{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:40:28Z","timestamp":1789605628639,"version":"build-2803163510"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"DOI":"10.1007\/s00592-024-02284-3","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T10:02:15Z","timestamp":1714730535000},"page":"831-840","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy of automated insulin delivery in pregnant women with type 1 diabetes: a meta-analysis and trial sequential analysis of randomized controlled trials"],"prefix":"10.1007","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5416-2187","authenticated-orcid":false,"given":"Tamara","family":"Teixeira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8666-7786","authenticated-orcid":false,"given":"Amanda","family":"Godoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2286-4582","authenticated-orcid":false,"given":"Pedro","family":"Romeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6926-0850","authenticated-orcid":false,"given":"Jo\u00e3o Vitor Levindo Coelho","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5895-9668","authenticated-orcid":false,"given":"Flavia Maria","family":"de Freitas Faria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1012-2341","authenticated-orcid":false,"given":"Sacha","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7432-9085","authenticated-orcid":false,"given":"Rodrigo Nunes","family":"Lamounier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"issue":"10","key":"2284_CR1","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/S2213-8587(22)00218-2","volume":"10","author":"GA Gregory","year":"2022","unstructured":"Gregory GA, Robinson TIG, Linklater SE et al (2022) Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: a modelling study. Lancet Diabetes Endocrinol 10(10):741\u2013760. https:\/\/doi.org\/10.1016\/S2213-8587(22)00218-2","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"7","key":"2284_CR2","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/S2213-8587(23)00116-X","volume":"11","author":"K Benhalima","year":"2023","unstructured":"Benhalima K, Beunen K, Siegelaar SE et al (2023) Management of type 1 diabetes in pregnancy: update on lifestyle, pharmacological treatment, and novel technologies for achieving glycaemic targets. Lancet Diabetes Endocrinol 11(7):490\u2013508. https:\/\/doi.org\/10.1016\/S2213-8587(23)00116-X","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"18","key":"2284_CR3","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1001\/JAMA.2019.4981","volume":"321","author":"AS Alexopoulos","year":"2019","unstructured":"Alexopoulos AS, Blair R, Peters AL (2019) Management of preexisting diabetes in pregnancy: a review. JAMA 321(18):1811\u20131819. https:\/\/doi.org\/10.1001\/JAMA.2019.4981","journal-title":"JAMA"},{"issue":"12","key":"2284_CR4","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.2337\/DC19-0830","volume":"42","author":"JH Pettus","year":"2019","unstructured":"Pettus JH, Zhou FL, Shepherd L et al (2019) Incidences of severe hypoglycemia and diabetic ketoacidosis and prevalence of microvascular complications stratified by age and glycemic control in U.S. adult patients with type 1 diabetes: a real-world study. Diabetes Care. 42(12):2220\u20132227. https:\/\/doi.org\/10.2337\/DC19-0830","journal-title":"Diabetes Care."},{"key":"2284_CR5","doi-asserted-by":"publisher","unstructured":"Foster NC, Beck RW, Miller KM et al (2019) State of type 1 diabetes management and outcomes from the T1D exchange in 2016\u20132018. Diabetes Technol Ther 21(2):66\u201372. https:\/\/doi.org\/10.1089\/DIA.2018.0384. https:\/\/home.liebertpub.com\/dia","DOI":"10.1089\/DIA.2018.0384"},{"key":"2284_CR6","doi-asserted-by":"publisher","unstructured":"Miller KM, Network for the TEC, Foster NC et al (2015) Current state of type 1 diabetes treatment in the U.S.: updated data from the T1D exchange clinic registry. Diabetes Care 38(6):971\u2013978. https:\/\/doi.org\/10.2337\/DC15-0078","DOI":"10.2337\/DC15-0078"},{"issue":"3","key":"2284_CR7","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/0029-7844(94)00415-A","volume":"85","author":"BM Rosenn","year":"1995","unstructured":"Rosenn