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The authors have no relevant financial or non-financial interests to disclose. All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was notified to the IRCCS \u201cCarlo Besta\u201d Foundation Ethics Committee (8 September 2021, protocol n. 87). The study was performed following the ethical standards of the 1964 Declaration of Helsinki and its later amendments. We followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}},{"value":"The study was notified to the IRCCS \"Carlo Besta\" Foundation Ethics Committee (8 September 2021, protocol n. 87). 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