{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:26:04Z","timestamp":1768926364989,"version":"3.49.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370839"],"award-info":[{"award-number":["82370839"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100887"],"award-info":[{"award-number":["82100887"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670715"],"award-info":[{"award-number":["81670715"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900708"],"award-info":[{"award-number":["81900708"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Jiangsu Province Youth Medical Talents Project","award":["QNRC2016584"],"award-info":[{"award-number":["QNRC2016584"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"DOI":"10.1007\/s00592-024-02389-9","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T14:02:54Z","timestamp":1729173774000},"page":"695-706","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A regulatory variant rs9379874 in T1D risk region 6p22.2 affects BTN3A1 expression regulating T cell function"],"prefix":"10.1007","volume":"62","author":[{"given":"Liying","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saisai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuanfeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7773-0055","authenticated-orcid":false,"given":"Heng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"2389_CR1","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1126\/science.abh1654","volume":"373","author":"JA Bluestone","year":"2021","unstructured":"Bluestone JA, Buckner JH, Herold KC, Immunotherapy (2021) Building a bridge to a cure for type 1 diabetes. Science 373:510\u2013516. https:\/\/doi.org\/10.1126\/science.abh1654","journal-title":"Science"},{"key":"2389_CR2","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1016\/s0140-6736(16)30582-7","volume":"387","author":"F Pociot","year":"2016","unstructured":"Pociot F, Lernmark \u00c5 (2016) Genetic risk factors for type 1 diabetes. Lancet 387:2331\u20132339. https:\/\/doi.org\/10.1016\/s0140-6736(16)30582-7","journal-title":"Lancet"},{"key":"2389_CR3","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/s41586-021-03552-w","volume":"594","author":"J Chiou","year":"2021","unstructured":"Chiou J, Geusz RJ, Okino ML, Han JY, Miller M, Melton R et al (2021) Interpreting type 1 diabetes risk with genetics and single-cell epigenomics. Nature 594:398\u2013402. https:\/\/doi.org\/10.1038\/s41586-021-03552-w","journal-title":"Nature"},{"key":"2389_CR4","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/s2213-8587(22)00159-0","volume":"10","author":"MJ Redondo","year":"2022","unstructured":"Redondo MJ, Gignoux CR, Dabelea D, Hagopian WA, Onengut-Gumuscu S, Oram RA et al (2022) Type 1 diabetes in diverse ancestries and the use of genetic risk scores. Lancet Diabetes Endocrinol 10:597\u2013608. https:\/\/doi.org\/10.1016\/s2213-8587(22)00159-0","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2389_CR5","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/ng.3245","volume":"47","author":"S Onengut-Gumuscu","year":"2015","unstructured":"Onengut-Gumuscu S, Chen WM, Burren O, Cooper NJ, Quinlan AR, Mychaleckyj JC et al (2015) Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nat Genet 47:381\u2013386. https:\/\/doi.org\/10.1038\/ng.3245","journal-title":"Nat Genet"},{"key":"2389_CR6","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1002\/gepi.21853","volume":"38","author":"M Evangelou","year":"2014","unstructured":"Evangelou M, Smyth DJ, Fortune MD, Burren OS, Walker NM, Guo H et al (2014) A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations. Genet Epidemiol 38:661\u2013670. https:\/\/doi.org\/10.1002\/gepi.21853","journal-title":"Genet Epidemiol"},{"key":"2389_CR7","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.2337\/dc18-2023","volume":"42","author":"M Zhu","year":"2019","unstructured":"Zhu M, Xu K, Chen Y, Gu Y, Zhang M, Luo F et al (2019) Identification of Novel T1D risk loci and their Association with Age and