BM, Miodovnik M, Holcberg G, Khoury JC, Siddiqi TA (1995) Hypoglycemia: the price of intensive insulin therapy for pregnant women with insulin-dependent diabetes mellitus. Obstet Gynecol 85(3):417\u2013422. https:\/\/doi.org\/10.1016\/0029-7844(94)00415-A","journal-title":"Obstet Gynecol"},{"issue":"14","key":"2284_CR8","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1056\/NEJM199309303291401","volume":"329","author":"Diabetes Control and Complications Trial Research Group","year":"1993","unstructured":"Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329(14):977\u2013986. https:\/\/doi.org\/10.1056\/NEJM199309303291401","journal-title":"N Engl J Med"},{"issue":"1","key":"2284_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13098-023-01144-4\/FIGURES\/5","volume":"15","author":"A Godoi","year":"2023","unstructured":"Godoi A, Reis Marques I, Padr\u00e3o EMH et al (2023) Glucose control and psychosocial outcomes with use of automated insulin delivery for 12 to 96 weeks in type 1 diabetes: a meta-analysis of randomised controlled trials. Diabetol Metab Syndr 15(1):1\u201318. https:\/\/doi.org\/10.1186\/S13098-023-01144-4\/FIGURES\/5","journal-title":"Diabetol Metab Syndr"},{"issue":"11","key":"2284_CR10","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1080\/17434440.2022.2142556","volume":"19","author":"J Ware","year":"2022","unstructured":"Ware J, Hovorka R (2022) Closed-loop insulin delivery: update on the state of the field and emerging technologies. Expert Rev Med Devices 19(11):859\u2013875. https:\/\/doi.org\/10.1080\/17434440.2022.2142556","journal-title":"Expert Rev Med Devices"},{"issue":"2","key":"2284_CR11","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1210\/ENDREV\/BNAC022","volume":"44","author":"M Phillip","year":"2023","unstructured":"Phillip M, Nimri R, Bergenstal RM et al (2023) Consensus recommendations for the use of automated insulin delivery technologies in clinical practice. Endocr Rev 44(2):254\u2013280. https:\/\/doi.org\/10.1210\/ENDREV\/BNAC022","journal-title":"Endocr Rev"},{"issue":"1","key":"2284_CR12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/S00125-022-05744-Z","volume":"66","author":"JL Sherr","year":"2022","unstructured":"Sherr JL, Heinemann L, Fleming GA et al (2022) Automated insulin delivery: benefits, challenges, and recommendations. A Consensus Report of the Joint Diabetes Technology Working Group of the European Association for the Study of Diabetes and the American Diabetes Association. Diabetologia 66(1):3\u201322. https:\/\/doi.org\/10.1007\/S00125-022-05744-Z","journal-title":"Diabetologia"},{"key":"2284_CR13","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1136\/BMJ.N71","volume":"2021","author":"MJ Page","year":"2020","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, The PRISMA et al (2020) statement: an updated guideline for reporting systematic reviews. BMJ 2021:372. https:\/\/doi.org\/10.1136\/BMJ.N71","journal-title":"BMJ"},{"key":"2284_CR14","unstructured":"Higgins JPT, Thomas J, Chandler J et al (2022) Cochrane handbook for systematic reviews of interventions. version 6.3. https:\/\/training.cochrane.org\/handbook. Accessed 28 Oct 2023"},{"issue":"1","key":"2284_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2288-14-135\/TABLES\/3","volume":"14","author":"X Wan","year":"2014","unstructured":"Wan X, Wang W, Liu J, Tong T (2014) Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med Res Methodol 14(1):1\u201313. https:\/\/doi.org\/10.1186\/1471-2288-14-135\/TABLES\/3","journal-title":"BMC Med Res Methodol"},{"key":"2284_CR16","doi-asserted-by":"publisher","first-page":"14898","DOI":"10.1136\/BMJ.L4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 366:14898. https:\/\/doi.org\/10.1136\/BMJ.L4898","journal-title":"BMJ."