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The association between <jats:italic>GALNT2<\/jats:italic> expression and serum metabolites was assessed using false discovery rate followed by stepwise selection and, finally, multivariate model including several clinical parameters as confounders. The association between <jats:italic>GALNT2<\/jats:italic> expression and the same clinical parameters was also investigated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p><jats:italic>GALNT2<\/jats:italic> expression was independently correlated with HbA1c levels (<jats:italic>P<\/jats:italic> value\u2009=\u20090.0052), a finding that is the likely consequence of the role of <jats:italic>GALNT2<\/jats:italic> on insulin sensitivity. <jats:italic>GALNT2<\/jats:italic> expression was also independently associated with serum levels of the aminoacid glycine (<jats:italic>P<\/jats:italic> value\u2009=\u20090.014) and two biogenic amines phenylethylamine (<jats:italic>P<\/jats:italic> value\u2009=\u20090.0065) and taurine (<jats:italic>P<\/jats:italic> value\u2009=\u20090.0011). The association of <jats:italic>GALNT2<\/jats:italic> expression with HbA1c was not mediated by these three metabolites.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our data indicate that in type 2 diabetes the expression of <jats:italic>GALNT2<\/jats:italic> is associated with several serum metabolites. This association needs to be further investigated to understand in depth its role in mediating the effect of GALNT2 on insulin sensitivity, glucose control and other clinical features in people with diabetes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00592-024-02280-7","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T03:51:01Z","timestamp":1713325861000},"page":"1007-1013","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["GALNT2 expression is associated with glucose control and serum metabolites in patients with type 2 diabetes"],"prefix":"10.1007","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1174-127X","authenticated-orcid":false,"given":"Vincenzo","family":"Trischitta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-5336","authenticated-orcid":false,"given":"Alessandra","family":"Antonucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Adamski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Prehn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7438-8955","authenticated-orcid":false,"given":"Claudia","family":"Menzaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8131-8317","authenticated-orcid":false,"given":"Antonella","family":"Marucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5837-9111","authenticated-orcid":false,"given":"Rosa","family":"Di Paola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"issue":"12","key":"2280_CR1","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.2337\/diab.37.12.1595","volume":"37","author":"GM Reaven","year":"1988","unstructured":"Reaven GM (1988) Banting lecture 1988: role of insulin resistance in human disease. 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