{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:56:47Z","timestamp":1771477007713,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20352"],"award-info":[{"award-number":["U20A20352"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guang Dong Clinical Research Center for Metabolic Diseases","award":["2020B1111170009"],"award-info":[{"award-number":["2020B1111170009"]}]},{"name":"Guang Zhou key laboratory for Metabolic Diseases","award":["202102100004"],"award-info":[{"award-number":["202102100004"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"DOI":"10.1007\/s00592-025-02518-y","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T11:11:55Z","timestamp":1758107515000},"page":"115-122","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Modified cut-off value of the urine albumin-to-creatinine ratio is helpful for identifying patients at high risk for chronic kidney disease in prediabetes"],"prefix":"10.1007","volume":"63","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinli","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9935-1449","authenticated-orcid":false,"given":"Meng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"issue":"24","key":"2518_CR1","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1001\/jama.2017.7596","volume":"317","author":"L Wang","year":"2017","unstructured":"Wang L, Gao P, Zhang M et al (2017) Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013. JAMA 317(24):2515\u20132523","journal-title":"JAMA"},{"issue":"9","key":"2518_CR2","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1001\/jama.2013.168118","volume":"310","author":"Y Xu","year":"2013","unstructured":"Xu Y, Wang L, He J et al (2013) Prevalence and control of diabetes in Chinese adults. JAMA 310(9):948\u2013959","journal-title":"JAMA"},{"key":"2518_CR3","doi-asserted-by":"crossref","unstructured":"Li W, Wang A, Jiang J et al (2020) Risk of chronic kidney disease defined by decreased estimated glomerular filtration rate in individuals with different prediabetic phenotypes: results from a prospective cohort study in China. BMJ Open Diabetes Res Care 8(1):e000955","DOI":"10.1136\/bmjdrc-2019-000955"},{"issue":"3","key":"2518_CR4","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.numecd.2017.12.005","volume":"28","author":"MRP Markus","year":"2018","unstructured":"Markus MRP, Ittermann T, Baumeister SE et al (2018) Prediabetes is associated with microalbuminuria, reduced kidney function and chronic kidney disease in the general population: the KORA (Cooperative health research in the Augsburg Region) F4-Study. Nutr Metab Cardiovasc Dis 28(3):234\u2013242","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"5","key":"2518_CR5","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.jacc.2021.05.004","volume":"78","author":"MC Honigberg","year":"2021","unstructured":"Honigberg MC, Zekavat SM, Pirruccello JP et al (2021) Cardiovascular and kidney outcomes across the glycemic spectrum: insights from the UK biobank. J Am Coll Cardiol 78(5):453\u2013464","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"2518_CR6","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12882-019-1307-0","volume":"20","author":"GS Kim","year":"2019","unstructured":"Kim GS, Oh HH, Kim SH et al (2019) Association between prediabetes (defined by HbA1(C), fasting plasma glucose, and impaired glucose tolerance) and the development of chronic kidney disease: a 9-year prospective cohort study. BMC Nephrol 20(1):130","journal-title":"BMC Nephrol"},{"key":"2518_CR7","doi-asserted-by":"crossref","unstructured":"Chen H, Wilson J, Ercanbrack C et al (2021) Genome-Wide screening of oxidizing agent resistance genes in Escherichia coli. Antioxid (Basel);10(6):861","DOI":"10.3390\/antiox10060861"},{"issue":"2","key":"2518_CR8","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/joim.13736","volume":"295","author":"F Arnold","year":"2024","unstructured":"Arnold F, Kappes J, Rottmann FA et al (2024) HbA1c-dependent projection of long-term renal outcomes. J Intern Med 295(2):206\u2013215","journal-title":"J Intern Med"},{"key":"2518_CR9","doi-asserted-by":"crossref","unstructured":"Kim H, Park S, Kwon SH et al (2020) Impaired fasting glucose and development of chronic kidney disease in non-diabetic population: a Mendelian randomization study. BMJ Open Diabetes Res Care 8(1):e001395","DOI":"10.1136\/bmjdrc-2020-001395"},{"key":"2518_CR10","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.diabres.2018.10.026","volume":"146","author":"T Koshi","year":"2018","unstructured":"Koshi T, Sagesaka H, Sato Y et al (2018) Elevated haemoglobin A1c but not fasting plasma glucose conveys risk of chronic kidney disease in non-diabetic individuals. Diabetes Res Clin Pract 