},{"issue":"2","key":"2284_CR17","doi-asserted-by":"publisher","first-page":"138","DOI":"10.17085\/APM.21038","volume":"16","author":"H Kang","year":"2021","unstructured":"Kang H (2021) Trial sequential analysis: novel approach for meta-analysis. Anesth Pain Med (Seoul) 16(2):138\u2013150. https:\/\/doi.org\/10.17085\/APM.21038","journal-title":"Anesth Pain Med (Seoul)"},{"issue":"12","key":"2284_CR18","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.2337\/DC11-1430\/-\/DC1","volume":"34","author":"HR Murphy","year":"2011","unstructured":"Murphy HR, Kumareswaran K, Elleri D et al (2011) Safety and efficacy of 24-h closed-loop insulin delivery in well-controlled pregnant women with type 1 diabetes: a randomized crossover case series. Diabetes Care 34(12):2527\u20132529. https:\/\/doi.org\/10.2337\/DC11-1430\/-\/DC1","journal-title":"Diabetes Care"},{"key":"2284_CR19","doi-asserted-by":"publisher","unstructured":"Buschur E, Snell-Bergeon JK, Pyle L et al (2023) 175-OR: Pregnancy Intervention with a Closed-Loop System (PICLS) study. Diabetes 72(Supplement_1). https:\/\/doi.org\/10.2337\/DB23-175-OR","DOI":"10.2337\/DB23-175-OR"},{"key":"2284_CR20","doi-asserted-by":"publisher","unstructured":"Lee TTM, Collett C, Bergford S et al (2023) Automated insulin delivery in women with pregnancy complicated by type 1 diabetes. N Engl J Med. Published online October 5, 2023. https:\/\/doi.org\/10.1056\/NEJMOA2303911\/SUPPL_FILE\/NEJMOA2303911_DATA-SHARING.PDF","DOI":"10.1056\/NEJMOA2303911\/SUPPL_FILE\/NEJMOA2303911_DATA-SHARING.PDF"},{"issue":"7","key":"2284_CR21","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.2337\/DC17-2534","volume":"41","author":"ZA Stewart","year":"2018","unstructured":"Stewart ZA, Wilinska ME, Hartnell S et al (2018) Day-and-night closed-loop insulin delivery in a broad population of pregnant women with type 1 diabetes: a randomized controlled crossover trial. Diabetes Care 41(7):1391\u20131399. https:\/\/doi.org\/10.2337\/DC17-2534","journal-title":"Diabetes Care"},{"issue":"7","key":"2284_CR22","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1056\/NEJMOA1602494\/SUPPL_FILE\/NEJMOA1602494_DISCLOSURES.PDF","volume":"375","author":"ZA Stewart","year":"2016","unstructured":"Stewart ZA, Wilinska ME, Hartnell S et al (2016) Closed-loop insulin delivery during pregnancy in women with type 1 diabetes. N Engl J Med 375(7):644\u2013654. https:\/\/doi.org\/10.1056\/NEJMOA1602494\/SUPPL_FILE\/NEJMOA1602494_DISCLOSURES.PDF","journal-title":"N Engl J Med"},{"key":"2284_CR23","doi-asserted-by":"publisher","unstructured":"De Ridder F, den Brinker M, De Block C (2019) The road from intermittently scanned continuous glucose monitoring to hybrid closed-loop systems. Part B: results from randomized controlled trials. Ther Adv Endocrinol Metab 10. https:\/\/doi.org\/10.1177\/2042018819871903\/ASSET\/IMAGES\/LARGE\/10.1177_2042018819871903-FIG1.JPEG","DOI":"10.1177\/2042018819871903\/ASSET\/IMAGES\/LARGE\/10.1177_2042018819871903-FIG1.JPEG"},{"issue":"9","key":"2284_CR24","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1007\/S00125-017-4314-3","volume":"60","author":"HR Murphy","year":"2017","unstructured":"Murphy HR, Bell R, Cartwright C et al (2017) Improved pregnancy outcomes in women with type 1 and type 2 diabetes but substantial clinic-to-clinic variations: a prospective nationwide study. Diabetologia 60(9):1668\u20131677. https:\/\/doi.org\/10.1007\/S00125-017-4314-3","journal-title":"Diabetologia"},{"issue":"2","key":"2284_CR25","doi-asserted-by":"publisher","first-page":"112","DOI":"10.2337\/CD17-0094","volume":"36","author":"AS Runge","year":"2018","unstructured":"Runge AS, Kennedy L, Brown AS et al (2018) Does time-in-range matter? Perspectives from people with diabetes on the success of current therapies and the drivers of improved outcomes. Clin Diabetes 36(2):112\u2013119. https:\/\/doi.org\/10.2337\/CD17-0094","journal-title":"Clin Diabetes"},{"issue":"3","key":"2284_CR26","doi-asserted-by":"publisher","first-page":"100245","DOI":"10.1016\/J.XAGR.2023.100245","volume":"3","author":"SM Thayer","year":"2023","unstructured":"Thayer SM, Williams KJ, Lawlor ML (2023) The role of technology in the care of diabetes mellitus in pregnancy: an expert review. AJOG Global Rep. 3(3):100245. https:\/\/doi.org\/10.1016\/J.XAGR.2023.100245","journal-title":"AJOG Global Rep."