":"2019","unstructured":"Brown SA, Kovatchev BP, Raghinaru D, Lum JW, Buckingham BA, Kudva YC et al (2019) Six-month randomized, multicenter trial of closed-loop control in type 1 diabetes. N Engl J Med 381:1707\u20131717","journal-title":"N Engl J Med"},{"key":"1929_CR56","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1089\/dia.2020.0572","volume":"23","author":"E Isganaitis","year":"2021","unstructured":"Isganaitis E, Raghinaru D, Ambler-Osborn L, Pinsker JE, Buckingham BA, Wadwa RP et al (2021) closed-loop insulin therapy improves glycemic control in adolescents and young adults: outcomes from the international diabetes closed-loop trial. Diabetes Technol Ther 23:342\u2013349","journal-title":"Diabetes Technol Ther"},{"key":"1929_CR57","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1089\/dia.2021.0089","volume":"23","author":"YC Kudva","year":"2021","unstructured":"Kudva YC, Laffel LM, Brown SA, Raghinaru D, Pinsker JE, Ekhlaspour L et al (2021) Patient-reported outcomes in a randomized trial of closed-loop control: the pivotal international diabetes closed-loop trial. Diabetes Technol Ther 23:673\u2013683","journal-title":"Diabetes Technol Ther"},{"key":"1929_CR58","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.2337\/dc20-0124","volume":"43","author":"SA Brown","year":"2020","unstructured":"Brown SA, Beck RW, Raghinaru D, Buckingham BA, Laffel LM, Wadwa RP et al (2020) glycemic outcomes of use of CLC versus plgs in type 1 diabetes: a randomized controlled trial. Diabetes Care 43:1822\u20131828","journal-title":"Diabetes Care"},{"key":"1929_CR59","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1089\/dia.2021.0097","volume":"23","author":"MD Breton","year":"2021","unstructured":"Breton MD, Kovatchev BP (2021) One year real-world use of the control-iq advanced hybrid closed-loop technology. Diabetes Technol Ther 23:601\u2013608","journal-title":"Diabetes Technol Ther"},{"key":"1929_CR60","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1056\/NEJMoa2004736","volume":"383","author":"MD Breton","year":"2020","unstructured":"Breton MD, Kanapka LG, Beck RW, Ekhlaspour L, Forlenza GP, Cengiz E et al (2020) A randomized trial of closed-loop control in children with type 1 diabetes. N Engl J Med 383:836\u2013845","journal-title":"N Engl J Med"},{"key":"1929_CR61","doi-asserted-by":"publisher","first-page":"473","DOI":"10.2337\/dc20-1729","volume":"44","author":"LG Kanapka","year":"2021","unstructured":"Kanapka LG, Wadwa RP, Breton MD, Ruedy KJ, Ekhlaspour L, Forlenza GP et al (2021) extended use of the control-IQ closed-loop control system in children with type 1 diabetes. Diabetes Care 44:473\u2013478","journal-title":"Diabetes Care"},{"issue":"3","key":"1929_CR62","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1111\/dom.14605","volume":"24","author":"E Renard","year":"2021","unstructured":"Renard E, Tubiana\u2010Rufi N, Bonnemaison E, Coutant R, Dalla\u2010Vale F, Bismuth E (2021) Outcomes of hybrid closed\u2010loop insulin delivery activated 24\/7 versus evening and night in free\u2010living prepubertal children with type 1 diabetes: A multicentre, randomized clinical trial. Obes Metabol 24(3):511\u2013521. https:\/\/doi.org\/10.1111\/dom.14605","journal-title":"Obes Metabol"},{"key":"1929_CR63","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S2213-8587(17)30001-3","volume":"5","author":"L Bally","year":"2017","unstructured":"Bally L, Thabit H, Kojzar H, Mader JK, Qerimi-Hyseni J, Hartnell S et al (2017) Day-and-night glycaemic control with closed-loop insulin delivery versus conventional insulin pump therapy in free-living adults with well controlled type 1 diabetes: an open-label, randomised, crossover study. Lancet Diabetes Endocrinol 5:261\u2013270","journal-title":"Lancet Diabetes Endocrinol"},{"key":"1929_CR64","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1016\/S0140-6736(18)31947-0","volume":"392","author":"M