Islet function at diagnosis in Autoantibody-positive T1D individuals: based on a two-stage genome-wide Association study. Diabetes Care 42:1414\u20131421. https:\/\/doi.org\/10.2337\/dc18-2023","journal-title":"Diabetes Care"},{"key":"2389_CR8","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41576-019-0127-1","volume":"20","author":"V Tam","year":"2019","unstructured":"Tam V, Patel N, Turcotte M, Boss\u00e9 Y, Par\u00e9 G, Meyre D (2019) Benefits and limitations of genome-wide association studies. Nat Rev Genet 20:467\u2013484. https:\/\/doi.org\/10.1038\/s41576-019-0127-1","journal-title":"Nat Rev Genet"},{"key":"2389_CR9","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1126\/science.1156409","volume":"322","author":"D Altshuler","year":"2008","unstructured":"Altshuler D, Daly MJ, Lander ES (2008) Genetic mapping in human disease. Science 322:881\u2013888. https:\/\/doi.org\/10.1126\/science.1156409","journal-title":"Science"},{"key":"2389_CR10","doi-asserted-by":"publisher","first-page":"9362","DOI":"10.1073\/pnas.0903103106","volume":"106","author":"LA Hindorff","year":"2009","unstructured":"Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, Collins FS et al (2009) Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A 106:9362\u20139367. https:\/\/doi.org\/10.1073\/pnas.0903103106","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2389_CR11","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/s41588-018-0084-1","volume":"50","author":"A Mahajan","year":"2018","unstructured":"Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY et al (2018) Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nat Genet 50:559\u2013571. https:\/\/doi.org\/10.1038\/s41588-018-0084-1","journal-title":"Nat Genet"},{"key":"2389_CR12","doi-asserted-by":"publisher","first-page":"e1006719","DOI":"10.1371\/journal.pgen.1006719","volume":"13","author":"MCY Ng","year":"2017","unstructured":"Ng MCY, Graff M, Lu Y, Justice AE, Mudgal P, Liu CT et al (2017) Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African ancestry Anthropometry Genetics Consortium. PLoS Genet 13:e1006719. https:\/\/doi.org\/10.1371\/journal.pgen.1006719","journal-title":"PLoS Genet"},{"key":"2389_CR13","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.1093\/hmg\/ddx280","volume":"26","author":"R M\u00e4gi","year":"2017","unstructured":"M\u00e4gi R, Horikoshi M, Sofer T, Mahajan A, Kitajima H, Franceschini N et al (2017) Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution. Hum Mol Genet 26:3639\u20133650. https:\/\/doi.org\/10.1093\/hmg\/ddx280","journal-title":"Hum Mol Genet"},{"key":"2389_CR14","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.ajhg.2013.10.012","volume":"93","author":"SL Edwards","year":"2013","unstructured":"Edwards SL, Beesley J, French JD, Dunning AM (2013) Beyond GWASs: illuminating the dark road from association to function. Am J Hum Genet 93:779\u2013797. https:\/\/doi.org\/10.1016\/j.ajhg.2013.10.012","journal-title":"Am J Hum Genet"},{"key":"2389_CR15","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1038\/ng.3437","volume":"47","author":"KJ Gaulton","year":"2015","unstructured":"Gaulton KJ, Ferreira T, Lee Y, Raimondo A, M\u00e4gi R, Reschen ME et al (2015) Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet 47:1415\u20131425. https:\/\/doi.org\/10.1038\/ng.3437","journal-title":"Nat Genet"},{"key":"2389_CR16","doi-asserted-by":"publisher","unstructured":"Thurner M, van de Bunt M, Torres JM, Mahajan A, Nylander V, Bennett AJ et al (2018) Integration of human pancreatic islet genomic data refines regulatory mechanisms at type 2 diabetes susceptibility loci. Elife 7. https:\/\/doi.org\/10.7554\/eLife.31977","DOI":"10.7554\/eLife.31977"},{"key":"2389_CR17","doi-asserted-by":"publisher","first-page":"898893","DOI":"10.3389\/fendo.2022.898893","volume":"13","author":"H Dai","year":"2022","unstructured":"Dai H, Qian Y, Lv H, Jiang L, Jiang H, Shen M et al (2022) Rs864745 in JAZF1, an islet function Associated variant, correlates with plasma lipid