},{"issue":"4","key":"2284_CR27","doi-asserted-by":"publisher","first-page":"969","DOI":"10.2337\/DC20-2250","volume":"44","author":"OJ Collyns","year":"2021","unstructured":"Collyns OJ, Meier RA, Betts ZL et al (2021) Improved glycemic outcomes with medtronic MiniMed Advanced Hybrid Closed-Loop delivery: results from a randomized crossover trial comparing automated insulin delivery with predictive low glucose suspend in people with type 1 diabetes. Diabetes Care 44(4):969\u2013975. https:\/\/doi.org\/10.2337\/DC20-2250","journal-title":"Diabetes Care"},{"issue":"2","key":"2284_CR28","doi-asserted-by":"publisher","first-page":"406","DOI":"10.2337\/DC10-1796","volume":"34","author":"HR Murphy","year":"2011","unstructured":"Murphy HR, Elleri D, Allen JM et al (2011) Closed-loop insulin delivery during pregnancy complicated by type 1 diabetes. Diabetes Care 34(2):406\u2013411. https:\/\/doi.org\/10.2337\/DC10-1796","journal-title":"Diabetes Care"},{"issue":"3","key":"2284_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/J.DIABET.2020.10.004","volume":"47","author":"N Tubiana-Rufi","year":"2021","unstructured":"Tubiana-Rufi N, Schaepelynck P, Franc S et al (2021) Practical implementation of automated closed-loop insulin delivery: a French position statement. Diabetes Metab 47(3):101206. https:\/\/doi.org\/10.1016\/J.DIABET.2020.10.004","journal-title":"Diabetes Metab"},{"issue":"10110","key":"2284_CR30","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1016\/S0140-6736(17)32400-5","volume":"390","author":"DS Feig","year":"2017","unstructured":"Feig DS, Donovan LE, Corcoy R et al (2017) Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial. Lancet 390(10110):2347\u20132359. https:\/\/doi.org\/10.1016\/S0140-6736(17)32400-5","journal-title":"Lancet"},{"issue":"Supplement_1","key":"2284_CR31","doi-asserted-by":"publisher","first-page":"S254","DOI":"10.2337\/DC23-S015","volume":"46","author":"NA Elsayed","year":"2023","unstructured":"Elsayed NA, Aleppo G, Aroda VR et al (2023) 15. Management of diabetes in pregnancy: standards of care in diabetes\u20142023. Diabetes Care 46(Supplement_1):S254\u2013S266. https:\/\/doi.org\/10.2337\/DC23-S015","journal-title":"Diabetes Care"},{"issue":"3","key":"2284_CR32","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/XEB.0000000000000065","volume":"13","author":"C Tufanaru","year":"2015","unstructured":"Tufanaru C, Munn Z, Stephenson M, Aromataris E (2015) Fixed or random effects meta-analysis? Common methodological issues in systematic reviews of effectiveness. Int J Evid Based Healthc 13(3):196\u2013207. https:\/\/doi.org\/10.1097\/XEB.0000000000000065","journal-title":"Int J Evid Based Healthc"},{"issue":"2","key":"2284_CR33","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1111\/DOM.15357","volume":"26","author":"M Lei","year":"2024","unstructured":"Lei M, Chen D, Ling P et al (2024) Effect of artificial pancreas system use on glycaemic control among pregnant women with type 1 diabetes mellitus: A meta-analysis of randomized controlled trials. Diabetes Obes Metab 26(2):673\u2013681. https:\/\/doi.org\/10.1111\/DOM.15357","journal-title":"Diabetes Obes Metab"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-024-02284-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00592-024-02284-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-024-02284-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T17:05:18Z","timestamp":1718643918000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00592-024-02284-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,3]]},"references-count":33,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["2284"],"URL":"https:\/\/doi.org\/10.1007\/s00592-024-02284-3","relation":{},"ISSN":["1432-5233"],"issn-type":[{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,3]]},"assertion":[{"value":"28 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers\u2019 bureaus; membership, employment, consultancies, stock ownership or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This is a systematic review and meta-analysis. No ethical approval was required as no new patient data was collected.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors report no relationships that could be construed as a conflict of interest. All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation. There were no external funding sources for this study.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}