146:233\u2013239","journal-title":"Diabetes Res Clin Pract"},{"issue":"3","key":"2518_CR11","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1055\/s-0041-1731107","volume":"13","author":"AS Shilpasree","year":"2021","unstructured":"Shilpasree AS, Patil VS, Revanasiddappa M et al (2021) Renal dysfunction in prediabetes: confirmed by glomerular hyperfiltration and albuminuria. J Lab Physicians 13(3):257\u2013262","journal-title":"J Lab Physicians"},{"issue":"2","key":"2518_CR12","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1111\/j.1753-0407.2012.00182.x","volume":"4","author":"G Ning","year":"2012","unstructured":"Ning G, Reaction Study G (2012) Risk evaluation of cAncers in Chinese diabetic individuals: a lONgitudinal (REACTION) study. J Diabetes 4(2):172\u2013173","journal-title":"J Diabetes"},{"issue":"5","key":"2518_CR13","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1053\/j.ajkd.2014.01.416","volume":"63","author":"LA Inker","year":"2014","unstructured":"Inker LA, Astor BC, Fox CH et al (2014) KDOQI US commentary on the 2012 KDIGO clinical practice guideline for the evaluation and management of CKD. Am J Kidney Dis 63(5):713\u2013735","journal-title":"Am J Kidney Dis"},{"issue":"10","key":"2518_CR14","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.2337\/diacare.28.10.2436","volume":"28","author":"CS Fox","year":"2005","unstructured":"Fox CS, Larson MG, Leip EP et al (2005) Glycemic status and development of kidney disease: the Framingham heart study. Diabetes Care 28(10):2436\u20132440","journal-title":"Diabetes Care"},{"issue":"4","key":"2518_CR15","doi-asserted-by":"publisher","first-page":"e1772","DOI":"10.1210\/clinem\/dgaa017","volume":"105","author":"JS Neves","year":"2020","unstructured":"Neves JS, Correa S, Baeta Baptista R et al (2020) Association of prediabetes with CKD progression and adverse cardiovascular outcomes: an analysis of the CRIC study. J Clin Endocrinol Metab 105(4):e1772\u20131780","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2518_CR16","doi-asserted-by":"publisher","first-page":"e14607","DOI":"10.1111\/dme.14607","volume":"38","author":"M Furukawa","year":"2021","unstructured":"Furukawa M, Onoue T, Kato K et al (2021) Prediabetes is associated with proteinuria development but not with glomerular filtration rate decline: A longitudinal observational study. Diabet Med 38(8):e14607","journal-title":"Diabet Med"},{"issue":"11","key":"2518_CR17","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1097\/HJH.0000000000002936","volume":"39","author":"A Santiago-Hernandez","year":"2021","unstructured":"Santiago-Hernandez A, Martin-Lorenzo M, Martinez PJ et al (2021) Early renal and vascular damage within the normoalbuminuria condition. J Hypertens 39(11):2220\u20132231","journal-title":"J Hypertens"},{"issue":"4","key":"2518_CR18","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.ekir.2018.01.015","volume":"3","author":"T Melsom","year":"2018","unstructured":"Melsom T, Solbu MD, Schei J et al (2018) Mild albuminuria is a risk factor for faster GFR decline in the nondiabetic population. Kidney Int Rep 3(4):817\u2013824","journal-title":"Kidney Int Rep"},{"key":"2518_CR19","doi-asserted-by":"publisher","first-page":"858267","DOI":"10.3389\/fendo.2022.858267","volume":"13","author":"WH Tang","year":"2022","unstructured":"Tang WH, Hung WC, Wang CP et al (2022) The lower limit of reference of urinary albumin\/creatinine ratio and the risk of chronic kidney disease progression in patients with type 2 diabetes mellitus. Front Endocrinol (Lausanne) 13:858267","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"12","key":"2518_CR20","doi-asserted-by":"publisher","first-page":"e0207843","DOI":"10.1371\/journal.pone.0207843","volume":"13","author":"S Hong","year":"2018","unstructured":"Hong S, Choi YM, Ihm SH et al (2018) Association between metabolic parameters and glomerular hyperfiltration in a representative Korean population without chronic kidney disease. PLoS ONE 13(12):e0207843","journal-title":"PLoS ONE"},{"key":"2518_CR21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12902-015-0043-0","volume":"15","author":"W Hu","year":"2015","unstructured":"Hu W, Hao H, Yu W et al (2015) Association of elevated glycosylated hemoglobin A1c with hyperfiltration in a middle-aged and elderly Chinese population with prediabetes or newly diagnosed diabetes: a cross-sectional study. BMC Endocr Disord 15:47","journal-title":"BMC Endocr Disord"},{"issue":"5","key":"2518_CR22","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1177\/1479164118776465","volume":"15","author":"S Low","year":"2018","unstructured":"Low S, Zhang X, Wang J et al (2018) Long-term prospective observation suggests that glomerular hyperfiltration is associated with