{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:41:29Z","timestamp":1780598489803,"version":"3.54.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T00:00:00Z","timestamp":1683936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T00:00:00Z","timestamp":1683936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"CHUC - Centro Hospitalar e Universit\u00e1rio de Coimbra"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Aims<\/jats:title>\n                <jats:p>Acute kidney injury (AKI) is highly prevalent during hospitalization of patients with type 2 diabetes (T2D). We aimed to assess the impact of AKI and its severity and duration on the risk of hypoglycaemia in hospitalized patients with T2D.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Retrospective cohort analysis of patients with T2D, admitted at a University Hospital in 2018\u20132019. AKI was defined as an increase in serum creatinine by\u2009\u2265\u20090.3\u00a0mg\/dl (48\u00a0h) or\u2009\u2265\u20091.5 times baseline (7\u00a0days), and hypoglycaemia as blood glucose concentration\u2009&lt;\u200970\u00a0mg\/dl. Patients with chronic kidney disease stage\u2009\u2265\u20094 were excluded. We registered 239 hospitalizations with AKI and randomly selected 239 without AKI (control). Multiple logistic regression was used to adjust for confounding factors and ROC curve analysis to determine a cutoff for AKI duration.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The risk of hypoglycaemia was higher in the AKI group (crude OR 3.6, 95%CI 1.8\u20139.6), even after adjusting for covariates (OR 4.2, 95%CI 1.8\u20139.6). Each day of AKI duration was associated with a 14% increase in the risk of hypoglycaemia (95%CI 1.1\u20131.2), and a cutoff of 5.5\u00a0days of AKI duration was obtained for increased risk of hypoglycaemia and mortality. AKI severity was also associated with mortality, but showed no significant association with hypoglycaemia. Patients with hypoglycaemia had 4.4 times greater risk of mortality (95%CI 2.4\u20138.2).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>AKI increased the risk of hypoglycaemia during hospitalization of patients with T2D, and its duration was the main risk factor. These results highlight the need for specific protocols to avoid hypoglycaemia and its burden in patients with AKI.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00592-023-02112-0","type":"journal-article","created":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T03:24:07Z","timestamp":1683948247000},"page":"1179-1185","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Acute kidney injury: a strong risk factor for hypoglycaemia in hospitalized patients with type 2 diabetes"],"prefix":"10.1007","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2543-9242","authenticated-orcid":false,"given":"Ana","family":"Carreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0555-4198","authenticated-orcid":false,"given":"Pedro","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5682-3116","authenticated-orcid":false,"given":"Filipe","family":"Mira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8365-1380","authenticated-orcid":false,"given":"Miguel","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5700-7922","authenticated-orcid":false,"given":"Pedro","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0761-5097","authenticated-orcid":false,"given":"L\u00e8lita","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,13]]},"reference":[{"issue":"12","key":"2112_CR1","doi-asserted-by":"publisher","first-page":"e445","DOI":"10.1111\/dme.12002","volume":"29","author":"K Nirantharakumar","year":"2012","unstructured":"Nirantharakumar K, Marshall T, Kennedy A, Narendran P, Hemming K, Coleman JJ (2012) Hypoglycaemia is associated with increased length of stay and mortality in people with diabetes who are hospitalized. 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