{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:13:19Z","timestamp":1740107599126,"version":"3.37.3"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Aims<\/jats:title>\n                <jats:p>In this study we evaluated the use of Continuous Glucose Monitoring system in adults with insulin-dependent diabetes in the course of Wolfram syndrome (WFS) in comparison to patients with type 1 diabetes (T1D).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Individuals with WFS (N\u2009=\u200910) used continuous glucose monitoring for 14 days and were compared with 30 patients with T1D matched using propensity score for age and diabetes duration. Glycemic variability was calculated with Glyculator 3.0.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We revealed significant differences in glycemic indices between adults with Wolfram syndrome-related diabetes and matched comparison group. Patients with Wolfram syndrome presented lower mean glucose in 24-h and nighttime records [24h: 141.1\u2009\u00b1\u200930.4mg\/dl (N\u2009=\u200910) vs 164.9\u2009\u00b1\u200931.3mg\/dl (N\u2009=\u200930), p\u2009=\u20090.0427; nighttime: 136.7\u2009\u00b1\u200939.6mg\/dl vs 166.2\u2009\u00b1\u200932.1mg\/dl (N\u2009=\u200930), p\u2009=\u20090.0442]. Moreover, they showed lower standard deviation of sensor glucose over all periods [24h: 50.3\u2009\u00b1\u20099.2mg\/dl (N\u2009=\u200910) vs 67.7\u2009\u00b1\u200918.7 mg\/dl (N\u2009=\u200930), p\u2009=\u20090.0075; daytime: 50.8\u2009\u00b1\u20098.7mg\/dl (N\u2009=\u200910) vs 67.4\u2009\u00b1\u200918.0mg\/dl (N\u2009=\u200930), p\u2009=\u20090.0082; nighttime: 45.1\u2009\u00b1\u200914.9mg\/dl (N\u2009=\u200910) vs 65.8\u2009\u00b1\u200923.2mg\/dl (n\u2009=\u200930), p\u2009=\u20090.0119] and coefficient of variation at night [33.3\u2009\u00b1\u20095.8% (N\u2009=\u200910) vs 40.5\u2009\u00b1\u20098.8% (N\u2009=\u200930), p\u2009=\u20090.0210]. Additionally, WFS patients displayed lower time in high-range hyperglycemia (&gt;\u2009250mg\/dl) across all parts of day [24h: 4.6\u2009\u00b1\u20093.8% (N\u2009=\u200910) vs 13.4\u2009\u00b1\u200910.5% (N\u2009=\u200930), p\u2009=\u20090.0004; daytime: 4.7\u2009\u00b1\u20093.9% (N\u2009=\u200910) vs 13.8\u2009\u00b1\u200911.2% (N\u2009=\u200930), p\u2009=\u20090.0005; nighttime: 4.2\u2009\u00b1\u20095.5% (N\u2009=\u200910) vs 12.1\u2009\u00b1\u200910.3% (N\u2009=\u200930), p\u2009=\u20090.0272].<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Adult patients with Wolfram syndrome show lower mean blood glucose, less extreme hyperglycemia, and lower glycemic variability in comparison to patients with type 1 diabetes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00592-024-02350-w","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T15:02:09Z","timestamp":1722697329000},"page":"1333-1338","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Continuous glycemic monitoring in managing diabetes in adult patients with wolfram syndrome"],"prefix":"10.1007","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8781-4469","authenticated-orcid":false,"given":"Agnieszka","family":"Zmys\u0142owska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8779-3907","authenticated-orcid":false,"given":"Julia","family":"Grzybowska-Adamowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6088-9636","authenticated-orcid":false,"given":"Arkadiusz","family":"Michalak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7695-5474","authenticated-orcid":false,"given":"Julia","family":"Wykrota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8281-4408","authenticated-orcid":false,"given":"Agnieszka","family":"Szadkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2714-5851","authenticated-orcid":false,"given":"Wojciech","family":"M\u0142ynarski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5083-9168","authenticated-orcid":false,"given":"Wojciech","family":"Fendler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,3]]},"reference":[{"issue":"S3","key":"2350_CR1","doi-asserted-by":"publisher","first-page":"S25","DOI":"10.1089\/dia.2017.0035","volume":"19","author":"D Rodbard","year":"2017","unstructured":"Rodbard D (2017) Continuous glucose monitoring: a review of recent studies demonstrating Improved Glycemic outcomes. Diabetes Technol