Tauschmann","year":"2018","unstructured":"Tauschmann M, Thabit H, Bally L, Allen JM, Hartnell S, Wilinska ME et al (2018) Closed-loop insulin delivery in suboptimally controlled type 1 diabetes: a multicentre, 12-week randomised trial. Lancet 392:1321\u20131329","journal-title":"Lancet"},{"key":"1929_CR65","doi-asserted-by":"publisher","first-page":"594","DOI":"10.2337\/dc18-1881","volume":"42","author":"M Tauschmann","year":"2019","unstructured":"Tauschmann M, Allen JM, Nagl K, Fritsch M, Yong J, Metcalfe E et al (2019) Home use of day-and-night hybrid closed-loop insulin delivery in very young children: a multicenter, 3-week. Random Trial Diabete Care 42:594\u2013600","journal-title":"Random Trial Diabete Care"},{"key":"1929_CR66","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1056\/NEJMoa2111673","volume":"386","author":"J Ware","year":"2022","unstructured":"Ware J, Allen JM, Boughton CK, Wilinska ME, Hartnell S, Thankamony A et al (2022) Randomized trial of closed-loop control in very young children with type 1 diabetes. N Engl J Med 386:209\u2013219","journal-title":"N Engl J Med"},{"key":"1929_CR67","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1016\/S2589-7500(19)30003-2","volume":"1","author":"PY Benhamou","year":"2019","unstructured":"Benhamou PY, Franc S, Reznik Y, Thivolet C, Schaepelynck P, Renard E et al (2019) Closed-loop insulin delivery in adults with type 1 diabetes in real-life conditions: a 12-week multicentre, open-label randomised controlled crossover trial. Lancet Digit Health 1:e17\u2013e25","journal-title":"Lancet Digit Health"},{"key":"1929_CR68","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1111\/dom.14442","volume":"23","author":"S Franc","year":"2021","unstructured":"Franc S, Benhamou PY, Borot S, Chaillous L, Delemer B, Doron M et al (2021) No more hypoglycaemia on days with physical activity and unrestricted diet when using a closed-loop system for 12 weeks: a post hoc secondary analysis of the multicentre, randomized controlled diabeloop WP7 trial. Diabetes Obes Metab 23:2170\u20132176","journal-title":"Diabetes Obes Metab"},{"key":"1929_CR69","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1111\/dom.13898","volume":"22","author":"H Hanaire","year":"2020","unstructured":"Hanaire H, Franc S, Borot S, Penfornis A, Benhamou PY, Schaepelynck P et al (2020) Efficacy of the diabeloop closed-loop system to improve glycaemic control in patients with type 1 diabetes exposed to gastronomic dinners or to sustained physical exercise. Diabetes Obes Metab 22:324\u2013334","journal-title":"Diabetes Obes Metab"},{"key":"1929_CR70","doi-asserted-by":"publisher","first-page":"844","DOI":"10.2337\/dc20-1809","volume":"44","author":"C Amadou","year":"2021","unstructured":"Amadou C, Franc S, Benhamou PY, Lablanche S, Huneker E, Charpentier G et al (2021) Diabeloop DBLG1 closed-loop system enables patients with type 1 diabetes to significantly improve their glycemic control in real-life situations without serious adverse events: 6-month follow-up. Diabetes Care 44:844\u2013846","journal-title":"Diabetes Care"},{"key":"1929_CR71","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1007\/s00125-016-4022-4","volume":"59","author":"H Thabit","year":"2016","unstructured":"Thabit H, Hovorka R (2016) Coming of age: the artificial pancreas for type 1 diabetes. Diabetologia 59:1795\u20131805","journal-title":"Diabetologia"},{"key":"1929_CR72","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1310","volume":"361","author":"E Bekiari","year":"2018","unstructured":"Bekiari E, Kitsios K, Thabit H, Tauschmann M, Athanasiadou E, Karagiannis T et al (2018) Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis. BMJ 361:k1310","journal-title":"BMJ"},{"key":"1929_CR73","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1089\/dia.2021.0184","volume":"23","author":"B Bode","year":"2021","unstructured":"Bode