{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T13:13:07Z","timestamp":1769346787217,"version":"3.49.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007137","name":"Helse Nord RHF","doi-asserted-by":"publisher","award":["HNF1470-19"],"award-info":[{"award-number":["HNF1470-19"]}],"id":[{"id":"10.13039\/501100007137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007465","name":"UiT The Arctic University of Norway","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007465","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Aim<\/jats:title>\n                <jats:p>We aimed to investigate the relationship between pre- and post-diagnostic 25-hydroxyvitamin D (25(OH)D) concentrations and type 2 diabetes (T2DM) over a period of 30\u00a0years in individuals who developed T2DM compared to healthy controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This case\u2013control study included 254 participants with blood samples collected at five different time-points (T1\u2013T5) between 1986 and 2016. Of the 254 participants, 116 were diagnosed with T2DM between T3 and T4, and were considered cases; the remaining 138 were controls. Linear mixed regression models were used to examine pre- and post-diagnostic changes in 25(OH)D concentrations, and logistic regression was used to examine associations between these concentrations and T2DM at each time-point.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>25(OH)D concentrations at different time-points and the longitudinal change in concentrations differed between cases and controls, and by sex. For women, each 5-nmol\/l increase in 25(OH)D concentrations was inversely associated with T2DM at T3 (odds-ratio, OR, 0.79), whereas for men, this same increase was positively associated with T2DM at T1 (OR 1.12). Cases experienced a significant decrease in pre-diagnostic 25(OH)D concentrations (<jats:italic>p<\/jats:italic> value &lt;\u20090.01 for women, <jats:italic>p<\/jats:italic> value =\u20090.02 for men) and a significant increase in post-diagnostic 25(OH)D concentrations (<jats:italic>p<\/jats:italic> value &lt;\u20090.01 for women, <jats:italic>p<\/jats:italic> value =\u20090.01 for men). As such, each 1-unit increase in month-specific <jats:italic>z<\/jats:italic>-score change between T1 and T3 was significantly inversely associated with T2DM (OR 0.51 for women, OR 0.52 for men), and each such increase between T3 and T5 was significantly positively associated with T2DM in women (OR 2.48).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>25(OH)D concentrations seem to be affected by disease progression and type 2 diabetes diagnosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00592-022-02001-y","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T01:56:02Z","timestamp":1669946162000},"page":"293-304","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Longitudinal changes in vitamin D concentrations and the association with type 2 diabetes mellitus: the Troms\u00f8 Study"],"prefix":"10.1007","volume":"60","author":[{"given":"Giovanni","family":"Allaoui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotta","family":"Rylander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole-Martin","family":"Fuskev\u00e5g","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Averina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Wilsgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magritt","family":"Brustad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Jorde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5620-9901","authenticated-orcid":false,"given":"Vivian","family":"Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"issue":"3","key":"2001_CR1","doi-asserted-by":"publisher","first-page":"e041846","DOI":"10.1136\/bmjopen-2020-041846","volume":"11","author":"PL Langholz","year":"2021","unstructured":"Langholz PL, Wilsgaard T, Nj\u00f8lstad I, Jorde R, Hopstock LA (2021) Trends in known and undiagnosed diabetes, HbA1c levels, cardiometabolic risk factors and diabetes treatment target achievement in repeated cross-sectional surveys: the population-based Troms\u00f8 study 1994\u20132016. 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The Regional Ethics Committee, REK, Nord approved the study protocol (REK reference: 2015\/1780\/REK Nord).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights disclosure"}},{"value":"This research did not involve the use of animals.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent disclosure"}}]}}