levels in both type 1 and type 2 diabetes status, but not healthy subjects. Front Endocrinol (Lausanne) 13:898893. https:\/\/doi.org\/10.3389\/fendo.2022.898893","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2389_CR18","doi-asserted-by":"publisher","first-page":"784","DOI":"10.2337\/db19-0831","volume":"69","author":"V Forgetta","year":"2020","unstructured":"Forgetta V, Manousaki D, Istomine R, Ross S, Tessier MC, Marchand L et al (2020) Rare genetic variants of large effect influence risk of type 1 diabetes. Diabetes 69:784\u2013795. https:\/\/doi.org\/10.2337\/db19-0831","journal-title":"Diabetes"},{"key":"2389_CR19","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.ajhg.2017.06.005","volume":"101","author":"PM Visscher","year":"2017","unstructured":"Visscher PM, Wray NR, Zhang Q, Sklar P, McCarthy MI, Brown MA et al (2017) 10 years of GWAS Discovery: Biology, function, and translation. Am J Hum Genet 101:5\u201322. https:\/\/doi.org\/10.1016\/j.ajhg.2017.06.005","journal-title":"Am J Hum Genet"},{"key":"2389_CR20","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s00393-014-1415-y","volume":"74","author":"YH Lee","year":"2015","unstructured":"Lee YH, Bae SC, Kim JH, Song GG (2015) Meta-analysis of genetic polymorphisms in programmed cell death 1. Associations with rheumatoid arthritis, ankylosing spondylitis, and type 1 diabetes susceptibility. Z Rheumatol 74:230\u2013239. https:\/\/doi.org\/10.1007\/s00393-014-1415-y","journal-title":"Z Rheumatol"},{"key":"2389_CR21","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1007\/s00592-018-1152-9","volume":"55","author":"Y Gu","year":"2018","unstructured":"Gu Y, Xiao L, Gu W, Chen S, Feng Y, Wang J et al (2018) Rs2227982 and rs2227981 in PDCD1 gene are functional SNPs associated with T1D risk in east Asian. Acta Diabetol 55:813\u2013819. https:\/\/doi.org\/10.1007\/s00592-018-1152-9","journal-title":"Acta Diabetol"},{"key":"2389_CR22","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s11892-015-0655-9","volume":"15","author":"T Fl\u00f8yel","year":"2015","unstructured":"Fl\u00f8yel T, Kaur S, Pociot F (2015) Genes affecting \u03b2-cell function in type 1 diabetes. Curr Diab Rep 15:97. https:\/\/doi.org\/10.1007\/s11892-015-0655-9","journal-title":"Curr Diab Rep"},{"key":"2389_CR23","doi-asserted-by":"publisher","first-page":"e64632","DOI":"10.1371\/journal.pone.0064632","volume":"8","author":"ML Andersen","year":"2013","unstructured":"Andersen ML, Rasmussen MA, P\u00f6rksen S, Svensson J, Vikre-J\u00f8rgensen J, Thomsen J et al (2013) Complex multi-block analysis identifies new immunologic and genetic disease progression patterns associated with the residual \u03b2-cell function 1 year after diagnosis of type 1 diabetes. PLoS ONE 8:e64632. https:\/\/doi.org\/10.1371\/journal.pone.0064632","journal-title":"PLoS ONE"},{"key":"2389_CR24","doi-asserted-by":"publisher","first-page":"10305","DOI":"10.1073\/pnas.1402571111","volume":"111","author":"T Fl\u00f8yel","year":"2014","unstructured":"Fl\u00f8yel T, Brorsson C, Nielsen LB, Miani M, Bang-Berthelsen CH, Friedrichsen M et al (2014) CTSH regulates \u03b2-cell function and disease progression in newly diagnosed type 1 diabetes patients. Proc Natl Acad Sci U S A 111:10305\u201310310. https:\/\/doi.org\/10.1073\/pnas.1402571111","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2389_CR25","doi-asserted-by":"publisher","first-page":"e1002216","DOI":"10.1371\/journal.pgen.1002216","volume":"7","author":"V Plagnol","year":"2011","unstructured":"Plagnol V, Howson JM, Smyth DJ, Walker N, Hafler JP, Wallace C et al (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genet 7:e1002216. https:\/\/doi.org\/10.1371\/journal.pgen.1002216","journal-title":"PLoS Genet"},{"issue":"Suppl 2","key":"2389_CR26","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.2337\/dcs15-2003","volume":"38","author":"CA Brorsson","year":"2015","unstructured":"Brorsson CA, Pociot F (2015) Shared genetic basis for type 1 diabetes, islet autoantibodies, and autoantibodies