rapid decline in renal filtration function: A multiethnic study. Diab Vasc Dis Res 15(5):417\u2013423","journal-title":"Diab Vasc Dis Res"},{"key":"2518_CR23","doi-asserted-by":"crossref","unstructured":"Hung CC, Zhen YY, Niu SW et al (2022) Predictive value of HbA1c and metabolic syndrome for renal outcome in Non-Diabetic CKD stage 1\u20134 patients. Biomedicines 10(8):1858","DOI":"10.3390\/biomedicines10081858"},{"issue":"6","key":"2518_CR24","doi-asserted-by":"publisher","first-page":"957","DOI":"10.2215\/CJN.08540814","volume":"10","author":"C Trivin","year":"2015","unstructured":"Trivin C, Metzger M, Haymann JP et al (2015) Glycated hemoglobin level and mortality in a nondiabetic population with CKD. Clin J Am Soc Nephrol 10(6):957\u2013964","journal-title":"Clin J Am Soc Nephrol"},{"issue":"7","key":"2518_CR25","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.3760\/cma.j.issn.0366-6999.20123504","volume":"126","author":"DF Gu","year":"2013","unstructured":"Gu DF, Shi YL, Chen YM et al (2013) Prevalence of chronic kidney disease and prediabetes and associated risk factors: a community-based screening in Zhuhai, Southern China. Chin Med J (Engl) 126(7):1213\u20131219","journal-title":"Chin Med J (Engl)"},{"issue":"5","key":"2518_CR26","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1007\/s11886-014-0476-5","volume":"16","author":"A Shah","year":"2014","unstructured":"Shah A, Kanaya AM (2014) Diabetes and associated complications in the South Asian population. Curr Cardiol Rep 16(5):476","journal-title":"Curr Cardiol Rep"},{"issue":"15","key":"2518_CR27","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1016\/j.cell.2024.06.029","volume":"187","author":"ED Abel","year":"2024","unstructured":"Abel ED, Gloyn AL, Evans-Molina C et al (2024) Diabetes mellitus-Progress and opportunities in the evolving epidemic. Cell 187(15):3789\u20133820","journal-title":"Cell"},{"issue":"6","key":"2518_CR28","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/S0003-4975(10)63092-5","volume":"41","author":"TE David","year":"1986","unstructured":"David TE (1986) Mitral valve replacement with preservation of chordae tendinae: rationale and technical considerations. Ann Thorac Surg 41(6):680\u2013682","journal-title":"Ann Thorac Surg"},{"issue":"4","key":"2518_CR29","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/jch.12668","volume":"18","author":"Y Imaizumi","year":"2016","unstructured":"Imaizumi Y, Eguchi K, Murakami T et al (2016) High salt intake is independently associated with hypertensive target organ damage. J Clin Hypertens (Greenwich) 18(4):315\u2013321","journal-title":"J Clin Hypertens (Greenwich)"},{"issue":"4","key":"2518_CR30","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1093\/ajcn\/nqac174","volume":"116","author":"SN Bhupathiraju","year":"2022","unstructured":"Bhupathiraju SN, Sawicki CM, Goon S et al (2022) A healthy plant-based diet is favorably associated with cardiometabolic risk factors among participants of South Asian ancestry. Am J Clin Nutr 116(4):1078\u20131090","journal-title":"Am J Clin Nutr"},{"key":"2518_CR31","doi-asserted-by":"crossref","unstructured":"Zarantonello D, Brunori G (2023) The role of Plant-Based diets in preventing and mitigating chronic kidney disease: more light than shadows. J Clin Med 12(19):6137","DOI":"10.3390\/jcm12196137"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-025-02518-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00592-025-02518-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-025-02518-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:11:55Z","timestamp":1769515915000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00592-025-02518-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["2518"],"URL":"https:\/\/doi.org\/10.1007\/s00592-025-02518-y","relation":{},"ISSN":["1432-5233"],"issn-type":[{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,17]]},"assertion":[{"value":"28 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No potential competing interests was reported by the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study has been approved by the ethics committee of Shanghai Jiao Tong University. This study is a non-interventional study not involving the human being, leveraging only anonymized structured data, which according to applicable legal requirements do not contain data subject to privacy laws. Hence, obtaining informed consent from patients was not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"As this study involved anonymized structured data, which according to applicable legal requirements do not contain data subject to privacy laws, obtaining consent to publish from patients was not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}