Ther 19(S3):S25\u2013S37. https:\/\/doi.org\/10.1089\/dia.2017.0035","journal-title":"Diabetes Technol Ther"},{"issue":"6","key":"2350_CR2","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1007\/s00592-015-0757-5","volume":"52","author":"A Zmyslowska","year":"2015","unstructured":"Zmyslowska A, Fendler W, Szadkowska A, Borowiec M, Mysliwiec M, Baranowska-Jazwiecka A, Buraczewska M, Fulmanska-Anders M, Mianowska B, Pietrzak I, Rzeznik D, Mlynarski W (2015) Glycemic variability in patients with Wolfram syndrome is lower than in type 1 diabetes. Acta Diabetol 52(6):1057\u20131062. https:\/\/doi.org\/10.1007\/s00592-015-0757-5","journal-title":"Acta Diabetol"},{"issue":"5","key":"2350_CR3","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.3390\/ijerph19052755","volume":"19","author":"D Iafusco","year":"2022","unstructured":"Iafusco D, Zanfardino A, Piscopo A, Curto S, Troncone A, Chianese A, Rollato AS, Testa V, Iafusco F, Maione G, Pennarella A, Boccabella L, Ozen G, Palma PL, Mazzaccara C, Tinto N, Giudice MD, E (2022) Metabolic treatment of Wolfram Syndrome. Int J Environ Res Public Health 19(5):2755. https:\/\/doi.org\/10.3390\/ijerph19052755","journal-title":"Int J Environ Res Public Health"},{"issue":"5","key":"2350_CR4","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1111\/j.1365-2265.2011.04102.x","volume":"75","author":"A Zmyslowska","year":"2011","unstructured":"Zmyslowska A, Borowiec M, Antosik K, Szalecki M, Stefanski A, Iwaniszewska B, Jedrzejczyk M, Pietrzak I, Mlynarski W (2011) Wolfram syndrome in the Polish population: novel mutations and genotype-phenotype correlation. Clin Endocrinol 75(5):636\u2013641. https:\/\/doi.org\/10.1111\/j.1365-2265.2011.04102.x","journal-title":"Clin Endocrinol"},{"key":"2350_CR5","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-0534","author":"J Chrzanowski","year":"2023","unstructured":"Chrzanowski J, Grabia S, Michalak A, Wielgus A, Wykrota J, Mianowska B, Szadkowska A, Fendler W, Data Sharing (2023) Diabetes Care 46(1):e3\u2013e5. https:\/\/doi.org\/10.2337\/dc22-0534. GlyCulator 3.0: A Fast, Easy-to-Use Analytical Tool for CGM Data Analysis, Aggregation, Center Benchmarking"},{"issue":"8","key":"2350_CR6","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.2337\/dci19-0028","volume":"42","author":"T Battelino","year":"2019","unstructured":"Battelino T, Danne T, Bergenstal RM, Amiel SA, Beck R, Biester T, Bosi E, Buckingham BA, Cefalu WT, Close KL, Cobelli C, Dassau E, DeVries JH, Donaghue KC, Dovc K, Doyle FJ 3rd, Garg S, Grunberger G, Heller S, Heinemann L, Phillip M (2019) Clinical targets for continuous glucose Monitoring Data Interpretation: recommendations from the International Consensus on Time in Range. Diabetes Care 42(8):1593\u20131603. https:\/\/doi.org\/10.2337\/dci19-0028","journal-title":"Diabetes Care"},{"issue":"9","key":"2350_CR7","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.2337\/dc07-0380","volume":"30","author":"A Cano","year":"2007","unstructured":"Cano A, Molines L, Val\u00e9ro R, Simonin G, Paquis-Flucklinger V, Vialettes B, French Group of Wolfram Syndrome (2007) Microvascular diabetes complications in Wolfram syndrome (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness [DIDMOAD]): an age- and duration-matched comparison with common type 1 diabetes. Diabetes Care 30(9):2327\u20132330. https:\/\/doi.org\/10.2337\/dc07-0380","journal-title":"Diabetes Care"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-024-02350-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00592-024-02350-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-024-02350-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T13:15:57Z","timestamp":1729170957000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00592-024-02350-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,3]]},"references-count":7,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["2350"],"URL":"https:\/\/doi.org\/10.1007\/s00592-024-02350-w","relation":{"references":[{"id-type":"uri","id":"","asserted-by":"subject"}]},"ISSN":["1432-5233"],"issn-type":[{"type":"electronic","value":"1432-5233"}],"subject":[],"published":{"date-parts":[[2024,8,3]]},"assertion":[{"value":"15 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations of interest"}}]}}