Associated With Other Immune-mediated diseases in families with type 1 diabetes. Diabetes Care 38(Suppl 2):S8\u201313. https:\/\/doi.org\/10.2337\/dcs15-2003","journal-title":"Diabetes Care"},{"key":"2389_CR27","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/s10038-019-0705-2","volume":"65","author":"Y Feng","year":"2019","unstructured":"Feng Y, Zhang Y, Chen Y, Chen S, Shen M, Fu Q et al (2019) The associations between three genome-wide risk variants for serum C-peptide of T1D and autoantibody-positive T1D risk, and clinical characteristics in Chinese population. J Hum Genet 65:297\u2013303. https:\/\/doi.org\/10.1038\/s10038-019-0705-2","journal-title":"J Hum Genet"},{"key":"2389_CR28","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/s41588-021-00880-5","volume":"53","author":"CC Robertson","year":"2021","unstructured":"Robertson CC, Inshaw JRJ, Onengut-Gumuscu S, Chen WM, Santa Cruz DF, Yang H et al (2021) Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes. Nat Genet 53:962\u2013971. https:\/\/doi.org\/10.1038\/s41588-021-00880-5","journal-title":"Nat Genet"},{"key":"2389_CR29","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nature14248","volume":"518","author":"A Kundaje","year":"2015","unstructured":"Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A et al (2015) Integrative analysis of 111 reference human epigenomes. Nature 518:317\u2013330. https:\/\/doi.org\/10.1038\/nature14248","journal-title":"Nature"},{"key":"2389_CR30","doi-asserted-by":"publisher","first-page":"406","DOI":"10.2337\/dc18-1727","volume":"42","author":"S Onengut-Gumuscu","year":"2019","unstructured":"Onengut-Gumuscu S, Chen WM, Robertson CC, Bonnie JK, Farber E, Zhu Z et al (2019) Type 1 diabetes risk in african-ancestry participants and utility of an ancestry-specific genetic risk score. Diabetes Care 42:406\u2013415. https:\/\/doi.org\/10.2337\/dc18-1727","journal-title":"Diabetes Care"},{"key":"2389_CR31","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1038\/s41588-021-00945-5","volume":"53","author":"E Mountjoy","year":"2021","unstructured":"Mountjoy E, Schmidt EM, Carmona M, Schwartzentruber J, Peat G, Miranda A et al (2021) An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci. Nat Genet 53:1527\u20131533. https:\/\/doi.org\/10.1038\/s41588-021-00945-5","journal-title":"Nat Genet"},{"key":"2389_CR32","doi-asserted-by":"publisher","first-page":"e1278099","DOI":"10.1080\/2162402x.2016.1278099","volume":"6","author":"MR Zocchi","year":"2017","unstructured":"Zocchi MR, Costa D, Ven\u00e8 R, Tosetti F, Ferrari N, Minghelli S et al (2017) Zoledronate can induce colorectal cancer microenvironment expressing BTN3A1 to stimulate effector \u03b3\u03b4 T cells with antitumor activity. Oncoimmunology 6:e1278099. https:\/\/doi.org\/10.1080\/2162402x.2016.1278099","journal-title":"Oncoimmunology"},{"key":"2389_CR33","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.it.2021.06.002","volume":"42","author":"M Rigau","year":"2021","unstructured":"Rigau M, Uldrich AP, Behren A (2021) Targeting butyrophilins for cancer immunotherapy. Trends Immunol 42:670\u2013680. https:\/\/doi.org\/10.1016\/j.it.2021.06.002","journal-title":"Trends Immunol"},{"key":"2389_CR34","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1126\/science.aay2767","volume":"369","author":"KK Payne","year":"2020","unstructured":"Payne KK, Mine JA, Biswas S, Chaurio RA, Perales-Puchalt A, Anadon CM et al (2020) BTN3A1 governs antitumor responses by coordinating \u03b1\u03b2 and \u03b3\u03b4 T cells. Science 369:942\u2013949. https:\/\/doi.org\/10.1126\/science.aay2767","journal-title":"Science"},{"key":"2389_CR35","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.immuni.2014.03.003","volume":"40","author":"A Sandstrom","year":"2014","unstructured":"Sandstrom A, Peign\u00e9 CM, L\u00e9ger A, Crooks JE, Konczak F, Gesnel MC et al (2014) The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human V\u03b39V\u03b42 T cells. Immunity 