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Candidate SNPs were genotyped using multiplex polymerase chain reaction (PCR) combined with next-generation sequencing methods, and the association of these SNPs with GDM was analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We found that <jats:italic>GCKR<\/jats:italic>\u00a0rs1260326 was significantly associated with an increased risk of GDM in the allele model, the codominant model (CC vs. TT), the dominant model, the recessive model, and the genotypic model distributions (<jats:italic>p<\/jats:italic>\u2009=\u20090.0029, <jats:italic>p<\/jats:italic>\u2009=\u20090.0022, <jats:italic>p<\/jats:italic>\u2009=\u20090.0402, <jats:italic>p<\/jats:italic>\u2009=\u20090.0038, and <jats:italic>p<\/jats:italic>\u2009=\u20090.0028, respectively). The rs1260326 polymorphism was shown to be associated with 1\u00a0h-OGTT level and gravidity in GDM patients (CC vs. TT: <jats:italic>p<\/jats:italic>\u2009=\u20090.0475 and <jats:italic>p<\/jats:italic>\u2009=\u20090.0220, respectively). Diastolic blood pressure (DBP) was significantly higher in the GDM patients with the rs266729 GG genotype compared to those with the CC or CG genotype (<jats:italic>p<\/jats:italic>\u2009=\u20090.0444 and <jats:italic>p<\/jats:italic>\u2009=\u20090.0339, respectively). The DBP of the GDM patients with the rs1501299 GT genotype was lower than that of those with the GG genotype (<jats:italic>p<\/jats:italic>\u2009=\u20090.0197). There was a weak linkage disequilibrium value between the <jats:italic>GCKR<\/jats:italic> and <jats:italic>ADIPOQ<\/jats:italic> SNPs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The genes <jats:italic>GCKR<\/jats:italic> and <jats:italic>ADIPOQ<\/jats:italic> may be involved in the pathophysiology of GDM.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00592-023-02165-1","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T16:07:44Z","timestamp":1690819664000},"page":"1709-1718","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["GCKR and ADIPOQ gene polymorphisms in women with gestational diabetes mellitus"],"prefix":"10.1007","volume":"60","author":[{"given":"Manning","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaer","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingnan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshuang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songcheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songxue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4724-0971","authenticated-orcid":false,"given":"Litao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"issue":"2","key":"2165_CR1","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1080\/14767058.2018.1446207","volume":"32","author":"Y Feng","year":"2019","unstructured":"Feng Y, Jiang CD, Chang AM et al (2019) Interactions among insulin resistance, inflammation factors, obesity-related gene polymorphisms, environmental risk factors, and diet in the development of gestational diabetes mellitus. 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