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The aim of the present study was to assess if fasting and post-load incretin concentrations were predictive of pregnancy insulin and glucose concentrations.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Pregnant women (n\u2009=\u2009394) with one or more risk factors for gestational diabetes were recruited at 28\u00a0weeks for a 75\u00a0g oral glucose tolerance test (OGTT). Glucose, insulin, GLP-1 and GIP were measured in the fasting state and 120\u00a0min after glucose ingestion.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Fasting plasma GLP-1 concentrations were associated with plasma insulin (standardised \u03b2\u2019 0.393 (0.289\u20130.498), <jats:italic>p<\/jats:italic>\u2009=\u20091.3\u2009\u00d7\u200910<jats:sup>\u201312<\/jats:sup>; n\u2009=\u2009306), but not with glucose concentrations (<jats:italic>p<\/jats:italic>\u2009=\u20090.3). The association with insulin was still evident when adjusting for BMI (\u03b2\u2019 0.271 (0.180\u20130.362), <jats:italic>p<\/jats:italic> =\u20091.1\u2009\u00d7\u200910<jats:sup>\u20138<\/jats:sup>; n\u2009=\u2009297). Likewise, at 120\u00a0min the OGTT GLP-1 concentrations were associated with plasma insulin concentrations (\u03b2\u2019 0.216 (0.100\u20130.331), <jats:italic>p<\/jats:italic> \u2009=\u20092.7\u2009\u00d7\u200910<jats:sup>\u20134<\/jats:sup>; n\u2009=\u2009306) even after adjusting for BMI (\u03b2\u2019 0.178 (0.061\u20130.294), <jats:italic>p<\/jats:italic>\u2009=\u20092.9\u2009\u00d7\u200910<jats:sup>\u20133<\/jats:sup>; n\u2009=\u2009296), but not with glucose (<jats:italic>p<\/jats:italic> \u2009=\u20090.9). GIP concentrations were not associated with insulin or glucose concentrations at either time point (all <jats:italic>p<\/jats:italic> \u2009&gt;\u20090.2). In pregnancy plasma GLP-1, but not GIP, concentrations appear to be predictive of circulating insulin concentrations, independently of associations with BMIs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>These results suggest that the relationship between insulin and incretins is preserved in pregnancy, but that other factors, such as placental hormones or counter-regulatory hormones, may be more important determinants of glycaemia and gestational diabetes aetiology.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00592-023-02142-8","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T15:03:42Z","timestamp":1689260622000},"page":"1635-1642","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pregnancy glucagon-like peptide 1 predicts insulin but not glucose concentrations"],"prefix":"10.1007","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0372-5579","authenticated-orcid":false,"given":"Danielle L.","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6642-9825","authenticated-orcid":false,"given":"Clive J.","family":"Petry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0109-7751","authenticated-orcid":false,"given":"Keith","family":"Burling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Barker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth H.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura C.","family":"Kusinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-8329","authenticated-orcid":false,"given":"Claire L.","family":"Meek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"2142_CR1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.metabol.2019.04.014","volume":"96","author":"JJ Holst","year":"2019","unstructured":"Holst JJ (2019) The incretin system in healthy humans: the role of GIP and GLP-1. 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