40:490\u2013500. https:\/\/doi.org\/10.1016\/j.immuni.2014.03.003","journal-title":"Immunity"},{"key":"2389_CR36","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1038\/s41419-022-05429-w","volume":"13","author":"W Yang","year":"2022","unstructured":"Yang W, Cheng B, Chen P, Sun X, Wen Z, Cheng Y (2022) BTN3A1 promotes tumor progression and radiation resistance in esophageal squamous cell carcinoma by regulating ULK1-mediated autophagy. Cell Death Dis 13:984. https:\/\/doi.org\/10.1038\/s41419-022-05429-w","journal-title":"Cell Death Dis"},{"key":"2389_CR37","doi-asserted-by":"publisher","first-page":"e2117523119","DOI":"10.1073\/pnas.2117523119","volume":"119","author":"J Zhou","year":"2022","unstructured":"Zhou J, Zhang J, Tao L, Peng K, Zhang Q, Yan K et al (2022) Up-regulation of BTN3A1 on CD14(+) cells promotes V\u03b39V\u03b42 T cell activation in psoriasis. Proc Natl Acad Sci U S A 119:e2117523119. https:\/\/doi.org\/10.1073\/pnas.2117523119","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2389_CR38","doi-asserted-by":"publisher","first-page":"343","DOI":"10.3389\/fendo.2017.00343","volume":"8","author":"AL Burrack","year":"2017","unstructured":"Burrack AL, Martinov T, Fife BT (2017) T cell-mediated Beta Cell Destruction: autoimmunity and alloimmunity in the context of type 1 diabetes. Front Endocrinol (Lausanne) 8:343. https:\/\/doi.org\/10.3389\/fendo.2017.00343","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2389_CR39","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.immuni.2019.01.020","volume":"50","author":"JB Wing","year":"2019","unstructured":"Wing JB, Tanaka A, Sakaguchi S (2019) Human FOXP3(+) Regulatory T cell heterogeneity and function in autoimmunity and Cancer. Immunity 50:302\u2013316. https:\/\/doi.org\/10.1016\/j.immuni.2019.01.020","journal-title":"Immunity"},{"key":"2389_CR40","doi-asserted-by":"publisher","first-page":"109157","DOI":"10.1016\/j.clim.2022.109157","volume":"245","author":"H Feng","year":"2022","unstructured":"Feng H, Guo Z, Chen X, Liu K, Li H, Jia W et al (2022) Excessive HSP70\/TLR2 activation leads to remodeling of the tumor immune microenvironment to resist chemotherapy sensitivity of mFOLFOX in colorectal cancer. Clin Immunol 245:109157. https:\/\/doi.org\/10.1016\/j.clim.2022.109157","journal-title":"Clin Immunol"},{"key":"2389_CR41","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s12026-019-09080-0","volume":"67","author":"SI Vlaicu","year":"2019","unstructured":"Vlaicu SI, Tatomir A, Anselmo F, Boodhoo D, Chira R, Rus V et al (2019) RGC-32 and diseases: the first 20 years. Immunol Res 67:267\u2013279. https:\/\/doi.org\/10.1007\/s12026-019-09080-0","journal-title":"Immunol Res"},{"key":"2389_CR42","doi-asserted-by":"publisher","unstructured":"Tebbenkamp ATN, Varela L, Choi J, Paredes MI, Giani AM, Song JE et al (2018) The 7q11.23 protein DNAJC30 interacts with ATP synthase and Links Mitochondria to Brain Development. Cell 175 1088\u2013\u2009104.e23. https:\/\/doi.org\/10.1016\/j.cell.2018.09.014","DOI":"10.1016\/j.cell.2018.09.014"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-024-02389-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00592-024-02389-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-024-02389-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T20:01:53Z","timestamp":1748376113000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00592-024-02389-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,17]]},"references-count":42,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["2389"],"URL":"https:\/\/doi.org\/10.1007\/s00592-024-02389-9","relation":{},"ISSN":["1432-5233"],"issn-type":[{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,17]]},"assertion":[{"value":"9 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The First Affiliated Hospital of Nanjing Medical University reviewed and approved the studies involving human participants. The participant\u2019s legal guardian\/next of kin provided written informed consent to participate in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}