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Here we determined whether G6PDd accelerates arterial aging (information linked stiffening) in diabetes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Plasma glucose, interleukin 6 (IL6), and arterial stiffness (indexed as carotid-femoral Pulse Wave Velocity, PWV) and red blood cell G6PD activity were assessed in a large (4448) Sardinian population.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Although high plasma glucose in diabetics<jats:italic>,<\/jats:italic> did not differ by G6DP status (178.2\u2009\u00b1\u200955.1 vs 169.0\u2009\u00b1\u200950.1\u00a0mg\/dl) in G6DPd versus non-G6PDd subjects, respectively, IL6, and PWV (adjusted for age and glucose) were significantly increased in G6PDd vs non-G6PDd subjects (PWV, 8.0\u2009\u00b1\u20090.4 vs 7.2\u2009\u00b1\u20090.2\u00a0m\/sec) and (IL6, 6.9\u2009\u00b1\u20095.0 vs 4.2\u2009\u00b1\u20093.0\u00a0pg\/ml). In <jats:italic>non-diabetics<\/jats:italic>, neither fasting plasma glucose, nor IL6, nor PWV were impacted by G6PDd.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>G6PDd in diabetics is associated with increased inflammatory markers and accelerated arterial aging.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00592-023-02118-8","type":"journal-article","created":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:01:41Z","timestamp":1695492101000},"page":"127-130","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Glucose-6-phosphate dehydrogenase deficiency accelerates arterial aging in diabetes"],"prefix":"10.1007","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4784-5441","authenticated-orcid":false,"given":"Angelo","family":"Scuteri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H.","family":"Morrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majd","family":"AlGhatrif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Orru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Fiorillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Marongiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Schlessinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cucca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward G.","family":"Lakatta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,23]]},"reference":[{"key":"2118_CR1","doi-asserted-by":"publisher","first-page":"F1040","DOI":"10.1152\/ajprenal.00076.2005","volume":"289","author":"Y Xu","year":"2005","unstructured":"Xu Y, Osborne BW, Stanton RC (2005) Diabetes causes inhibition of glucose-6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex. 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