B, Carlson A, Liu R, Hardy T, Bergenstal R, Boyd J et al (2021) Ultrarapid lispro demonstrates similar time in target range to lispro with a hybrid closed-loop system. Diabetes Technol Ther 23:828\u2013836","journal-title":"Diabetes Technol Ther"},{"key":"1929_CR74","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1111\/dom.14355","volume":"23","author":"CK Boughton","year":"2021","unstructured":"Boughton CK, Hartnell S, Thabit H, Poettler T, Herzig D, Wilinska ME et al (2021) Hybrid closed-loop glucose control with faster insulin aspart compared with standard insulin aspart in adults with type 1 diabetes: a double-blind, multicentre, multinational, randomized, crossover study. Diabetes Obes Metab 23:1389\u20131396","journal-title":"Diabetes Obes Metab"},{"key":"1929_CR75","doi-asserted-by":"crossref","unstructured":"Garcia-Tirado J, Diaz JL, Esquivel-Zuniga R, Koravi CLK, Corbett JP, Dawson M, et al. Advanced Closed-Loop Control System Improves Postprandial Glycemic Control Compared With a Hybrid Closed-Loop System Following Unannounced Meal. Diabetes Care. 2021; dc210932. Online ahead of print.","DOI":"10.2337\/figshare.14999709"},{"key":"1929_CR76","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.2337\/dc21-0172","volume":"44","author":"SA Brown","year":"2021","unstructured":"Brown SA, Forlenza GP, Bode BW, Pinsker JE, Levy CJ, Criego AB et al (2021) Multicenter Trial of a Tubeless, On-Body Automated Insulin Delivery System With Customizable Glycemic Targets in Pediatric and Adult Participants With Type 1 Diabetes. Diabetes Care 44:1630\u20131640","journal-title":"Diabetes Care"},{"key":"1929_CR77","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1056\/NEJMe2119915","volume":"386","author":"LL Levitsky","year":"2022","unstructured":"Levitsky LL (2022) Reducing Caretaker Burden, Protecting Young Brains and Bodies. N Engl J Med 386:285\u2013286","journal-title":"N Engl J Med"},{"key":"1929_CR78","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1111\/dom.12999","volume":"19","author":"E Dassau","year":"2017","unstructured":"Dassau E, Renard E, Place J, Farret A, Pelletier MJ, Lee J et al (2017) Intraperitoneal insulin delivery provides superior glycaemic regulation to subcutaneous insulin delivery in model predictive control-based fully-automated artificial pancreas in patients with type 1 diabetes: a pilot study. Diabetes Obes Metab 19:1698\u20131705","journal-title":"Diabetes Obes Metab"},{"issue":"5","key":"1929_CR79","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1111\/dme.12706","volume":"32","author":"KD Barnard","year":"2015","unstructured":"Barnard KD, Wysocki T, Thabit H, Evans ML, Amiel S, Heller S, Young A, Hovorka R (2015) Psychosocial aspects of closed- and open-loop insulin delivery: closing the loop in adults with Type 1 diabetes in the home setting. Diabet Med 32(5):601\u2013608. https:\/\/doi.org\/10.1111\/dme.12706","journal-title":"Diabet Med"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-022-01929-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00592-022-01929-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-022-01929-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T02:48:38Z","timestamp":1674182918000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00592-022-01929-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,22]]},"references-count":79,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["1929"],"URL":"https:\/\/doi.org\/10.1007\/s00592-022-01929-5","relation":{},"ISSN":["1432-5233"],"issn-type":[{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,22]]},"assertion":[{"value":"11 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author reports serving on advisory boards for Abbott, Dexcom Inc, Insulet, Sanofi, Roche Diabetes Care, Novo Nordisk and Eli Lilly, and received research support from Dexcom Inc and Tandem.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}